KR102046566B1 - cosmetic composition for improving pruritus of skin - Google Patents

Abstract

The present invention is quercetin or derivatives thereof; Vitamin D or derivatives thereof; And it provides a cosmetic composition and a pharmaceutical composition excellent in the effect of preventing, improving or treating itching caused by dry skin and the like by containing vitamin K or derivatives thereof as an active ingredient.

Description

Cosmetic composition for improving skin itch {cosmetic composition for improving pruritus of skin}

The present invention relates to a cosmetic composition, a pharmaceutical composition, and a method for preparing the same, having an effect of improving skin itch, and more particularly, by containing quercetin, vitamin D, and vitamin K as an active ingredient to improve the itching caused by dry skin and the like. It relates to a cosmetic composition, a pharmaceutical composition and a method for producing the same.

Skin is the largest organ in the body and is exposed to the outside, so it is an immune organ that is sensitive to various external stimuli. For this reason, various diseases accompanied by itching occur frequently on the skin. Representative skin diseases accompanied by itching are contact dermatitis including atopic dermatitis and febrile pruritus, urticaria, psoriasis and the like. These itching-related diseases are often scratched and scratched, which is accompanied by skin infections caused by bacterial infection and secondary infections caused by external allergens. As a result, immune cells such as T-cells and macrophages are activated to secrete various cytokines and neuropeptides, including IL-1, causing itching. Scratching again causes the symptoms of dermatitis to amplify and develop into a more serious condition.

However, no composition has been developed to date that can clearly release itching. Conventionally, in order to ameliorate the itch, a lipid complex of ceramide for moisturizing and restoring the skin barrier is applied (Korean Patent Publication No. 2001-0044622), oral administration of antihistamines to treat the itch, a steroid for anti-inflammatory Methods such as application of the formulations have been generally used, and methods of applying oligosaccharides to improve skin immune status have been proposed (Korean Patent Publication No. 2000-0029754), but topical and systemic agents such as steroids, There are problems such as drowsiness due to oral administration of antihistamines, immunosuppressants, and the like, lowering immunity and safety to the skin by topical administration, and stability when formulating the composition for external application of the skin, and their use is also limited.

Therefore, there is no side effect on the human body, the development of substances that can alleviate or heal skin itching is urgently required.

Skin drying, which is considered to be one of the major diseases in modern society, has recently been increasing due to increased exposure to environmental pollution, dry environment such as apartments and high-rise buildings, and various factors such as stress and excessive bathing culture. Itching is the skin and skin itching is the most common symptom.

Quercetin is a common edible polyphenolic compound and is present in many edible plants and is known to play an important role in health. Flavonoids having such a biphenyl propane skeleton are known to have anti-cancer, antioxidant and anti-inflammatory and anti-allergic effects.

Vitamin D, also known as calciferol, is a fat-soluble vitamin synthesized from cholesterol derivatives (7-hydrocholesterol) in skin cells in the sun and plays a crucial role in strengthening bones by increasing calcium absorption in the small intestine. It is known to help phosphates reabsorb and help produce immune cells in the thymus.

Without vitamin D, bones can be thin, brittle, fragile or deformed. Therefore, lack of vitamin D causes rickets or osteomalacia, a skeletal disease caused by a defect in bone weakness.

Vitamin D is relatively abundant in egg yolks in food and is found in butter and milk. Vitamin D is found in food, but it can also be made in the human body by the sun's rays. In other words, humans not only consume vitamin D from food, but also provitamin D is converted into vitamin D by ultraviolet rays in the body.

Vitamin K is a type of fat-soluble vitamin that is unstable to light and alkali and stable to heat, and is an essential vitamin for blood coagulation, which is involved in the synthesis of blood coagulation factors in the liver. Coagulation factors are synthesized in the form of inactive proteins in the liver and require vitamin K to activate them. Vitamin K acts as a coenzyme of carboxylase, converting glutamic acid from the coagulation factor precursor protein to gamma carboxyl glutamic acid to activate the coagulation factor. Kinds include K1, K2, and K3, of which K3 (menadione) of the composite is strong.

Thus, the present inventors have tried to enhance the effect of improving the itch compared to the drug or cosmetic composition to improve the itch of the existing dry skin, quercetin or derivatives thereof; Vitamin D or derivatives thereof; And the present invention was completed by confirming that the composition containing vitamin K or derivatives thereof as an active ingredient can significantly improve skin itching.

Korean Patent Publication No. 2001-0044622 Korean Patent Publication No. 2000-0029754

It is an object of the present invention to quercetin or derivatives thereof; Vitamin D or derivatives thereof; And cosmetic compositions or pharmaceutical compositions which significantly alleviate or improve the itching of the skin, including vitamin K or derivatives thereof.

Still another object of the present invention is to provide a method for preparing a cosmetic composition or a pharmaceutical composition that significantly alleviates or improves the itching of the skin according to the present invention.

The present invention to achieve the above object,

Quercetin or derivatives thereof;

Vitamin D or derivatives thereof; And

It provides a cosmetic composition for improving skin itching containing vitamin K or a derivative thereof; as an active ingredient.

The content of quercetin or derivatives thereof may be 0.01 to 2.0% by weight, the content of vitamin D or derivatives thereof may be 0.01 to 1.0% by weight, and the content of vitamin K or derivatives thereof may be 0.01 to 1.0% by weight.

The content of quercetin or derivatives thereof may be 0.05 to 1.0% by weight, the content of vitamin D or derivatives thereof may be 0.05 to 0.5% by weight, and the content of vitamin K or derivatives thereof may be 0.05 to 0.5% by weight.

In addition, the cosmetic composition for improving skin itch is 1.5 to 4.5% by weight of ethanol, 2.5% to 7.5% by weight of glycerin, 2.5% to 7.5% by weight of 1,3-butylene glycol, 0.5% to 1.5% by weight of cetyl alcohol, It may further include 0.5% by weight to 1.5% by weight of Sheskiolein oxygen rubitan, 0.005% by weight to 0.015% by weight of lavender oil and the remaining amount of purified water.

The quercetin derivative may be at least one selected from the group consisting of dihydro quercetin, isoquecetin, quercimeritrine, rutin, and hyperin,

Vitamin D derivative may be at least one selected from the group consisting of calcitriol, cholecalciferol, ergocalciferol,

Vitamin K derivatives may be one or more selected from the group consisting of phylloquinone, menaquinone, menadione.

In addition, the present invention,

Stirring a composition comprising 0.01-2.0% by weight of quercetin or derivatives thereof, 0.01-1.0% by weight of vitamin D or derivatives thereof, and 0.01-1.0% by weight of vitamin K or derivatives thereof at 60-80 ° C. for 20-50 minutes (S1 ); And

Lavender oil and purified water are added to uniformly emulsify for 20 to 50 minutes at 60 ~ 80 ℃, it provides a method for producing a cosmetic composition for improving skin itch comprising the step (S2) of gradually cooling to room temperature.

In addition, the present invention,

Quercetin or derivatives thereof;

Vitamin D or derivatives thereof; And

It provides a pharmaceutical composition for improving skin itching containing vitamin K or a derivative thereof; as an active ingredient.

In addition, the present invention,

Quercetin or derivatives thereof;

Vitamin D or derivatives thereof; And

It provides a health functional food composition for improving skin itching containing vitamin K or derivatives thereof as an active ingredient.

In addition, the present invention,

Quercetin or derivatives thereof;

Vitamin D or derivatives thereof; And

It provides a quasi-drug composition for improving skin itching containing vitamin K or a derivative thereof.

The present invention is quercetin or derivatives thereof; Vitamin D or derivatives thereof; And by preparing a cosmetic and pharmaceutical composition containing vitamin K or derivatives thereof as an active ingredient, it is very excellent in preventing, improving or treating the itching caused by dry skin and the like.

1 is quercetin or a derivative thereof according to the present invention; Vitamin D or derivatives thereof; And a product prepared using a cosmetic and pharmaceutical composition containing vitamin K or a derivative thereof as an active ingredient.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail. In the following description of the present invention, detailed descriptions of related well-known configurations or functions may be omitted.

The terms or words used in the specification and claims are not to be construed as being limited to conventional or dictionary meanings, but should be construed as meanings and concepts corresponding to the technical matters of the present invention.

The embodiments described in the specification and the configuration shown in the drawings are preferred embodiments of the present invention, and do not represent all of the technical idea of the present invention, various equivalents and modifications that can replace them at the time of the present application are There may be.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

The present invention

Quercetin or derivatives thereof;

Vitamin D or derivatives thereof; And

It provides a cosmetic composition for improving skin itching containing vitamin K or a derivative thereof; as an active ingredient.

The content of quercetin or derivatives thereof may be 0.01 to 2.0% by weight, the content of vitamin D or derivatives thereof may be 0.01 to 1.0% by weight, and the content of vitamin K or derivatives thereof may be 0.01 to 1.0% by weight.

More preferably, the content of quercetin or derivatives thereof is 0.05 to 1.0% by weight, the content of vitamin D or derivatives thereof is 0.05 to 0.5% by weight and the content of vitamin K or derivatives thereof is 0.05 to 0.5% by weight. Can be.

If the content of quercetin or derivatives thereof is 0.01% or less, the concentration of quercetin or derivatives thereof is too low to have an effect, and if the content is more than 2%, toxic symptoms such as an increase in itching due to skin irritation may occur due to high quercetin concentration. have.

Also vitamin D or derivatives thereof; And vitamin D or derivatives thereof when the content of vitamin K or derivatives thereof is 0.01% or less; And the concentration of vitamin K or derivatives thereof is too low to have no effect, and if the content is more than 1% by weight vitamin D and K are fat-soluble vitamins may cause symptoms of poisoning from continuous intake of excess.

In addition, the cosmetic composition for improving skin itch is 1.5 to 4.5% by weight of ethanol, 2.5% to 7.5% by weight of glycerin, 2.5% to 7.5% by weight of 1,3-butylene glycol, 0.5% to 1.5% by weight of cetyl alcohol, It may further include 0.5% by weight to 1.5% by weight of Sheskiolein oxygen rubitan, 0.005% by weight to 0.015% by weight of lavender oil and the remaining amount of purified water.

The quercetin derivative may be at least one selected from the group consisting of dihydro quercetin, isoquecetin, quercimeritrine, rutin, and hyperin,

Vitamin D derivative may be at least one selected from the group consisting of calcitriol, cholecalciferol, ergocalciferol,

Vitamin K derivatives may be one or more selected from the group consisting of phylloquinone, menaquinone, menadione.

The itching includes dry skin, atopic dermatitis, geriatric pruritus, contact dermatitis, urticaria, psoriasis and itching by ultraviolet rays, and particularly itching by skin drying is preferred.

The cosmetic composition of the present invention may further contain, in addition to the above components, other components that can give a synergistic effect to the main effect, preferably within the range of not impairing the main effect of the present invention.

 The cosmetic composition may take the form of a solution, an emulsion, a viscous mixture, or the like.

The cosmetic composition is not particularly limited in the formulation, but for example, a skin adhesive type cosmetic such as milky lotion, lotion, cream, lotion, essence, pack, gel, powder, lipstick, makeup base, foundation, etc. It may be a cleansing cosmetic formulation such as cosmetics having, cosmetics, cleansing foam, cleansing cream, cleansing water.

The cosmetic composition may be blended with the essential components, such as cosmetically acceptable cosmetic auxiliary additives, if necessary within the range of 0.01 to 5% by weight.

As a compounding component which may be added, an oil-fat component, a humectant, an emollient, surfactant, organic and inorganic pigment, organic powder, a ultraviolet absorber, a preservative, a fungicide, antioxidant, a plant extract, a pH adjuster, alcohol, a pigment, a fragrance, a blood circulation And accelerators, cooling agents, limiting agents, purified water, and the like.

In addition, the present invention,

Stirring a composition comprising 0.01-2.0% by weight of quercetin or derivatives thereof, 0.01-1.0% by weight of vitamin D or derivatives thereof, and 0.01-1.0% by weight of vitamin K or derivatives thereof at 60-80 ° C. for 20-50 minutes (S1 ); And

Lavender oil and purified water are added to uniformly emulsify for 20 to 50 minutes at 60 ~ 80 ℃, it provides a method for producing a cosmetic composition for improving skin itch comprising the step (S2) of gradually cooling to room temperature.

In addition, the present invention,

Quercetin or derivatives thereof;

Vitamin D or derivatives thereof; And

It provides a pharmaceutical composition for improving skin itching containing vitamin K or a derivative thereof; as an active ingredient.

The content of quercetin or derivatives thereof may be 0.01 to 2.0% by weight, the content of vitamin D or derivatives thereof may be 0.01 to 1.0% by weight, and the content of vitamin K or derivatives thereof may be 0.01 to 1.0% by weight.

If the content of quercetin or derivatives thereof is 0.01% or less, the concentration of quercetin or derivatives thereof is too low to be effective, and if the content is more than 2%, toxic symptoms such as an increase in itching due to skin irritation may occur due to high quercetin concentration. have.

Also vitamin D or derivatives thereof; And vitamin D or derivatives thereof when the content of vitamin K or derivatives thereof is 0.01% or less; And the concentration of vitamin K or derivatives thereof is too low to have no effect, and if the content is more than 1% by weight vitamin D and K are fat-soluble vitamins may cause symptoms of poisoning from continuous intake of excess.

In addition, the pharmaceutical composition for improving skin itch may further include ethanol, glycerin, 1,3-butylene glycol, cetyl alcohol, sheskiolein oxygen sorbitan, lavender oil and purified water.

The quercetin derivative may be at least one selected from the group consisting of dihydro quercetin, isoquecetin, quercimeritrine, rutin, and hyperin,

Vitamin D derivative may be at least one selected from the group consisting of calcitriol, cholecalciferol, ergocalciferol,

Vitamin K derivatives may be one or more selected from the group consisting of phylloquinone, menaquinone, menadione.

The itching includes dry skin, atopic dermatitis, geriatric pruritus, contact dermatitis, urticaria, psoriasis and itching by ultraviolet rays, and particularly itching by skin drying is preferred.

The pharmaceutical composition of the present invention may further contain, in addition to the above components, other components that can give a synergistic effect to the main effect, preferably within the range of not impairing the main effect of the present invention.

 The pharmaceutical composition may be used in the form of powder, granules, tablets, capsules, suspensions, emulsions, syrups, oral dosage forms such as aerosols, transdermal dosage forms such as lotions, ointments, gels, creams, patches, and sprays. And may be formulated into any form suitable for pharmaceutical preparations.

The pharmaceutical composition may be combined with other essential ingredients, such as pharmaceutically acceptable carriers, additives or excipients, if necessary in the range of 0.01 to 5% by weight.

 The pharmaceutical composition may be administered to mammals such as livestock, humans, etc. by various routes such as parenteral or oral, and all modes of administration may be expected, for example, oral, rectal, intravenous, intramuscular, subcutaneous. , Intrauterine dural or cerebrovascular injections.

Preferred dosages of the pharmaceutical compositions vary depending on the subject's age, sex, weight, symptoms, extent of disease, drug form, route of administration and duration, and may be appropriately selected by those skilled in the art. However, for the desired effect, the pharmaceutical composition of the present invention may be administered at 0.001 to 1000 mg / day. Administration may be once a day or may be divided several times.

In addition, the present invention,

Stirring a composition comprising 0.01-2.0% by weight of quercetin or derivatives thereof, 0.01-1.0% by weight of vitamin D or derivatives thereof, and 0.01-1.0% by weight of vitamin K or derivatives thereof at 60-80 ° C. for 20-50 minutes (S1 ); And

Lavender oil and purified water are added to uniformly emulsify at 60 ~ 80 ℃ for 20 to 50 minutes, and provides a method for producing a pharmaceutical composition for improving skin itch comprising the step (S2) of gradually cooling to room temperature.

In addition, the present invention,

Quercetin or derivatives thereof;

Vitamin D or derivatives thereof; And

It provides a health functional food composition for improving skin itching containing vitamin K or derivatives thereof as an active ingredient.

In addition, the present invention,

Quercetin or derivatives thereof; Vitamin D or derivatives thereof; And it provides a method for producing a health functional food composition for improving skin itching comprising the step of mixing; vitamin K or derivatives thereof.

The content of the quercetin or derivatives thereof may be 0.01 to 2.0% by weight, the content of the vitamin D or derivatives thereof may be 0.01 to 1.0% by weight, and the content of the vitamin K or derivatives thereof may be 0.01 to 1.0% by weight.

In addition, the health functional food composition for improving skin itch may further include ethanol, glycerin, 1,3-butylene glycol, cetyl alcohol, sheskiolein oxygen sorbitan, lavender oil and purified water.

The quercetin derivative may be at least one selected from the group consisting of dihydro quercetin, isoquecetin, quercimeritrine, rutin, and hyperin,

Vitamin D derivative may be at least one selected from the group consisting of calcitriol, cholecalciferol, ergocalciferol,

Vitamin K derivatives may be one or more selected from the group consisting of phylloquinone, menaquinone, menadione.

The health functional food includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners. , pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated drinks, and the like.

The health functional food may further include food additives, and the suitability as a "food additive", unless otherwise specified, according to the General Regulations of the Food Additives Code and General Test Act, etc. approved by the Food and Drug Administration, etc. And based on the criteria.

The health functional food composition according to the present invention is added to the food in the manufacturing process can be appropriately added or subtracted as needed, preferably added to include 0.01% to 10% by weight in 100% by weight food It is preferable.

In addition, the present invention,

Quercetin or derivatives thereof;

Vitamin D or derivatives thereof; And

It provides a quasi-drug composition for improving skin itching containing vitamin K or a derivative thereof.

In addition, the present invention,

Quercetin or derivatives thereof; Vitamin D or derivatives thereof; And it provides a method for producing a quasi-drug composition for improving skin itching, comprising the step of mixing;

The content of quercetin or derivatives thereof may be 0.01 to 2.0% by weight, the content of vitamin D or derivatives thereof may be 0.01 to 1.0% by weight, and the content of vitamin K or derivatives thereof may be 0.01 to 1.0% by weight.

In addition, the quasi-drug composition for improving skin itch may further include ethanol, glycerin, 1,3-butylene glycol, cetyl alcohol, sheskiolein oxygen sorbitan, lavender oil and purified water.

The quercetin derivative may be at least one selected from the group consisting of dihydro quercetin, isoquecetin, quercimeritrine, rutin, and hyperin,

Vitamin D derivative may be at least one selected from the group consisting of calcitriol, cholecalciferol, ergocalciferol,

Vitamin K derivatives may be one or more selected from the group consisting of phylloquinone, menaquinone, menadione.

The quasi-drug composition is not particularly limited, but may preferably be a disinfectant cleaner, shower foam, gagreen, wet tissue, detergent soap, hand wash, humidifier filler, mask, ointment or filter filler.

The quasi-drug composition may include other components such as carriers, additives or excipients that can be used in the manufacture of quasi-drugs within the range of 0.01 to 5% by weight.

The quasi-drug composition may include an external preparation for skin and personal hygiene products, and the external preparation for skin is not particularly limited thereto, and preferably an ointment, lotion, spray, patch, cream, powder, suspension, gel or gel It can be manufactured and used in the form of, and the personal hygiene products are not particularly limited, but preferably soap, wet tissue, tissue paper, shampoo, body wash, skin cream, face cream, toothpaste, perfume, hair care product, air fresh It may be a nugget, a cleaning gel, etc.

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. These Examples and Experimental Examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these Examples and Experimental Examples according to the gist of the present invention having ordinary skill in the art. It is self-evident to him.

Example 1 Preparation of Cosmetic Composition for Skin Itching Improvement

0.2% by weight of quercetin, 0.1% by weight of vitamin D, 0.1% by weight of vitamin K, 5% by weight of glycerin, 5% by weight of 1,3-butylene glycol, 3% by weight of ethanol, 1% by weight of cetyl alcohol, Mix (a) phase consisting of 1% by weight of skiolein oxygen rubitan and stir at 70 ° C. for 30 minutes with a stirrer, and then add (a) phase consisting of 0.01% by weight of lavender oil and 84.59% by weight of purified water. Emulsified uniformly at 70 ℃ for 30 minutes using a mixer, and slowly cooled to room temperature to prepare a cosmetic composition.

Composition Comparative Example 1 Weight (%) Comparative Example 2 Weight (%) Comparative Example 3 Weight (%) Example 1 Weight (%) end Quercetin 0.2 - - 0.2 Vitamin D - 0.1 - 0.1 Vitamin K - - 0.1 0.1 glycerin 5 5 5 5 1,3-butylene glycol 5 5 5 5 ethanol 3 3 3 3 Cetyl alcohol One One One One Sheski Olein Oxyrubitan One One One One I Lavender oil 0.01 0.01 0.01 0.01 Purified water  to 100 to 100 to 100 to 100

< Comparative example  1> Vitamin D and Vitamins K  Free Cosmetics  Preparation of the composition

Except for vitamin D and vitamin K in the production method of <Example 1> contained 84.79% by weight of purified water, the rest was prepared in the same manner.

< Comparative example  2> Quercetin and  vitamin K  Free Cosmetics  Preparation of the composition

Except for quercetin and vitamin K, 84.89% by weight of purified water was included in the manufacturing method of <Example 1>, and the rest was prepared in the same manner.

< Comparative example  3> Quercetin and  vitamin D  Free Cosmetics  Preparation of the composition

Except for quercetin and vitamin D, 84.89% by weight of purified water was included in the manufacturing method of <Example 1>, and the rest was prepared in the same manner.

< Experimental Example  1> Cosmetics  Evaluation of Itching Improvement Effect of Composition

Evaluation was performed to measure the skin itch improvement effect of the cosmetic composition obtained in the Examples and Comparative Examples. The evaluating agents included 40 people in their 40s and 70s who had itching symptoms. They established a stable criterion for the characteristics to be evaluated through the curriculum and evaluated the effect of improving itching. Itching symptoms by dividing the evaluation staff of 40 people in their 40's to 70's with itch symptoms in four groups of 10 persons each, and providing the cosmetic composition of Comparative Example 1, Comparative Example 2, Comparative Example 3 or Example 1 to each group. The cosmetic composition was applied to the site for 3 weeks. The itch improvement effect was determined through a three-time self-examination every three weeks after application of the cosmetic composition. Self-finding was determined by dividing the total into four stages: very good, good, normal and poor compared to before using the cosmetic composition.

The results are shown in Table 2 below.

Applicator Itching Improvement Effect Questionnaire Very good Good usually Inadequate Comparative Example 1 One 4 4 One Comparative Example 2 One 4 5 Comparative Example 3 2 4 4 Example 1 8 One One

Evaluation Results As shown in Table 2, in the case of applying the quercetin, vitamin D and vitamin K-containing cosmetic composition of Example 1 of the present invention, Comparative Example 1 using only quercetin or Comparative Example 2 using only vitamin D, and comparative example using only vitamin K Compared with 3, itching effect was significantly higher.

Experimental Example 2 Measurement of the Number of Scratches After Applying the Cosmetic Composition

In order to measure the skin itch improvement effect of the cosmetic composition obtained in Examples and Comparative Examples, divided into four groups of five people each of the 20 age group between the 40s and 70s with itching symptoms in the legs, The cosmetic composition of Comparative Example 1, Comparative Example 2, Comparative Example 3 or Example 1 was provided to apply the cosmetic composition to the site where the symptoms of itching appeared for 2 weeks. The itch improvement effect was measured before and after the application of the cosmetic composition for two hours, respectively, for 2 hours to measure the number of scratches. The results were expressed as the number of scratches per hour, adding up the number of scratches of each of the five subjects.

Applicator Number of scratches (times / h) Before application 2 weeks Comparative Example 1 47 25 Comparative Example 2 45 41 Comparative Example 3 44 39 Example 1 48 7

As shown in the results of Table 3, when applying the cosmetic composition (Example 1) containing the quercetin, vitamin D and vitamin K of the present invention, Comparative Example 1 using only quercetin or Comparative Example 2, vitamin K using only vitamin D It was confirmed that the improvement effect of the number of times of scratching was superior to Comparative Example 3 which was used only.

Claims (11)

Quercetin;
Vitamin D; And
Vitamin K; as an active ingredient,
The amount of quercetin is 0.01 ~ 2.0% by weight of the total amount, the content of the vitamin D is 0.01 ~ 1.0% by weight and the content of the vitamin K is 0.01 ~ 1.0% by weight cosmetic composition for improving skin itching.
delete The method of claim 1,
The amount of quercetin is 0.05 ~ 1.0% by weight of the total amount, the content of the vitamin D is 0.05 ~ 0.5% by weight and the content of the vitamin K is 0.05 ~ 0.5% by weight cosmetic composition for improving skin itching.
delete delete delete delete Stirring the composition comprising quercetin 0.01-2.0% by weight, vitamin D 0.01-1.0% by weight, and vitamin K 0.01-1.0% by weight at 60-80 ° C. for 20-50 minutes (S1); And
Adding lavender oil and purified water to emulsify uniformly at 60 to 80 minutes for 20 to 50 minutes, and gradually cooling to room temperature (S2) method for producing a cosmetic composition for improving skin itching. delete delete delete

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