KR20080090101A - Health functional foods using seaweed foods and their manufacturing method - Google Patents

Abstract

The present invention relates to a functional health food containing capsosiphon fulvescens (Mesangi), and more particularly, hangover in the form of tablets, capsules, beverages that ensure long-term stability, containing spiruna, calcium as a main component The present invention relates to a dietary supplement for eliminating and lowering cholesterol.

Description

Nutraceuticals using marine, plant Capsosiphon fulvescens (MESANGI) and its process}

The present invention relates to a health functional food having a hangover resolution and cholesterol lowering effect using a seaweed algae (Capsosiphon fulvescens (Mesangi)), and a method for preparing the same as a health functional food. It is in making a drink by extracting the falcons.

Algae falcons are harvested, washed, packaged and sold as general cooked food from mid-October to the end of February of the year.

However, the problems of these products have a lot of problems in the freshness and various distribution of the product according to the storage, and easy to deteriorate according to the storage conditions according to the climate and temperature, and also the problems such as freezing transport in the state containing water There is a problem that can not be stored for a long time.

To improve these problems and to find a way that anyone can easily and easily ingest at any time during the four seasons came to the present invention.

In the present invention, all of these problems (storage, transport, long-term intake, safety) are designed to be easily and safely ingested by anyone at any time.

That is, in the present invention, amino acids, vitamins, proteins, chlorophyll, and the like contained in falcons, referred to as sea treasury, are essential ingredients for humans to maintain life. However, these essential ingredients are supplied through food in daily life, but most of them do not receive enough food alone.

It is an object of the present invention to provide a simple and safe enough nutrition to those who do not receive enough in daily life and lose their health.

The present invention relates to a dietary supplement for hangover and cholesterol lowering containing capsosiphon fulvescens, spiruna and calcium as main ingredients.

More specifically,

Capsosiphon fulvescens (Mesangi) 70-85% by weight of lyophilized powder, 5-10% by weight of spiruna, 5-10% by weight of calcium components selected from seaweed calcium, calcium carbonate, edible bone flour or calcined calcium, lactose or corn starch Tablets consisting of 3-8% by weight of an excipient selected from 1 to 3% by weight of a lubricant selected from magnesium stearate, sodium gluconate or talc, or 1-3% by weight of a coating base selected from hydroxypropyl cellulose or povidone, or It relates to the health functional food of capsule type,

Capsosiphon fulvescens (Mesangi) 70-85% by weight lyophilized powder, 5-10% by weight spiruna, 5-10% by weight calcium component selected from algae calcium, calcium carbonate, edible bone flour or calcined calcium, lactose or corn starch 3 to 8% by weight of the excipient selected from the mixture is homogenized, and then mixed with 1-3% by weight of the lubricant selected from magnesium stearate, starch sodium gluconate or talc and mixed into tablets or capsules, or hydroxypropyl cellulose or The present invention relates to a method for producing a dietary supplement of the form of a tablet or capsule, characterized by coating with 1-3 wt% of the coating base selected from povidone.

In addition, the present invention is to provide a health functional beverage, capsosiphon fulvescens (Mesangi) lyophilized powder with 5 times the weight of ethanol extracted 3-4 times at 5-40 ℃ for 3 minutes (intensity; 75-520 W, frequency: 20,000 ± 2,000 times / second), and filtered, and then, 20-40% by weight of the extract of perilla extract obtained by concentrating and reducing the volume to 1/5 under the conditions of 65-85 ° C. and 600-760 mmHg; Spiruna 1-3% by weight; 0.3-1% by weight of a calcium component selected from seaweed calcium, calcium carbonate, edible bone meal or calcined calcium; 30-60% by weight of one or more sweeteners selected from sugar, honey, aspartame, stevioside, mannitol, oligosaccharides, fructose, glucose; 3-6% by weight of one acidulant selected from citric acid, vitamin C, sodium citrate, salt (NaCl); 0.5-1% by weight of one flavor selected from herbal, orange or cherry flavors; And it relates to a functional beverage consisting of purified water, furthermore 20-40% by weight of extract persimmon, 1-3% by weight of spiruna; 0.3-1% by weight of a calcium component selected from seaweed calcium, calcium carbonate, edible bone meal or calcined calcium; 30-60% by weight of one or more sweeteners selected from sugar, honey, aspartame, stevioside, mannitol, oligosaccharides, fructose, glucose; 3-6% by weight of one acidulant selected from citric acid, vitamin C, sodium citrate, salt (NaCl); It relates to a method for producing a health functional beverage, characterized in that the homogenized by adding purified water to 0.5-1% by weight of one flavor selected from herbs, oranges or cherry flavors, and then filtered by 100% by weight. .

In the present invention, the lyophilized lyophilized powder is harvested from mid-October to the end of February, which is a seaweed algae from all over the south coast, washed with water, lyophilized and finely powdered to remove 100-200 mesh bodies. The powder passed through. For the functional food of the present invention, 70-85% by weight of the total weight of the capsules or tablets or 20-40% by weight of the total weight of the liquid beverage is not only stable, but also lowers high cholesterol and prevents cardiovascular diseases. It is desirable for hangover relief, diet and obesity prevention. According to the official data of the FDA, every life is effective,

1) Very weak to organic acids, falcons are soft and digestible.

2) It contains various inorganic salts such as iron, potassium, and iodine, and vitamins A and C, which are effective for promoting children's growth and preventing osteoporosis.

3) It is excellent in preventing and calming gastric ulcer or duodenal ulcer.

4) lower cholesterol content, high blood pressure to reduce the components, people with constipation is said to be effective.

In the present invention, spiruna and calcium components are further included to reinforce hangover, cholesterol lowering, children's growth promotion, and constipation treatment.

Spiruna, also known as Spirulina, is a turquoise blue algae classified as spirulina, spiraling 10 microns wide and 300-500 microns long, and has been endowed with bird life that has appeared on Earth for 3 billion years ago. As it contains nutrients necessary for the human body, development is being actively made as a health supplement food. Its components include 70% vegetable protein (beef is 18% animal protein), carotene 100-200 mg / 100 g (carotene is converted to vitamin A in the body), 8% vegetable fatty acid, vitamins A, B ₁ , It contains a lot of B ₂ , B ₆ , B ₁₂ , E, nicotinic acid, folic acid and pantothenic acid, nucleic acid, phycocyanin, and chlorophyll, iron and calcium. In terms of effects, carotene and nucleic acid deplete free radicals and delay aging, and high levels of vitamin B ₁₂ and iron increase red blood cells, making them ideal for infants and the sick. In addition, it boosts immune function (self healing), decreases blood cholesterol, improves absorption of minerals, and 1.6% of chlorophyll is effective in potent bactericidal action, strengthening heart function, relieving constipation, preventing and healing anemia. It is designated as the future food of human beings, and is being researched as a space food of astronauts.In particular, it has a therapeutic effect on constitution improvement, gastric ulcer, liver disease, diabetes, pancreatitis, cataracts, alopecia areata, leukopenia, and cancer prevention and diet. Supplements, anti-stress action is known.

In the present invention, it is preferable for spiruna to contain 5-10% by weight of the total weight of tablets or capsules or 1-3% by weight of the total weight of liquid beverages for formulation or maintaining proper efficacy.

As a calcium component, it additionally contains one selected from seaweed calcium, calcium carbonate, edible bone meal, calcium citrate or calcined calcium, and it is a tablet or capsule supplemented with calcium supplements such as promoting growth and development, osteoporosis treatment and pregnant women. It is preferable to contain 5-10% by weight or 0.3-1% by weight of the total weight of the liquid beverage in order to maintain the stability of the preparation or the proper efficacy.

Hereinafter, the content of the present invention will be described in more detail with reference to Examples and Test Examples. This is intended to explain the present invention in more detail and is not limited to the present invention.

Example 1 . Preparation of lyophilized powders perennially.

Freeze-dried (temperature: -10 ~ -170 ℃, time: 24-) after washing 1,000 Kg of Capsosiphon fulvescens (Mesangi) harvested from mid-October to the end of February of the year. 48 hr) was finely powdered by a pulverizer (hamma mill) and filtered through a 100-200 mesh sieve to obtain 102 Kg of lyophilized powder having been removed from coarse fibers.

Example 2 . Preparation of Perennial Extracts.

Ultrasonic extraction was performed 3-4 times at 5-40 ° C. for 30 minutes at 70 kg of lyophilized powder 102 kg of lyophilized powder, which was obtained by weight 5 times by weight (intensity: 75-520 W, frequency: 20,000 ± 2,000 Per second), and the resultant was filtered and concentrated under reduced pressure to 1/5 of the original volume under the conditions of 65-85 ° C. and 600-760 mmHg to obtain 100 L of the extract of the perennial extract having the final concentration equal to the weight ratio of the perennial dose.

Formulation Example 1 . refine.

70% by weight of lyophilized powder, 10% by weight of spiruna, 10% by weight of seaweed calcium, and 8% by weight of corn starch were added to a V-type mixer using 100 mesh sieve, and finally, magnesium stearate 2 After mixing for 20 minutes by weight, using a tablet machine was prepared by tableting so that the strength (purification pressure) of the tablet is 3.5-5.5 Kg / ㎠.

Formulation Example 2 . refine.

Each of the lyophilized powders obtained in Example 1 were 80% by weight, 10% by weight of spiruna, 5% by weight of seaweed calcium, and 3% by weight of corn starch, respectively, using a 100 mesh sieve and placed in a V-type mixer, and finally magnesium stearate 1 weight% of the mixture was mixed for 20 minutes, and the tablet was tableted to have a strength (tablet pressure) of 2.5-4.5 Kg / cm 2, and then dust was removed, and then placed in a film coater (Hycota) and hydrated in ethanol. Roxypropyl cellulose (HPC) was melted to just 1% by weight to prepare a spray coating.

Formulation Example 3 . refine.

Each of the lyophilized powders obtained in Example 1 were 85% by weight, 5% by weight of spiruna, 5% by weight of seaweed calcium, and 4% by weight of corn starch, respectively, using a 100 mesh sieve and placed in a V-type mixer. Finally, magnesium stearate 1 After mixing 20% by weight, the tablet was prepared by tableting so that the strength (tablet pressure) of the tablet was 3.0-5.0 Kg / cm 2.

Formulation Example 4 . Capsules.

The lyophilized powder obtained in Example 1 was 75% by weight of lyophilized powder, 10% by weight of spiruna, 5% by weight of seaweed calcium, 8% by weight of corn starch, respectively, using a 100 mesh sieve and put into a V-type mixer, and finally stearic acid After mixing for 2 minutes by adding 2% by weight of magnesium, the contents of the filling using a capsule filling machine was prepared by filling to 250-500 mg according to the size of the capsule (No. 2, No. 1, No. 0).

Formulation Example 5 . Capsules.

Each weight of the lyophilized powder obtained in Example 1 was separated into 80% by weight of lyophilized powder, 7.5% by weight of spiruna, 7.5% by weight of seaweed calcium and 4% by weight of corn starch in a V-type mixer using 100 mesh sieve. After adding 20% of the mixture and mixing the contents using a capsule charger was prepared by filling the 250-500 mg according to the size of the capsule (No. 2, No. 1, No. 0).

Formulation Example 6 . Liquid.

20% by weight of ethanol extract of lyophilized powder, 3% by weight of spiruna, 1% by weight of seaweed calcium, 10% by weight of sugar, 20% by weight of oligosaccharide, 3% by weight of mannitol, 3% by weight of stevioside, citric acid 3% by weight, sodium citrate 2% by weight, 1.0% by weight of the herb flavor was homogenized, water was added to 100% by weight, and then filtered and prepared using 1 micro filter.

Formulation Example 7 . Liquid.

The ethanol extract of the lyophilized powder obtained in Example 2 was 40% by weight, 1% by weight of spiruna, 0.3% by weight of seaweed calcium, 20% by weight of sugar, 20% by weight of oligosaccharide, 3% by weight of citric acid, 2% by weight of mannitol, salt Water was added to 2% by weight and 1.0% by weight of the herb flavor to make 100% by weight, and then filtered and prepared using 1 micro filter.

Experimental Example  One

The average value of the lyophilized powder used for the product was determined by performing three times the "chlorophyll test and crude protein test according to the health functional foods" for the raw material lyophilized powder, as shown in Table 1 below.

Table 1 . (Raw raw material powder test)

Experimental Example  2

For the seven examples carried out above, the sensory test and the physical and chemical tests of the other products were carried out. The results are as shown in Tables 2 and 3 below.

Table 2 . (Tablet and capsule)

Table 3 . (Liquid drink)

Experimental Example  3

Experimental Example of Hangover Relief .

A hangover refers to headache, diarrhea, anorexia, nausea, vomiting, chills, and cold sweating after drinking alcohol. Objective symptoms include perception, decreased motor skills, hematologic changes, and hormonal changes.

The causes include dehydration, toxicity of alcohols and alcohol metabolites (acetaldehyde, formaldehyde, acetone, etc.), nutrient deficiencies due to malabsorption (blood glucose, vitamins, mineral deficiencies), and the degree of variation according to individuals. That is, the degree of difference is very severe depending on genetic literacy or environmental conditions (nutrition state, exercise state, dehydration degree, health state), so the hangover symptoms are difficult to scientifically and objectively evaluate hangover resolution, but in the present invention alcohol As a control, 100% of the test group syphilis powder and 80% of the syphilis powder were mixed, 7.5% spiruna, 7.5% seaweed calcium (Formulation 5, capsule formulation), or 40% of medicinal extract, 1% spirulina, 0.3% algae calcium The effect of hangover relief was indirectly confirmed by mixing% (preparative example 7, liquid formulation) by artificially oral administration to animals and measuring the alcohol concentration in the blood.

    1) Test Method:

200-500 g males of Sprague Dawley rats are freely fed with solid feed and drinking water for 1 week, followed by oral administration of 3 g / Kg of alcohol.

After 30 minutes, alcohol is orally administered and blood is collected for 1 hour, 3 hours, and 5 hours after administration.

Blood was centrifuged at 3,000 rpm for 20 minutes to separate serum, and then ethanol concentration was measured.

Table 4 . (Product Design)

Table 5 . Experimental animal design

Table 6 . (Evaluation of results and effectiveness)

The alcohol concentration in blood was significantly lower (p <0.001) in the experimental group than in the control group in each time period. In addition, blood alcohol levels in all three groups decreased over time. In the case of the control group, the alcohol concentration sharply decreased from 1 hour to 3 hours after alcohol administration, and remained similar until 5 hours. In the Experiment 1 group, the decrease in blood alcohol concentration after 1 hour of alcohol consumption was smaller than that of the control group, and the concentration change was less with time.

On the other hand, in the case of experimental group 2 and 3, the alcohol concentration in the solution solution drastically decreased one hour after the control group and the experimental group 1, and the blood alcohol concentration was lowered with time.

Therefore, in Experiment 2 and Experiment 3, it can be estimated that alcohol is effective in resolving hangovers.

Experimental Example  4

Animal Experimental Example on Cholesterol-lowering Action .

Hypercholesterolemia develops when cholesterol accumulates in the body and progresses to atherosclerosis if cholesterol is not controlled over a long period of time. If the degree of synthesis in cholesterol metabolism is unregulated or if blood cholesterol levels are too high, cholesterol is deposited on the walls of blood vessels, resulting in "atherosclerotic plaques." According to the Korean Guidelines for Treatment of Hyperlipidemia established in 1996, if the total cholesterol level is less than 200 ㎎ / ㎗, it is recommended to classify it as a normal group and reexamine within 2 years, and if it is 200-239 ㎎ / ㎗, the behavioral therapy and diet In case of more than 240 ㎎ / ㎗ is classified as a high risk group to be combined with medication in addition to diet.

LDL in the total cholesterol is responsible for transporting cholesterol from the liver to other tissues, so the high cholesterol content of LDL increases the risk of cholesterol accumulation in the walls of the coronary arteries, so if LDL-cholesterol is more than 130 mg / dL, it is borderline. HDL-cholesterol has a protective effect against atherosclerosis because HDL carries cholesterol from peripheral tissues to the liver and synthesizes bile acids from cholesterol in the liver to excrete into the intestine. This is because the back transportation efficiency is lowered, which causes atherosclerosis.

Therefore, long-term high concentrations of total cholesterol, high concentrations of LDL cholesterol and low concentrations of HDL cholesterol induce atherosclerosis. To prevent this, cholesterol control by supplementation with drugs, dietary supplements, and dietary supplements should be performed.

On the basis of the health functional food of the present invention it was confirmed that the cholesterol lowering effect through the cholesterol lowering test.

    1) Test method

The male rats, 5-8 weeks old, were divided into five groups, including normal control group, cholesterol group, test group 1, test group 2, and test group 3, based on 5 rats in 1 week. Freely intake of modified diet) and drinking water, add basic experimental diet to the normal control group, add cholesterol concentration to 1.0% for the cholesterol group, and add 1% to the cholesterol group in the test group 1 and 5% to the test group 2 Add 5% Formulation 2 (Formulation 5, capsule formulation) to the Cholesterol group, and add 3% Formulation 3 (Formula 7, liquid formulation) to the Cholesterol group for 4 weeks. The time was kept on an empty stomach, and then blood was collected to measure total cholesterol and HDL cholesterol in the blood.

Table 7 . (Product Design)

Table 8 . (FORMULATION OF EXPERIMENTAL DIETS)

Table 9 . (Evaluation of results and effectiveness)

According to the results of the experiment, the test group 1, test group 2, and test group 3 can confirm the lowering of cholesterol level compared to the cholesterol group, and also the high density cholesterol (HDL) level can be seen to be close to normal.

Therefore, the present invention also can be seen that when the conventional intake of only one and the formulation 2, formulation 3, that is, the medicinal, spiruna, the formulation containing algae calcium is more effective in lowering cholesterol.

Through the present invention, there is a feature that can provide a functional health food containing medicinal for all ages, anywhere, anytime, anywhere, anytime, anywhere, safe, easy to carry, easy to take and secured long-term stability. Nutritional ingredients such as vitamins, proteins, chlorophyll, and amino acids can be easily consumed through tablets, capsules, and beverages, and they can be supplied with the necessary nutritional ingredients, which can relieve hangovers and lower cholesterol. .

Claims (5)

Capsosiphon fulvescens (Mesangi) 70-85% by weight lyophilized powder, 5-10% by weight spiruna, 5-10% by weight calcium component selected from seaweed calcium, calcium carbonate, edible bone flour or calcined calcium, lactose or corn starch Hangover composed of 3-8% by weight of excipients selected from among them, 1-3% by weight of lubricant selected from magnesium stearate, sodium gluconate or talc, or 1-3% by weight of coating base selected from hydroxypropyl cellulose or povidone And dietary supplements for lowering cholesterol. The health functional food of claim 1 wherein the formulation is a tablet, film coating or capsule. Capsosiphon fulvescens (Mesangi) 70-85% by weight lyophilized powder, 5-10% by weight spiruna, 5-10% by weight calcium component selected from seaweed calcium, calcium carbonate, edible bone flour or calcined calcium, lactose or corn starch 3-8% by weight of the excipient selected from the mixture is homogenized, mixed with 1-3% by weight of a lubricant selected from magnesium stearate, starch sodium gluconate or talc and mixed into tablets or capsules, or the obtained tablet is hydroxypropyl A method for producing a dietary supplement for reducing hangover and lowering cholesterol in a tablet or capsule form, characterized by coating with 1-3 wt% of a coating base selected from cellulose or povidone. After lyophilization (Capsosiphon fulvescens, Mesangi) lyophilized powder with 5 times the weight of ethanol for 3-4 times at 30 minutes at 5-40 ℃ ultrasonic extraction (intensity 75-520 W, frequency 20,000 ± 2,000 times / second), 20-40% by weight of lyophilized powder ethanol extract obtained by drying under reduced pressure and concentrating the volume at 1/5 under the conditions of 65-85 ° C. and 600-760 mmHg; Spiruna 1-3% by weight; Calcium component selected from seaweed calcium, calcium carbonate, edible bone meal or calcined calcium 0.3-1 weight%; 30-60% by weight of one or more sweeteners selected from sugar, honey, aspartame, stevioside, mannitol, oligosaccharides, fructose, glucose; 3-6% by weight of one acidulant selected from citric acid, vitamin C, sodium citrate, salt (NaCl); 0.5-1% by weight of one flavor selected from herbal, orange or cherry flavors; And functional drink for reducing hangover and cholesterol lowering composed of purified water. Capsosiphon fulvescens (Mesangi) lyophilized powder ethanol extract 20-40% by weight of claim 4; Spiruna 1-3% by weight; 0.3-1% by weight of a calcium component selected from seaweed calcium, calcium carbonate, edible bone meal or calcined calcium; 30-60% by weight of one or more sweeteners selected from sugar, honey, aspartame, stevioside, mannitol, oligosaccharide, fructose, glucose; 3-6% by weight of one acidulant selected from citric acid, vitamin C, sodium citrate, salt (NaCl); 0.5-1% by weight of one flavor selected from the herb, orange or cherry flavor is added to homogenized purified water, 100% by weight, and then filtered to produce a hangover and cholesterol lowering health functional Method of making a drink.