KR830005160A - 피리미돈 유도체의 제조방법 - Google Patents
피리미돈 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830005160A KR830005160A KR1019810001024A KR810001024A KR830005160A KR 830005160 A KR830005160 A KR 830005160A KR 1019810001024 A KR1019810001024 A KR 1019810001024A KR 810001024 A KR810001024 A KR 810001024A KR 830005160 A KR830005160 A KR 830005160A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- substituted
- furanyl
- thienyl
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000008318 pyrimidones Chemical class 0.000 title claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 5
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 5
- -1 4-Imidazolyl group Chemical group 0.000 claims 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000003573 thiols Chemical group 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 229910052757 nitrogen Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 229910052760 oxygen Chemical group 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 구조식(Ⅱ)의 화합물을 구조식(Ⅲ)의 피리미돈 유도체와 반응시킨 후 B1이 2-푸라닐 또는 2-티에닐이고 임의로는 W가 2-푸라닐 또는 2-티에닐인 경우에는 제조된 생성물을 치환체 R1R2N(CH2)m-(m은 1)을 제공하는 만니히 시약과 반응시킨 다음 제조된 구조식(Ⅰ)의 화합물을 염으로 변환시킴을 특징으로 하여 구조식(Ⅰ)의 화합물 및 그의 약제학적으로 무독한 산부가염을 제조하는 방법.상기 구조식중W는 5-위치가 R1R2N(CH2)m-그룹으로 임의 치환된 2-푸라닐 또는 2-티에닐그룹, 3- 또는 4-위치가 R1R2N(CH2)m그룹으로 치환된 페닐그룹, 5-위치가 메틸 또는 브롬으로 임의 치환된 4-이미다졸릴그룹, 3-위치가 C1-4알킬, C1-4알콕시, 할로겐, 아미노 또는 하이드록시로 임의 치환된 2-피리딜그룹, 2-티아졸릴그룹 또는 2-구아니디노-4-티아졸릴그룹이며X는 메틸렌 또는 유황이고Y는 메틸렌 또는, 단 X가 메틸렌이고 W가 치환된 페닐그룹일 경우에는 산소이며Z는 수소 또는 C1-4알킬이고B는 5-위치가 R1R2N(CH2)m-그룹으로 치환된 2-푸라닐 또는 2-티에닐그룹, 3-또는 4-위치가 R1R2N(CH2)m그룹으로 치환된 페닐그룹, 또는 R1R2N(CH2)m그룹으로 5- 또는 6-위치가 치환된 3-피리딜그룹, 2-위치가 치환된 4-피리딜그룹 또는 4- 또는 5-위치가 치환된 2-피리딜그룹이며 이때 R1과 R2는 C1-4알킬 또는 이들이 부착되어 있는 질소원자와 함께 피롤리디노, 피페리디노 또는 모르폴리노그룹이고 m은 1내지 4이고D는 -XCH2CH2NH2또는 단 Y가 메틸렌일 경우에는 티올로 치환될 수 있는 그룹이며B1은 2-푸라닐, 2-티에닐 또는 B이고A는 D가 -XCH2CH2NH2인 경우에는 아민에 의해 치환될 수 있는 그룹이고 D가 티올로 치환될 수 있는 그룹인 경우에는 HS-CH2-CH2NH이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8010663 | 1980-03-29 | ||
| GB8010663 | 1980-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830005160A true KR830005160A (ko) | 1983-08-03 |
Family
ID=10512493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810001024A Ceased KR830005160A (ko) | 1980-03-29 | 1981-03-28 | 피리미돈 유도체의 제조방법 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS56154482A (ko) |
| KR (1) | KR830005160A (ko) |
| ZA (1) | ZA812097B (ko) |
-
1981
- 1981-03-27 JP JP4611981A patent/JPS56154482A/ja active Pending
- 1981-03-28 KR KR1019810001024A patent/KR830005160A/ko not_active Ceased
- 1981-03-30 ZA ZA00812097A patent/ZA812097B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56154482A (en) | 1981-11-30 |
| ZA812097B (en) | 1982-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19810328 |
|
| PG1501 | Laying open of application | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19840531 Patent event code: PE09021S01D |
|
| PE0601 | Decision on rejection of patent |
Patent event date: 19840906 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19840531 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |