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KR860008166A - 카바모일이미다졸의 제조방법 - Google Patents

카바모일이미다졸의 제조방법 Download PDF

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KR860008166A
KR860008166A KR1019860002337A KR860002337A KR860008166A KR 860008166 A KR860008166 A KR 860008166A KR 1019860002337 A KR1019860002337 A KR 1019860002337A KR 860002337 A KR860002337 A KR 860002337A KR 860008166 A KR860008166 A KR 860008166A
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요시오 구라하시
고죠 시오까와
도시오 고또
신조 가가부
아쭈미 가모찌
고이찌 모리야
히데노리 하야까와
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다데노 고자부로
니혼 도꾸슈 노야꾸 세이조 가부시끼가이샤
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    • C07D215/08Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
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    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

내용 없음

Description

카바모일이미다졸의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 일반식(Ⅱ)의 화합물을, 필요시 불활성 용매의 존재하에서, 구조식(Ⅲ)의 N,N'-카보닐디이미다졸과 반응시키거나 : 일반식(Ⅳ)의 화합물을, 필요시 불활성 용매의 존재하 및/또는 산결합제의 존재하에서, 구조식(Ⅴ)의 이미다졸과 반응시킴을 특징으로 하여 일반식(Ⅰ)의 카바모일이미다졸을 제조하는 방법.
    상기식에서, X는 할로겐, 저급알킬, 저급알콕시, 저급알킬티오, 할로겐-치환된 저급 알킬, 할로겐-치환된 저급 알콕시, 할로겐-치환된 저급 알킬티오, 니트로, 시아노, 저급 알킬설포닐, 저급 알킬설피닐, 할로겐-치환된 저급 알킬설포닐, 할로겐-치환된 저급 알킬설피닐, 페닐, 펜옥시 또는 페닐티오이고 n은 0,1,2 또는 3이며, Y1, Y2, Y3, Y4, Y5및 Y6는 각각 수소, 저급 알킬, 할로겐 또는 페닐이거나, Y2와 Y3가 함께는 헤테로사이클릭환내에 이중결합이 형성될 수 있도록 단일 결합을 형성할 수 있거나, Y4와 Y5가 함께는 테트라메틸렌 그룹을 형성할 수 있으며, 단, Y1, Y2, Y3, Y4, Y5및 Y6가 동시에 모두 수소는 아니어야 한다.
  2. 제1항에 있어서, X가 가 불소, 염소, 브롬, 탄소수 1 내지 4의 알킬, 탄소수 1 내지 4의 알콕시, 탄소수 1 내지 4의 알킬티오, 불소 및/또는 염소-치환된 탄소수 1 내지 4의 알킬, 불소 및/또는 염소-치환된 탄소수 1 내지 4의 알콕시, 불소 및/또는 염소 -치환된 탄소수 1 내지 4의 알킬티오, 니트로, 시아노, 탄소수 1 내지 4의 알킬설포닐, 탄소수 1 내지 4의 알킬설피닐, 탄소수 1 내지 4의 할로겐-치환된 알킬설포닐, 페닐, 펜옥시 또는 페닐티오이고 : n은 0,1 또는 2이며, Y1,Y2,Y3,Y4,Y5및 Y6는 각각 수소, 탄소수 1 내지 4의 알킬, 염소 또는 페닐이거나, Y2와 Y3가 함께는 헤테로 사이클릭환내에 이중결합이 형성되도록 단일 결합을 형성할 수 있거나, Y4와 Y5가 함께는 태트라메틸렌 그룹을 형성할 수 있으며, 단 Y1,Y2,Y3,Y4,Y5및 Y6가 동시에 모두 수소가 아닌 일반식(Ⅰ)의 화합물을 제조하는 방법.
  3. 일반식(Ⅱ)의 화합물을 구조식 COCl2의 포스겐 또는 구조식 ClCOOCCl3의 트리클로로메틸-클로로포르메이트와 반응시킴을 특징으로 하여, 일반식(Ⅳ)의 화합물을 제조하는 방법.
    상기식에서, X는 할로겐, 저급 알킬, 저급 알콕시, 저급 알킬티오, 할로겐-치환된 저급 알킬, 할로겐-치환된 저급 알콕시, 할로겐, 치환된 저급 알킬티오, 니트로, 시아노, 저급 알킬설포닐, 저급 알킬설피닐, 할로겐-치환된 저급 알킬설포닐, 할로겐-치환된 저급 알킬설피닐, 페닐, 펜옥시 또는 페닐티오이고 n은 0,1,2 또는 3이며 : Y1,Y2,Y3,Y4,Y5및 Y6는 각각 수소, 저급 알킬, 할로겐 또는 페닐이거나, Y2와 Y3가 함께는 헤테로사이클릭환내에 이중결합이 형성되도록 단일 결합을 형성할 수 있거나, Y4와 Y5가 함께는 테트라 메틸렌 그룹을 형성할 수 있으며 단, Y1,Y2,Y3,Y4,Y5및 Y6는 동시에 모두 수소는 아니어야 한다.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860002337A 1985-04-01 1986-03-28 카바모일이미다졸의 제조방법 Withdrawn KR860008166A (ko)

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JP66636 1985-04-01
JP60066636A JPS61227506A (ja) 1985-04-01 1985-04-01 カルバモイルイミダゾ−ル類、その中間体、それらの製法並びに除草剤又は農園芸用殺菌剤

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EP (1) EP0198264A3 (ko)
JP (1) JPS61227506A (ko)
KR (1) KR860008166A (ko)
AU (1) AU5423286A (ko)
BR (1) BR8601429A (ko)
DK (1) DK142686A (ko)
ES (1) ES8800199A1 (ko)
HU (1) HUT42269A (ko)
IL (1) IL78304A0 (ko)
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JPS6160682A (ja) * 1984-08-30 1986-03-28 Nippon Tokushu Noyaku Seizo Kk テトラヒドロキノリン−1−イルカルボニルイミダゾ−ル誘導体、その中間体、それらの製法並びに除草又は農園芸用殺菌剤
DE3641343A1 (de) * 1986-12-03 1988-06-16 Hoechst Ag Carbamoylimidazol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
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JP2009536954A (ja) 2006-05-11 2009-10-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Cetp阻害剤としての3,4−ジヒドロ−2h−ベンゾ[1,4]オキサジンおよびチアジン誘導体
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
MX370535B (es) 2013-11-18 2019-12-17 Forma Therapeutics Inc Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.
CN105330644B (zh) * 2015-11-18 2017-12-19 中国农业大学 (1,2,3,4‑四氢喹啉‑1‑基)(取代吡唑基)甲酮类化合物及其应用

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JPS60222479A (ja) * 1984-04-20 1985-11-07 Nippon Tokushu Noyaku Seizo Kk テトラヒドロキノリン―1―イルカルボニルイミダゾール誘導体、その製法並びに除草又は農園芸用殺菌剤
JPS6160682A (ja) * 1984-08-30 1986-03-28 Nippon Tokushu Noyaku Seizo Kk テトラヒドロキノリン−1−イルカルボニルイミダゾ−ル誘導体、その中間体、それらの製法並びに除草又は農園芸用殺菌剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020012116A (ko) * 2000-08-05 2002-02-15 주정호 항암제로서 유용한 이미다졸릴우레아 유도체 및 그의제조방법

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EP0198264A2 (de) 1986-10-22
AU5423286A (en) 1986-10-09
JPS61227506A (ja) 1986-10-09
HUT42269A (en) 1987-07-28
IL78304A0 (en) 1986-07-31
ES8800199A1 (es) 1987-10-16
DK142686A (da) 1986-10-02
ZA862324B (en) 1986-11-26
BR8601429A (pt) 1986-12-09
EP0198264A3 (de) 1987-08-19
ES553569A0 (es) 1987-10-16
DK142686D0 (da) 1986-03-26

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