KR101697246B1 - Composition for abirritating tooth-whitening product and kit containing the composition - Google Patents

Abstract

The present invention relates to a tooth whitening composition or composition applied prior to application of a tooth whitening composition or patch containing an oral irritation mitigating component capable of reducing the irritation of a tooth whitening patch. The present invention also relates to a tooth whitening kit in which mouth irritation is alleviated. The composition applied before application of the teeth whitening composition or patch of the present invention alleviates the intraoral irritation caused by the rapid activity of the tooth whitening component by the tooth whitening component activator, thereby providing an excellent tooth whitening effect while relieving pain.

Description

TECHNICAL FIELD The present invention relates to a composition for alleviating oral irritation of a tooth whitening product, and a kit containing such a composition.

The present invention relates to a composition capable of alleviating irritation of a tooth whitening product, and a tooth whitening kit comprising such a composition and a tooth whitening product. More particularly, the present invention relates to a tooth whitening kit comprising a rapid whitening agent And to a means for providing this reduced tooth whitening effect.

In recent years, public interest in teeth whitening has increased as public interest in the beauty has increased. Choices for tooth whitening include toothpaste, mouthrinse, chewing gum, indoor whitening, and tooth whitening solutions using trays purchased from the most common shops or dentists. The tooth whitening solution typically contains an active ingredient that bleaches teeth, such as hydrogen peroxide.

Hydrogen peroxide dissolves well in water, ethanol, and ether, and some hydrogen ions dissociate from the aqueous solution, resulting in weak acidity. This hydrogen peroxide is an unstable substance, and its activity is continuously lowered over time. Thus, a typical tooth whitening product maintains its activity by using a hydrogen peroxide stabilizer to prevent the hydrogen peroxide activity from deteriorating during the distribution process.

However, when the actual tooth whitening agent is used, such a stabilizer acts as an obstacle for preventing the activity of hydrogen peroxide. In order to solve this problem, the hydrogen peroxide is rapidly activated by using a catalyst.

On the other hand, when the gum is abruptly exposed to peroxide, it may cause tooth sensitivity and gingival irritation. In order to induce rapid activation of the above-mentioned peroxide (for example, hydrogen peroxide) These gum stimulations are often caused by the sudden action of the agent.

Therefore, there is a need for a solution for minimizing irritation to the gums and the like, while maintaining the stability of the peroxide during the distribution process, while enjoying a sufficient tooth whitening effect of the peroxide.

Accordingly, it is an object of the present invention to provide a composition for relieving irritation of a tooth whitening product that can alleviate tooth and gum irritation of a tooth whitening product in order to solve the above problems.

Furthermore, the present invention provides a tooth whitening kit which is excellent in teeth whitening effect but less irritating to the gum.

The present invention also provides a tooth whitening method having an excellent tooth whitening effect while reducing gum irritation.

In order to solve the above problems, the present invention provides a tooth whitening kit comprising an oral irritation-mitigating component, preferably a tooth whitening component that is effective in relieving gum irritation due to activation of peroxides, For example.

A tooth whitening kit according to the present invention comprises a first agent containing an oral irritation mitigating component, preferably an oral irritation alleviating component and a tooth whitening component activator; And a second agent containing a tooth whitening component.

As used herein, oral stimulation includes all irritation phenomena including swelling, redness, pain, etc. appearing on teeth and gums, which may occur due to activation of peroxides, among the whitening ingredients.

Also, relaxation means that the oral stimulation or the like is reduced or relieved as described above, and can be understood as a broad concept including improvement, prevention, and treatment.

The tooth whitening component according to the present invention includes at least one selected from hydrogen peroxide, carbamide peroxide, calcium peroxide, tetrasodium pyrophosphate peroxidate, sodium hypochlorite and chlorine bleach And may be one or more selected from among hydrogen peroxide, carbamide peroxide, calcium peroxide, and tetrasodium pyrophosphate peroxidate, and more preferably, Hydrogen peroxide or a peroxide element.

The tooth whitening component may include 0.01 wt% to 50 wt%, preferably 1 wt% to 30 wt%, and most preferably 2.5 wt% to 20 wt% of the total weight of the second agent.

The tooth whitening ingredients may be further mixed with a stabilizing agent to prevent lowering activity during circulation.

Examples of the stabilizer include sodium pyrophosphate, sodium pyrophosphate, sodium metaphosphate, sodium polyphosphate, potassium sodium pyrophosphate, potassium pyrophosphate, ultrametaphosphate, acidic sodium polyphosphate, ethylenediamine tetraacetate, aminotrimethylene phosphate, Salts thereof, hydroxyethylenepolyphosphonates and salts thereof, ethylenediamine tetramethylenephosphonate and salts thereof, diethylenetriaminepenta methylenephosphonate and salts thereof, alkylarylsulfonates, alkylsulfonate salts, alkylcarboxylates Span 20, Sorbitan Monoalate, Span 40, Sorbitan Monopalmitate, Span 60, Sorbitan Mono stearate, Span 80, Sorbitan Monooleate, , Span 85 (Sorbitan Trioleate), Tween (POE sorbitan fatty acid ester), and mixtures thereof. Or more species.

The whitening component active agent can act to accelerate the activity of the tooth whitening component and prevent the whitening activity of the teeth from being inhibited by the stabilizing agent used for stabilizing the whitening component during the product distribution, .

As the tooth whitening component activator, components for activating peroxides generally used in the industry can be used, and they are not particularly limited thereto. However, preferably a divalent or trivalent metal catalyst, a pH adjusting agent or a mixture thereof may be included.

The bivalent or trivalent metal catalyst can promote decomposition of the peroxide. The bivalent or trivalent metal catalyst is preferably capable of releasing calcium, magnesium, manganese, copper, iron or potassium ions, more preferably magnesium chloride, magnesium gluconate, iron lactate, ferrous gluconate, Manganese, manganese gluconate, manganese chloride and manganese citrate may be used.

The pH adjusting agent may react with peroxides to generate perhydroxy radicals to enhance the tooth whitening effect. Examples of the alkaline pH adjusting agent include sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, sodium phosphate, sodium pyrophosphate , Sodium citrate, and EDTA-4Na may be used, but the present invention is not limited thereto. Such an alkaline pH adjusting agent may be used in an appropriate amount so that the pH of the composition is from 8 to 11. [

When the tooth whitening agent containing the tooth whitening components is used, the stabilizing agent acts as an obstacle which prevents the whitening component from exhibiting activity. To solve this problem, the above-mentioned tooth whitening component activator is used. At this time, the sudden whitening activity causes the irritation in the oral cavity, which causes the irritation and damage of the gums in particular.

The first of the kits of the present invention comprises an amino acid including methionine, cysteine, and taurine in order to exert an excellent whitening action while alleviating the intraoral irritation as described above; Organic acids including ursodeoxycholic acid and tauroursodeoxycholic acid; And vitamins including vitamins A, C, and E, and preferably an amino acid including methionine, cysteine, and taurine, more preferably taurine is used. do.

The oral irritation mitigation component may be included in the first agent, the second agent, or both the first agent and the second agent, but may be preferably included in the first agent.

This is because when the second agent containing the tooth whitening component is applied to the tooth surface together with the whitening component activator, the stimulation relaxation effect will be most excellent.

The oral irritation mitigation ingredient according to the present invention may be contained in an amount of 0.001 to 10% by weight, preferably 0.01 to 5% by weight, more preferably 0.05 to 3% by weight based on the total weight of the first agent.

If the content of the oral irritation mitigating component is less than 0.001% by weight, it may be difficult to expect an appropriate effect on stimulation relaxation. If the content exceeds 10% by weight, the whitening effect by hydrogen peroxide may be affected, The effect may be deteriorated.

The first agent contained in the tooth whitening kit of the present invention is preferably in a gel state capable of being adhered to teeth by its own viscosity, but it can also be used as a dry state.

Polymers usable herein include polyalkyl vinyl ether-maleic acid copolymers (PVM / MA copolymer, Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, polyacrylic acid, polyoxamer polyvinylpyrrolidone-vinyl acetate copolymer (PVV / VA copolymer: Luviskol VA, Plasdone S PVP / VA), polyvinylpyrrolidone (PVP, K15 to K-120), Polyquaterium-11 (Gafquat 755N), Polyquaterium-39 (Merquat plus 3330), Carbopol, Carbopol, hydroxypropylmethyl cellulose, , Gelatin, Sodium Alginate, or a mixture thereof. These solvents may be mainly water, ethanol alone or a mixture thereof, and other organic solvents such as ethyl acetate, methylene chloride, isopropyl alcohol, acetonitrile alone or a mixture thereof.

The second agent contains a tooth whitening component and can maintain the shape of the product and protect the active ingredient. The second agent of the present invention can be produced in the form of a patch capable of adhering to a tooth surface. The patch for dental attachment according to the present invention can be produced by, for example, the methods disclosed in U.S. Patent Nos. 6,682,721, 6,689,344, 6,780,401, 6,946,142, etc., .

According to another embodiment of the present invention, there is provided a tooth whitening product comprising an amino acid comprising methionine, cysteine and taurine as an effective ingredient for alleviating oral stimulation of a tooth whitening product; Organic acids including ursodeoxycholic acid and tauroursodeoxycholic acid; And vitamins including vitamins A, C, and E. The present invention provides a composition for relieving oral stimulation of a tooth whitening product.

The composition may further comprise a tooth whitening component active agent.

The composition for alleviating oral irritation is used before application of a tooth whitening product in order to alleviate pain or relieve oral irritation caused by the rapid activation of a tooth whitening ingredient by a tooth whitening component activator.

The oral irritation mitigation ingredient may be included in an amount of 0.01 to 10% by weight, preferably 0.1 to 5% by weight, more preferably 0.15 to 3% by weight based on the total weight of the composition.

The present invention relates to a composition for relieving irritation of a tooth whitening product which can alleviate oral irritation which may occur when a tooth whitening component alone or a tooth whitening component and a tooth whitening component activator are used together, and a tooth whitening product And a tooth whitening kit.

The composition for relieving irritation and the tooth whitening agent according to the present invention have an excellent tooth whitening effect and can minimize irritation in the oral cavity, especially gums.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a graph showing changes in posterior toothiness using a tooth whitening kit of the present invention. FIG.
2 is a graph showing the degree of skin irritation.
3 is a graph showing the result of questionnaire evaluation on the degree of stimulus.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the above-described embodiments. The embodiments of the present invention are provided by way of example to facilitate a specific understanding of the present invention.

≪ Examples and Comparative Examples &

The tooth whitening kits according to the present invention were produced in a manner customary in the art with the composition ratios shown in Table 1 below. The content units in the following Table 1 are% by weight.

Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 First agent (gel) efficacy material - - 0.5% 0.5% 0.5% 0.5% Taurine 0.2% VitE 0.2% UDCA 0.2% First agent (gelatin)
Additive substance Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Silica 10% Silica 10% Silica 10% Silica 10% Silica 10% Silica 10% Povidone 10% Povidone 10% Povidone 10% Povidone 10% Povidone 10% Povidone 10% Ethanol 10% Ethanol 10% Ethanol 10% Ethanol 10% Ethanol 10% Ethanol 10% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Purified water to 100% Second agent (patch) efficacy material - Hydrogen peroxide
3.0% Hydrogen peroxide
3.0% Hydrogen peroxide
3.0% Hydrogen peroxide
3.0% Hydrogen peroxide
3.0%

Test Example  1. Whitening effect experiment - Change in brightness

1) Experimental method

Comparative Example 2, Example 1 and Example 2 were attached to an artificially colored HAP disk, respectively, and after 1 hour had elapsed, the initial contrast change was measured.

2) Experimental results

The results are shown in Fig. As shown in Fig. 1, it can be seen that Example 1 and Example 2 showed a whitening effect improved by about 70% or more as compared with Comparative Example 2 in which only hydrogen peroxide was prescribed.

Test Example  2. Irritation Related Patch Test

1) Experimental method

Eleven men with no skin disease on their arms were selected, and the comparative example and the example were applied / attached in a size of 2.5 cm x 2.5 cm, respectively, and left for 1 hour. After 1 hour, the gel was removed, and the remaining gel was washed with running water. After 30 minutes, the skin irritation was judged according to the following criteria.

<Criteria>

(CTFA / ICDRG Guideline, Textbook of contact dermatitis)

reaction Score Symptoms and judging criteria -
+/-
+
++
+++ 0
0.5
1.0
2.0
3.0 No response
Weak erythema
Clear erythema
Severe erythema with edema
Severe erythema with blistering and edema

2) Experimental results

According to the result shown in FIG. 2, skin irritation was significantly reduced in Examples 2 to 4 as compared with Comparative Examples 1 and 2 as a result of judging skin irritation degree. In particular, Example 2 in which taurine was added among the skin irritation mitigating ingredients showed the lowest skin irritancy.

In addition, it has been demonstrated through experiments that, when the whitening component active agent is not used with the skin irritation mitigating component, much stronger skin irritation can be induced as compared to Comparative Examples 1 and 2.

Therefore, when the results of Experimental Examples 1 and 2 are combined, it can be seen that when a whitening component activator and a skin irritation reducing ingredient are used together, an excellent tooth whitening effect can be obtained without irritation to the gums and the like.

Test Example  3. Evaluation of stimulation related questionnaires

The subjects of Comparative Example 2, Example 1 and Example 2 were each allowed to use a three-point scale for the degree of irritation according to the following evaluation criteria.

<Evaluation Criteria>

0: No stimulation at all

1: There is slight stimulation.

2: There is a certain stimulus.

3: Disruption due to stimulation

The results shown in FIG. 3 show that when iron chloride is used, irritation is more severe than when it is not used, but the degree of skin irritation is significantly reduced when taurine is added.

The results of the questionnaire evaluation showed that the skin irritation was alleviated by taurine and the like as in the stimulus related patch test of Experimental Example 2.

Claims (14)

A first agent containing an oral irritation mitigating component which is taurine, tauroursodeoxycholic acid or a mixture thereof; And
A tooth whitening kit comprising a second agent containing at least one tooth whitening component selected from hydrogen peroxide, peroxide element, calcium peroxide, sodium pyrophosphate, sodium hypochlorite and chlorine bleach. 2. The apparatus according to claim 1, wherein the first agent
The above-mentioned taurine, tauroursodeoxycholic acid or a mixture thereof, and
Characterized in that it comprises a tooth whitening component active agent which is magnesium chloride, magnesium gluconate, iron lactate, iron ferric gluconate, manganese sulfate, manganese gluconate, manganese chloride, manganese citrate, pH adjusting agent or a mixture thereof. delete delete delete delete The kit according to any one of claims 1 to 3, wherein the oral irritation mitigation ingredient is contained in an amount of 0.001 to 10 wt% based on the total weight of the first agent. The kit according to claim 1, wherein the second agent is in the form of a patch. As an effective ingredient to alleviate mouth irritation in tooth whitening products
Taurine, tauroursodeoxycholic acid, or a mixture thereof. &Lt; RTI ID = 0.0 &gt;
A composition for alleviating oral irritation of a tooth whitening product. 10. The composition of claim 9, wherein the composition further comprises a tooth whitening component active agent selected from the group consisting of magnesium chloride, magnesium gluconate, iron lactate, ferric gluconate iron chloride, manganese sulfate, manganese gluconate, manganese chloride, manganese citrate, pH adjusting agent, &Lt; / RTI &gt; delete delete 10. The composition of claim 9, wherein the composition is applied prior to application of a tooth whitening product. The composition of any one of claims 9,10 and 13, wherein the oral irritation mitigating component is present in an amount of 0.01 to 10% by weight relative to the total weight of the composition.

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