KR20250061274A - Liposome composition - Google Patents

Abstract

The liposome composition according to the present invention comprises:
A composition containing an oily component and an aqueous component,
Liposomes containing oil components inside and having an average particle size of 300 to 500 nm that can be deposited on the sheet; and
It has a matrix that is provided on the outside of the liposome and contains water,
It is characterized in that the oily component is contained in an amount of 4.7 to 6.4 parts by weight for 100 parts by weight of the water-based component.

Description

Liposome composition and sheet impregnated therewith {Liposome composition}

The present invention relates to a liposome composition and a sheet impregnated therewith.

In the case of a composition that is deposited on a sheet such as a wet tissue or cleansing tissue and used, compatibility between the sheet and the liquid is important, and it is common to use a solubilized type of precipitate that can quickly absorb the liquid composition into the sheet.

These solubilized type compositions are less sticky and easier to apply to the skin than general emulsion formulations, and are sold commercially in various types, such as wet tissues and cleansing tissues.

However, liquid compositions of the solubilized type have a low oil content, so they have a low skin wetting effect, and when applied to the skin, there is a disadvantage in that moisture loss may occur along with the formulation.

Accordingly, when a large amount of oil is contained in a liquid composition of the solubilized type to prevent moisture loss of the formulation, the oil is not evenly distributed on the sheet, and problems such as separation or precipitation of the liquid composition formulation often occur.

That is, since the emulsifying type composition, which is easier to contain oil than the solubilizing type, has larger particle sizes than the solubilizing type composition, its compatibility with the sheet is low and it is not evenly absorbed into the sheet. Even when the viscosity is simply lowered to make it into a liquid for absorption, the particle sizes are larger than those of the solubilizing type composition, so the oil particles are not evenly absorbed into the sheet and only the moisture layer is absorbed, which is a disadvantage. In addition, since the viscosity of the composition itself is low, the same stability problems, such as separation and precipitation, may occur.

In order to solve the above problems, only some of the raw materials used in the product were nano-sized and manufactured, but there were limitations in that when a product is manufactured by simply nano-sizing only some of the raw materials, the oil content is lower than that of a general emulsion, so the skin softening effect is lower, and the stability of the composition itself is not secured.

Korean Patent No. 10-2011-0058240

The present invention has been designed to solve the problems of the prior art, and aims to provide a liposome composition having a high oil content, excellent stability and uniformity without separation and precipitation problems, and easy impregnation into a sheet.

In addition, the purpose is to provide a sheet impregnated with a liposome composition having a high oil content, low moisture loss when applied to the skin, and excellent stability and uniformity without problems of separation and precipitation.

The liposome composition contains an oily component and an aqueous component,

It is characterized by containing an oil component inside liposomes having an average particle diameter of 300 to 500 nm, having a matrix containing water on the outside of the liposomes, and containing 4.7 to 6.4 parts by weight of an oil component per 100 parts by weight of an aqueous component.

In addition, the liposome composition is characterized in that the liposomes have a size of 330 to 490 nm, the oil component includes at least one of hydrocarbon oil, ester oil, and vegetable oil, and particularly the oil component includes medium-chain fatty acid oil, the liposomes are formed by the action of a surfactant and an emulsifying agent, the surfactant includes hydrogenated lecithin and is included in an amount of 0.1 to 2 parts by weight per 100 parts by weight of water, the emulsifying agent includes both an emulsifying agent for an aqueous component and an emulsifying agent for an oily component, the emulsifying agent for the oily component is a higher alcohol, and the emulsifying agent for the aqueous component is a water-soluble emulsifying polymer, and the difference in water loss before and after use when measuring TEWL using a Tewameter is 3 or more.

Meanwhile, the method for manufacturing a liposome composition includes a step of providing an oily component including an oil component, a step of providing an aqueous component including water, a step of forming particles by mixing and stirring the oily component and the aqueous component, a step of cooling to 20 to 35°C, and a step of forming liposome structure droplets of 300 to 500 nm by high-pressure emulsification and homogenization after the cooling. The aqueous component providing step is characterized by heating to 50 to 75°C in a manufacturing tank, the oily component providing step is heated to 60 to 90°C in a manufacturing tank, stirring is performed at 1000 to 3500 rpm, and the nanoparticle forming step is characterized by processing a high-pressure emulsification and homogenization device at least once at a pressure of 800 to 1200 bar.

Another aspect of the present invention is:

Liposomes containing oil components inside and having an average particle size of 300 to 500 nm; and

It has a matrix that is provided on the outside of the liposome and contains water,

A liposome composition containing 4.7 to 6.4 parts by weight of the oily component relative to 100 parts by weight of the water-based component; and

A liposome composition-impregnated sheet comprising a sheet impregnated with the above liposome composition is provided.

The liposome composition according to the present invention is liquefied through a high-pressure emulsification homogenizer, so it has excellent stability without problems such as separation or precipitation, has high compatibility with sheets, is easy to absorb, and has the effect of preventing the oil layer from separating.

In addition, the sheet according to the present invention can contain more oil than a general liquid type composition, so it has excellent skin flexibility and moisturizing effects.

The sheet according to the present invention is impregnated with a liquid, so that it can be applied to a wider area of skin than a conventional gel-type sheet. In addition, since it is impregnated with a composition with a high oil content, it forms a protective layer on the skin even when used for wiping the skin, and can protect, for example, damaged skin. Therefore, it can be used as a disposable wound cleansing or protective tissue.

Figure 1 is a photograph taken after the 45°C stability test of Example 3.
Figure 2 is a photograph taken after the 45℃ stability test of three comparative examples.
Figure 3 is a photograph taken immediately after the sheet usability test of Example 1 and Comparative Example 4.
Figure 4 is a photograph taken 24 hours after the sheet usability test of Example 1 and Comparative Example 4.

Before describing the present invention in detail below, it is to be understood that the terminology used in this specification is only for the purpose of describing specific embodiments and is not limited only by the scope of the appended claims. All technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the art, unless otherwise stated.

In addition, when interpreting terms or words used in this specification and claims below, they should not necessarily be interpreted only by their usual or dictionary meanings, based on the principle that the inventor can appropriately define the concept of the term to best explain his or her own invention, but should be interpreted with meanings and concepts that are consistent with the technical idea of the present invention as described in this specification.

Throughout this specification and claims, unless the context clearly dictates otherwise, the terms “comprise,” “comprises,” and “comprising” are intended to mean including a stated item, step, group of items, or steps, but not to exclude any other item, step, group of items, or group of steps.

Meanwhile, the various embodiments of the present invention may be combined with any other embodiments unless there is a clear indication to the contrary. In particular, any feature indicated as being preferable or advantageous may be combined with any other feature or features indicated as being preferable or advantageous.

In this specification, 'solubilization' means that one substance is homogenized in another substance and mixed at the molecular level. For example, solubilization refers to a form in which a solute is completely dispersed in a solvent. Unlike emulsification, solubilization is a thermodynamically stable state, and has the characteristic of appearing transparent because the size of the droplets is smaller than visible light (400 nm to 800 nm).

In this specification, 'emulsification' is the process of mixing two or more immiscible liquids to form a stable mixture in which one is dispersed in the form of fine droplets within the other. In this case, the two liquids appear to be mixed at a visual level, but are still separated at a microscopic level. The emulsification process is accomplished using an emulsifier.

In this specification, the term ‘sheet’ refers to a fabric that can absorb a liquid composition, and can be manufactured by including one or more of cotton, cellulose, Tencel, and Biocel, but is not limited thereto. The types of sheets include pure cotton, microfiber, Biocel, cupro, and Sontara, and it is preferable to use pure cotton to reduce friction with the skin and provide a soft feeling when used. In addition, the sheet is a concept that includes tissues used for purposes such as cleansing, such as a thin and soft piece of fabric used in wet tissues and cleansing tissues.

In the present invention, a droplet is a particle formed during emulsification, which means that two liquids with different properties (e.g., oil and water) are mixed and one liquid is dispersed in the other liquid in the form of small droplets.

A liposome composition according to one aspect of the present invention comprises a liposome and a matrix.

A liposome is a structure having a central receiving space surrounded by a positively charged lipid layer, and the lipid layer takes the form of having polar heads facing the outside and inside water layers, and lipid tails meeting each other in the center. In the present invention, the liposome contains an oil component inside, and has a size of 300 to 500 nm in diameter.

That is, the liposome of the present invention is of a nano-sized size, and is manufactured by including a surfactant and an emulsifying agent in an emulsion having nano-sized particles, which will be described later, and then under the homogeneous conditions of a high-pressure homogenizer.

High pressure emulsification homogenizers use pressure to break down ingredients into microscopic particles. This works by forcing the ingredients through tiny gaps or holes under high pressure. High pressure emulsification homogenizers can homogenize ingredients down to a size of tens of nanometers (nm).

Accordingly, the liposome contains an oil component, and the oil component may be one or a mixture of two or more selected from hydrocarbon oil, ester oil, vegetable oil, and silicone oil.

The hydrocarbon oil may be selected from the group consisting of, but not limited to, cyclododecane, isooctane, liquid paraffin, petrolatum, hydrogenated polydecene, and squalane.

The ester oil may be selected from the group consisting of, but not limited to, one or more of isopropyl myristate, ethyl laurate, ethyl myristate, isopropyl palmitate, butyl laurate, hexyl laurate, caprylic/capric triglyceride, pentaerythrityl tetraisostearate, butylene glycol dicaprylate/dicaprate, isopropyl myristate, triethylhexanoin, and cetyl ethylhexanoate.

Vegetable oils may be selected from the group consisting of, but are not limited to, jojoba oil, sunflower seed oil, almond oil, olive oil, sesame oil, wheat germ oil, safflower oil, camellia oil, castor oil, grape seed oil, green tea seed oil, macadamia nuts, meadowfoam seed oil, palm oil, rosehip oil, argan oil, argania kernel oil, lavender oil, and shea butter, coconut butter, jojoba butter, and mango seed butter in butter form.

Silicone oil may be selected from the group consisting of, but is not limited to, one or more of dimethicone, dimethiconol, cyclopentasiloxane, dimethicone/vinyl dimethicone crosspolymer, cyclohexasiloxane, amodimethicone, and amodimethicone/morpholinomethylsilsesquioxane copolymer. Silicone oil forms a protective film on the skin and helps lock in moisture.

In particular, it is preferable to include medium-chain triglyceride oils such as caprylic/capric triglycerides as an oil component. Medium-chain triglycerides (MCTs) have high stability, so they are prevented from being deteriorated or decomposed during the high-pressure emulsification and homogenization process, and can be stably dispersed at the interface, allowing liposomes to be uniformly distributed. Since they are compatible with various ingredients, they can be used together with other ingredients during the liposome process, and are easy to be liposomeized, allowing the active ingredients of the composition to penetrate deep into the skin and work more effectively.

The oil component used in the mixture is used in an amount of 1 to 5 parts by weight, preferably 2 to 3 parts by weight, per 100 parts by weight of water.

If the oil content exceeds the above range, the product may feel too oily, remain on the skin and clog pores, and the product's absorbency may be reduced.

If the oil content is below the above range, the moisturizing power may be reduced, resulting in high transepidermal moisture loss, and the texture may be uncomfortable, making the product feel rough or thick.

The matrix contains water, so that when applied to the skin, it can provide moisture and provide a cool and moist feeling. In one embodiment of the present invention, the water content of the matrix is preferably 50 to 85 wt% based on the total content of the composition.

Liposomes are made by including the action of a surfactant and an emulsifying agent. The surfactant may be at least one selected from the group consisting of hydrogenated lecithin, glyceryl stearate, cetearyl olivate, sorbitan olivate arachidyl glucoside, polyglyceryl-10 stearate, C12-20 alkyl glucoside, polyglyceryl-3 methyl glucose distearate, polyglyceryl-10 myristate, sorbitan stearate, sorbitan laurate, and polyoxyethylene stearate, but is not limited thereto.

In particular, from the viewpoint of increasing skin penetration and stability, it is suitable to use hydrogenated lecithin in an amount of 0.1 to 5 parts by weight, and preferably 0.5 to 2 parts by weight, per 100 parts by weight of water.

In the high-pressure emulsification process, droplets, which are particles of a hydrogenated emulsified solution, can be dispersed, and liposomes can be formed so that the dispersion can be maintained over time.

At this time, in order to form nano-sized liposomes, the HLB value (Hydrophilic-Lipophilic Balance) of hydrogenated lecithin is preferably in the range of 9 to 10. If it exceeds or falls short of the above range, the ability to form liposomes may decrease, liposome particles may not be formed, making it difficult to implement the formulation, and stability problems such as aggregation of liposome particles may occur.

In order to stably form and maintain liposomes, an emulsifying agent may be further included. It is preferable to use both aqueous and oily emulsifying agents.

The water-soluble emulsifying polymer may be included as an emulsifying auxiliary agent. The water-soluble emulsifying polymer may be carboxymethylcellulose, carbomer, polyvinyl alcohol, polyethylene glycol (PEG), soluble collagen, hyaluronic acid, and acrylates/C10-30 alkyl acrylate crosspolymer.

In particular, Acrylates/C10-30 Alkyl Acrylate Crosspolymer can provide excellent stability while providing a pleasant feeling.

The emulsifying agent of the oil may include a higher alcohol. As the higher alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, arachidyl alcohol, octyl alcohol, etc. can be used, but are not limited thereto.

The content of the surfactant and emulsifying agent is preferably 0.5 to 4 parts by weight, and preferably 1 to 3 parts by weight, per 100 parts by weight of water. If it exceeds the above range, liposomes may not be formed or the viscosity of the liposomes may be high, making it difficult to convert a solid-state emulsified cream into a liquid-state emulsified type through a high-pressure homogenization emulsifier.

The liposome composition may contain functional additives, such as skin irritation-relieving ingredients commonly used in compositions, as needed, and may use ingredients that can provide skin moisturizing ingredients, moisturizing sensation, conditioning, and nutrition without limitation.

The skin irritation-relieving ingredient may be at least one selected from the group consisting of, for example, allantoin, aloe vera, purslane extract, green tea extract, chamomile extract, grape extract, licorice root extract, and honeysuckle extract, but is not limited thereto.

The skin moisturizing ingredient may be at least one selected from the group consisting of glycerin, dipropylene glycol, isopentyldiol, hyaluronic acid, 1,3-butylene glycol, glucose, hydroxyethyl urea, urea, sorbitol, lactic acid, galactose, propylene glycol, and isopropyl myristate, but is not limited thereto.

In addition, a preservative or antiseptic may be further included. Preferably, the content of the preservative or antiseptic is 0.1 to 2 parts by weight per 100 parts by weight of water.

If it is contained below the above range, the preservation effect is not sufficient, and if it exceeds the above range, there is concern about skin irritation and there are uneconomical problems.

The preservative or antiseptic may be, but is not limited to, at least one selected from the group consisting of caprylyl glycol, chlorophenesin, trisodium EDTA, hydroxyacetophenone, potassium sorbate, phenoxyethanol, benzyl alcohol, and 1,2-hexanediol.

The liposome composition may further include a thickening agent such as a polymer compound to provide formulation stability to the composition. The polymer compound can evenly disperse the emulsified particles to produce a composition with excellent stability. If the emulsified particles are produced without including the polymer compound, the particles may separate or precipitate, which may cause stability problems.

The above polymer may or may not select one or more of thickeners such as ammonium acryloyldimethyltaurate/VP copolymer, xanthan gum, and carbomer, but is not limited thereto.

Additionally, silicone oil may be included for skin texture, and amino acid components may be included for skin regeneration.

Hereinafter, a method for producing a nanoemulsion composition using a high-pressure emulsification homogenizer is described. The method for producing a nanoemulsion composition includes an oily component providing step, an aqueous component providing step, a stirring step, a cooling step, and a nanoparticleization step.

The oily component providing step is a step for providing oily components including oil components, and is a step for putting the oily components into a tank and heating to 60 to 90°C to dissolve them. In the case of butter or solid-form surfactants and emulsifying aids included in the oily components, it is suitable to heat them in liquid form and use them in order to uniformly emulsify them. This process is suitable to be performed at a minimum of 60 to a maximum of 90°C. If heated below 60°C, the solid-form oily components may not be uniformly dissolved, and if heated above 90°C, the oily components may be deformed. Therefore, it is suitable to heat them at a temperature of 60 to 90°C.

At this time, the oil-based ingredients include oil, oil-based surfactants, oil-based emulsifying agents, and oil-based moisturizing ingredients.

The step of providing water-based components is the step of putting them in a tank and heating them to 50 to 75°C to dissolve them. Among the water-based components, solid and powder-type components such as allantoin must go through a heating process to be transparently dissolved in the water phase, so it is appropriate to heat the water phase to a certain temperature or higher. In addition, if the temperature difference between the water phase and the oil phase is large, it is difficult to form uniform emulsified particles, so it is appropriate to heat them to a temperature similar to that of the oil phase and use them.

Mercury ingredients include water, skin moisturizing ingredients, preservatives, and aqueous emulsifying agents.

At this time, it is preferable that the water-based component and the oil-based component are included in an amount of 4.7 to 6.4 parts by weight of the oil-based component per 100 parts by weight of the water-based component. If the oil-based component is less than the above range, the content of the oil component decreases, thereby deteriorating the original function of the composition. If it exceeds the above range, the interaction between particles is strengthened, so that the particles may combine with each other to form larger particles or have an uneven structure.

The emulsification step is the step of mixing all of the oil-based and water-based components and stirring them at 1000 to 3500 rpm to emulsify them and create emulsified droplets.

The cooling step is the step of cooling the mixture to a final temperature of 20 to 35°C after the stirring step.

The nanoparticle step is a step of forming liposomes having a diameter of 300 to 500 nm by treating the emulsified solution containing droplets in the emulsification step with a high-pressure emulsification homogenizer at a pressure of 800 to 1200 bar, preferably 900 to 1100 bar, at least once. If the pressure is below the above range, the droplets of the raw material are not sufficiently broken and thus are not homogenized into liposomes of the desired size. If the pressure exceeds the above range, the quality of the raw material deteriorates or deteriorates, and due to the characteristics of the raw material, it is homogenized into too fine a particle size and liposomes of the desired particle size cannot be obtained.

[Example]

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are only intended to illustrate the present invention, and the content of the present invention is not limited to the following examples.

< Manufacture of liposome composition>

<Examples 1 to 3 and Comparative Examples 1 to 3>

Examples and comparative examples of liposome compositions were prepared according to Table 1 below. Specifically, aqueous components were added to the preparation tank and heated to 75°C to dissolve them.

In addition, the oil components (7-15) were placed in an oil tank, heated to 75°C, stirred, and the contents of the two tanks were stirred at 3500 rpm to prepare an emulsion composition. The prepared emulsion composition was finally cooled to 30°C.

Thereafter, in Examples 1 to 3, the manufactured emulsion composition was treated once at a pressure of 1000 bar through a high-pressure emulsification homogenizer to form a liposome composition having a liposome size in the range of 300 to 500 nm.

Example 1 used higher alcohol and emulsifying polymer as emulsifying assistants, and Examples 2 and 3 used higher alcohol and emulsifying polymer by adjusting the content, respectively.

Comparative Example 1 was liquefied without including hydrogenated lecithin as a surfactant, Comparative Example 2 has a low content of hydrogenated lecithin and does not include an emulsifying agent. In addition, Comparative Example 3 does not include an oil phase.

Raw Material No. Ingredient name Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 1 Purified water 78.45 78.55 78.65 79.35 79.35 83.5 2 glycerin 5 5 5 5 5 5 3 Dipropylene glycol 10 10 10 10 10 10 4 Hydroxyacetophenone 0.5 0.5 0.5 0.5 0.5 0.5 5 Alginine 0.1 0.1 - 0.1 0.1 0.1 6 Acrylate/C10-30 alkyl acrylate crosspolymer 0.1 0.1 - 0.1 0.1 0.1 7 Hydrogenated Lecithin 0.8
(HLB 9) 0.8
(HLB 9.5) 0.8
(HLB 10) - 0.1
(HLB 8.5) 0.8
(HLB 10.5) 8 Caprylic/Capric Triglyceride 2 2 2 2 2 - 9 Dimethicone 1.5 1.5 1.5 1.5 1.5 - 10 Cetyl alcohol 0.2 0.1 0.2 0.1 - - 11 Cetearyl Olivate 0.1 0.1 0.1 0.1 0.1 - 12 Solbitan Olivate 0.1 0.1 0.1 0.1 0.1 - 13 Glyceryl stearate 0.05 0.05 0.05 0.05 0.05 - 14 Stearic acid 0.1 0.1 0.1 0.1 - 0.1 15 Squalane 1 1 1 1 - 1

Experimental Example 1. Measurement of liposome size

The average size (particle diameter) of liposomes in nanoemulsions was measured using a BX53 polarizing microscope from OLYMPUS, and is summarized in Table 2. The average liposome size refers to the average value obtained when more than 50 liposomes were measured using a polarizing microscope.

condition Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Entry 332nm 487nm 453nm 3350nm 2870nm Immeasurable

Accordingly, it can be seen that the examples have particle sizes of 300 to 500 nm, while the comparative examples have particle sizes of 2000 nm or more. In the case of comparative example 3, since it does not contain an oily component, particles were not formed, making it impossible to measure the particle size.

Experimental Example 2. Confirmation of Formulation Stability

The compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were stored for a long period of time under various temperature conditions to confirm the formulation stability. The compositions were stored for a long period of time in incubators at 25°C, 0°C, and 45°C, respectively, and the stability of the products (foreign body sensation, homogeneity of contents, change in appearance) was confirmed through visual analysis after a certain period of time. The formulation stability was evaluated as ◎ for good, ○ for average, and △ for poor, and the evaluation results are summarized in Table 3 below.

condition Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 25 (℃) 1 week ◎ ◎ ◎ △ ○ ◎ 2 weeks ◎ ◎ ◎ △ △ ◎ 3 weeks ◎ ◎ ◎ △ △ ◎ 2 months ◎ ◎ ◎ △ △ ◎ 4 months ◎ ◎ ◎ △ △ ◎ 0 (℃) 1 week ◎ ◎ ◎ △ ○ ◎ 2 weeks ◎ ◎ ◎ △ ○ ◎ 3 weeks ◎ ◎ ◎ △ △ ◎ 2 months ◎ ◎ ○ △ △ ◎ 4 months ◎ ◎ ○ △ △ ◎ 45 (℃) 1 week ◎ ◎ ◎ △ △ ◎ 2 weeks ◎ ◎ ◎ △ △ ◎ 3 weeks ◎ ○ ◎ △ △ ◎ 2 months ◎ ○ ○ △ △ ◎ 4 months ◎ ○ ○ △ △ ◎

As described in Table 2 above, the stability of the composition of Example 1 was confirmed to exist stably without unification or separation under all temperature conditions. In the case of Example 2, the content of higher alcohol was low, so it showed a somewhat unstable appearance at high temperatures, and in the case of Example 3, the content of polymer compound was low, so it showed a somewhat unstable appearance at high and low temperatures, but it did not separate even after 4 months and maintained a good state.

In the case of Comparative Examples 1 and 2, all groups showed unstable stability, such as separation and precipitation. Comparative Example 3 showed a stable appearance where separation and unification of the formulation did not occur because it did not contain oil. Fig. 1 is a photograph taken after the 45°C stability test of three examples, and it can be confirmed that all three examples were stable. Fig. 2 is a photograph taken after the 45°C stability test of three comparative examples, and it can be confirmed that the separation occurred.

Experimental Example 3. Evaluation of epidermal moisture loss

In order to measure the transepidermal water loss according to the oil content of the composition according to the present invention, a Tewameter was used. The temperature and humidity sensors inside the probe measure the amount of water evaporation over time per unit area of the test area, that is, the amount of water loss is calculated from the relative humidity that increases within the probe using the principle of water diffusion. In addition, since the moisture of the skin itself is measured at the beginning of the TEWL measurement, an accurate value is measured after about 30-60 seconds of stabilization. The forearm area of 10 testers was measured before using the product, and the same area was measured 30 minutes after using the product, and the results are summarized in Table 4. The standard measurement temperature is 25 °C and the humidity is 40%.

Measurement point Amount of moisture loss from the epidermis before using the product Amount of moisture loss from the epidermis after using the product Example 1 11.61 ± 6.75 8.01±6.75 Example 2 13.55 ± 4.50 10.55 ± 2.92 Example 3 13.48 ± 4.47 10.42 ± 3.89 Comparative Example 1 12.17 ± 4.35 10.37 ± 2.70 Comparative Example 2 12.47 ± 3.83 9.78 ± 3.37 Comparative Example 3 11.35 ± 5.66 10.72 ± 3.50

When comparing Example 1 and Comparative Example 2, the transepidermal water loss in the forearm area significantly decreased by an average of 3.6 in Example 1 compared to before use of the product. However, in the case of Comparative Example 3, which did not use an oily component, it was confirmed that the transepidermal water loss decreased by 0.63. In addition, the transepidermal water loss of the Example decreased by an average of 3.22, while the Comparative Example showed an average decrease of 1.7.

Through this, it was confirmed that the liquid cream formulation containing oil had a superior skin moisturizing effect and moisture loss prevention function than the liquid formulation not containing oil.

Experimental Example 4: Sheet Absorption Evaluation

To determine the sheet compatibility of the composition according to the present invention, a sheet absorption evaluation was conducted.

The sheets used for the evaluation were made of 100% cotton and were divided into equal parts, 15 cm wide and 5 cm long, for absorption evaluation. The sheets were deposited in 10 g each in Example 1, which was nano-emulsified using a high-pressure emulsification homogenizer, and Example 1 (hereinafter referred to as Comparative Example 4) of the same formulation without using a high-pressure emulsification homogenizer, to determine the usability and absorbency with the sheets. For smooth testing, blue pigment was added to Example 1 and Comparative Example 4, and the area absorbed in blue was measured to determine the absorbency.

Fig. 3 is a photograph immediately after Example 1 and Comparative Example 4 were absorbed into the sheet, and Fig. 4 is a photograph 24 hours later. In the case of Fig. 3, it can be seen that blue pigment is confirmed in the same location for both Example 1 and Comparative Example 4. However, in the case of Fig. 4, which was taken 24 hours after precipitation, it can be seen that, compared to Example 1, where the area of blue pigment was expanded, in the case of Comparative Example 4, absorption was not observed to the extent that there was no difference from Fig. 3.

That is, in Example 1, it was possible to confirm the sedimentation range of blue pigment up to a maximum of 14 cm in width and 5 cm in height, whereas in the case of Comparative Example 4, it was confirmed that the absorption rate was lower than that of Example 1, with a maximum of 4.5 cm in width and 5 cm in height.

Through this, it was confirmed that general emulsion formulations have poor compatibility, such as difficulty in absorption into sheets due to particle size, and that formulations that are liposomized through a high-pressure homogenization emulsifier have high compatibility with sheets, and absorption is achieved at values similar to those of solubilized formulations.

The features, structures, effects, etc. exemplified in each of the above-described embodiments can be combined or modified and implemented in other embodiments by a person having ordinary knowledge in the field to which the embodiments belong. Therefore, the contents related to such combinations and modifications should be interpreted as being included in the scope of the present invention.

Claims (18)

A composition containing an oily component and an aqueous component,
Liposomes containing oil components inside and having an average particle size of 300 to 500 nm that can be deposited on the sheet; and
It has a matrix that is provided on the outside of the liposome and contains water,
A liposome composition comprising 4.7 to 6.4 parts by weight of the oily component relative to 100 parts by weight of the water-based component. In the first paragraph,
The above liposome is a liposome composition having a size of 330 to 490 nm. In the second paragraph,
A liposome composition comprising at least one oil component selected from the group consisting of hydrocarbon oil, ester oil, and vegetable oil. In the third paragraph,
The above oil component is a liposome composition containing medium chain fatty acid oil. In paragraph 4,
The above liposome is formed by the action of a surfactant and an emulsifying agent, and the surfactant is a liposome composition containing hydrogenated lecithin. In paragraph 5,
A liposome composition comprising the hydrogenated lecithin in an amount of 0.1 to 2 parts by weight per 100 parts by weight of water. In Article 6,
The above emulsifying agent is a liposome composition including both an aqueous component emulsifying agent composed of an aqueous component and an oily component emulsifying agent composed of an aqueous component. In Article 7,
A liposome composition in which the emulsifying agent of the above-mentioned oily component is a high-grade alcohol. In Article 7,
The above emulsifying agent of the water-based component is a liposome composition which is a water-soluble emulsifying polymer. In the first paragraph,
A liposome composition having a difference of 3 or more in the amount of water loss measured before and after use when measuring TEWL (Transepidermal Water Loss) using a Tewameter. Step of providing an oily component containing an oil component;
Step of providing an aqueous component containing water;
An emulsification step of forming emulsion particles by mixing and stirring the oily component and the aqueous component;
A cooling step of cooling the above-mentioned aqueous component and the above-mentioned oily component to 20 to 35°C; and
A method for producing a liposome composition, comprising a liposome formation step of homogenizing the mixture under high pressure after the cooling step to form liposomes having a diameter of 300 to 500 nm. In Article 11,
The above-mentioned aqueous component providing step is a method for producing a liposome composition, which comprises putting the aqueous component into a manufacturing tank and heating it to 50 to 75°C. In Article 12,
The above oily component providing step is a method for producing a liposome composition, which comprises putting the oily component into a manufacturing tank and heating it to 60 to 90°C. In Article 13,
A method for producing a liposome composition, wherein the above stirring is performed at 1000 to 3500 rpm. In Article 14,
A method for producing a liposome composition, wherein the above liposome-forming step is performed at least once at a pressure of 800 to 1200 bar. Liposomes containing oil components inside and having an average particle size of 300 to 500 nm; and
It has a matrix that is provided on the outside of the liposome and contains water,
A liposome composition comprising 4.7 to 6.4 parts by weight of an oily component per 100 parts by weight of a water-based component; and
A liposome composition-impregnated sheet comprising a sheet impregnated with the above liposome composition. In Article 16,
The above liposome is a liposome composition-impregnated sheet having a size of 330 to 490 nm. In Article 17,
The above liposome is formed by the action of a surfactant and an emulsifying agent, and the surfactant is a liposome composition-impregnated sheet containing hydrogenated lecithin.