KR101687337B1 - The composition of foot dip disinfectant for livestock quarantine and method for manufacturing thereof - Google Patents
The composition of foot dip disinfectant for livestock quarantine and method for manufacturing thereof Download PDFInfo
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- KR101687337B1 KR101687337B1 KR1020150078054A KR20150078054A KR101687337B1 KR 101687337 B1 KR101687337 B1 KR 101687337B1 KR 1020150078054 A KR1020150078054 A KR 1020150078054A KR 20150078054 A KR20150078054 A KR 20150078054A KR 101687337 B1 KR101687337 B1 KR 101687337B1
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- 239000000645 desinfectant Substances 0.000 title claims description 31
- 238000000034 method Methods 0.000 title claims description 4
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- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 66
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 66
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- 238000003756 stirring Methods 0.000 claims description 25
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- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 2
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims description 2
- 230000003373 anti-fouling effect Effects 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 18
- 230000000249 desinfective effect Effects 0.000 description 17
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- KZDCMKVLEYCGQX-UDPGNSCCSA-N 2-(diethylamino)ethyl 4-aminobenzoate;(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;hydrate Chemical compound O.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 KZDCMKVLEYCGQX-UDPGNSCCSA-N 0.000 description 1
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- 241000283690 Bos taurus Species 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241001360526 Escherichia coli ATCC 25922 Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 210000003608 fece Anatomy 0.000 description 1
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- 150000002366 halogen compounds Chemical class 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
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- 210000004400 mucous membrane Anatomy 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
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- Plant Pathology (AREA)
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- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
본 발명은 구제역 및 조류인플루엔자 등 가축 전염병 방역을 위한 발판 소독약품 복합조성물 및 그 제조방법으로서, 보다 상세하게는 동절기에도 얼지 않고 고온이나 햇빛에 안정하며 유기물에 의한 소독력 저하 문제를 개선시킨 가축 방역용 발판 소독약품 복합조성물 및 그 제조방법에 관한 것이다.The present invention relates to a composite composition for scaffold disinfection chemicals for preventing livestock epidemic diseases such as foot-and-mouth disease and avian influenza, and more particularly, to a composition for preventing livestock diseases which does not freeze in winter and is stable at high temperatures and sunlight, And a method of manufacturing the same.
Description
본 발명은 구제역 및 조류인플루엔자 등 가축 전염병 방역을 위한 발판 소독약품 복합조성물 및 그 제조방법으로서, 보다 상세하게는 동절기에도 얼지 않고 고온이나 햇빛에 안정하며 유기물에 의한 소독력 저하 문제를 개선시킨 가축 방역용 발판 소독약품 복합조성물 및 그 제조방법에 관한 것이다.
The present invention relates to a composite composition for scaffold disinfection chemicals for preventing livestock epidemic diseases such as foot-and-mouth disease and avian influenza, and more particularly, to a composition for preventing livestock diseases which does not freeze in winter and is stable at high temperatures and sunlight, And a method of manufacturing the same.
최근 구제역(Foot and mouth disease) 및 조류 인플루엔자(Avian influenza)가 국내에서 지속적으로 발병하면서 경제적, 사회적으로 막대한 피해를 가중시키고 있다.Recently, foot and mouth disease and Avian influenza have been continuing to develop in Korea, causing serious economic and social damage.
상기 구제역은 소, 돼지, 사슴 등 발굽이 갈라진 우제류 동물의 급성 바이러스 질병으로 주로 발굽이나 구강 점막, 유두 부위에 수포 형성을 특징으로 하며 전염성이 매우 강하여 한번 발생시 종식시키기가 쉽지 않고 피해가 막대하기 때문에 국가에서 제1법정 가축전염병으로 지정하여 관리하고 있다. 구제역 바이러스는 사람에게 전파되지는 않지만 동물간 전파 속도가 매우 빠르고 치사율이 50%까지 이르기 때문에 대부분의 선진국에서는 살처분 정책을 통하여 전파 확산을 차단하고 있다. 최근 연구 결과 구제역 바이러스는 주로 사람이나 차량을 통하여 멀리 떨어진 농장까지 전파될 수 있으며 특히 사람 신발이나 차량 바퀴에 오염되어 전파되는 경우가 주된 전파 요인으로 보고되고 있다.The foot-and-mouth disease is acute viral disease of hoofed animals such as cattle, pigs, and deer, characterized by formation of vesicles mainly on hoofs, oral mucous membranes and papillae and is very infectious. It is designated as the first livestock infectious disease in the country and managed. Although foot-and-mouth disease viruses do not spread to humans, the transmission rate between animals is very fast and the mortality rate is up to 50%. Recently, foot-and-mouth disease virus ("FMD") has been reported to spread to remote farms mainly through people or vehicles, especially when contaminated by human shoes or wheels.
한편, 조류인플루엔자는 조류에 감염되는 급성 호흡기질병으로 조류독감이라 불리 우기도 하며 감염시 치사율이 100%까지 이르는 바이러스 질병이다. 특히 조류인플루엔자는 동물에서 사람으로 감염될 수 있기 때문에 공중 보건상 매우 중요하게 취급되는 질병으로 대부분의 국가에서는 조류인플루엔자 발생시 초기부터 살처분 정책을 택하고 있다. 우리나라에서도 조류인플루엔자 발생시 살처분 정책을 택하기 때문에 살처분으로 인한 경제적 피해가 막대할 뿐만 아니라 양계 산물의 소비 위축 및 수출 금지로 피해가 가중되어 양계관련 산업의 발전을 저해하고 있다. 조류인플루엔자 바이러스는 감염된 철새의 분변이 사람의 신발에 오염되어 전파되는 경우가 주된 요인으로 보고되고 있다.On the other hand, avian influenza is an acute respiratory disease that is infected with avian influenza, which is called avian influenza. Avian influenza, especially avian influenza, can be transmitted from animals to humans, so it is a very important disease in public health. In Korea, because of the disposal policy for the avian influenza, the economic damage caused by the disposal is not only large but also the growth of the industry related to the poultry industry is hindered because of the decrease in consumption of the products and the prohibition of export. The avian influenza virus has been reported to be caused by contaminated feces of infected migratory birds in human shoes.
따라서, 우리나라 정부에서도 구제역과 조류인플루엔자 방역을 위하여 막대한 인력과 예산을 투입하여 예방 및 차단에 만전을 기하고 있으며 그 일환으로 구제역 및 조류인플루엔자 방역소독약품을 구입하여 축산 농가 및 관련 기관에 무상으로 공급하고 있다. Therefore, the government of Korea is also investing huge amount of manpower and budget for the prevention of foot-and-mouth disease and avian influenza, so as to prevent and block the disease. As part of this, the disinfection drug for foot-and- mouth disease and avian influenza is purchased and supplied to livestock farmers and related organizations free of charge .
구제역 및 조류인플루엔자 방역용 소독약품이란 구제역 바이러스 및 조류인플루엔자 바이러스가 가축을 사육하고 있는 농장으로 유입되는 것을 방지하기 위하여 축사내부 소독, 축사외부 소독, 발판소독, 차량외부 및 바퀴소독, 차량내부 소독, 사람 소독 및 도로 및 철새도래지 등 오염지역 소독을 실시하기 위하여 사용하는 소독약품을 말한다. 이러한 소독약품은 소독대상에 적합하도록 개발되어 공급되는 것이 바람직하다. Disinfection drugs for foot-and-mouth disease and avian influenza are used for disinfection of domestic animals, disinfection of domestic animals, disinfection of footbaths, disinfection of vehicles and wheels, disinfection of vehicles, disinfection of animals inside the vehicle to prevent influenza virus and avian influenza virus from entering the farm, Disinfecting chemicals used to disinfect polluted areas such as disinfecting people and roads and migratory birds. It is desirable that such disinfectant drugs are developed and supplied to be suitable for disinfection.
예를 들어 축사 내부 소독약품은 축사 내에 가축이 사육되고 있기 때문에 가축의 피부 및 호흡기 장애를 유발하지 않는 성분으로 제조되어야 하며, 도로 및 철새 도래지 소독약품은 주변 식물이나 냇물, 호수 및 토양 등에 위해가 없는 성분으로 제조되어야 한다. 발판 소독조는 농장입구나 축사입구, 축산관련자가 많이 드나드는 관공서 등 건물 입구, 철새도래지 출입구 등 실외에 비치되기 때문에 발판 소독조용 발판 소독약품은 동절기에 얼지 않고 햇빛이나 고온 등에 안정성이 높아야하며 유기물에 의한 소독력 저하가 적어야 한다. 독일, 영국 등 일부 선진국에서는 상기 예처럼 소독대상에 적합한 소독약품이 분야별로 개발되어 시판되고 있으나, 아직 국내에서는 초기 연구단계에 머무르고 있는 실정이다. For example, domestic disinfectants must be manufactured from ingredients that do not cause skin and respiratory disturbance of livestock because domestic animals are kept in the house, and disinfectants for roads and migratory birds are harmful to nearby plants, streams, lakes and soils. It should be manufactured with no ingredients. Since the disinfection tank is provided outdoors such as a farm entrance, a housing entrance such as a farm entrance, a building entrance such as a government office where a lot of livestock related personnel go by, a door entrance of a migratory bird, etc., the disinfection of the footbath disinfectant should not be frozen in the winter season and should be stable to sunlight and high temperature. The lowering of the disinfection power by the water should be small. In some advanced countries, such as Germany and the UK, disinfectants suitable for the disinfection target have been developed and marketed in various fields, but they are still in the early stage of research in Korea.
특히, 구제역 및 조류인플루엔자 바이러스가 사람의 신발이나 차량바퀴를 통해 빠르게 먼 지역까지 전파된다는 연구 보고가 나오면서 사람 신발이나 차량바퀴를 소독할 수 있는 발판 소독의 중요성이 강조되고 있으며 발판 소독조용 전문 소독약품의 개발이 요구되고 있다.In particular, the outbreak of foot-and-mouth disease and avian influenza viruses spread rapidly through people's shoes or vehicle wheels, and it is emphasized the importance of disinfection of pedestal shoes that can disinfect people's shoes or wheels. Has been demanded.
현재 국내에서 구제역 및 조류인플루엔자 방역을 위해 발판 소독조용 전문 소독약품은 개발되지 않았으나 페놀 화합물, 알데히드 화합물, 계면활성제, 할로겐족 화합물 및 산성제제 소독약품이 발판소독약품 대용으로 권장 사용되고 있다. 이러한 소독약품들은 발판 전용 소독약품이 아니기 때문에 다음과 같은 여러 가지 문제점을 앉고 있다.At present, there is no special disinfectant for disinfection of foot-and-mouth disease for the prevention of foot-and-mouth disease and avian influenza in Korea. However, phenolic compounds, aldehyde compounds, surfactants, halogen compounds and acid disinfectants have been recommended as substitutes for footing disinfectants. Since these disinfecting chemicals are not exclusive disinfectants for footing, they have various problems as follows.
페놀 화합물 소독약은 올소디클로르벤젠이 주성분이며 발판 소독약품으로 사용시 햇빛에 효과가 빠르게 감소하며 유기물내 침투력이 낮고 냄새가 강하며 신발 부식성이 높고 빙점이 낮아 겨울 혹한기에 소독액이 얼어버리는 문제점이 있다.Phenol compound disinfectant is the main component of the disinfectant of phenolic compound. When used as a foot disinfectant, the effect of the disinfectant decreases rapidly in sunlight. It has low penetration power in organic matter, strong smell, high shoe corrosion and low freezing point.
알데히드 화합물 소독약은 글루탈알데히드가 주성분이며 발판 소독약품으로 사용시 겨울철 혹한기에 소독액이 동결되며 자극성이 강하고 호흡기에 노출시 암을 유발하는 등 독성이 강하다는 문제점이 있다.Aldehyde compound disinfectant is mainly composed of glutaraldehyde, and when it is used as a footing disinfectant drug, the disinfectant liquid is frozen in the winter when it is cold and has strong irritation, and it is toxic such as cancer when it is exposed to the respiratory tract.
계면활성제는 4급암모늄염이 주성분이며 발판 소독약품으로 사용시 햇빛과 고온에 노출시 소독력이 감소되고 겨울철 혹한기에 소독액이 얼어버리는 문제점이 있다. Surfactants are mainly quaternary ammonium salts, and when used as a footing disinfectant, the disinfecting power is reduced when exposed to sunlight and high temperature, and the disinfectant solution is frozen in the cold of winter.
할로겐족 화합물은 염소가 주성분이며 발판 소독약품으로 사용시 햇빛에 노출되거나 온도가 상승시 소독력이 빠르게 저하되고 겨울철 혹한기에 소독액이 동결되는 문제점이 있다.Halogenated compounds are chlorine-based, and they are a disinfectant for footing, and when exposed to the sunlight or when the temperature rises, the disinfection power drops rapidly and the disinfectant solution is frozen in the cold of winter.
산성제제는 시트르산 및 락트산이 주성분이며 발판 소독약품으로 사용시 소독력과 유기물내 침투력이 미흡하고 동절기시 소독액이 얼어버리는 문제점이 있다.The acidic preparation is mainly composed of citric acid and lactic acid, and is a disinfectant for scaffolds. When used as a scaffold, it has insufficient disinfecting power and penetration ability in organic matter, and disinfectant solution is frozen in winter.
이와 같은 종래의 발판 소독에 사용되는 약품들의 취약점들로 인해 투입되는 비용과 노동력에 비해 소독 효과가 크지 않아 대책 마련이 시급한 실정이다.
Due to the weaknesses of the conventional chemicals used in footing disinfection, disinfection effect is not so much compared with the input cost and labor, and it is urgent to prepare countermeasures.
따라서, 본 발명은 상기와 같은 종래의 축산용 소독제의 문제점들을 해결하기 위한 것으로, 구제역 및 조류인플루엔자 등 가축 전염병을 효과적으로 방역하기 위한 발판 소독조용 소독약품으로서 겨울철 혹한기에도 동결되지 않으며 온도, 햇빛 및 유기물에 따른 소독력 감소문제를 개선시켜 소독의 효율성 및 경제성을 크게 향상시킬 수 있도록 한 가축 방역용 발판 소독약품 복합조성물 및 그 제조방법을 제공하고자 안출된 목적이 있다.
DISCLOSURE OF THE INVENTION Accordingly, the present invention has been made to solve the above-mentioned problems of the conventional disinfectant for animal husbandry, and it is a disinfectant for disinfecting foot care for effectively preventing livestock infectious diseases such as foot-and-mouth disease and avian influenza, The present invention has been made to provide a composite composition for disinfectant for disinfection of footbath and a method of manufacturing the same, which can greatly improve the efficiency and economical efficiency of disinfection.
상기와 같은 목적을 달성하기 위한 본 발명의 기술적 수단은 4급암모늄(Quarternary ammonium compound)에 락트산(Lactic acid), 글리세린(Glycerin), 폴리소르베이트 80(Polysorbate 80) 및 에탄올(Ethanol)을 함유하는 복합조성물로서, 상기 복합조성물의 성분 조성비는 4급암모늄 0.01~0.2중량%, 락트산 0.002~0.05중량%, 글리세린 20~60중량%, 폴리소르베이트 80 0.01~1중량%, 에탄올 5~20중량% 및 정제수 18.75~74.978중량%로 이루어진 것을 특징으로 한다.Technical Solution In order to achieve the above object, the technical means of the present invention is a method for purifying a quaternary ammonium compound, which comprises reacting Lactic acid, Glycerin, Polysorbate 80 and Ethanol with a quaternary ammonium compound, Wherein the composite composition comprises 0.01 to 0.2% by weight of quaternary ammonium, 0.002 to 0.05% by weight of lactic acid, 20 to 60% by weight of glycerin, 0.01 to 1% by weight of polysorbate 80, 5 to 20% And 18.75 to 74.978% by weight of purified water.
또한, 가온용 교반기에 적당량의 정제수를 넣고 20rpm속도로 교반하면서 락트산, 글리세린, 폴리소르베이트 80을 순서대로 투입하여 교반속도를 35rpm속도로 올리고 교반조의 온도를 서서히 상승시켜 65℃까지 이르도록 하여 30분간 교반한 다음 실온으로 냉각시킨 중간 제조액에 4급암모늄을 가하여 10rpm속도로 6~12시간 동안 교반시킨 다음 에탄올과 잔량의 정제수를 투입하여 복합조성물이 100중량%가 되도록 하여 35rpm속도로 30분간 혼합하여서 된 것을 특징으로 한다.
An appropriate amount of purified water was added to a warming stirrer and lactic acid, glycerin, and polysorbate 80 were added in order while stirring at a speed of 20 rpm. The stirring speed was increased at a speed of 35 rpm, the temperature of the stirring tank was gradually increased, Quaternary ammonium was added to the intermediate preparation which had been cooled to room temperature and then stirred at a speed of 10 rpm for 6 to 12 hours. Then, ethanol and the remaining amount of purified water were added to the mixture to adjust the composition to 100 wt% Are mixed with each other.
본 발명은 4급암모늄(Quarternary ammonium compound), 락트산(Lactic acid), 글리세린(Glycerin), 폴리소르베이트 80(Polysorbate 80) 및 에탄올(Ethanol)을 함유하는 것을 특징으로 하는 발판 소독 약품 복합조성물로서, 겨울철 혹한기에도 동결되지 않으며 온도, 햇빛 및 유기물에 의해 소독력이 크게 감소되지 않기 때문에 구제역 또는 조류인플루엔자 등 가축 전염병 발생시 효과적인 발판 소독을 실시할 수 있고, 소독의 효율성과 경제성을 크게 향상시킬 수 있는 효과가 있다.
The present invention relates to a footing disinfecting drug composition comprising Quaternary ammonium compound, Lactic acid, Glycerin, Polysorbate 80 and Ethanol, It is not frozen even in cold weather in winter, and disinfection power is not greatly reduced by temperature, sunlight and organic matter. Therefore, effective disinfection can be performed when a livestock infectious disease such as foot-and-mouth disease or avian influenza occurs and the efficiency and economical efficiency of sterilization can be greatly improved have.
이하, 본 발명을 구체적으로 설명한다.Hereinafter, the present invention will be described in detail.
본 발명에 따른 가축 방역용 발판 소독약품 복합조성물은 소독 성분으로 4급암모늄과 락트산에 안정제로 글리세린, 폴리소르베이트 80 및 에탄올을 정제수에 혼합하여 구성한 것으로, 겨울철 혹한기에 발판 소독약품이 얼어 발판 소독을 실시할 수 없는 문제점뿐만 아니라 발판 소독약품이 햇빛이나 고온 및 유기물에 의해 빠르게 분해되어 소독력이 감소되는 문제점을 동시에 해결하여 효과적인 발판 소독 실시가 가능하도록 하기 위한 것이다.The disinfectant composition for livestock poultry disinfection according to the present invention is composed of quaternary ammonium as a disinfecting ingredient and glycerin, polysorbate 80 and ethanol as a stabilizer in lactic acid and is mixed with purified water. In the winter, when the disinfectant is freezing, In addition, the present invention solves the problem that the disinfectant is quickly decomposed by sunlight, high temperature, and organic matter, and the disinfecting power is reduced, thereby enabling effective disinfection of footplate.
이러한, 상기 복합조성물의 각각의 성분들을 설명하면, 소독 성분인 4급암모늄(Quarternary ammonium compound)은 총 조성물을 기준으로 0.01~0.2중량%인 것이 바람직하다. 이때 4급암모늄이 0.01중량% 미만인 경우에는 소독력이 미흡하고 0.2중량% 이상인 경우에는 과량 사용으로 바람직하지 못하다. The quaternary ammonium compound, which is a disinfecting component, is preferably 0.01 to 0.2% by weight based on the total composition. At this time, if quaternary ammonium is less than 0.01 wt%, the disinfecting power is insufficient, and when it is more than 0.2 wt%, it is not preferable because of excessive use.
이때, 상기 4급암모늄은 염화벤잘코늄(Benzalkonium chloride) 또는 디데실 디메칠 암모늄클로라이드(Didecyl dimethyl ammonium chloride) 중 어느 하나인 것이 바람직하다.The quaternary ammonium may be benzalkonium chloride or Didecyl dimethyl ammonium chloride.
본 발명의 조성물 락트산(Lactic acid)은 락트산균에 의해 당으로부터 생성되는 유기산으로서, 총 조성물의 0.002~0.05중량%를 사용하는 것이 바람직하며, 본 발명에서 락트산의 양이 0.002중량% 이하일 경우에는 소독력 개선효과가 미흡하고 0.05중량%이상일 경우는 과량 사용으로 바람직하지 못하다.The composition of the present invention is preferably an organic acid produced from lactic acid by a lactic acid bacterium in an amount of 0.002 to 0.05% by weight of the total composition. When the amount of lactic acid is 0.002% by weight or less in the present invention, If the improvement effect is insufficient and 0.05 wt% or more, it is not preferable because of excessive use.
본 발명에 사용되는 글리세린(Glycerin)은 방부작용이 있으며, 희박용액의 자극을 완화하며 국소를 연화하고, 관장약, 국소를 포섭보호하며 외부자극을 완화하고 유해물질의 침입을 방지할 목적으로 외용하는 것으로서, 총 조성물의 20~60중량%를 사용하는 것이 바람직하며, 본 발명에서 글리세린의 양이 20중량%이하일 경우에는 내동결성 및 안정성 개선효과가 미흡하고 60중량% 이상 시에는 소독력이 감소되는 문제점이 있다. Glycerin used in the present invention has a side effect, and it is used for relieving the irritation of the diluted solution, softening the locality, protecting the local drug, locust, alleviating external stimuli and preventing intrusion of harmful substances It is preferable to use 20 to 60% by weight of the total composition. When the amount of glycerin in the present invention is 20% by weight or less, the effect of improving the resistance to frost formation and stability is insufficient and the disinfecting power is decreased .
본 발명의 조성물 중 폴리소르베이트 80(Polysorbate 80)은 표면 활성제이며 유용성 비타민, 호르몬류, 프로카인 페니실린 등을 수액(水液)에 분산시키는데 사용하는 것으로서, 총 조성물 중 0.01~1중량%가 바람직하고, 0.01중량%이하에서는 내동결성 및 햇빛, 온도 및 유기물에 대한 안정성 개선효과가 낮아 바람직하지 않고 1중량% 이상 시에는 제조원가 상승으로 인하여 바람직하지 못하다.Among the compositions of the present invention, Polysorbate 80 is a surface active agent used for dispersing vitality, hormones, procaine penicillin and the like in a water solution, and is preferably 0.01 to 1% by weight in the total composition When the content is less than 0.01% by weight, the effect of improving the stability against sunlight, temperature and organic matters is low, and when it is 1% by weight or more, it is not preferable due to an increase in production cost.
본 발명에 사용되는 에탄올(Ethanol)은 총 조성물의 5~20중량%를 사용하는 것이 바람직하며, 5중량%이하일 경우에는 소독력 및 내동결성 개선효과가 미흡하고 20중량% 이상 시에는 화기에 취약하여 안전성에 문제를 초래할 수 있어 바람직하지 못하다. Ethanol used in the present invention is preferably used in an amount of 5 to 20% by weight of the total composition. When the amount is less than 5% by weight, the effect of improving disinfecting power and resistance to frost formation is insufficient. When the amount is more than 20% by weight, It may cause a problem in safety, which is not preferable.
본 발명에 따른 가축 방역용 발판 소독약품 복합조성물 중 정제수는 모두 사용되는 소독 성분과 안정화 성분 중량% 합산 값에 따라 발판 소독약품 조성물의 총 중량%가 100중량%가 되도록 부형제로 사용되는 것이다.The purified water of the scaffold disinfecting drug composition according to the present invention is used as an excipient so that the total weight percentage of the scouring disinfectant composition is 100% by weight based on the sum of disinfection components and stabilizing component weight percentages used.
이와 같은, 본 발명에 따른 가축 방역용 발판 소독약품 복합조성물의 제조방법은 중간 제조액 제조단계와 복합조성물 제조단계로 구성된다.The method for manufacturing the scaffold disinfecting drug composite composition for livestock protection according to the present invention comprises the steps of preparing an intermediate preparation liquid and preparing a composite composition.
상기 중간 제조액 제조단계는 가온용 교반기에 40중량%의 정제수를 넣고 20rpm속도로 교반하면서 0.01중량%의 락트산과 40중량%의 글리세린 및 0.1중량%의 폴리소르베이트 80을 순서대로 투입하여 교반속도를 35rpm으로 올리고 교반조의 온도를 서서히 상승시켜 65℃까지 이르도록 하여 30분간 교반한 다음 실온으로 냉각시켜 중간 제조액을 제조한다.In the intermediate preparation step, 40 wt% of purified water was added to a warming stirrer, and 0.01 wt% of lactic acid, 40 wt% of glycerin and 0.1 wt% of polysorbate 80 were sequentially added thereto while stirring at 20 rpm, Is stirred at 35 rpm, the temperature of the stirring tank is gradually raised to 65 DEG C, stirred for 30 minutes, and cooled to room temperature to prepare an intermediate preparation liquid.
상기 복합조성물 제조단계는 중간 제조액에 0.05중량의 4급암모늄을 가하여 10rpm속도로 서서히 6~12시간 동안 교반시킨 다음 10중량%의 에탄올과 복합조성물 총 중량이 100중량%가 되도록 정제수를 가하여 35rpm속도로 30분간 혼합하여 최종적으로 가축 방역용 발판 소독약품 복합조성물을 제조하는 것으로 4급암모늄 반응시간은 9시간이 가장 바람직할 것이다.0.05 part by weight of quaternary ammonium was added to the intermediate preparation solution and stirred slowly at a rate of 10 rpm for 6 to 12 hours. Then, purified water was added to the mixture in an amount of 10% by weight of ethanol and 100% At a rate of 30 minutes to finally prepare a composite composition for disinfection of footpad for livestock, and quaternary ammonium reaction time is most preferably 9 hours.
본 발명은 다음 실시예 및 실험 예에 의해서 보다 구체적으로 이해될 수 있으며, 다음의 실시예는 본 발명을 예시하기 위한 것에 지나지 않으며 본 발명의 범위를 제조하고자 하는 것은 아님을 밝히는 것이다.The present invention can be understood more specifically by the following examples and experimental examples, and it is to be understood that the following examples are merely illustrative of the present invention and are not intended to limit the scope of the present invention.
다수의 원료를 표 1과 같이 혼합하여 복합조성물을 제조한다.A plurality of raw materials are mixed as shown in Table 1 to prepare a composite composition.
실시예 1의 복합조성물을 제조하는 과정은 다음과 같다. The process for preparing the composite composition of Example 1 is as follows.
가온용 교반기에 40중량%의 정제수를 넣고 20rpm 속도로 교반하면서 락트산, 글리세린, 폴리소르베이트 80을 각각 순서대로 투입하여 교반속도를 35rpm으로 올리고 교반조의 온도를 서서히 상승시켜 65℃에 이르도록 하여 30분간 교반한 다음 실온으로 냉각시키고 염화벤잘코늄을 투입하여 10rpm 속도로 9시간 동안 서서히 교반한 다음 에탄올과 잔량의 정제수를 넣고 35rpm속도로 30분간 혼합하여 일정량씩 소분, 포장하여 제조하는 것이다.40 wt% of purified water was put into a stirrer for warming, lactic acid, glycerin and polysorbate 80 were sequentially added thereto while stirring at a speed of 20 rpm, the stirring speed was raised to 35 rpm, the temperature of the stirring tank was gradually raised, After stirring the mixture for a minute, the mixture was cooled to room temperature, added with benzalkonium chloride, stirred slowly at a speed of 10 rpm for 9 hours, mixed with ethanol and the remaining amount of purified water, and mixed at 35 rpm for 30 minutes.
다수의 원료를 표 2와 같이 혼합하여 복합조성물을 제조한다.A plurality of raw materials are mixed as shown in Table 2 to prepare a composite composition.
실시예 2의 복합조성물을 제조하는 과정은 다음과 같다.The process for preparing the composite composition of Example 2 is as follows.
가온용 교반기에 40중량%의 정제수를 넣고 20rpm 속도로 교반하면서 글리세린, 폴리소르베이트 80을 각각 순서대로 투입하여 교반속도를 35rpm으로 올리고 교반조의 온도를 서서히 상승시켜 65℃에 이르도록 하여 30분간 교반한 다음 실온으로 냉각시키고 염화벤잘코늄을 투입하여 10rpm 속도로 9시간 동안 서서히 교반한 다음 에탄올과 잔량의 정제수를 넣고 35rpm속도로 30분간 혼합하여 일정량씩 소분, 포장하여 제조하는 것이다.40% by weight of purified water was put into a stirrer for warming, and glycerin and polysorbate 80 were sequentially added thereto while stirring at a speed of 20 rpm, the stirring speed was increased to 35 rpm, the temperature of the stirring tank was gradually raised, The mixture was cooled to room temperature, added with benzalkonium chloride, stirred slowly at a speed of 10 rpm for 9 hours, mixed with ethanol and the remaining amount of purified water, and mixed at 35 rpm for 30 minutes.
다수의 원료를 표 3과 같이 혼합하여 복합조성물을 제조한다.A plurality of raw materials are mixed as shown in Table 3 to prepare a composite composition.
실시예 3의 복합조성물을 제조하는 과정은 다음과 같다.The process for preparing the composite composition of Example 3 is as follows.
가온용 교반기에 40중량%의 정제수를 넣고 20rpm 속도로 교반하면서 락트산, 글리세린, 폴리소르베이트 80을 각각 순서대로 투입하여 교반속도를 35rpm으로 올리고 교반조의 온도를 서서히 상승시켜 65℃에 이르도록 하여 30분간 교반한 다음 실온으로 냉각시키고 에탄올과 잔량의 정제수를 넣고 35rpm속도로 30분간 혼합하여 일정량씩 소분, 포장하여 제조하는 것이다.40 wt% of purified water was put into a stirrer for warming, lactic acid, glycerin and polysorbate 80 were sequentially added thereto while stirring at a speed of 20 rpm, the stirring speed was raised to 35 rpm, the temperature of the stirring tank was gradually raised, The mixture was stirred for a minute, cooled to room temperature, mixed with ethanol and the remaining amount of purified water, and mixed at a speed of 35 rpm for 30 minutes.
다수의 원료를 표 4와 같이 혼합하여 복합조성물을 제조한다.A plurality of raw materials are mixed as shown in Table 4 to prepare a composite composition.
실시예 4의 복합조성물을 제조하는 과정은 다음과 같다.The process for preparing the composite composition of Example 4 is as follows.
가온용 교반기에 40중량%의 정제수를 넣고 20rpm 속도로 교반하면서 락트산, 폴리소르베이트 80을 각각 순서대로 투입하여 교반속도를 35rpm으로 올리고 교반조의 온도를 서서히 상승시켜 65℃에 이르도록 하여 30분간 교반한 다음 실온으로 냉각시키고 염화벤잘코늄을 투입하여 10rpm 속도로 9시간 동안 서서히 교반한 다음 에탄올과 잔량의 정제수를 넣고 35rpm속도로 30분간 혼합하여 일정량씩 소분, 포장하여 제조하는 것이다.40% by weight of purified water was put into a stirrer for warming, lactic acid and polysorbate 80 were sequentially added while stirring at a speed of 20 rpm, the stirring speed was raised to 35 rpm, the temperature of the stirring tank was gradually raised, and the mixture was stirred at 65 캜 for 30 minutes The mixture was cooled to room temperature, added with benzalkonium chloride, stirred slowly at a speed of 10 rpm for 9 hours, mixed with ethanol and the remaining amount of purified water, and mixed at 35 rpm for 30 minutes.
다수의 원료를 표 5와 같이 혼합하여 복합조성물을 제조한다.A plurality of raw materials are mixed as shown in Table 5 to prepare a composite composition.
실시예 5의 복합조성물을 제조하는 과정은 다음과 같다.The process for preparing the composite composition of Example 5 is as follows.
가온용 교반기에 40중량%의 정제수를 넣고 20rpm 속도로 교반하면서 락트산, 글리세린을 각각 순서대로 투입하여 교반속도를 35rpm으로 올리고 교반조의 온도를 서서히 상승시켜 65℃에 이르도록 하여 30분간 교반한 다음 실온으로 냉각시키고 염화벤잘코늄을 투입하여 10rpm 속도로 9시간 동안 서서히 교반한 다음 에탄올과 잔량의 정제수를 넣고 35rpm속도로 30분간 혼합하여 일정량씩 소분, 포장하여 제조하는 것이다.40% by weight of purified water was added to the stirrer for warming, and lactic acid and glycerin were added in this order while stirring at a speed of 20 rpm, the stirring speed was increased to 35 rpm, the temperature of the stirring tank was gradually raised, stirring was continued for 30 minutes at 65 ° C, And the mixture was stirred at 10 rpm for 9 hours. Then, ethanol and the remaining amount of purified water were added and mixed at a speed of 35 rpm for 30 minutes.
다수의 원료를 표 6과 같이 혼합하여 복합조성물을 제조한다.A plurality of raw materials are mixed as shown in Table 6 to prepare a composite composition.
실시예 6의 복합조성물을 제조하는 과정은 다음과 같다.The process for preparing the composite composition of Example 6 is as follows.
교반기에 염화벤잘코늄, 락트산, 에탄올 및 정제수를 순서대로 투입한 후 35rpm속도로 30분간 혼합하여 일정량씩 소분, 포장하여 제조하는 것이다.After adding benzalkonium chloride, lactic acid, ethanol and purified water to the agitator in order, the mixture was mixed at a speed of 35 rpm for 30 minutes and subdivided by a predetermined amount.
다수의 원료를 표 7과 같이 혼합하여 복합조성물을 제조한다.A plurality of raw materials are mixed as shown in Table 7 to prepare a composite composition.
실시예 7의 복합조성물을 제조하는 과정은 다음과 같다.The process for preparing the composite composition of Example 7 is as follows.
교반기에 염화벤잘코늄, 에탄올 및 정제수를 순서대로 투입한 후 35rpm속도로 30분간 혼합하여 일정량씩 소분, 포장하여 제조하는 것이다.Benzalkonium chloride, ethanol and purified water were sequentially added to the agitator, and the mixture was mixed at a speed of 35 rpm for 30 minutes and subdivided by a predetermined amount.
다수의 원료를 표 8과 같이 혼합하여 복합조성물을 제조한다.A plurality of raw materials are mixed as shown in Table 8 to prepare a composite composition.
실시예 8의 복합조성물을 제조하는 과정은 다음과 같다.The process for preparing the composite composition of Example 8 is as follows.
교반기에 락트산, 에탄올 및 정제수를 순서대로 투입한 후 35rpm속도로 30분간 혼합하여 일정량씩 소분, 포장하여 제조하는 것이다.
Lactic acid, ethanol, and purified water are sequentially added to the agitator, and the mixture is mixed at a rate of 35 rpm for 30 minutes and subdivided by a predetermined amount.
상기의 실시예 1 내지 8의 복합조성물을 형성하는 원료들은 아래의 표 9와 같이 요약된다.The raw materials for forming the composite compositions of Examples 1 to 8 above are summarized in Table 9 below.
<실험 예 1> 내동결성 시험≪ Experimental Example 1 >
1. 실험 방법1. Experimental Method
실시예 1 내지 8에 의해 형성된 복합조성물의 내동결성 실험을 실시하기 위하여 각 조성물을 500ml 비이커에 400ml씩 정량하여 채우고 영하 5℃, 10℃, 15℃, 20℃에서 24시간 동안 방치한 후 동결 여부를 관찰하였다.In order to carry out the cross-linking test of the composite compositions formed in Examples 1 to 8, each composition was weighed in a 500 ml beaker in an amount of 400 ml and allowed to stand at 5 ° C, 10 ° C, 15 ° C and 20 ° C for 24 hours, Respectively.
2. 실험 결과2. Experimental results
각 실시예에 따른 복합조성물의 내동결성 시험의 결과는 표 10과 같다.Table 10 shows the results of the cross-linking test of the composite composition according to each example.
<실험 예 2> 햇빛에 대한 안정성 시험<Experimental Example 2> Test for stability against sunlight
1. 실험 방법1. Experimental Method
실시예 1 내지 8에 의해 형성된 복합조성물의 햇빛에 대한 안정성을 알아보기 각각의 조성물을 100ml 비이커에 50ml씩 채워 햇빛이 들지 않는 실내와 햇빛이 잘 내리쬐는 실외에 각각 48시간 방치한 후 4급암모늄염과 락트산의 함량을 측정하였다.Determination of stability against sunlight of the composite composition formed by Examples 1 to 8 Each composition was filled in a 100 ml beaker in an amount of 50 ml each for 48 hours in a room free of sunshine and outdoors exposed to sunlight and then quaternary ammonium salt And lactic acid were measured.
2. 실험 결과2. Experimental results
각 실시예에 따른 복합조성물의 햇빛에 대한 안정성 시험의 결과는 표 11과 같다.The results of the stability test on the sunlight of the composite composition according to each example are shown in Table 11.
<실험 예 3> 온도에 대한 안정성 시험≪ Experimental Example 3 >
1. 실험 방법1. Experimental Method
실시예 1 내지 8에 의해 형성된 복합조성물의 온도에 대한 안정성을 알아보기 각각의 조성물을 100ml 비이커에 50ml씩 채워 항온 항습기에 넣어 30℃와 50℃에 48시간 방치한 후 4급암모늄염과 락트산의 함량을 측정하였다.Each composition was filled into a 100 ml beaker in an amount of 50 ml, placed in a constant-temperature and humidity chamber, and allowed to stand at 30 ° C and 50 ° C for 48 hours. The content of quaternary ammonium salt and lactic acid Were measured.
2. 실험 결과2. Experimental results
각 실시예에 따른 복합조성물의 온도에 대한 안정성 시험의 결과는 표 12와 같다.The results of the stability test for the temperature of the composite composition according to each example are shown in Table 12.
<실험 예 4> 유기물 존재하 소독력 시험<Experimental Example 4> Disinfection test in the presence of organic substances
1. 실험 방법1. Experimental Method
실시예 1 내지 8에 의해 형성된 복합조성물이 유기물 존재하에서 소독력 저하 정도를 알아보기 위하여 MIC측정법을 사용하여 비교 평가하였다. Nutrition agar 100mL에 공시균(E. coli ATCC 25922) 0.2mL를 접종하여 24시간 배양한 후 배지위에 직경 8mm, 두께 1.5mm 시험편을 올려놓고 시험액으로서 상기 실시 예 각 조성물에 효모추출액(Yeast extract)을 가하여 제조한 5% 유기물 희석액을 각각의 시험편에 50㎛씩 접종하고 다시 배양기에 넣어 24시간 배양 한 후 세균 발육 저지환의 평균 직경을 측정하였다. The composite compositions formed according to Examples 1 to 8 were comparatively evaluated using the MIC measurement method to investigate the degree of degradation of disinfection ability in the presence of organic matter. 0.2 mL of E. coli ATCC 25922 was inoculated into 100 mL of nutrition agar and cultured for 24 hours. Then, a test piece having a diameter of 8 mm and a thickness of 1.5 mm was placed on the culture medium. Yeast extract was added to each composition of the above Example as test solution The 5% organic matter diluent prepared was added to each test specimen in an amount of 50 쨉 m. After incubation for 24 hours, the average diameter of the bacterial growth inhibition rings was measured.
2. 실험 결과2. Experimental results
각 실시예에 따른 복합조성물의 유기물 존재하 소독력 시험의 결과는 다음의 표 13과 같다.The results of the sanitization test in the presence of the organic compound of the composite composition according to each Example are shown in Table 13 below.
상기와 같이 본 발명에 따른 가축 방역용 발판 소독약품 복합조성물 및 그 제조방법은 종래의 문제점으로 지적되었던 내동결성과 햇빛에 대한 안정성과 온도에 대한 안정성 및 소독력이 매우 우수하여 소독의 효율성을 크게 향상시킬 수 있고, 소독에 따른 비용을 절감을 꾀하여 경제적인 측면까지도 고려한 산업상 이용가능성이 매우 높은 발명인 것이다.
As described above, the scaffold disinfecting chemical composition for livestock defense according to the present invention and the method for producing the same have remarkably improved the efficiency of sterilization due to excellent stability against frost formation, sunlight stability, and temperature, And it is an extremely highly industrially applicable invention that considers economical aspects by reducing the cost of disinfection.
이상에서 설명된 본 발명의 가축 방역용 발판 소독약품 복합조성물 및 그 제조방법의 실시예는 예시적인 것에 불과하며, 본 발명이 속한 기술분야의 통상의 지식을 가진 자라면 이로부터 다양한 변형 및 균등한 타 실시예가 가능하다는 점을 잘 알 수 있을 것이다. 그러므로 본 발명은 상기의 상세한 설명에서 언급되는 형태로만 한정되는 것은 아님을 잘 이해할 수 있을 것이다. 따라서 본 발명의 진정한 기술적 보호 범위는 첨부된 특허청구범위의 기술적 사상에 의해 정해져야 할 것이다.The embodiments of the pedicure disinfecting drug composite composition for livestock defense of the present invention described above and the method of manufacturing the same are merely illustrative and those skilled in the art will appreciate that various modifications and equivalent It will be appreciated that other embodiments are possible. Therefore, it is to be understood that the present invention is not limited to the above-described embodiments. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.
또한, 본 발명은 첨부된 청구범위에 의해 정의되는 본 발명의 정신과 그 범위 내에 있는 모든 변형물과 균등물 및 대체물을 포함하는 것으로 이해되어야 한다.
It is also to be understood that the invention includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.
Claims (4)
Wherein the composition is selected from quaternary ammonium, lactic acid, glycerin, polysorbate 80, ethanol, and purified water.
Characterized in that it comprises 0.01 to 0.2 wt% of quaternary ammonium, 0.002 to 0.05 wt% of lactic acid, 20 to 60 wt% of glycerin, 0.01 to 1 wt% of polysorbate 80, 5 to 20 wt% of ethanol and 18.75 to 74.978 wt% of purified water Wherein the disinfectant composition is a composition for disinfection of scum.
상기 4급암모늄은 염화벤잘코늄(Benzalkonium chloride) 또는 디데실 디메칠 암모늄클로라이드(Didecyl dimethyl ammonium chloride) 중 어느 하나인 것을 특징으로 하는 가축 방역용 발판 소독약품 복합조성물.
The method according to claim 1,
Wherein the quaternary ammonium is any one selected from the group consisting of benzalkonium chloride and Didecyl dimethyl ammonium chloride.
상기 중간 제조액에 0.05중량의 4급암모늄을 가하여 10rpm속도로 서서히 6~12시간 동안 교반시킨 다음 10중량%의 에탄올과 복합조성물 총 중량이 100중량%가 되도록 정제수를 가하여 35rpm속도로 30분간 혼합하여 최종적으로 가축 방역용 발판 소독약품 복합조성물을 제조하는 것을 특징으로 하는 가축 방역용 발판 소독약품 복합조성물의 제조방법.
40 wt% of purified water was put into a stirrer for warming, and 0.01 wt% of lactic acid, 40 wt% of glycerin and 0.1 wt% of polysorbate 80 were sequentially added while stirring at 20 rpm, the stirring speed was increased to 35 rpm, And stirring the mixture for 30 minutes so as to reach 65 占 폚 and cooling the mixture to room temperature to prepare an intermediate preparation liquid;
0.05 part by weight of quaternary ammonium was added to the intermediate preparation solution and stirred slowly at a speed of 10 rpm for 6 to 12 hours. Then, purified water was added thereto so that the total weight of the composite composition was 10% by weight of ethanol and 100% Thereby producing a scaffold antifouling drug composite composition for animal control.
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| KR20210098650A (en) | 2020-02-03 | 2021-08-11 | 최형규 | The composition of disinfectant for veterinary usage containing thymol |
| KR20230003771A (en) | 2021-06-30 | 2023-01-06 | 명전바이오 주식회사 | Environment-friendly disinfectant composition for preventing spread of infectious disease having excellent antibacterial and deodorizing function with liquid sodium silicate and environment-friendly disinfectant for preventing spread of infectious disease with the same |
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| KR102106811B1 (en) * | 2018-10-12 | 2020-05-06 | 농업회사법인 주식회사 과농 | Sterilization and cleansing agent of antifreezing for cattle shed |
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| KR20210098650A (en) | 2020-02-03 | 2021-08-11 | 최형규 | The composition of disinfectant for veterinary usage containing thymol |
| KR20230003771A (en) | 2021-06-30 | 2023-01-06 | 명전바이오 주식회사 | Environment-friendly disinfectant composition for preventing spread of infectious disease having excellent antibacterial and deodorizing function with liquid sodium silicate and environment-friendly disinfectant for preventing spread of infectious disease with the same |
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