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KR870006894A - 니코란딜의 안정화제제의 제조방법 - Google Patents

니코란딜의 안정화제제의 제조방법 Download PDF

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Publication number
KR870006894A
KR870006894A KR860011645A KR860011645A KR870006894A KR 870006894 A KR870006894 A KR 870006894A KR 860011645 A KR860011645 A KR 860011645A KR 860011645 A KR860011645 A KR 860011645A KR 870006894 A KR870006894 A KR 870006894A
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KR
South Korea
Prior art keywords
acid
nicolandyl
saturated
producing
preparation according
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Application number
KR860011645A
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English (en)
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KR940000232B1 (ko
Inventor
요시미쓰 이이다
슈지 스미다
Original Assignee
우에노 기미오
쥬우 가이세이야꾸 가부시끼 가이샤
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26342067&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR870006894(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 우에노 기미오, 쥬우 가이세이야꾸 가부시끼 가이샤 filed Critical 우에노 기미오
Publication of KR870006894A publication Critical patent/KR870006894A/ko
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Publication of KR940000232B1 publication Critical patent/KR940000232B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

니코란딜의 안정화제제의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 니코딜과 상온에서 고체의 포화 고급 지방산 또는 포화 고급알콜의 1종 또는 2종 이상의 혼합물을 함유함을 특징으로 하는 안정한 니코란딜 제제의 제법.
  2. 니코란딜에 1종 또는 2종 이상의 유기산 및 상온에서 고체의 1종 또는 2종 이상의 포화 고급지방산 및 포화 고급알콜을 혼합함을 특징으로 하는 안정한 니코란딜 제제의 제법.
  3. 제1항에 있어서, 포화 고급지방산이 팔미틴산, 스테아린산으로써 된 군으로부터 선택되는 지방산인 니코란딜 제제의 제조방법.
  4. 제1항에 있어서, 포화 고급알콜이 세틸알콜, 스테아릴알콜로써 된 군으로부터 선택되는 알콜인 니코란딜 제제의 제조방법.
  5. 제2항에 있어서 유기산이 프말산, 수산, 살리틸산, 주석산, 글루탈산으로써 된 군으로 부터 선택되는 2염기산인 니코란딜 제제의 제조방법.
  6. 제2항에 있어서, 유기산의 첨가량이 제제총중량의 0.1중량 %이상인 니코란딜 제제의 제조방법.
  7. 제1 및 2항에 있어서, 상온에서 고체의 포화 고급지방산 및 포화 고급알콜의 첨가량이 제제총중량의 0.5중량% 이상인 니코란딜 제제의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860011645A 1986-01-17 1986-12-31 니코란딜 제제의 안정화 방법 Expired - Lifetime KR940000232B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP7722 1986-01-17
JP61-7722 1986-01-17
JP772286 1986-01-17
JP6185686 1986-03-19
JP61856 1986-03-19
JP61-61856 1986-03-19

Publications (2)

Publication Number Publication Date
KR870006894A true KR870006894A (ko) 1987-08-13
KR940000232B1 KR940000232B1 (ko) 1994-01-12

Family

ID=26342067

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860011645A Expired - Lifetime KR940000232B1 (ko) 1986-01-17 1986-12-31 니코란딜 제제의 안정화 방법

Country Status (21)

Country Link
US (1) US4822808A (ko)
EP (1) EP0230932B1 (ko)
KR (1) KR940000232B1 (ko)
CN (1) CN1009525B (ko)
AR (1) AR241514A1 (ko)
AU (1) AU591958B2 (ko)
CA (1) CA1285486C (ko)
CS (1) CS276587B6 (ko)
DE (1) DE3769662D1 (ko)
DK (1) DK174918B1 (ko)
EG (1) EG18088A (ko)
ES (1) ES2054623T3 (ko)
FI (1) FI87043C (ko)
GR (1) GR3002288T3 (ko)
HK (1) HK66193A (ko)
HU (1) HU196705B (ko)
MX (1) MX167912B (ko)
NO (1) NO173590C (ko)
NZ (1) NZ218917A (ko)
PT (1) PT84124B (ko)
SG (1) SG64893G (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2148220A1 (en) * 1992-11-06 1994-05-26 Kiyoshi Tamura Method for producing composition for solid medicine
US6218411B1 (en) * 1997-08-08 2001-04-17 Chugai Seiyaku Kabushiki Kaisha Therapeutics for diabetic complications
IT1293835B1 (it) * 1997-08-08 1999-03-10 Foscama Biomed Chim Farma Composizioni farmaceutiche orali in forma solida a cessione modulata contenenti nicorandil e procedimento per la loro preparazione
ATE272395T1 (de) * 1998-05-15 2004-08-15 Chugai Pharmaceutical Co Ltd Präparationen zur kontrollierten freisetzung
US6417207B1 (en) 1999-05-12 2002-07-09 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
TWI324074B (en) * 2001-10-09 2010-05-01 Bristol Myers Squibb Co Flashmelt oral dosage formulation
FR2872705B1 (fr) * 2004-07-08 2008-07-18 Aventis Pharma Sa Compositions contenant du nicorandil, procede de preparation et utilisation
WO2008112227A1 (en) * 2007-03-12 2008-09-18 Reliant Pharmaceuticals, Inc. Treatment with nicorandil and omega-3 fatty acids, and a combination product thereof
DK2098249T3 (da) * 2008-03-05 2013-01-07 Rivopharm Sa Nicorandil-bærere med forbedret stabilitet
KR20100007082A (ko) * 2008-07-11 2010-01-22 주식회사 엘지생명과학 니코란딜을 포함하는 서방성 제제
CN102186474A (zh) * 2008-08-14 2011-09-14 杏林制药株式会社 稳定的医药组合物
CN105338982B (zh) 2013-04-25 2017-10-10 杏林制药株式会社 固体药用组合物
CN110123749B (zh) * 2019-06-03 2022-01-25 太阳升(亳州)生物医药科技有限公司 尼可地尔脂微球制剂及其制备方法
CN111574441B (zh) * 2020-05-26 2021-12-31 中国科学院上海药物研究所 一种尼可地尔与水杨酸的共晶及其制备方法和应用
CN115429763B (zh) * 2021-06-02 2024-01-02 北京四环科宝制药股份有限公司 尼可地尔片剂及其制备方法
CN114732792A (zh) * 2022-03-25 2022-07-12 北京诺康达医药科技股份有限公司 一种尼可地尔口腔崩解片及其制备方法
CN115317456A (zh) * 2022-08-17 2022-11-11 北京科源创欣科技有限公司 一种尼可地尔片组合物及其制备方法
CN115282123B (zh) * 2022-09-13 2023-11-03 南京比逊医药科技有限公司 一种稳定的尼可地尔制剂的制备方法
CN117547534B (zh) * 2023-11-10 2024-07-12 江南大学 尼可地尔缓释制剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168438A (en) * 1962-08-09 1965-02-02 Synergistics Inc Vasodilation by nitric acid ester derivatives of nicotinic acid
US3332848A (en) * 1963-07-10 1967-07-25 Hoffmann La Roche Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
JPS599539B2 (ja) * 1979-11-13 1984-03-03 日本化薬株式会社 ニトログリセリン水溶液及びその製造法
US4490377A (en) * 1980-07-29 1984-12-25 Syntex (U.S.A.) Inc. Acid stabilized compositions of thieno-pyridine derived compounds
JPS57145659A (en) * 1981-03-06 1982-09-08 Chugai Pharmaceutical Co Ltd Production of tablet
US4382091A (en) * 1981-04-30 1983-05-03 Syntex (U.S.A.) Inc. Stabilization of 1-substituted imidazole derivatives in talc
JPS5839618A (ja) * 1981-09-04 1983-03-08 Chugai Pharmaceut Co Ltd 持続性積層錠剤
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
JPH0653658B2 (ja) * 1984-12-17 1994-07-20 中外製薬株式会社 安定な錠剤の製造法
US5188840A (en) * 1985-09-26 1993-02-23 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent

Also Published As

Publication number Publication date
EG18088A (en) 1992-08-30
PT84124A (en) 1987-02-01
AU6764887A (en) 1987-07-23
DK19187A (da) 1987-07-18
CS276587B6 (en) 1992-07-15
DE3769662D1 (de) 1991-06-06
NO870212L (no) 1987-07-20
KR940000232B1 (ko) 1994-01-12
GR3002288T3 (en) 1992-12-30
HU196705B (en) 1989-01-30
AU591958B2 (en) 1989-12-21
NO173590B (no) 1993-09-27
MX167912B (es) 1993-04-22
AR241514A1 (es) 1992-08-31
EP0230932A2 (en) 1987-08-05
ES2054623T3 (es) 1994-08-16
CN87100285A (zh) 1987-08-19
DK19187D0 (da) 1987-01-15
NO870212D0 (no) 1987-01-19
FI87043B (fi) 1992-08-14
DK174918B1 (da) 2004-02-23
SG64893G (en) 1993-08-06
PT84124B (pt) 1989-02-28
FI87043C (fi) 1992-11-25
FI870131A0 (fi) 1987-01-14
NO173590C (no) 1994-01-05
HUT44435A (en) 1988-03-28
CS8700282A2 (en) 1991-07-16
NZ218917A (en) 1989-10-27
US4822808A (en) 1989-04-18
CN1009525B (zh) 1990-09-12
HK66193A (en) 1993-07-16
EP0230932A3 (en) 1987-12-09
CA1285486C (en) 1991-07-02
EP0230932B1 (en) 1991-05-02
FI870131L (fi) 1987-07-18

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