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KR900003157A - 트리아졸 항진균제 - Google Patents

트리아졸 항진균제 Download PDF

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KR900003157A
KR900003157A KR1019890011503A KR890011503A KR900003157A KR 900003157 A KR900003157 A KR 900003157A KR 1019890011503 A KR1019890011503 A KR 1019890011503A KR 890011503 A KR890011503 A KR 890011503A KR 900003157 A KR900003157 A KR 900003157A
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pyridinyl
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피터 디킨슨 로저
리챠드슨 케네스
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데이비드 존 우드
화이자 인코페레이티드
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Abstract

내용 없음

Description

트리아졸 항진균제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (19)

  1. 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염.
    상기식에서, R은 할로 및 CF3중에서 각각 독립적으로 선택된 1 내지 3개의 치환체로 임의 치환된 페닐이고; R1은 C1내지 C4알킬이며; R2는 H 또는 C1 내지 C4이고; "Het"는 환 탄소원자에 의해 인접한 탄소 원자에 결합되어 있고, 피리딘일, 피리다진일, 피리미딘일, 피라진일 및 트리아진일 중에서 선택되며 "Het"는 C1내지 C4알킬, C1내지 C4알콕시, 할로, CF3, CN, NO2, -NH (C1내지 C4알카노일) 또는 -NHCO2(C1내지 C4알킬)로 임의 치환된다.
  2. 제1항에 있어서, "Het"가 C1내지 C4알킬, C1내지 C4알콕시, 할로, CF3, NO2, NH2, 또는 -NH(C1내지 C4알카노일)로 임의 치환된 피리딘일, 피리다진일, 피리미딘일, 피라진일 및 트리아진일 중에서 선택되는 일반식(Ⅰ)의 화합물.
  3. 제1항에 있어서, "Het"가 C1내지 C4알킬, C1내지 C4알콕시, 할로, CF3, CN, NO2, NH2, -NH(C1내지 C4알카노일) 및 -NHCO2(C1내지 C4알킬)중에서 각각 독립적으로 선택된 1 또는 2개의 치환체로 모두 임의 치환된 피리딘일, 피리다진일, 피리미딘일, 피라진일 및 트리아진일 중에서 선택되는 일반식(Ⅰ)의 화합물.
  4. 제3항에 있어서, "Het"가 C1내지 C4알킬, C1내지 C4알콕시, 할로, CF3, CN, NH2, -NH(C1내지 C4알카노일) 및 -NHCO2(C1내지 C4알킬)중에서 각각 독립적으로 선택된 1 또는 2개의 치환체로 모두 임의 치환된 피리딘일, 피리다진일, 피리미딘일, 피라진일 중에서 선택되는 일반식(Ⅰ)의 화합물.
  5. 제4항에 있어서, "Het"가 하나의 CN, NH2또는 -NHCO2(C1내지 C4알킬)치환체로 모두 임의 치환된 피리딘일, 피리다진일, 피리미딘일 및 피라진일 중에서 선택되는 일반식(Ⅰ)의 화합물.
  6. 제1 내지 5항중 어느 한 항에 있어서, "Het"가 2-피리딘일, 4-피리딘일 또는 4-피리미딘일인 일반식(Ⅰ)의 화합물.
  7. 제1항에 있어서, R이 1 내지 3개의 할로치환체로 치환된 페닐 그룹인 일반식(Ⅰ)의 화합물.
  8. 제1항에 있어서, R이 1 내지 2개의 할로치환체로 치환된 페닐 그룹인 일반식(Ⅰ)의 화합물.
  9. 제8항에 있어서, R이 2,4-디플루오로페닐, 2,4-디클로로페닐, 2-플루오로페닐 또는 2-클로로페닐인 일반식(Ⅰ)의 화합물.
  10. 제9항에 있어서, R이 2,4-디플루오로페닐인 일반식(Ⅰ)의 화합물.
  11. 제1항에 있어서, R1이 메틸이고 R2가 H 또는 메틸인 일반식(Ⅰ)의 화합물.
  12. 제11항에 있어서, R1이 메틸이고 R2가 H인 일반식(Ⅰ)의 화합물.
  13. 제1항에 있어서, 2-(2,4-디플루오로페닐)-3-(피리딘-2-일)-1-(1H-1,2,4-트리아졸-1-일)부탄-2-올, 2-(2,4-디플루오로페닐)-3-(피리딘-4-일)-1-(1H-1,2,4-트리아졸-1-일)부탄-2-올 또는 2-(2,4-디플루오로페닐)-3-(피리딘-4-일)-1-(1H-1,2,4-트리아졸-1-일)부탄-2-올인 일반식(Ⅰ)의 화합물; 또는 이의 약제학적으로 허용하는 염.
  14. 제1항에 있어서, R2가 H이며 하기와 같은 (2R, 3S)배위를 갖는 일반식(Ⅰ)의 화합물.
  15. 제1 내지 제14항중 어느 한 항에 따른 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염을 약제학적으로 허용되는 희석제 또는 담체와 함께 함유하는 약제학적 조성물.
  16. 약제로서 사용하기 위한, 제1 내지 14항중 어느한 항에 따른 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염 또는 제15항에 따른 그의 조성물.
  17. 항진균제를 제조하기 위한, 제1 내지 14항중 어느 한 항에 따른 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염 또는 제15항에 따른 그의 조성물의 용도.
  18. 일반식(Ⅳ),(Ⅵ),(Ⅸ) 또는 (Ⅹ)의 화합물.
    상기식에서, R, R1및 R2는 제1항에서 정의한 바와 같고; "Het"은 C1내지 C4알킬, C1내지 C4알콕시, 할로, CF3, CN 또는 NO2로 임의 치환된 피리딘일, 피리다진일, 피리미딘일, 피라진일 또는 트리아진일 그룹이며; Y는 이탈 그룹이다.
  19. 제18항에 있어서, Y가 클로로, 브로모 또는 C1내지 C4알칸설폰일옥시인 일반식(Ⅵ)의 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890011503A 1988-08-13 1989-08-12 트리아졸 항진균제 Expired - Lifetime KR930002729B1 (ko)

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GB888819308A GB8819308D0 (en) 1988-08-13 1988-08-13 Triazole antifungal agents
GB8819308.1 1988-08-13

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KR900003157A true KR900003157A (ko) 1990-03-23
KR930002729B1 KR930002729B1 (ko) 1993-04-09

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GB9107055D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
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