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KR860008111A - 인딘과 나프탈렌 유도체의 제조방법 - Google Patents

인딘과 나프탈렌 유도체의 제조방법 Download PDF

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Publication number
KR860008111A
KR860008111A KR1019860002448A KR860002448A KR860008111A KR 860008111 A KR860008111 A KR 860008111A KR 1019860002448 A KR1019860002448 A KR 1019860002448A KR 860002448 A KR860002448 A KR 860002448A KR 860008111 A KR860008111 A KR 860008111A
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KR
South Korea
Prior art keywords
compound
group
formula
alkyl
hydroxy
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KR1019860002448A
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English (en)
Inventor
토마스 로간 로버트
레드 패스 제임스
깁슨 로이 로버트
Original Assignee
아. 게. 유트. 베르메텐, 아. 데. 도우마
악조 엔. 브이
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Application filed by 아. 게. 유트. 베르메텐, 아. 데. 도우마, 악조 엔. 브이 filed Critical 아. 게. 유트. 베르메텐, 아. 데. 도우마
Publication of KR860008111A publication Critical patent/KR860008111A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/20—Polycyclic condensed hydrocarbons
    • C07C15/24—Polycyclic condensed hydrocarbons containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

인딘과 나프탈렌 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기식(Ⅰ)의 화합물의 활성성분과 약학적으로 허용가능한 담체로 구성된 약학적 조성물.
    상기식에서 R1은 1-4개의 같거나 다른 치환체로서 알킬(1-6C), 알콕시(1-6C), 히드록시, 할로겐, NO2, CF2또는 -NR5R6기중에서 선택되는데 이들중 치환제 2개가 함께 메틸렌-디옥시기를 나타내기도 한다. X는, -CH2-CH2- 또는 -CH=CH- n은 0,1 또는 2, R3은또는R2,R4,R5와 R6는 H 또는 알킬(1-6C)이다.
  2. (a) 하기식(Ⅱ)의 화합물 또는 그의 할라이드 또는 무수물을 하기식(Ⅲ)의 화합물 또는 수소원자(질소위치)가 알칼리금속과 같은 반응성이 큰 부로 치환된 반응성 유도체와 반응시키거나 (b) 하기식(Ⅳ)의 화합물을 하기식(Ⅲ)의 화합물 또는 수소원자(질소위치)가 알칼리금속과 같은 반응성이 큰 부로 치환된 반응성 유도체와 반응시키거나 (C) 하기식(Ⅴ)의 화합물을 아미노-구아니딘 또는 그 염과 반응시킨 뒤 생성된 혼합물의 R1이 최소한 하나의 알콕시기인 화합물을 R1이 최소한 하나의 히드록시기인 대응되는 화합물로 가수분해시키거나 생성된 화합물의 R1이 최소한 하나의 히드록시기인 화합물을 R1이 최소한 하나의 알콕시기인 대응되는 화합물로 알킬화시키거나 생성된 화합물의 R1이 최소한 2개의 히드록시기일 때는 R1이 최소한 하나의 메틸렌디옥시기인 대응되는 화합물로 전환시키거나 생성된 화합물의 R1이 최소한 하나의 니트로기일 때는 R1이 최소한 한의 아미노기인 대응되는 화합물로 전화시킨 뒤 생성된 화합물을 약학적으로 허용가능한 염으로 전환시키는 것을 특징으로 하는 하기식(Ⅰ) 화합물의 제조방법.
    상기식에서 R1은 1-4개의 같거나 다른 치환체로서 알킬(1-6C), 알콕시(1-6C), 히드록시, 할로겐, NO2, CF2또는 -NR5R6기중에서 선택되는 이들중 치환제 2개가 함께 메틸렌-디옥시기를 나타내기도 한다. X는, -CH2-CH2- 또는 -CH=CH- n은 0,1 또는 2, R3은또는R2,R4,R5와 R6는 H 또는 알킬(1-6C)이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860002448A 1985-04-02 1986-04-01 인딘과 나프탈렌 유도체의 제조방법 Ceased KR860008111A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858508588A GB8508588D0 (en) 1985-04-02 1985-04-02 Indene & napthalene derivatives
GB8508588 1985-04-02

Publications (1)

Publication Number Publication Date
KR860008111A true KR860008111A (ko) 1986-11-12

Family

ID=10577079

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860002448A Ceased KR860008111A (ko) 1985-04-02 1986-04-01 인딘과 나프탈렌 유도체의 제조방법

Country Status (14)

Country Link
US (1) US4705782A (ko)
EP (1) EP0199393B1 (ko)
JP (1) JPS61246152A (ko)
KR (1) KR860008111A (ko)
AU (1) AU593793B2 (ko)
CA (1) CA1312871C (ko)
DE (1) DE3661356D1 (ko)
DK (1) DK139286A (ko)
ES (1) ES8800122A1 (ko)
FI (1) FI82928C (ko)
GB (1) GB8508588D0 (ko)
GR (1) GR860779B (ko)
PT (1) PT82319B (ko)
ZA (1) ZA862280B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661522A (en) * 1984-05-24 1987-04-28 Akzo N.V. Cycloalkane-indene-carboximidamide derivatives
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
US4870210A (en) * 1987-12-18 1989-09-26 American Home Products Corporation Aminoguanidine derivative as anti-inflammatory agents
ES2051986T3 (es) * 1988-07-05 1994-07-01 Akzo Nv Compuestos con actividad broncodilatadora.
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
US5093356A (en) * 1990-01-16 1992-03-03 Merck Frosst Canada, Inc. Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
US5028629A (en) * 1990-03-28 1991-07-02 Eli Lilly And Company 5-Lipoxygenase inhibitors
US5276052A (en) * 1990-10-26 1994-01-04 Akzo N.V. Use of a benzo[b]thiopene-2-carboximidamide derivative
IE913683A1 (en) * 1990-10-26 1992-05-22 Akzo Nv USE OF A BENZO[b]THIOPHENE-2-CARBOXIMIDAMIDE DERIVATIVE
DE19736921A1 (de) * 1997-08-25 1999-03-04 Bayer Ag Verfahren zur Herstellung von 2-Cyanoindan-1-onen
CA2834548C (en) 2011-04-28 2021-06-01 The Broad Institute, Inc. Inhibitors of histone deacetylase
US9790184B2 (en) 2012-07-27 2017-10-17 The Broad Institute, Inc. Inhibitors of histone deacetylase
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
JP2021510733A (ja) 2018-01-12 2021-04-30 ケーディーエーシー セラピューティクス，インコーポレーテッドＫｄａｃ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． がんの処置のための選択的ヒストンデアセチラーゼ３（ｈｄａｃ３）インヒビターと免疫治療剤との組み合わせ

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB304441A (en) * 1927-12-19 1929-01-24 Ig Farbenindustrie Ag The manufacture of naphthol ether carboxy-amides and aminonaphthol ethers
US3130232A (en) * 1963-02-12 1964-04-21 Upjohn Co Amidinohydrazones of cyclic halovinyl aldehydes
US3530165A (en) * 1967-12-08 1970-09-22 Du Pont Pharmaceutically active 4 - phenylbicyclo(2.2.2)-octane and oct-2-ene-1-carboxamides and derivatives thereof
US3560519A (en) * 1969-03-28 1971-02-02 Sinclair Research Inc Aromatic mono(nitrile carbonates)
US3829467A (en) * 1972-07-03 1974-08-13 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
JPS5623982B2 (ko) * 1972-12-07 1981-06-03
US4013682A (en) * 1973-08-03 1977-03-22 Akzona Incorporated N-hydroxy-amidine compounds
CH601166A5 (ko) * 1974-02-14 1978-06-30 Ciba Geigy Ag
NL7407469A (nl) * 1974-06-01 1975-12-03 Akzo Nv Nieuwe amidinohydrazonverbindingen.
DE2620369C3 (de) * 1976-05-08 1979-01-04 Bayer Ag, 5090 Leverkusen Verfahren zur Wiedergewinnung von (l-S)-2-Oxo-bornansulfonat-(10)
DE2804576A1 (de) * 1977-02-15 1978-08-17 Lafon Labor Phenylamidin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE2824409A1 (de) * 1977-06-13 1978-12-21 Degussa 5,6,7-trimethoxy-naphthalin-(2)-carbonsaeure- und -hydronaphthalin-(2)-carbonsaeure-derivate sowie verfahren zu ihrer herstellung
NL7908922A (nl) * 1979-12-12 1981-07-16 Akzo Nv Carboximidamide derivaten.
JPS57179147A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine derivative
DE3360148D1 (en) * 1982-02-10 1985-06-05 Beecham Group Plc Guanidine derivatives
EP0097463A3 (en) * 1982-06-16 1985-05-15 Beecham Group Plc Amidine derivatives
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Also Published As

Publication number Publication date
ZA862280B (en) 1986-11-26
GR860779B (en) 1986-06-24
PT82319A (en) 1986-05-01
AU5539686A (en) 1986-10-16
CA1312871C (en) 1993-01-19
FI861379A7 (fi) 1986-10-03
PT82319B (pt) 1988-03-03
AU593793B2 (en) 1990-02-22
ES8800122A1 (es) 1987-10-16
EP0199393A1 (en) 1986-10-29
DE3661356D1 (de) 1989-01-12
US4705782A (en) 1987-11-10
JPS61246152A (ja) 1986-11-01
DK139286D0 (da) 1986-03-25
FI861379A0 (fi) 1986-04-01
ES553601A0 (es) 1987-10-16
EP0199393B1 (en) 1988-12-07
DK139286A (da) 1986-10-03
FI82928B (fi) 1991-01-31
FI82928C (fi) 1991-05-10
GB8508588D0 (en) 1985-05-09

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