KR20180032825A - Insulin Injection Appartus with Pulse Oximeter - Google Patents

Abstract

The present invention relates to an insulin injector capable of measuring oxygen saturation and heart rate, the insulin injector for injecting insulin into a user, the insulin injector comprising: at least one light emitting part 121 And a photoplethysmographic signal (PPG) signal measured by the light receiving unit 122. The photoplethysmographic signal measured by the light receiving unit 122 is measured by a light receiving unit 122 measuring a light source irradiated from the light emitting unit 121 and passing through the user's body end, An oxygen saturation and heartbeat measurement module (120) comprising a pulse oximeter (123) measuring in real time a measurement signal including at least one of oxygen saturation and heartbeat; And an insulin injector (100) capable of measuring oxygen saturation and heart rate.

Description

{Insulin Injection Appartus with Pulse Oximeter}

The present invention relates to an insulin injector capable of measuring oxygen saturation and heart rate, the insulin injector for injecting insulin into a user, the insulin injector comprising: at least one light emitting part 121 And a photoplethysmographic signal (PPG) signal measured by the light receiving unit 122. The photoplethysmographic signal measured by the light receiving unit 122 is measured by a light receiving unit 122 measuring a light source irradiated from the light emitting unit 121 and passing through the user's body end, An oxygen saturation and heartbeat measurement module (120) comprising a pulse oximeter (123) measuring in real time a measurement signal including at least one of oxygen saturation and heartbeat; And an insulin injector (100) capable of measuring oxygen saturation and heart rate.

Diabetes mellitus is known to be a common disease with about 200 million people globally, and complications and accompanying diseases associated with diabetes are becoming important health problems with human, social and economic losses.

As Korea is no exception, the Health Insurance Review and Assessment Service analyzed the health insurance data for the last 10 years. As of 2020, it is estimated that 7.22 million (14.4% of the nation) The loss of socioeconomic costs is also expected to be significant.

In the treatment and management of diabetes, the blood sugar control of the patient, that is, the blood glucose control, is most important. Insulin is usually injected into the patient using an insulin syringe, an insulin pen, and an insulin pump.

Insulin syringes are the most common method of administering insulin, which can be administered at very low cost, easy to use, and easy to learn to use.

Insulin pens are devices for injecting insulin into their cartridges, and there are many kinds of products and models. Most insulin pens are divided into two types: reusable pen and disposable pen. Compared to insulin syringes, insulin pens are simple and convenient to inject during going out, and they have the advantage of being able to inject the correct amount of dosage by simple dial operation.

An insulin pump is a medical device that acts like a pancreas. It attaches to the patient's in vitro system and supplies insulin properly to maintain normal blood glucose levels and slowly regenerate pancreas function. The insulin pump injects insulin more subcutaneously for 24 hours than the insulin pen.

The insulin pen which is most widely used among such insulin injecting means is usually equipped with a cartridge containing insulin as disclosed in "pen-type portable insulin injecting apparatus (Korean Patent Registration No. 10-1217147)" A pen-type portable insulin infusion device for inserting a pen into a human body, comprising: a case; a motor fixed inside the case; a plurality of gears fixed to the inside of the case, A drive unit including an installed gear box; A pusher housing having a through hole formed in a longitudinal direction thereof and having one end formed with a through hole rotatably connected to the case; one end connected to the gear box so as to receive rotational force from the gear box; And a pushing unit that is installed inside the through hole of the pusher housing and receives a rotational force of the transmission shaft and is constrained to slide in the longitudinal direction within the through hole of the pusher housing. In this case, an injection amount measurement module capable of measuring the amount of injected insulin is generally added through the configuration of an encoder or the like installed in the motor.

On the other hand, in the case of diabetes, heart-related symptoms such as hypertension contribute not only to the complications of diabetes but also to the major cause of death in diabetic patients. Therefore, cardiovascular symptoms such as hypertension in diabetic patients must be identified promptly and actively treated. However, the conventional insulin injector has a blood glucose measurement function in addition to the injection amount measurement, but there is a problem that the heart rate related indicators such as oxygen saturation, heart rate, and blood pressure can not be measured as described above.

In connection with this blood pressure measurement method, non-open blood pressure measurement methods include auscultatory measurement, palpatory measurement, oscillometric measurement, Finapres (Finger Arterial Pressure measurement), tactile There are various methods such as a phase shift method of a sensor and a method using a pulse wave transmission time.

In general, the most commonly used non-invasive blood pressure measurement methods are stethoscopy and oscillometric methods. In both methods, a cuff is attached to the upper arm or wrist of the subject to pressurize the artery with a pressure higher than the systolic blood pressure, While measuring blood pressure. The pinna press method measures the blood pressure by acquiring the fluctuation of the blood flow through the optical method after providing the pressure in the same manner as the oscillometric method, using the finger as the measurement position. However, the measurement method using the cuff is not suitable for continuous blood pressure measurement or observation of long-time blood pressure change because the occluded artery can not be re-measured until it returns to its original state. Or you may get skin trauma. In particular, the use of such a cuff is a great inconvenience for patients who need to regularly measure and manage blood pressure.

Another method is to use Pulse Transit Time (PTT). This method estimates blood pressure using the inverse relationship between blood pressure and pulse wave transfer time. When blood pressure increases, The blood pressure is measured based on the phenomenon that the pulse wave transmission time is decreased and the blood pressure is decreased to increase the blood vessel wall tension and the pulse wave transmission time is increased. However, the method using the pulse wave transmission time has a problem that an additional acquisition of the electrocardiogram signal is required.

Korean Patent No. 10-1217147

It is an object of the present invention to provide an insulin injector capable of measuring oxygen saturation and heart rate as well as blood pressure by simply contacting a body part of a user's finger or the like by solving the problems of the above- .

It is another object of the present invention to provide an insulin injector capable of measuring oxygen saturation and heart rate capable of sharing and verifying in real-time by transmitting blood pressure to a database server such as a user terminal or a medical institution as well as measured oxygen saturation and heart rate.

In order to achieve the above object, the present invention provides an insulin injector for injecting insulin into a user, the insulin injector being capable of measuring the oxygen saturation and heart rate of the insulin injector, A photodetector 122 for measuring a light source irradiated from the light emitting unit 121 and transmitted through a user's body end and a photodetector 122 for measuring a light flow measurement signal PPG : a pulse oximeter (123) for measuring in real time a measurement signal including at least one of oxygen saturation and heartbeat via a photoplethysmographic signal; And further comprising:

The light emitting unit 121 includes a red light emitting unit 121a and a near-infrared light emitting unit 121b for emitting red light and near-infrared light, respectively.

In addition, the oxygen saturation and heart rate measurement module 120 may be configured to measure the heart rate,

The measurement signal including the systolic blood pressure signal and the diastolic blood pressure is further measured through the systolic blood pressure signal (PPGsys) and the diastolic blood pressure signal (hereinafter referred to as PPGdia).

A wireless communication unit 130 connected to the oxygen saturation and heart rate measurement module 120 and transmitting the measurement signal to the user terminal 200 or the database server 300 through a communication network; And further comprising:

According to the present invention, it is possible to provide an insulin injector capable of measuring blood pressure as well as oxygen saturation and heart rate by simply contacting a body part of a user's finger or the like.

In addition, the blood pressure can be transmitted to a database server such as a user terminal or a medical institution, and can be shared and confirmed in real time, as well as the measured oxygen saturation and heart rate.

Brief Description of the Drawings Fig. 1 is a diagram showing the absorption coefficients of dioxyhemoglobin (Hb) and oxyhemoglobin (HbO2) according to the wavelength of light.
2 shows an example of a PPG signal;
3 is a schematic diagram showing a configuration of an insulin injector capable of measuring oxygen saturation and heart rate according to an embodiment of the present invention.
4 is a schematic diagram showing the configuration of a light emitting unit and a light receiving unit of an insulin injector capable of measuring oxygen saturation and heart rate according to an embodiment of the present invention.
5 is a block diagram illustrating the configuration of an insulin injector capable of measuring oxygen saturation and heart rate according to an embodiment of the present invention.

Hereinafter, an insulin injector capable of measuring oxygen saturation and heart rate according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. First, it should be noted that, in the drawings, the same components or parts are denoted by the same reference numerals whenever possible. In describing the present invention, a detailed description of known functions and configurations incorporated herein will be omitted so as not to obscure the subject matter of the present invention

As shown in FIG. 3, an insulin injector capable of measuring oxygen saturation and heart rate according to an embodiment of the present invention includes an oxygen saturation and heart rate measurement module 120; And further comprising:

In this case, the insulin injector may include various conventional insulin injectors including an insulin pen or an insulin pump as described above. The insulin injector typically includes a drug cartridge 10 for storing insulin, an injection driving unit 20 for injecting insulin stored in the drug cartridge, an insulin injection amount measuring unit 30 for measuring a dose of the insulin, And a display 50 for displaying information such as an operating state and an insulin dose, and the like. Since the conventional insulin injector has been widely known and practiced through many existing inventions including Patent Document 1, detailed description thereof will be omitted.

Next, the oxygen saturation and heart rate measurement module 120 will be described. As shown in FIG. 3, the oxygen saturation and heartbeat measurement module 120 includes at least one light emitting part 121 provided outside the insulin injector such that a user's fingertip, such as a finger of a user, A photodetector 122 for measuring a light source irradiated by the user's body end irradiated by the photodetector 121 and a photoplethysmographic signal (PPG) signal measured by the photodetector 122, And a pulse oximeter 123 for measuring in real time a measurement signal including at least one of them. In this case,

On the other hand, as shown in FIG. 1, when the red light passes through oxyhemoglobin, the absorption rate is lower than dioxyhemoglobin and the absorption rate is higher than that of dioxyhemoglobin when infrared light passes through. This difference has been used as a basic theory to calculate oxygen saturation up to now. In this theory, the absorption depends on the transmission distance and the concentration of hemoglobin. In general, two sources of red and infrared light are selected to obtain oxygen saturation. Accordingly, the light emitting unit 121 may include a red light emitting unit 121a and an infrared light emitting unit 121b, which emit red light and infrared light, respectively, as shown in FIG.

In this case, a nonlinear calibration process is performed to calculate oxygen saturation through optical absorption. Optical absorption depends on hematocrit and blood volume. In addition, oxygen saturation depends on the difference between the anatomical differences of the blood vessels and the blood flow through the blood vessels. The optical absorbance changes with time, with the blood vessel having the highest value in the systole and the lowest value in the diastole. This is because the blood pressure causes the blood to fluctuate in the blood vessel. In other words, red blood cells in the systole carry more oxygen hemoglobin to the tissue. Therefore, the voltage of the pulse wave of the pulse oximeter transmitted through the absorbance dc element of the PPG signal and the ductus arteriosum, as well as the transient volume increase of the absorbing tissue depending on the amount of oxygen hemoglobin which temporarily increases in the systole, . The output voltage of a typical pulse oximeter therefore follows the waveform of the blood pressure. Therefore, the pulse oximeter can basically calculate heart rate. After correction, not only the oxygen saturation but also the blood pressure can be calculated.

On the other hand, the characteristics of the PPG signal in the skin are absorbed by the arterial blood, venous blood, tissue and the like in the light absorption in the skin, that is, when the light source is transmitted through the skin. Is detected as an excitation waveform. A waveform having a pulsating component having a DC component (DC) component and an amplitude (AM) as shown in FIG. 2 is detected. Here, the pulsatile component is affected by the contraction and relaxation of the heart in arterial blood vessels. This part reflects the maximum value during contraction of the heart, and the minimum value during relaxation. 2, the amplitude AM is referred to as a pulse wave signal (hereinafter referred to as PR), the DC component is referred to as a systolic blood volume signal (hereinafter referred to as PPGsys), the amplitude AM is added to a DC component, (Hereinafter referred to as " PPG ").

The PPG signal measures the transmission of light through tissue in the form of a function of time. Tissue blood volume increases during systole. Therefore, the PPG signal shows a low transmittance of light. It also appears to oscillate with the cardiac cycle. As shown in FIG. 2, the PPG signal has elements such as a baseline (hereinafter referred to as BL), an amplitude (hereinafter referred to as AM), and a period (hereinafter referred to as P). BL is inversely proportional to tissue blood volume, AM is proportional to tissue volume increase during systole, and P is the actual cardiovascular cycle.

The relationship between blood pressure and PPG signal is as follows: According to the hemodynamic rule, the pressure = resistance × cardiac output. Therefore, the increase in blood pressure can be represented by an increase in resistance of peripheral blood vessels and an increase in cardiac output. And similar changes in the mechanism of vasoconstriction and relaxation. Therefore, it is possible to measure the blood pressure using the PPG signal. Using this characteristic, the oxygen saturation and heartbeat measurement module 120 further measures the measurement signal including the systolic blood pressure and the diastolic blood pressure through the systolic blood volume signal PPGsys and the diastolic blood volume signal PPGdia .

The measurement signal including at least one of the oxygen saturation, the heart rate, the systolic blood pressure, and the diastolic blood pressure measured through the oxygen saturation and heart rate measurement module 120 is transmitted to the display 50 of the insulin injector, It can be expressed in real time.

In addition, the measurement signal including at least one of oxygen saturation, heart rate, systolic blood pressure, and diastolic blood pressure measured through the oxygen saturation and heart rate measurement module 120 is stored, displayed, and managed in real time or cumulatively As shown in FIG. 5, the insulin injector 100 capable of measuring oxygen saturation and heart rate of the present invention is connected to the oxygen saturation and heart rate measurement module 120, and transmits the measurement signal to a user terminal To a database server (300) such as a medical institution or the like, as well as a wireless communication unit (130).

In the foregoing, optimal embodiments have been disclosed in the drawings and specification. Although specific terms have been employed herein, they are used for purposes of illustration only and are not intended to limit the scope of the invention as defined in the claims or the claims. Therefore, those skilled in the art will appreciate that various modifications and equivalent embodiments are possible without departing from the scope of the present invention. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.

100: insulin injector capable of measuring oxygen saturation and heart rate
110:
120: Oxygen saturation and heart rate measurement module
121:
122: Light sensor
123: pulse oximeter
130:
200: user portable terminal
300: Database server

Claims (4)

An insulin injector for injecting insulin into a user,
A light receiving unit 122 for measuring a light source irradiated from the light emitting unit 121 and passing through the body end of the user, And a pulse oximeter 123 for measuring in real time a measurement signal including at least one of oxygen saturation and heartbeat through a photoplethysmographic signal (PPG) signal measured at the light receiving unit 122 An oxygen saturation and heart rate measurement module 120 configured to measure the heart rate; And an insulin injector (100) capable of measuring oxygen saturation and heart rate.
The method according to claim 1,
Wherein the light emitting unit 121 comprises a red light emitting unit 121a and a near infrared ray emitting unit 121b for emitting red light and near infrared light, respectively. The method according to claim 2,
The oxygen saturation and heart rate measurement module 120,
Wherein the measurement signal further includes a systolic blood pressure signal and a diastolic blood pressure signal (hereinafter, referred to as " PPG ") and further measures a systolic blood pressure and a diastolic blood pressure of the insulin injector. . The method according to any one of claims 1 to 3,
A wireless communication unit 130 connected to the oxygen saturation and heart rate measurement module 120 and transmitting the measurement signal to the user terminal 200 or the database server 300 through a communication network; And an insulin injector (100) capable of measuring oxygen saturation and heart rate.

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