JPWO2019169004A5 - - Google Patents
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- JPWO2019169004A5 JPWO2019169004A5 JP2020545159A JP2020545159A JPWO2019169004A5 JP WO2019169004 A5 JPWO2019169004 A5 JP WO2019169004A5 JP 2020545159 A JP2020545159 A JP 2020545159A JP 2020545159 A JP2020545159 A JP 2020545159A JP WO2019169004 A5 JPWO2019169004 A5 JP WO2019169004A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- protein
- capsid
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024088641A JP2024115558A (ja) | 2018-02-27 | 2024-05-31 | 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用 |
Applications Claiming Priority (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862635964P | 2018-02-27 | 2018-02-27 | |
| US201862635968P | 2018-02-27 | 2018-02-27 | |
| US62/635,964 | 2018-02-27 | ||
| US62/635,968 | 2018-02-27 | ||
| US201862663788P | 2018-04-27 | 2018-04-27 | |
| US201862663797P | 2018-04-27 | 2018-04-27 | |
| US62/663,797 | 2018-04-27 | ||
| US62/663,788 | 2018-04-27 | ||
| US201862667587P | 2018-05-06 | 2018-05-06 | |
| US62/667,587 | 2018-05-06 | ||
| US201862667881P | 2018-05-07 | 2018-05-07 | |
| US201862667888P | 2018-05-07 | 2018-05-07 | |
| US62/667,888 | 2018-05-07 | ||
| US62/667,881 | 2018-05-07 | ||
| US201862677471P | 2018-05-29 | 2018-05-29 | |
| US201862667585P | 2018-05-29 | 2018-05-29 | |
| US201862677474P | 2018-05-29 | 2018-05-29 | |
| US62/677,471 | 2018-05-29 | ||
| US62/677,474 | 2018-05-29 | ||
| US62/667,585 | 2018-05-29 | ||
| US201862703673P | 2018-07-26 | 2018-07-26 | |
| US201862703670P | 2018-07-26 | 2018-07-26 | |
| US62/703,673 | 2018-07-26 | ||
| US62/703,670 | 2018-07-26 | ||
| US201862722382P | 2018-08-24 | 2018-08-24 | |
| US201862722388P | 2018-08-24 | 2018-08-24 | |
| US62/722,388 | 2018-08-24 | ||
| US62/722,382 | 2018-08-24 | ||
| PCT/US2019/019861 WO2019169004A1 (en) | 2018-02-27 | 2019-02-27 | Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024088641A Division JP2024115558A (ja) | 2018-02-27 | 2024-05-31 | 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021515548A JP2021515548A (ja) | 2021-06-24 |
| JPWO2019169004A5 true JPWO2019169004A5 (es) | 2022-02-18 |
| JP7498665B2 JP7498665B2 (ja) | 2024-06-12 |
Family
ID=67809202
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545159A Active JP7498665B2 (ja) | 2018-02-27 | 2019-02-27 | 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用 |
| JP2024088641A Pending JP2024115558A (ja) | 2018-02-27 | 2024-05-31 | 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024088641A Pending JP2024115558A (ja) | 2018-02-27 | 2024-05-31 | 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12416016B2 (es) |
| EP (1) | EP3768695A4 (es) |
| JP (2) | JP7498665B2 (es) |
| KR (1) | KR102848518B1 (es) |
| CN (2) | CN112236443B (es) |
| AU (1) | AU2019228504B2 (es) |
| BR (1) | BR112020017278A2 (es) |
| CA (1) | CA3091795A1 (es) |
| CL (1) | CL2020002201A1 (es) |
| IL (1) | IL276860A (es) |
| MA (1) | MA52087A (es) |
| MX (1) | MX2020008932A (es) |
| SG (1) | SG11202007942YA (es) |
| WO (1) | WO2019169004A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL292830B2 (en) | 2015-09-28 | 2023-06-01 | Univ Florida | Methods and compositions for stealth virus antibody vectors |
| CN112236443B (zh) * | 2018-02-27 | 2025-02-07 | 宾夕法尼亚州大学信托人 | 新颖腺相关病毒(aav)载体、具有降低的衣壳脱酰胺化的aav载体及其用途 |
| AU2019247746B2 (en) | 2018-04-03 | 2024-08-15 | Ginkgo Bioworks, Inc. | Antibody-evading virus vectors |
| AU2019247748A1 (en) | 2018-04-03 | 2020-10-08 | Ginkgo Bioworks, Inc. | Antibody-evading virus vectors |
| US12359181B2 (en) | 2018-12-21 | 2025-07-15 | The University Of North Carolina At Chapel Hill | Optimized GALC genes and expression cassettes and their use |
| MX2021011468A (es) | 2019-03-21 | 2021-12-15 | Vectores de virus adenoasociados recombinantes. | |
| WO2020223232A1 (en) | 2019-04-29 | 2020-11-05 | The Trustees Of The University Of Pennsylvania | Novel aav capsids and compositions containing same |
| WO2021076925A1 (en) | 2019-10-17 | 2021-04-22 | Stridebio, Inc. | Adeno-associated viral vectors for treatment of niemann-pick disease type c |
| WO2021080991A1 (en) * | 2019-10-21 | 2021-04-29 | The Trustees Of The University Of Pennsylvania | Aav3b variants with improved production yield and liver tropism |
| WO2021138381A1 (en) * | 2020-01-03 | 2021-07-08 | Sarepta Therapeutics, Inc. | Methods for analyzing aav capsid proteins |
| EP4117735A4 (en) * | 2020-03-09 | 2024-04-10 | University of Massachusetts | Gene replacement therapy for foxg1 syndrome |
| MX2022016528A (es) | 2020-06-17 | 2023-06-02 | Univ Pennsylvania | Composiciones y métodos para el tratamiento de pacientes de terapia génica. |
| WO2022015715A1 (en) | 2020-07-13 | 2022-01-20 | The Trustees Of The University Of Pennsylvania | Compositions useful for treatment of charcot-marie-tooth disease |
| IL300717A (en) | 2020-08-19 | 2023-04-01 | Sarepta Therapeutics Inc | ADENO-related virus vectors for the treatment of RETT syndrome |
| TW202229315A (zh) * | 2020-10-18 | 2022-08-01 | 賓州大學委員會 | 改良的腺相關病毒(aav)載體及其用途 |
| MX2023008826A (es) | 2021-02-01 | 2023-09-15 | Regenxbio Inc | Terapia génica para lipofuscinosis neuronal ceroidea. |
| AU2022258312A1 (en) | 2021-04-12 | 2023-10-26 | The Trustees Of The University Of Pennsylvania | Compositions useful for treating spinal and bulbar muscular atrophy (sbma) |
| WO2023081807A1 (en) * | 2021-11-04 | 2023-05-11 | The Trustees of the University of Pennsylvania Penn Center for Innovation | Compositions and methods for reducing pcsk9 levels in a subject |
| WO2023133584A1 (en) | 2022-01-10 | 2023-07-13 | The Trustees Of The University Of Pennsylvania | Compositions useful in treatment of metachromatic leukodystrophy |
| WO2023133574A1 (en) | 2022-01-10 | 2023-07-13 | The Trustees Of The University Of Pennsylvania | Compositions and methods useful for treatment of c9orf72-mediated disorders |
| WO2023196892A1 (en) | 2022-04-06 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Passive immunization with anti- aav neutralizing antibodies to prevent off-target transduction of intrathecally delivered aav vectors |
| EP4661965A1 (en) * | 2023-03-25 | 2025-12-17 | Duke University | Compositions comprising kidney-tropic aavs and methods of use thereof |
| WO2025250683A1 (en) * | 2024-05-29 | 2025-12-04 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US6268213B1 (en) | 1992-06-03 | 2001-07-31 | Richard Jude Samulski | Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy |
| US5869305A (en) | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| DE69824859T2 (de) | 1997-04-14 | 2005-08-04 | Cell Genesys, Inc., Foster City | Methoden zur erhöhung der effizienz rekombinanter aav produkte |
| EP1080218A1 (en) | 1998-05-27 | 2001-03-07 | University of Florida | Method of preparing recombinant adeno-associated virus compositions by using an iodixanol gradient |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| AU781958C (en) | 1999-08-09 | 2006-03-30 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs |
| AU2001268149B2 (en) | 2000-06-01 | 2005-08-18 | University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| SG10201506627PA (en) | 2001-11-13 | 2015-10-29 | Univ Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
| US20070015238A1 (en) | 2002-06-05 | 2007-01-18 | Snyder Richard O | Production of pseudotyped recombinant AAV virions |
| WO2004083441A2 (en) * | 2003-03-19 | 2004-09-30 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Random peptide library displayed on aav vectors |
| US8005620B2 (en) | 2003-08-01 | 2011-08-23 | Dna Twopointo Inc. | Systems and methods for biopolymer engineering |
| WO2005012877A2 (en) | 2003-08-01 | 2005-02-10 | Dna Twopointo Inc. | Systems and methods for antibody engineering |
| CN102212558B (zh) * | 2003-09-30 | 2016-08-03 | 宾夕法尼亚大学托管会 | 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用 |
| US20060246079A1 (en) | 2003-11-14 | 2006-11-02 | Morrow Phillip R | Neutralizing human antibodies to anthrax toxin |
| CN101203613B (zh) * | 2005-04-07 | 2012-12-12 | 宾夕法尼亚大学托管会 | 增强腺相关病毒载体功能的方法 |
| JP4495210B2 (ja) | 2005-06-09 | 2010-06-30 | パナソニック株式会社 | 振幅誤差補償装置及び直交度誤差補償装置 |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| US20130023033A1 (en) | 2010-03-29 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| US8628966B2 (en) | 2010-04-30 | 2014-01-14 | City Of Hope | CD34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer |
| PL3198018T3 (pl) * | 2014-09-24 | 2021-07-19 | City Of Hope | Warianty wektora wirusa związanego z adenowirusami dla wysokiej skuteczności edycji genomu i jego sposoby |
| WO2016086227A2 (en) * | 2014-11-26 | 2016-06-02 | The Regents Of The University Of California | Therapeutic compositions comprising transcription factors and methods of making and using the same |
| AU2016344065A1 (en) | 2015-10-28 | 2018-05-10 | The Trustees Of The University Of Pennsylvania | Intrathecal administration of adeno-associated-viral vectors for gene therapy |
| EP3387138B1 (en) | 2015-12-11 | 2022-01-26 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav9 |
| EP4215605A1 (en) | 2015-12-11 | 2023-07-26 | The Trustees of The University of Pennsylvania | Scalable purification method for aav8 |
| WO2017100674A1 (en) | 2015-12-11 | 2017-06-15 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav1 |
| BR112018071156A2 (pt) | 2016-04-15 | 2019-03-12 | The Trustees Of The University Of Pennsylvania | terapia de gene para tratar mucopolissacaridose tipo ii |
| IL298604A (en) * | 2016-04-15 | 2023-01-01 | Univ Pennsylvania | Novel aav8 mutant capsids and compositions containing same |
| EP3491008A2 (en) * | 2016-07-26 | 2019-06-05 | BioMarin Pharmaceutical Inc. | Novel adeno-associated virus capsid proteins |
| ES2863674T3 (es) * | 2016-08-15 | 2021-10-11 | Genzyme Corp | Métodos para detectar AAV |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| SG10201912973XA (en) | 2017-02-28 | 2020-03-30 | Univ Pennsylvania | Adeno-associated virus (aav) clade f vector and uses therefor |
| CN112236443B (zh) * | 2018-02-27 | 2025-02-07 | 宾夕法尼亚州大学信托人 | 新颖腺相关病毒(aav)载体、具有降低的衣壳脱酰胺化的aav载体及其用途 |
-
2019
- 2019-02-27 CN CN201980029022.1A patent/CN112236443B/zh active Active
- 2019-02-27 EP EP19760152.9A patent/EP3768695A4/en active Pending
- 2019-02-27 BR BR112020017278-2A patent/BR112020017278A2/pt unknown
- 2019-02-27 WO PCT/US2019/019861 patent/WO2019169004A1/en not_active Ceased
- 2019-02-27 KR KR1020207027462A patent/KR102848518B1/ko active Active
- 2019-02-27 AU AU2019228504A patent/AU2019228504B2/en active Active
- 2019-02-27 MA MA052087A patent/MA52087A/fr unknown
- 2019-02-27 SG SG11202007942YA patent/SG11202007942YA/en unknown
- 2019-02-27 JP JP2020545159A patent/JP7498665B2/ja active Active
- 2019-02-27 CN CN202510015875.7A patent/CN120519403A/zh active Pending
- 2019-02-27 MX MX2020008932A patent/MX2020008932A/es unknown
- 2019-02-27 CA CA3091795A patent/CA3091795A1/en active Pending
- 2019-02-27 US US16/975,545 patent/US12416016B2/en active Active
-
2020
- 2020-08-23 IL IL276860A patent/IL276860A/en unknown
- 2020-08-26 CL CL2020002201A patent/CL2020002201A1/es unknown
-
2024
- 2024-05-31 JP JP2024088641A patent/JP2024115558A/ja active Pending
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