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KR840002819A - 벤조티아제핀 유도체의 제조방법 - Google Patents

벤조티아제핀 유도체의 제조방법 Download PDF

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Publication number
KR840002819A
KR840002819A KR1019820005453A KR820005453A KR840002819A KR 840002819 A KR840002819 A KR 840002819A KR 1019820005453 A KR1019820005453 A KR 1019820005453A KR 820005453 A KR820005453 A KR 820005453A KR 840002819 A KR840002819 A KR 840002819A
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South Korea
Prior art keywords
acetone
lower alkyl
mixture
formula
compound
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KR1019820005453A
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KR860002034B1 (ko
Inventor
미쯔노리 가이노 (외 4)
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마쓰하라 이찌로
다나베 세이야꾸 가부시끼가이사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

벤조티아제핀 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 다음 일반식(Ⅱ)의 화합물을 아세톤 중 수산화 칼륨의 존재하에서 또는 아세톤, 저급 알킬 아세테이트, 아세톤 및 문의 혼합물 및 저급 알킬 아세테이트 및 물의 혼합물로부터 선택한 용매중 탄산칼륨의 존재하에서 2-(디메틸아미노)-에틸할리드와 죽합시키고, 필요하다면, 생성물을 이의 약학적으로 허용되는 산 부가염으로 전환시킴을 특징으로 하는, 다음 일반식(Ⅰ)의 벤조티아제핀 유도체 또는 이의 약학적으로 허용되는 산 부가염의 제조방법.
    상기식에서
    R은 수소 또는 아세틸이다.
  2. 제1항에 있어서, 축합을 아세톤중 일반식(Ⅱ)의 화합물 몰당 수산화칼륜 1내지 3몰의 존재하에 30℃내지 아세톤의 환류온도에서 또는 아세톤, 저급 알킬 아세테이트, 아세톤 및 물의 혼합물 및 저급 알킬 아세테이트 및 물의 혼합물로부터 선택한 용매중 일반식(Ⅱ)의 화합물 몰당 탄산칼륨 1내지 5몰의 존재하에 30℃내지 사용한 용매의 환류 온도에서 진행시키는 방법.
  3. 제1또는 2항에 있어서, 수산화칼륨 및 아세톤을 사용할때에는, 축합을 일반식(Ⅱ)의 화합물, 2-(디메틸아미노)에틸 클로라이드, 수산화칼륨 및 아세톤의 혼합물을 40내지 57℃에서 교반함으로서 진행시키고; 탄산 칼륨 및 아세톤 또는 저급알킬 아세테이트를 사용할때에는, 축합을 일반식(Ⅱ)의 화합물, 2-(디메틸아미노)에틸 클로라이드, 탄산칼륨 및 아세톤 또는 저급 알킬 아세테이트의 혼합물을 환류함으로써 진행시키고; 탄산칼륨 및 아세톤 및 물의 혼합물 또는 저급 알킬 아세테이트 및 물의 혼합물을 사용할 때에는, 축합을 일반식(Ⅱ)의 화합물, 2-(디메틸아미노)에틸 클로라이드, 탄산 칼륨 및 아세톤 또는 저급 알킬 아세테이트의 혼합물을 환류하고, 이 혼합물에 물을 가한후 이수성 혼합물을 더욱 환류함으로써 진행시키는 방법.
  4. 제1또는 2항에 있어서, 저급알킬 아세테이트가 메틸 아세테이트 또는 에틸 아세테이트인 방법.
  5. 제3항에 있어서, 저급 알킬 아세테이트가 메틸 아세테이트 또는 에틸 아세테이트인 방법.
  6. 제3항에 있어서, 2-(디메틸아미노)에틸 클로라이드를 이의 염산염 형태로 사용하는 방법.
  7. 제6항에 있어서, 수산화나트륨의 양이 일반식(Ⅱ)의 화합물 몰당 2내지 2.5몰이고, 탄산칼륨의 양이 일반식(Ⅱ)의 화합물 몰당 2내지 3몰인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8205453A 1981-12-07 1982-12-06 벤조티아제핀 유도체의 제조방법 Expired KR860002034B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56197358A JPS5899471A (ja) 1981-12-07 1981-12-07 ベンゾチアゼピン誘導体の新規製造法
JP56-197358 1981-12-07

Publications (2)

Publication Number Publication Date
KR840002819A true KR840002819A (ko) 1984-07-21
KR860002034B1 KR860002034B1 (ko) 1986-11-17

Family

ID=16373149

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205453A Expired KR860002034B1 (ko) 1981-12-07 1982-12-06 벤조티아제핀 유도체의 제조방법

Country Status (15)

Country Link
US (1) US4438035B1 (ko)
EP (1) EP0081234B1 (ko)
JP (1) JPS5899471A (ko)
KR (1) KR860002034B1 (ko)
AT (1) ATE15799T1 (ko)
BG (1) BG38937A3 (ko)
CA (1) CA1177075A (ko)
DE (1) DE3266583D1 (ko)
DK (1) DK154022C (ko)
ES (1) ES517966A0 (ko)
FI (1) FI79705C (ko)
HK (1) HK95488A (ko)
HU (1) HU187431B (ko)
IE (1) IE54241B1 (ko)
SU (1) SU1176839A3 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241379B2 (en) 2015-12-01 2022-02-08 Sun Pharmaceutical Industries Limited Parenteral dosage form of diltiazem

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8316032D0 (en) * 1983-06-11 1983-07-13 Tanabe Seiyaku Co Benzothiazepine derivatives
IT1206505B (it) * 1983-07-22 1989-04-27 Schiapparelli Farma Nuovi derivati benzotiazepinonici, metodo per la loro preparazione e composizioni farmaceutiche che licontengono.
GB2154577A (en) * 1984-02-18 1985-09-11 Tanabe Seiyaku Co 1,5-benzothiazepines
IL71538A (en) * 1984-04-13 1987-07-31 Abic Ltd Process for the preparation of benzothiazepine derivatives
US4758954A (en) * 1984-07-25 1988-07-19 Computer Services Corporation Method of adjusting ticket fares
US4652561A (en) * 1986-02-26 1987-03-24 Hoffmann-La Roche Inc. Naphtho[1,2-b]-1,4-thiazepinones
IL81954A0 (en) * 1986-03-24 1987-10-20 Hoffmann La Roche Naphthothiazocinones,their manufacture and pharmaceutical compositions containing them
US4871731A (en) * 1987-10-07 1989-10-03 Marion Laboratories, Inc. Captopril and diltiazem composition and the like
US4808580A (en) * 1987-12-17 1989-02-28 Hoffmann-La Roche Inc. Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering
IT1226301B (it) * 1988-07-26 1990-12-27 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem.
FR2641535B1 (fr) * 1989-01-11 1991-03-15 Synthelabo Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
USRE34935E (en) * 1989-01-11 1995-05-09 Synthelabo Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-one and chlorinated derivatives thereof
US5128469A (en) * 1989-04-28 1992-07-07 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
JPH085869B2 (ja) * 1990-03-08 1996-01-24 田辺製薬株式会社 １，５−ベンゾチアゼピン誘導体の製法
NL9000763A (nl) * 1990-03-31 1991-10-16 Stamicarbon Werkwijze voor het bereiden van 1,5-benzothiazepine-derivaten.
IT1255545B (it) * 1992-10-23 1995-11-09 Procedimento per la preparazione di diltiazem
ATE167858T1 (de) * 1994-09-16 1998-07-15 Orion Corp Fermion Verfahren zur herstellung von pharmazeutisch aktiven benzothiazepinderivaten.
FI97725C (fi) * 1995-02-17 1997-02-10 Orion Yhtymae Oy Menetelmä diltiatseemin valmistamiseksi
WO1996038429A1 (en) * 1995-06-01 1996-12-05 Acic (Canada) Inc. Method for the manufacture of benzothiazepine derivatives
US5559229A (en) * 1995-06-01 1996-09-24 Acic (Canada) Inc. Method for the manufacture of benzothiazepine
SG50796A1 (en) * 1996-02-23 1998-07-20 Tanabe Seiyaku Co Process for preparing 1,5-benzothiazepine derivative
TW438787B (en) 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
US6635277B2 (en) 2000-04-12 2003-10-21 Wockhardt Limited Composition for pulsatile delivery of diltiazem and process of manufacture

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
US3562257A (en) 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS57106673A (en) * 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241379B2 (en) 2015-12-01 2022-02-08 Sun Pharmaceutical Industries Limited Parenteral dosage form of diltiazem

Also Published As

Publication number Publication date
HU187431B (en) 1986-01-28
DK154022B (da) 1988-10-03
ES8401953A1 (es) 1984-01-01
JPS5899471A (ja) 1983-06-13
KR860002034B1 (ko) 1986-11-17
IE54241B1 (en) 1989-08-02
FI824165L (fi) 1983-06-08
ATE15799T1 (de) 1985-10-15
FI824165A0 (fi) 1982-12-03
HK95488A (en) 1988-12-02
DE3266583D1 (en) 1985-10-31
DK540382A (da) 1983-06-08
US4438035A (en) 1984-03-20
CA1177075A (en) 1984-10-30
FI79705B (fi) 1989-10-31
EP0081234A1 (en) 1983-06-15
US4438035B1 (en) 1994-07-26
ES517966A0 (es) 1984-01-01
FI79705C (fi) 1990-02-12
BG38937A3 (en) 1986-03-14
DK154022C (da) 1989-02-20
EP0081234B1 (en) 1985-09-25
IE822836L (en) 1983-06-07
JPS6317832B2 (ko) 1988-04-15
SU1176839A3 (ru) 1985-08-30

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