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KR860008176A - Method for producing 8-phenylxanthines - Google Patents

Method for producing 8-phenylxanthines Download PDF

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Publication number
KR860008176A
KR860008176A KR1019860003211A KR860003211A KR860008176A KR 860008176 A KR860008176 A KR 860008176A KR 1019860003211 A KR1019860003211 A KR 1019860003211A KR 860003211 A KR860003211 A KR 860003211A KR 860008176 A KR860008176 A KR 860008176A
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South Korea
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compound
hydrogen
alkyl
formula
nitro
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KR1019860003211A
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Korean (ko)
Inventor
메리 달루지 수잔
제퍼슨 라이톤 해리
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마이클 피터 잭슨
더 웰컴 파운데이숀 리미티드
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Publication of KR860008176A publication Critical patent/KR860008176A/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

8-페닐크산틴류의 제조방법Method for producing 8-phenylxanthines

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

상화 방지제의 존재하에서, 하기식(Ⅱ)의 화합물을 고리화하거나, 하기 기중 Y가 C3-6알케닐렌옥시 또는 C3-6알키닐렌옥신인 경우 하기식(Ⅶ)의 화합물을 하기식(Ⅷ)의 화합물과 반응시키거나, 하기식(Ⅹ)의 화합물을 고리화하고, 그 후 결과의 하기식(Ⅰ)의 화합물의 기중 X1내지 X6를 각각 상이한 X1내지 X6로 전환시키거나 하기식(Ⅰ)의 화합물의 염 또는 그 용매 화합물을 형성하는 단계로 구성되는 하기식(Ⅰ)의 화합물, 이것의 염 또는 이것의 용매 화합제조하는 방법.In the presence of an anti-inflammatory agent, the compound of formula (II) is cyclized, or when Y is C 3-6 alkenyleneoxy or C 3-6 alkynyleneoxine in the following group, the compound of formula (VII) Reacting with the compound of iii) or cyclizing the compound of formula (iii), and then converting X 1 to X 6 in the groups of the resulting compound of formula (I) to different X 1 to X 6 , respectively. Or forming a salt of the compound of the formula (I) or a solvent compound thereof. 상기식에서, X1및 X3는 서로 상이하거나 동일한 수소, C1-6알킬, C2-6알케닐 또는 아릴링에 C1-6알킬, C1-6알콕시, 히드록시, 할로, 니트로, 아미노 아지도, 및 시아노로부터 선택된 적어도 하나의 치환제에 의해 치환된 C7-12아르알킬로서, X1및 X2가 모두 수소가 아님을 조건으로 하여 ; X3및 X4중 어느하나는 수소, C1-6알킬, 트리플루오로메틸, C1-6알콕시, 할로, 니트로, 아미노,C1-6알콕시카르보닐 또는 카르복시이며, 다른 하나는 -Y-Z인데, Y는 C2-6알케닐렌, C3-6알케닐 렌옥시, C2-6알키닐렌 또는 C3-6알킬닐렌옥시이며, Z는 카르복시, 설포닐 또는 포스포닐 또는 C1-9알킬에스테르, C7-12아르알킬에스테르 또는 C6-12아릴에스테르이거나 혹은 5-테트라졸릴이며 ; X5및 X6는 서로 상이하거나 동일한 산소 또는 황이며 ; X1 3및 X1 4중 어느하나는 상기의 X3및 X4중 어느하나로서 정의괸 바와 같으며, 다른 하나는 히드록시이며 ; L은 이탈기이며 ; Y1은 C3-6알케닐렌 또는 C3-6알키닐렌이며 ; A 및 B중 어느 하나는 수소이며, 다른 하나는 3-X3)-4-(X4)-벤조일(X3및 X4는 상기에서 정의된 바와 같음)이다.Wherein X 1 and X 3 are different from or identical to each other hydrogen, C 1-6 alkyl, C 2-6 alkenyl or aryl to C 1-6 alkyl, C 1-6 alkoxy, hydroxy, halo, nitro, C 7-12 aralkyl substituted with amino azido and at least one substituent selected from cyano, provided that X 1 and X 2 are not both hydrogen; X 3 and any one of X4 is the hydrogen, C 1-6 alkyl, trifluoromethyl, C 1-6 alkoxy, halo, nitro, amino, C1-6 alkoxycarbonyl, and carbonyl, or carboxyl, and the other is -YZ, Y is C 2-6 alkenylene, C 3-6 alkenyleneoxy, C 2-6 alkynylene or C 3-6 alkylyleneeneoxy, Z is carboxy, sulfonyl or phosphonyl or C 1-9 alkyl ester , C 7-12 aralkyl ester or C 6-12 aryl ester or 5-tetrazolyl; X 5 and X 6 are different from or the same as oxygen or sulfur; Any one of X 1 3 and X 1 4 is as defined as any one of X 3 and X 4 above, and the other is hydroxy; L is a leaving group; Y 1 is C 3-6 alkenylene or C 3-6 alkynylene; One of A and B is hydrogen and the other is 3-X 3 ) -4- (X 4 ) -benzoyl (X 3 and X 4 as defined above). 제1항에 있어서, X1및 X2중 어느하나 혹은 모두는 아릴에 C1-6알킬, C1-6알콕시, 히드록시, 할로, 니트로, 아미노, 아지도 및 시아노보쿠터 선택된 적어도 하나의 치환체에 의해 임의적으로 치환된 벤질인 것을 특징으로 하는 제조방법.The compound of claim 1, wherein any one or both of X 1 and X 2 are at least one selected from C 1-6 alkyl, C 1-6 alkoxy, hydroxy, halo, nitro, amino, azido and cyanobokuter in aryl. A benzyl optionally substituted by a substituent of. 제2항에서, 상기 임의의 치환체는 메틸, 메톡시, 히드록시, 클로로, 니트로, 아미노, 아지도 및 시아노로부터 선택되는 것을 특징으로 하는 제조방법.The method of claim 2, wherein the optional substituent is selected from methyl, methoxy, hydroxy, chloro, nitro, amino, azido and cyano. 제1항 내지 제3항중 어느 한항에 있어서, X1및 X2는 수소 또는 C1-6알킬인 것을 특징으로 하는 제조방법.4. The process according to claim 1 , wherein X 1 and X 2 are hydrogen or C 1-6 alkyl. 제1항 내지 제4항중 어느 한항에 있어서, Y는 비닐렌 또는 아세틸렌인 것을 특징으로 하는 제조방법.The method according to any one of claims 1 to 4, wherein Y is vinylene or acetylene. 제1항 내지 제5항중 어느 한항에 있어서, X3는 수소이며, X4는 -Y-Z인데, Y는 비닐렌이고 Z는 카르복시 또는 이것의 C1-6에스테르인 것을 특징으로 하는 제조방법.The process according to any one of claims 1 to 5, wherein X 3 is hydrogen, X 4 is -YZ, Y is vinylene and Z is carboxy or C 1-6 ester thereof. ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is to be disclosed based on the initial application.
KR1019860003211A 1985-04-27 1986-04-25 Method for producing 8-phenylxanthines Ceased KR860008176A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8510758 1985-04-27
GB858510758A GB8510758D0 (en) 1985-04-27 1985-04-27 Compounds

Publications (1)

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KR860008176A true KR860008176A (en) 1986-11-12

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US (2) US4879296A (en)
EP (1) EP0203721B1 (en)
JP (1) JPH0788381B2 (en)
KR (1) KR860008176A (en)
AP (1) AP22A (en)
AT (1) ATE77088T1 (en)
AU (1) AU581507B2 (en)
CA (1) CA1286666C (en)
DE (1) DE3685608T2 (en)
DK (1) DK169271B1 (en)
ES (1) ES8800945A1 (en)
FI (1) FI861750L (en)
GB (1) GB8510758D0 (en)
GR (1) GR861107B (en)
HU (1) HUT41027A (en)
IE (1) IE60022B1 (en)
IL (1) IL78605A (en)
MC (1) MC1743A1 (en)
NO (1) NO861643L (en)
NZ (1) NZ215948A (en)
PT (1) PT82451B (en)
ZA (1) ZA863132B (en)

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DK190486A (en) 1986-10-28
EP0203721A2 (en) 1986-12-03
JPS6242986A (en) 1987-02-24
ES554380A0 (en) 1987-12-01
PT82451A (en) 1986-05-01
CA1286666C (en) 1991-07-23
FI861750A7 (en) 1986-10-28
MC1743A1 (en) 1987-02-26
IE861104L (en) 1986-10-27
GB8510758D0 (en) 1985-06-05
ATE77088T1 (en) 1992-06-15
GR861107B (en) 1986-08-04
JPH0788381B2 (en) 1995-09-27
AU581507B2 (en) 1989-02-23
NZ215948A (en) 1989-10-27
US4981857A (en) 1991-01-01
PT82451B (en) 1988-11-30
ES8800945A1 (en) 1987-12-01
IL78605A (en) 1989-07-31
ZA863132B (en) 1987-12-30
US4879296A (en) 1989-11-07
EP0203721B1 (en) 1992-06-10
IL78605A0 (en) 1986-08-31
IE60022B1 (en) 1994-05-18
DK190486D0 (en) 1986-04-24
AP22A (en) 1988-07-20
FI861750L (en) 1986-10-28
FI861750A0 (en) 1986-04-25
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AP8600036A0 (en) 1986-02-01
DE3685608D1 (en) 1992-07-16
HUT41027A (en) 1987-03-30
EP0203721A3 (en) 1988-06-08
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AU5670786A (en) 1986-10-30
DE3685608T2 (en) 1992-12-24

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