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KR840007009A - 1,1-디옥소 페니실라노일옥시메틸 6-β-아미노 페니실라네이트의 제조방법 - Google Patents

1,1-디옥소 페니실라노일옥시메틸 6-β-아미노 페니실라네이트의 제조방법 Download PDF

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Publication number
KR840007009A
KR840007009A KR1019830005159A KR830005159A KR840007009A KR 840007009 A KR840007009 A KR 840007009A KR 1019830005159 A KR1019830005159 A KR 1019830005159A KR 830005159 A KR830005159 A KR 830005159A KR 840007009 A KR840007009 A KR 840007009A
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KR
South Korea
Prior art keywords
temperature
preparing
formula
mentioned
penicilanoyloxymethyl
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KR1019830005159A
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English (en)
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KR860001494B1 (ko
Inventor
위크스 폴다글라스
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윌리암 데비스 훈
화이자 인코포레이티드
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Publication of KR840007009A publication Critical patent/KR840007009A/ko
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Publication of KR860001494B1 publication Critical patent/KR860001494B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cultivation Of Plants (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용없음

Description

1,1-디옥소 페니실라노일옥시메틸 6-β-아미노 페니실라네이트의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 일반식(Ⅱ)의 화합물을 무수 상태하 -70 내지 20˚C의 온도에서 반응 불활성 유기용매 및 3급 아민의 존재하에 할로 겐화제와 반응시켜 이미노 할라이드를 제조하고 생성된 이미노 할라이드를 -70 내지 0˚C의 온도에서 일반식 R2OH의 1급알콜과 반응시켜 이미노 에테르를 제조하고, 생성된 이미노 에테르를 -70 내지 0˚C의 온도에서 물과 반응시킴을 특징으로 하는 하기 구조식(Ⅰ) 화합물의 제조방법.
  3. 상기식에서,
  4. R1은 C6H5CH2또는 C6H5OCH2이고, R2는 1 내지 4개의 탄소원자를 갖는 알킬이다.
  5. 제 1항에 있어서, R1이 C6H5CH2이고, 언급된 할로 겐화제가 포스포러스 펜타클로라이드이며, 언급된 3급 아민이 피리딘 또는 N,N-디메틸아닐린인 방법.
  6. 제 1항에 있어서, 각 단계에서 반응 온도가 약 -40 내지 -20˚C인 방법.
  7. 제 1항에 있어서, 언급된 용매가 디클로로메탄인 방법
  8. 제 1항에 있어서, R2가 메틸, 에틸 또는 n-부틸인 방법.
  9. ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005159A 1982-11-01 1983-10-31 1,1-디옥소페니실라노일옥시메틸 6-β-아미노 페니실라네이트의 제조방법 Expired KR860001494B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US438,228 1982-11-01
US438228 1982-11-01
US06/438,228 US4530792A (en) 1982-11-01 1982-11-01 Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate

Publications (2)

Publication Number Publication Date
KR840007009A true KR840007009A (ko) 1984-12-04
KR860001494B1 KR860001494B1 (ko) 1986-09-27

Family

ID=23739781

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830005159A Expired KR860001494B1 (ko) 1982-11-01 1983-10-31 1,1-디옥소페니실라노일옥시메틸 6-β-아미노 페니실라네이트의 제조방법

Country Status (25)

Country Link
US (1) US4530792A (ko)
EP (1) EP0108545B1 (ko)
JP (1) JPS5998090A (ko)
KR (1) KR860001494B1 (ko)
AT (1) ATE24322T1 (ko)
AU (1) AU541962B2 (ko)
CA (1) CA1204736A (ko)
CS (1) CS235986B2 (ko)
DD (1) DD213926A5 (ko)
DE (1) DE3368417D1 (ko)
DK (1) DK163515C (ko)
EG (1) EG15987A (ko)
ES (1) ES526942A0 (ko)
FI (1) FI76576C (ko)
GR (1) GR78943B (ko)
GT (1) GT198303898A (ko)
HU (1) HU189769B (ko)
IE (1) IE56179B1 (ko)
IL (1) IL70095A (ko)
NZ (1) NZ206108A (ko)
PH (1) PH19573A (ko)
PL (1) PL142735B1 (ko)
PT (1) PT77580B (ko)
YU (1) YU43989B (ko)
ZA (1) ZA838091B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01139584A (ja) * 1987-11-25 1989-06-01 Yoshitomi Pharmaceut Ind Ltd ペニシラン酸化合物の製造法
GB2231049A (en) * 1989-04-14 1990-11-07 Yoshitomi Pharmaceutical Method for producing diester compounds
US5399678A (en) * 1990-04-13 1995-03-21 Pfizer Inc. Process for sultamicillin intermediate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896110A (en) * 1971-10-04 1975-07-22 American Home Prod Process for preparation of 6-aminopenicillanic acid
GB1382736A (en) * 1971-11-16 1975-02-05 Yamanouchi Pharma Co Ltd Process of producing semi-synthetic penicillin
FR2275460A1 (fr) * 1974-06-20 1976-01-16 Schmoller & Bompard Procede pour la preparation de l'acide 6-aminopenicillanique
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49880B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4364957A (en) * 1979-09-26 1982-12-21 Pfizer Inc. Bis-esters of alkanediols as antibacterial agents
US4376076A (en) * 1981-03-23 1983-03-08 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide
US4359472A (en) * 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4375434A (en) * 1982-06-21 1983-03-01 Pfizer Inc. Process for 6'-amino-penicillanoyloxymethyl penicillanate 1,1-dioxide

Also Published As

Publication number Publication date
FI833961A0 (fi) 1983-10-28
ATE24322T1 (de) 1987-01-15
AU2082183A (en) 1984-05-10
PL244352A1 (en) 1985-02-27
GT198303898A (es) 1985-04-20
KR860001494B1 (ko) 1986-09-27
PH19573A (en) 1986-05-21
FI76576C (fi) 1988-11-10
DK163515B (da) 1992-03-09
GR78943B (ko) 1984-10-02
DK497483A (da) 1984-05-02
DD213926A5 (de) 1984-09-26
US4530792A (en) 1985-07-23
FI833961L (fi) 1984-05-02
HU189769B (en) 1986-07-28
PT77580A (en) 1983-11-01
FI76576B (fi) 1988-07-29
IL70095A0 (en) 1984-01-31
ES8602014A1 (es) 1985-11-01
CS235986B2 (en) 1985-05-15
JPS5998090A (ja) 1984-06-06
YU216283A (en) 1986-02-28
EP0108545B1 (en) 1986-12-17
ZA838091B (en) 1985-06-26
EG15987A (en) 1989-03-30
ES526942A0 (es) 1985-11-01
CA1204736A (en) 1986-05-20
EP0108545A1 (en) 1984-05-16
PL142735B1 (en) 1987-11-30
AU541962B2 (en) 1985-01-31
DE3368417D1 (en) 1987-01-29
IE832539L (en) 1984-05-01
DK497483D0 (da) 1983-10-31
YU43989B (en) 1990-02-28
PT77580B (en) 1986-05-27
NZ206108A (en) 1986-06-11
DK163515C (da) 1992-08-24
IE56179B1 (en) 1991-05-08
IL70095A (en) 1988-03-31
JPH0329796B2 (ko) 1991-04-25

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