KR101670335B1 - A ultrasound and nuclear medicine integrated imaging probe system for obtaining high-resolution image - Google Patents

Abstract

The present invention relates to an ultrasound and nuclear medicine fusion image probe system capable of obtaining a high resolution image, and more particularly, to a system and method for diagnosing a disease by diagnosing high-resolution image acquisition (ultrasound) In particular, it is possible to reduce the unnecessary number of biopsy runs in the breast or liver biopsy and to enable accurate diagnosis in real time. Therefore, it is possible to improve the convenience of the procedure for physicians and to provide a high resolution image The present invention relates to an ultrasound and nuclear medicine fusion image probe system.

Description

[0001] The present invention relates to an ultrasound and nuclear medicine fusion imaging probe system capable of acquiring high resolution images,

The present invention relates to an ultrasound and nuclear medicine fusion image probe system capable of obtaining a high resolution image, and more particularly, to a system and method for diagnosing a disease by diagnosing high-resolution image acquisition (ultrasound) In particular, it is possible to reduce the unnecessary number of biopsy runs in the breast or liver biopsy and to enable accurate diagnosis in real time. Therefore, it is possible to improve the convenience of the procedure for physicians and to provide a high resolution image The present invention relates to an ultrasound and nuclear medicine fusion image probe system.

As shown in FIG. 1, a conventional ultrasound imaging system is an ultrasound imaging system that transmits ultrasound (20,000 Hz or more) to the inside of a human body and provides a structural image through diffusion, absorption, Device.

Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography ("SPECT") devices, which are imaging devices for general nuclear medicine (Nuclear Medicine), can be used to measure molecules such as glucose, peptides, (Radioactive medicines) with radioactive isotopes, injecting them into living organisms, and imaging them with a PET scanner to image the physiological distribution and the body concentration of the radioactive tracer.

In other words, distribution of radiopharmaceuticals is a video device that provides functional information rather than structural information.

For example, it provides malignant / benign distinction of cancer, distribution of scooped molecules, and so on.

On the other hand, as shown in FIG. 2, the diagnosis area and the purpose of use according to the probe, which is a main component of the ultrasound medical imaging apparatus, are distinguished.

(A) for the heart, (b) for blood vessels and micro-tissues, (c) for abdomen, and (d) for obstetrics and gynecology.

Conventional ultrasound probes have a disadvantage in that they only show the position and shape of the tumor in terms of ultrasound, and thus can not determine whether the tumor is malignant or benign.

Ultrasonic probes developed to improve this are classified into malignant and benign tumors by elastic imaging, which is a method of examining the tissue stiffness and elasticity in recent years. However, there is a serious problem that the accuracy is less than 70% and reliability is low.

On the other hand, in the case of conventional nuclear medicine probes in the aspect of nuclear medicine, a probe (a radiation detector) is applied to a suspected region during surgery (after resection) to detect the presence or absence of a nuclear medicine radiation isotope. In other words, after the surgeon has resected the patient, the position of the suspicious part should be confirmed with the naked eye and the probe should be used.

Accordingly, there is a need for a probe system capable of complexly providing functions of a nuclear medicine probe while improving disadvantages of the ultrasonic probe.

Korean Patent Publication No. 10-2013-0066821 (June 31, 2013)

SUMMARY OF THE INVENTION Accordingly, the present invention has been made in view of the above problems of the prior art, and it is an object of the present invention to provide a diagnostic ultrasound diagnostic apparatus and a diagnostic ultrasound diagnostic apparatus, In particular, it is possible to reduce the unnecessary number of biopsy executions during breast or liver biopsy and to enable accurate diagnosis in real time, thereby improving the convenience of the procedure for physicians and reducing the inconvenience of the patients.

According to an aspect of the present invention, there is provided an ultrasound and nuclear medicine fusion image probe system capable of acquiring a high resolution image according to an embodiment of the present invention,

An ultrasonic probe unit 100 including an ultrasonic probe 150 having one side connected to the flexible board 120 through a wire bonding 110 and the other side connected to a biopsy needle 300;

A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side;

An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit 100;

And a radiation detection and analysis unit (500) for processing signals obtained from the nuclear medicine probe unit (200) and providing malignant information on the tumor to the screen.

According to another aspect of the present invention, there is provided an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images,

The ultrasound-nuclear medicine fusion image probe is used to diagnose high-resolution image acquisition (ultrasound) and functional information of the object, thereby improving the diagnostic accuracy of the disease.

In addition, it is possible to reduce the unnecessary number of biopsy executions during breast or liver biopsy and to enable accurate diagnosis in real time, so that doctors can increase the convenience of the procedure and reduce the inconvenience of the patients.

1 is an exemplary diagram showing a conventional ultrasound imaging apparatus;
Figure 2 is an exemplary probe that is configured differently according to the diagnostic area and intended use.
3 is a schematic block diagram of an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images according to an embodiment of the present invention.
4 is a schematic block diagram of a nuclear medicine probe unit of an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images according to an embodiment of the present invention.

The following merely illustrates the principles of the invention. Therefore, those skilled in the art will be able to devise various apparatuses which, although not explicitly described or illustrated herein, embody the principles of the invention and are included in the concept and scope of the invention.

Furthermore, all of the conditional terms and embodiments listed herein are, in principle, only intended for the purpose of enabling understanding of the concepts of the present invention, and are not to be construed as limited to such specifically recited embodiments and conditions do.

It is also to be understood that the detailed description, as well as the principles, aspects and embodiments of the invention, as well as specific embodiments thereof, are intended to cover structural and functional equivalents thereof.

It is also to be understood that such equivalents include all elements contemplated to perform the same function irrespective of currently known equivalents as well as equivalents to be developed in the future.

Thus, for example, it should be understood that the block diagrams herein illustrate conceptual aspects of exemplary circuits embodying the principles of the invention. Similarly, all flowcharts, state transition diagrams, pseudo code, and the like are representative of various processes that may be substantially represented on a computer-readable medium and executed by a computer or processor, whether or not the computer or processor is explicitly shown .

The functions of the various elements shown in the figures, including the functional blocks depicted in the processor or similar concept, may be provided by use of dedicated hardware as well as hardware capable of executing software in connection with appropriate software.

When provided by a processor, the functions may be provided by a single dedicated processor, a single shared processor, or a plurality of individual processors, some of which may be shared.

Also, the explicit use of terms such as processor, control, or similar concepts should not be interpreted exclusively as hardware capable of running software, and may be used without limitation as a digital signal processor (DSP) (ROM), random access memory (RAM), and non-volatile memory. Other hardware may also be included.

It is to be understood that the invention defined by the appended claims is not to be construed as encompassing any means capable of providing such functionality, as the functions provided by the various listed means are combined and combined with the manner in which the claims require .

An embodiment of the present invention for solving the problems of the present invention is as follows.

That is, in the ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images, the flexible board 120 is connected to the flexible board 120 through the wire bonding 110, and the other side is connected to the ultrasonic probe 300 connected to the biopsy needle 300 150; < / RTI >

A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side;

A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;

An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit 100;

And a radiation detection and analysis unit (500) for processing signals obtained from the nuclear medicine probe unit (200) and providing malignant information on the tumor to the screen.

According to another aspect of the present invention, the ultrasonic probe 150 is connected to the flexible board 120 through wire bonding 110 and the other end is connected to the biopsy needle 300, An ultrasonic probe unit 100 including the ultrasonic probe 100;

A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side;

A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;

An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit 100;

A radiation detection and analysis means (500) for processing signals obtained from the nuclear medicine probe unit (200) and providing malignant information on the tumor to the screen;

And an optical sensor 600 formed on one side of the optical fiber for detecting light generated by the reaction with the radiation.

According to another aspect of the present invention, the flexible board 120 is connected to the flexible board 120 through the wire bonding 110 and the other end is connected to the ultrasonic probe 150 An ultrasonic probe part 100 including the ultrasonic probe 100;

A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side;

A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;

An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit 100;

A radiation detection and analysis means (500) for processing signals obtained from the nuclear medicine probe unit (200) and providing malignant information on the tumor to the screen;

An optical sensor 600 formed on one side of the optical fiber for detecting light generated by reaction with radiation;

A preprocessing circuit unit 700 for preprocessing the electrical signal generated by the optical sensor and providing the electrical signal to the data acquisition unit;

       The data obtained by preprocessing in the preprocessing circuit is obtained,

And a data acquisition unit 800 for providing the data to the controller 500.

At this time, the preprocessing circuit unit includes a preamplifier 710, a shaper 720,

One or more discriminators 730 for sorting the radiation species,

And an ADC 740 for converting an analog signal into a digital signal.

In addition, the data acquisition unit 800 may include a user interface unit for counting the number of radiation detections according to additional features and displaying the detected number of radiation detectors as a sound or a screen.

According to another aspect of the present invention, the flexible board 120 is connected to the flexible board 120 through the wire bonding 110, and the other end of the flexible board 120 is connected to the ultrasonic probe 150 The ultrasonic probe 100 includes an ultrasonic probe 100,

A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side,

A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;

An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit;

And a radiation detection and analysis unit (500) for processing the signal obtained from the nuclear medicine probe unit to provide both malignant information of the tumor to the screen,

Around the radiation detector (scintillator) 210, a light generated by surrounding with a reflector is transmitted to the optical fiber.

In the above embodiments, when the ultrasonic probe 150 is an ultrasonic probe for an array, a multiplexer circuit is formed on the flexible board to reduce the number of connected wires.

The radiation detector (scintillator) 210 is characterized in that any one of L (Y) SO, GAGG and LaBr3 is used, and the optical sensor 600 is amplified to detect a small amount of light generated in the scintillator And a photomultiplier tube having a high rate and low noise is applied.

The ultrasonic probe 150 may be mounted on the inner surface of the biopsy needle 300 and then a biopsy guide wire 350 may be used to accurately locate the tissue cell or the specimen. .

The flexible board 120 separates the grounding point and the signal, thereby providing data to the analog signal through the wire without noise distortion to the ultrasonic analysis means 400. In the ultrasonic analysis means 400, The image information is transmitted to the user interface unit to visually display the information.

Further, the radiation detector (scintillator) 210 is formed into a needle structure and inserted into a suspected region to increase the sensitivity to the beta particles, and it is possible to use any one of a plastic scintillator and a scintillating optical fiber .

At this time, the optical sensor 600 is characterized in that any one of an avalanche photodiode and a silicon photomultiplier (SiPM) is used to detect a minute amount of light generated in the scintillator,

And a black paint for blocking light is applied around the radiation detector (scintillator) 210 so as not to react with ambient light.

Hereinafter, embodiments of an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images according to the present invention will be described in detail with reference to the drawings.

3 is a schematic block diagram of an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images according to an embodiment of the present invention.

As shown in FIG. 3, the ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images of the present invention includes an ultrasound probe unit 100; A nuclear medicine probe unit 200; A biopsy needle 300; An ultrasound analysis means 400; And a radiation detection and analysis means (500).

In the case of the above-described embodiment, the ultrasonic probe and the nuclear medical radiation detector probe are combined with each other to obtain a high-resolution image and the exact position and shape of the tumor can be determined. The nuclear medicine radiation detector is used to detect both malignancy (More than 90% accuracy).

In the conventional case, as described above, since the ultrasonic diagnostic apparatus and the nuclear medicine diagnostic apparatus are separately configured and the inspection is performed accordingly, the introduction cost is increased and the medical burden is increased for the patients. However, , And the malignant information of both the location, the morphology, and the tumor can be provided by a single examination. Thus, the above-mentioned problems are solved at once.

The ultrasonic probe unit 100 is connected to the flexible board 120 through wire bonding 110 and the other end is connected to an ultrasonic probe 300 connected to the biopsy needle 300. [

(150).

That is, in order to mount the ultrasonic probe on the flexible board 120, the probe is connected by wire-bonding and fixed on the inside of the biopsy needle.

Then, the ultrasonic probe part is connected to the outside (ultrasonic analysis means) using a small cable and connected to a biopsy guide wire 350 for a biopsy needle, thereby completing the manufacture of the ultrasonic probe part. That is, the biopsy guide wire 350 serves as a support for supporting the ultrasound probe on the inside of the biopsy needle. However, as mentioned above, the biopsy guide wire 350 serves to accurately locate the tissue cell or the specimen It will be done.

As described above, the ultrasonic probe unit 100 including the ultrasonic probe is mounted on the inner surface of the biopsy needle, and the biopsy guide wire helps to locate the precise tissue cell or specimen will be.

In addition, by attaching an ultrasonic probe to the flexible board, an advantage of fixing the ultrasonic probe can be obtained, and preferably, the ASIC (chip) can be implemented on a flexible board.

The flexible board is configured to be suitable for performing accurate transmission of an analog signal by distinguishing a ground (grounding point) from a signal (signal).

Then, the ultrasound probe unit manufactured as described above is driven through an external connected electronic device (Pulser / Receiver system) such as an ultrasonic analyzer through a wire to amplify signals received from tissue cells or specimens .

That is, the position and the shape of the tumor are analyzed through the signal obtained from the ultrasonic probe unit 100 by the ultrasonic analyzer 400.

The technique for analyzing the position and the morphology of the above-described tumor is a general technique, and thus a detailed description thereof will be omitted.

In the meantime, the embodiment of the present invention constitutes a single ultrasonic probe. If necessary, an ultrasonic probe for an array may be used. With the above configuration, the total angle of view of the ultrasonic image , But it is necessary to connect many cables to connect the sensor for array use.

However, if the size of the biopsy needle is limited, implementing a multiplexer circuit on the flexible board to accommodate the ultrasonic probe inside the biopsy needle will reduce the number of connecting wires.

4 is a schematic block diagram of a nuclear medicine probe unit of an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images according to an embodiment of the present invention.

The nuclear medicine probe unit 200 includes a radiation detector (scintillator) 210, and an optical fiber 220 is connected to one side.

At this time, the signal obtained from the nuclear medicine probe unit 200 is processed by the radiation detection and analysis means 500 to provide the user with both malignant information of the tumor.

Since the nuclear medicine probe unit is composed of a non-electric radiation detector (scintillator), it is easy to be embedded in a biopsy needle and an electronic part such as an electronic circuit is positioned outside a patient, thereby reducing the risk of electric shock. .

As shown in FIG. 4, the nuclear medicine probe unit 200 located inside the biopsy needle includes a radiation detector 210 (scintillator), and the radiation detector (scintillator) Light is transmitted outside the patient through an optical fiber (optical fiber 220), and light is detected by the optical sensor 600.

Preprocesses the electrical signal generated by the optical sensor through the preprocessing circuit unit 700, and then transmits data processed by the data acquisition unit 800. [

The preprocessing circuit unit includes a preamplifier 710, a shaper 720, at least one discriminator 730 for selecting a kind of radiation, and an ADC 740 for digitally converting an analog signal Respectively.

The data acquisition unit 800 may further include a user interface unit. The user interface unit counts the number of radiation detections using data obtained by the data acquisition unit, displays the result in a sound or a screen, The ultrasound image information provided by the imaging unit can be simultaneously displayed.

Radioactive isotopes used in nuclear medicine release gamma rays with good permeability and positron (beta particles) with very short permeability. Therefore, the detection efficiency may be improved by varying the detector design according to the object to be detected.

Examples of the scintillator include inorganic scintillating crystals such as L (Y) SO, GAGG and LaBr ₃ which are bright and capable of blocking radiation, plastic scintillators, and scintillating optical fibers. In the present invention, any one of the scintillators may be used.

Around the scintillator, the light generated by the reflection (for example, Teflon film, reflective film, etc.) is transmitted to the optical fiber.

In order to prevent the light from reacting with the ambient light, an additional black paint or the like is used to enclose the light.

Further, the scintillator is formed into a sharp needle-like shape and inserted into the suspected portion to increase the sensitivity to the beta particles.

The function of the optical fiber is to transmit a photon generated by the reaction of radiation emitted from the nuclear radioactive isotope to the outside of the patient in the scintillator.

In addition, the optical sensor performs a function of detecting a photon from outside the patient. In order to detect a minute amount of light generated in the scintillator, a photosensor having a high amplification factor and a low noise is required.

Therefore, a photomultiplier tube or a semiconductor photodiode such as avalanche photodiode or silicon photomultiplier (SiPM) should be used as the optical sensor applicable to the present invention.

The preprocessing circuit unit 700 may be configured as an individual device or a circuit in the form of an application specific integrated circuit (ASIC), and may include a preamplifier and a shaper for preprocessing.

Generally, since the energy (signal size) of beta particles and gamma rays are different, one or more discriminators can be selected to select the kind of radiation, and an analog-to-digital converter (ADC) .

The digital signal generated by the preprocessing circuit may be acquired by the data acquiring unit and provided to the computer terminal, the result may be displayed through the user interface (GUI), or an operation of controlling the detector may be possible .

For example, the digitized signal is transmitted to a data acquisition unit, which is a next data processing step, by wire / wireless, so that the number of radiation detections is counted and displayed on a sound or a screen.

Then, it is operated through the detector operation or the GUI, and the detection result is displayed by fusion with the ultrasonic wave.

Through the above-described structure and operation, the diagnosis accuracy of the disease can be improved by diagnosing the high-resolution image acquisition (ultrasound) and the functional information of the object through the ultrasound-nuclear medicine fusion image probe.

In addition, it is possible to reduce the unnecessary number of biopsy executions during breast or liver biopsy and to enable accurate diagnosis in real time, so that doctors can increase the convenience of the procedure and reduce the inconvenience of the patients.

Meanwhile, the method according to various embodiments of the present invention may be stored in a computer-readable recording medium. The computer-readable recording medium may be a ROM, a RAM, CDROMs, magnetic tapes, floppy disks, optical data storage devices, and the like, as well as carrier waves (e.g., transmission over the Internet).

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It should be understood that various modifications may be made by those skilled in the art without departing from the spirit and scope of the present invention.

100: Ultrasonic probe section
200: Nuclear Medicine Probe Department
300: Biopsy needle
400: ultrasonic analyzing means
500: radiation detection analysis means
600: Light sensor
700: preprocessing circuit
800: Data acquisition unit

Claims (16)

In an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images,
An ultrasonic probe unit 100 including an ultrasonic probe 150 having one side connected to the flexible board 120 through a wire bonding 110 and the other side connected to a biopsy needle 300;
A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side;
A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;
An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit 100;
And a radiation detection and analysis unit (500) for processing the signal obtained from the nuclear medicine probe unit (200) and providing malignant information on the tumor to the screen. The ultrasound and nuclear medicine fusion image Probe system. In an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images,
An ultrasonic probe unit 100 including an ultrasonic probe 150 having one side connected to the flexible board 120 through a wire bonding 110 and the other side connected to a biopsy needle 300;
A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side;
A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;
An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit 100;
A radiation detection and analysis means (500) for processing signals obtained from the nuclear medicine probe unit (200) and providing malignant information on the tumor to the screen;
And a photosensor (600) formed on one side of the optical fiber and detecting light generated by the reaction with the radiation. The ultrasound and nuclear medicine fusion image probe system according to claim 1, In an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images,
An ultrasonic probe unit 100 including an ultrasonic probe 150 having one side connected to the flexible board 120 through a wire bonding 110 and the other side connected to a biopsy needle 300;
A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side;
A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;
An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit 100;
A radiation detection and analysis means (500) for processing signals obtained from the nuclear medicine probe unit (200) and providing malignant information on the tumor to the screen;
An optical sensor 600 formed on one side of the optical fiber for detecting light generated by reaction with radiation;
A preprocessing circuit unit 700 for preprocessing the electrical signal generated by the optical sensor and providing the electrical signal to the data acquisition unit;
And a data acquiring unit (800) for acquiring data obtained by preprocessing in the preprocessing circuit and providing the acquired data to the radiation detecting and analyzing unit. The ultrasound and nuclear medicine fusion image probe system of the present invention is capable of acquiring high resolution images. In an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images,
An ultrasonic probe unit 100 including an ultrasonic probe 150 having one side connected to the flexible board 120 through a wire bonding 110 and the other side connected to a biopsy needle 300;
A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side,
A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;
An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit;
And a radiation detection and analysis unit (500) for processing the signal obtained from the nuclear medicine probe unit to provide both malignant information of the tumor to the screen,
Wherein the ultrasound and nuclear medicine fusion image probe system is capable of acquiring a high resolution image by transmitting light generated by surrounding a radiation detector (scintillator) 210 with a reflector. In an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images,
An ultrasonic probe unit 10 including an ultrasonic probe 150 having one side connected to the flexible board 120 through a wire bonding 110 and the other side connected to a biopsy needle 300;
A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side,
A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;
An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit;
A radiation detection and analysis unit (500) for processing signals obtained from the nuclear medicine probe unit and providing malignant information on the tumor to the screen;
An optical sensor 600 formed on one side of the optical fiber for detecting light generated by reaction with radiation;
A preamplifier 710, a shaper 720, at least one discriminator 730 for selecting the kind of radiation, and an analog signal generator 710 for pre-processing the electrical signal generated by the optical sensor and providing the electrical signal to the data acquiring unit. A preprocessing circuit unit 700 including an ADC 740 for digitally converting the input signal;
And a data acquiring unit (800) for acquiring data obtained by preprocessing in the preprocessing circuit and providing the acquired data to the radiation detecting and analyzing unit. The ultrasound and nuclear medicine fusion image probe system of the present invention is capable of acquiring high resolution images. In an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images,
An ultrasonic probe unit 100 including an ultrasonic probe 150 having one side connected to the flexible board 120 through a wire bonding 110 and the other side connected to a biopsy needle 300;
A nuclear medicine probe unit 200 including a radiation detector (scintillator) 210 and an optical fiber 220 connected to one side,
A biopsy needle 300 for receiving the ultrasound probe unit 100 and the nuclear medicine probe unit 200 inside;
An ultrasound analysis unit 400 for analyzing the position and shape of the tumor through the signal obtained from the ultrasound probe unit;
A radiation detection and analysis unit (500) for processing signals obtained from the nuclear medicine probe unit and providing malignant information on the tumor to the screen;
An optical sensor 600 formed on one side of the optical fiber for detecting light generated by reaction with radiation;
A preamplifier 710, a shaper 720, at least one discriminator 730 for selecting the kind of radiation, and an analog signal generator 710 for pre-processing the electrical signal generated by the optical sensor and providing the electrical signal to the data acquiring unit. A preprocessing circuit unit 700 including an ADC 740 for digitally converting the input signal;
A data acquiring unit 800 for acquiring pre-processed data from the preprocessing circuit and supplying the pre-processed data to the radiation detecting and analyzing unit and outputting the preprocessed data to a screen,
And an ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images. 7. The method according to any one of claims 1 to 6,
Wherein when the ultrasonic probe is an ultrasonic probe for an array, a multiplexer circuit is formed on the flexible board to reduce the number of wires connected to the flexible board, thereby obtaining a high-resolution image of the ultrasound and nuclear medicine fusion image probe system. 7. The method according to any one of claims 1 to 6,
Wherein the radiation detector (scintillator) 210 is a scintillation crystal for radiation detection, which is any one of L (Y) SO, GAGG and LaBr3. The method according to any one of claims 2, 3, 5, and 6,
The optical sensor 600 includes a photomultiplier tube having a high amplification rate and a low noise so as to detect a small amount of light generated in the scintillator. Image probe system. 7. The method according to any one of claims 1 to 6,
The ultrasonic probe 150 is mounted on the inner surface of the biopsy needle 300 so that the biopsy guide wire 350 can accurately locate the tissue cell or the specimen. Ultrasound and nuclear medicine fusion image probe system capable of acquiring images. 7. The method according to any one of claims 1 to 6,
Wherein the flexible board 120 is provided with an analog signal by means of an ultrasonic analysis unit without noise distortion by distinguishing between a ground point and a signal. 7. The method according to any one of claims 3 and 5 to 6,
The data acquisition unit 800 may further include a user interface unit, which counts the number of radiation detections using the preprocessed data in the preprocessing circuit unit, displays the result in a sound or a screen, And displaying the ultrasound image information at the same time. The ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images. 7. The method according to any one of claims 1 to 6,
Wherein the radiation detector (scintillator) 210 is formed into a needle structure and inserted into a suspected site to enhance sensitivity to the beta particles. 7. The method according to any one of claims 1 to 6,
Wherein the radiation detector (scintillator) 210 uses any one of a plastic scintillator and a scintillating optical fiber. 2. The ultrasound and nuclear medicine fusion image probe system according to claim 1, The method according to any one of claims 2, 3, 5, and 6,
The optical sensor 600 applies any one of avalanche photodiode and silicon photomultiplier (SiPM) to detect a minute amount of light generated in the scintillator. The ultrasound and nuclear medicine fusion image probe system capable of acquiring high resolution images. 7. The method according to any one of claims 1 to 6,
And a black paint for blocking light is applied around the radiation detector (scintillator) 210 so as not to react with ambient light.

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