JPS6382671A - Blood purifying apparatus - Google Patents
Blood purifying apparatusInfo
- Publication number
- JPS6382671A JPS6382671A JP61226200A JP22620086A JPS6382671A JP S6382671 A JPS6382671 A JP S6382671A JP 61226200 A JP61226200 A JP 61226200A JP 22620086 A JP22620086 A JP 22620086A JP S6382671 A JPS6382671 A JP S6382671A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- membrane
- hemodialysis
- dialysate
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008280 blood Substances 0.000 title claims description 54
- 210000004369 blood Anatomy 0.000 title claims description 54
- 239000012528 membrane Substances 0.000 claims description 67
- 238000000034 method Methods 0.000 claims description 35
- 238000004821 distillation Methods 0.000 claims description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
- 238000001631 haemodialysis Methods 0.000 claims description 28
- 230000000322 hemodialysis Effects 0.000 claims description 28
- 239000002699 waste material Substances 0.000 claims description 13
- 230000002209 hydrophobic effect Effects 0.000 claims description 7
- 238000000746 purification Methods 0.000 claims description 7
- 239000011148 porous material Substances 0.000 claims description 6
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 2
- -1 polytetrafluoroethylene Polymers 0.000 claims 3
- 239000002033 PVDF binder Substances 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 238000000502 dialysis Methods 0.000 description 15
- 239000012530 fluid Substances 0.000 description 9
- 238000001914 filtration Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000007485 conventional hemodialysis Methods 0.000 description 3
- 239000004627 regenerated cellulose Substances 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 206010018852 Haematoma Diseases 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229940037395 electrolytes Drugs 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Abstract] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
（産業上の利用分野〕
本発明は血液透析法による老廃物除去工程と膜蒸留法に
よる除水工程とを同一もしくは各別のモジュールとして
組合せた血液の浄化装置に関する。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a blood purification device that combines a waste removal process by hemodialysis and a water removal process by membrane distillation, either in the same module or in separate modules.
従来血液の浄化は主に血液透析法により行なわれている
。Conventionally, blood purification has mainly been carried out by hemodialysis.
血液透析法とは、再生セルロース、合成高分子膜等の透
析膜で区画した一方の空に血液を、使方の苗に透析液を
通じ、血液と透析液間の濃度差により、血液中の老廃物
、例えば尿素、尿酸、クレアチニン、電解質等を除去し
、同時に、血液と透析液との間に圧力差をかけ、血液中
の水分を透析液側へ濾過し、除去を行なう方法である。Hemodialysis is a method in which blood is passed through one side of the membrane divided by a dialysis membrane such as regenerated cellulose or a synthetic polymer membrane, and dialysate is passed through the seedlings. This method removes substances such as urea, uric acid, creatinine, electrolytes, etc., and at the same time applies a pressure difference between the blood and the dialysate to filter water in the blood to the dialysate side.
（発明が解決しようとする問題点）
ところが、従来の血液浄化法には以下の様な欠点がある
。すなわち、血液中の比較的分子但の大きい老廃物（分
子＠１万程度）を除去しようとすると、血液透析膜の孔
径をある程度大きくすることが必要である。一方、血液
中の水分の除去は血液と透析液との間の圧力差による枦
過で行なうため、血液透析膜の孔径が大きいと血液中の
有用成分が多量に体外に流出してしまうことになる。ま
た、孔径が大きいと濾過速度が速く、濾過速度のコント
ロールが難しいという問題もある。(Problems to be Solved by the Invention) However, conventional blood purification methods have the following drawbacks. That is, in order to remove waste products with relatively large molecules (approximately 10,000 molecules) from blood, it is necessary to increase the pore size of the hemodialysis membrane to some extent. On the other hand, water in the blood is removed by filtration due to the pressure difference between the blood and the dialysate, so if the pore size of the hemodialysis membrane is large, a large amount of useful components in the blood will flow out of the body. Become. Another problem is that when the pore size is large, the filtration rate is high and it is difficult to control the filtration rate.
本発明の目的は、従来は血液透析法で同時に行なわれて
いた血液中の老廃物の除去と水分の除去をそれぞれ血液
透析法と膜蒸留法によって別々に行わせるように両者を
組合せることにある。その結果、老廃物の除去は血液透
析法で、実質的な水分の除去は膜蒸留法で行なうのでそ
れぞれ最適の条件で操作することが可能でおる。The purpose of the present invention is to combine hemodialysis and membrane distillation so that the removal of waste products and water in the blood, which were conventionally performed at the same time by hemodialysis, can be performed separately by hemodialysis and membrane distillation. be. As a result, since waste products are removed by hemodialysis and substantial water is removed by membrane distillation, it is possible to operate under optimal conditions for each.
〔問題点を解決するための手段）
本発明の要旨とする所は実質的な水分の除去を伴う圧力
差を血液と透析液の間にかけない血液透析法による老廃
物除去工程と、膜蒸留法による除水工程とを同一もしく
は各別のモジュールとして組合わせたことを特徴とする
血液浄化装置に存する。[Means for Solving the Problems] The gist of the present invention is to provide a waste removal process using a hemodialysis method that does not apply a pressure difference that involves substantial water removal between the blood and the dialysate, and a membrane distillation method. A blood purification device is characterized in that a water removal step is combined in the same module or in separate modules.
本発明に用いる膜蒸留装置は、気体は通すが液体は通さ
ない性質を有する疎水性多孔質膜で区画した一方の側に
血液を通すとともに、他方の側に血液の水蒸気圧より低
い水蒸気圧の流体を通して、血液中の水分を水蒸気とし
て前記多孔質膜を通過さぜることにより血液から水分を
除去するものである。また、前記水蒸気圧の低い流体の
かわりに、血液の他方の側を減圧にして血液から水分を
除去することも可能である。The membrane distillation apparatus used in the present invention is partitioned with a hydrophobic porous membrane that allows gases to pass through but not liquids, and allows blood to pass through one side, while the other side has a water vapor pressure lower than that of blood. Water is removed from the blood by passing a fluid through the porous membrane, converting the water in the blood into water vapor. Moreover, instead of using the fluid with a low water vapor pressure, it is also possible to remove water from the blood by reducing the pressure on the other side of the blood.
以上の様に、膜蒸留法によれば、血液より水分のみを除
去することが可能である。As described above, according to the membrane distillation method, only water can be removed from blood.
したがって、本発明において膜蒸留法と組み合わせる血
液透析法においては、血液中の老廃物を除去するだけで
よい。すなわち、圧力差による水分の濾過を行なう必要
はない。Therefore, in the hemodialysis method combined with the membrane distillation method in the present invention, it is only necessary to remove waste products from the blood. In other words, there is no need to filter moisture using a pressure difference.
そのため、血液透析膜の孔径をある程度大きくすること
が可能となり比較的分子量の大きい老廃物を効果的に除
去できる。換言すれば大孔径の孔を有する膜を血液透析
膜として用いた場合でも、多量の濾過は起こらず、血液
中の有用成分を多量に失うことはない。Therefore, it is possible to increase the pore size of the hemodialysis membrane to a certain extent, and waste products with relatively large molecular weights can be effectively removed. In other words, even when a membrane with large pores is used as a hemodialysis membrane, a large amount of filtration does not occur, and a large amount of useful components in the blood is not lost.
すなわら、膜蒸留法で実質的な水分の除去を、血液透析
法で老廃物の除去をそれぞれ独立して行なうことができ
るので、各々に最適な膜とその操作条件を選択すること
ができる。In other words, since the membrane distillation method can effectively remove water and the hemodialysis method can remove waste products, it is possible to select the optimal membrane and operating conditions for each method. .
本発明における血液透析法では血液と透析液との間には
実質的な水分の除去を伴う圧力差をかけないものである
が必ずしも必要な水分除去量のすべてを膜蒸留法で行な
う必要はなく、例えば水分除去量のうち８０％は膜蒸留
法で、残り２０％を血液透析法で行なうことも可能であ
る。Although the hemodialysis method of the present invention does not apply a pressure difference between the blood and the dialysate that involves the removal of substantial water, it is not necessary to remove all of the necessary water by membrane distillation. For example, it is possible to remove 80% of the water by membrane distillation and the remaining 20% by hemodialysis.
従って本発明の実施において血液と透析液との間には４
０ｍＨ９以下好ましくは３０ｍＨ９以下の圧力差をかけ
ることは許容される。Therefore, in the practice of the present invention, there are 4
It is permissible to apply a pressure difference of 0 mH9 or less, preferably 30 mH9 or less.
〔作 用］ 本発明の基本構成を第１図に示す。[For production] The basic configuration of the present invention is shown in FIG.
（１）は膜蒸留装置、（２）は血液透析装置でおる。血
液（３）は血液ポンプ（４）により膜蒸留装置（１）次
いで血液透析装置（２）に供給される。(1) is a membrane distillation device, and (2) is a hemodialysis device. Blood (3) is supplied by a blood pump (4) to a membrane distillation device (1) and then to a hemodialysis device (2).
膜蒸留装置（１）は疎水性多孔質膜（１４）で区画され
、一方の室に血液を疎水性多孔質膜（１４）に直接接触
させながら流す。ざらに、他方の室には血液よりも水蒸
気圧の低い流体（５）を疎水性多孔質膜（１４）に直接
接触させながら流す。流体（５）はタンク（８）よりポ
ンプ（６）により熱交換器（７）を経て供給される。熱
交換器（７）により流体（５）の温度は低く保たれ、流
体（５）は血液の水蒸気圧よりも低い水蒸気圧となる。The membrane distillation apparatus (1) is divided by a hydrophobic porous membrane (14), and blood flows into one chamber while being in direct contact with the hydrophobic porous membrane (14). Roughly speaking, a fluid (5) having a lower water vapor pressure than blood flows into the other chamber while being in direct contact with the hydrophobic porous membrane (14). Fluid (5) is supplied from a tank (8) by a pump (6) via a heat exchanger (7). The temperature of the fluid (5) is kept low by the heat exchanger (7), and the fluid (5) has a water vapor pressure lower than that of blood.
したがって膜蒸留装置（１）内で、血液（３）より発生
した水蒸気は流体（５）に吸収され、その結果血液より
除水が行なわれる。Therefore, in the membrane distillation device (1), the water vapor generated from the blood (3) is absorbed by the fluid (5), so that water is removed from the blood.
続いて、血液（３）は血液透析装置（２）に供給される
。血液透析装置（２）は、透析膜（１９）により区画さ
れ、一方の至に血液を透析１１！（１９）に直接接触さ
せながら流す。ざらに、他方の至には透析液タンク（１
２）より、透析液ポンプ（１１）を経て透析液（９）が
透析膜（１９）に直接接触させながら供給され、透析膜
（１９）を介して血液中の老廃物を吸収後、透析液タン
ク（１０）に導かれる。血液透析装置（２）内の透析膜
（１９）を介した血液（３）と、透析液（９）の圧力差
は（１５）〜（１８）のバルブにより調節される。具体
的には血液側より透析液側の圧力を多少具体的には４０
ｍＨｇ以下好ましくは３０ｍ）１ｇ以下の範囲で低く設
定することにより、血液側への透析液の流入がなく、か
つ濾過が多量に起こらず、血液から多量の有効成分が流
出しない様にすることが可能でおる。Subsequently, the blood (3) is supplied to the hemodialysis machine (2). The hemodialysis device (2) is partitioned by a dialysis membrane (19), and one end dialyzes blood (11!). (19) while being in direct contact with the water. Roughly, there is a dialysate tank (1
2), the dialysate (9) is supplied through the dialysate pump (11) while being in direct contact with the dialysis membrane (19), and after absorbing waste products in the blood through the dialysis membrane (19), the dialysate is It is guided to the tank (10). The pressure difference between the blood (3) passing through the dialysis membrane (19) in the hemodialyzer (2) and the dialysate (9) is regulated by valves (15) to (18). Specifically, the pressure on the dialysate side is 40% more than the blood side.
mHg or less (preferably 30mHg) By setting it low in the range of 1g or less, there is no inflow of dialysate into the blood side, no large amount of filtration occurs, and it is possible to prevent a large amount of active ingredients from flowing out from the blood. It's possible.
この様に、除水および老廃物の除去が行われた血液は、
熱交換器（１３）で温度をコントロールした後、体内に
もどされる。Blood that has been dehydrated and waste products removed in this way is
After controlling the temperature with a heat exchanger (13), it is returned to the body.
膜蒸留と血液透析は、必ずしもこの順に行なう必要はな
く、第１図の場合とは逆の順序で血液透析を行なった後
にｉ蒸留を行なってもよい。Membrane distillation and hemodialysis do not necessarily have to be carried out in this order, and i-distillation may be carried out after hemodialysis in the reverse order to that shown in FIG.
また、第２図に示すように透析液（９）を血液透析装置
（２）における透析液として使用した後これを熱交換器
（７）で温度調節してこれを膜蒸留装置（１）における
膜蒸留法の血液よりも水蒸気圧の低い流体（５）として
再利用することも可能でおる。Further, as shown in Fig. 2, after the dialysate (9) is used as a dialysate in the hemodialyzer (2), the temperature is adjusted with a heat exchanger (7), and the dialysate is transferred to the membrane distillation device (1). It is also possible to reuse it as a fluid (5) with a lower water vapor pressure than blood produced by membrane distillation.
ざらに、第３図に示すように膜蒸留に用いる疎水性多孔
質膜（１４）と、血液透析に用いる透析膜（１９）を１
つのモジュール中に併設的に組み込み、両膜（１４）と
（１９）の間に血液（３）を供給し膜（１４）を介した
膜蒸留法による除水工程と膜（１９）を介した老廃物除
去工程を併行して行わせるように使用することも可能で
おる。Roughly speaking, as shown in Figure 3, a hydrophobic porous membrane (14) used for membrane distillation and a dialysis membrane (19) used for hemodialysis are combined into one
The blood (3) is supplied between both membranes (14) and (19), and the water removal process is carried out by the membrane distillation method via the membrane (14), and the water removal process is carried out via the membrane (19). It is also possible to use it so that the waste removal process is carried out concurrently.
（実施例）
比較例
第４図は従来の血液透析装置（２）による血液の透析法
を示すが、透析膜（１９）には再生セルロース系の膜を
用い、血液（３）は生血をヘマト２０％に調整して用い
た。透析液（９）には市販のものを用いた。実験結果を
表１に示す。(Example) Comparative Example Fig. 4 shows a blood dialysis method using a conventional hemodialysis device (2), in which a regenerated cellulose membrane is used for the dialysis membrane (19), and blood (3) is made by converting live blood into hematopoietic membranes. It was adjusted to 20% and used. A commercially available dialysate was used as the dialysate (9). The experimental results are shown in Table 1.
表１．従来法 ＴＭＰは血液側出口のバルブ（１６）により調節した。Table 1. Conventional method TMP was regulated by the blood side outlet valve (16).
実施例 第５図に本発明に基づく方法を示した。Example FIG. 5 shows the method according to the invention.
第４図に示した従来の透析法による血液透析装置（２）
の前段に膜蒸留法による膜蒸留装置（１）を組合せたも
ので必る。透析膜（１９）には再生セルロース系の膜を
用い、血液は生血をヘマト２０％に調整して用いた。透
析液（９）は市販のものを用いた。膜蒸留に用いた膜（
１４）は、ＰＴＦＥ製多孔質多孔質膜０．４μｍ、膜厚
５５μ而。Hemodialysis device (2) using the conventional dialysis method shown in Figure 4
It is necessary to combine a membrane distillation device (1) using a membrane distillation method in the front stage of the membrane distillation method. A regenerated cellulose-based membrane was used as the dialysis membrane (19), and fresh blood adjusted to 20% hematoma was used as the blood. A commercially available dialysate was used as the dialysate (9). Membrane used for membrane distillation (
14) is a porous porous membrane made of PTFE with a thickness of 0.4 μm and a thickness of 55 μm.
有効面積０．０５ｍ＞を用いた。実験結果を表２に示す
。An effective area of 0.05 m> was used. The experimental results are shown in Table 2.
表２より、膜蒸留法では水以外は除去されないこと、温
度差が大きいほど除水量は大きいことがわかる。一方、
透析法の方は、ＴＭＰが低いく圧力をかけていない）の
で除水量は少ないが、他の物質の除去に関しては従来法
と同様である。透析法において、血液温度が低い時にク
リアランスが低いのは、血液の粘度の増加による物質移
動速度の減少のためでおる。Table 2 shows that the membrane distillation method does not remove anything other than water, and that the greater the temperature difference, the greater the amount of water removed. on the other hand,
In the case of the dialysis method, since the TMP is low and no pressure is applied, the amount of water removed is small, but the removal of other substances is similar to the conventional method. In the dialysis method, the clearance is low when the blood temperature is low because the mass transfer rate decreases due to the increase in blood viscosity.
表２中、Ｒｕｎ３においては仝除水量９．３ｍｌ／分の
うち、膜蒸留が７．８ ｍ／分と約８４％をしめている
。一方、膜蒸留では他の物質の除去は行なわれないので
、膜蒸留で除水、透析でその他の物質の除去という役割
分担が行われている。In Table 2, in Run 3, membrane distillation accounted for approximately 84% of the water removal rate of 9.3 ml/min at 7.8 m/min. On the other hand, since membrane distillation does not remove other substances, the roles of membrane distillation to remove water and dialysis to remove other substances are shared.
（発明の効果）
本発明によれば血液中の老廃物の除去を血液透析法で、
又血液中の水分の除去を実質的に膜蒸留法で夫々分担し
て行うことにより、上記の血液透析法および膜蒸留法に
それぞれ最適な操作をとることが可能となり、その結果
慢性腎不全患者の透析治療あるいは心臓疾患の治療等に
おいて、より良い治療を施すことができる。(Effects of the Invention) According to the present invention, waste products in the blood can be removed by hemodialysis.
In addition, by substantially dividing the removal of water from the blood using the membrane distillation method, it becomes possible to use the optimal operations for the hemodialysis method and the membrane distillation method, respectively, and as a result, patients with chronic renal failure Better treatment can be provided in dialysis treatment or treatment of heart disease.
第１図ないし第３図は本発明装置の各実施態様を示した
説明図であり、第４図は比較例に示した従来の血液透析
法の説明図、第５図は実施例に示した本発明に血液浄化
装置の説明図でおる。
１・・・・・・・・膜蒸留装置
２・・・・・・・・血液透析装置
３・・・・・・・・血液
５・・・・・・・・流体
９・・・・・・・・透析液
１４・・・・・・・・疎水性多孔質膜
１９・・・・・・・・透析膜
代理人 弁理士 高 橋 章
第１図
第２図
第３図
第４図Figures 1 to 3 are explanatory diagrams showing each embodiment of the device of the present invention, Figure 4 is an explanatory diagram of the conventional hemodialysis method shown in the comparative example, and Figure 5 is the explanatory diagram showing the conventional hemodialysis method shown in the example. This is an explanatory diagram of a blood purification device according to the present invention. 1... Membrane distillation device 2... Hemodialysis device 3... Blood 5... Fluid 9... ... Dialysate 14 ... Hydrophobic porous membrane 19 ... Dialysis membrane agent Patent attorney Akira Takahashi Figure 1 Figure 2 Figure 3 Figure 4
Claims (2)
の間にかけない血液透析法による老廃物除去工程と、膜
蒸留法による除水工程とを同一もしくは各別のモジュー
ルとして組合わせたことを特徴とする血液浄化装置。(1) Combining the waste removal process using hemodialysis, which does not apply a pressure difference that involves substantial water removal between the blood and dialysate, and the water removal process using membrane distillation, either in the same module or in separate modules. A blood purification device characterized by:
エチレン、ポリプロピレン、ポリフッ化ビニリデン、ポ
リエチレン等の疎水性多孔質膜で、孔径として０．０２
〜１０μｍの孔を多数有したものである特許請求の範囲
第１項記載の血液浄化装置。(2) The membrane used in the membrane distillation method is a hydrophobic porous membrane made of polytetrafluoroethylene, polypropylene, polyvinylidene fluoride, polyethylene, etc., and has a pore size of 0.02
The blood purification device according to claim 1, which has a large number of holes of ~10 μm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61226200A JPS6382671A (en) | 1986-09-26 | 1986-09-26 | Blood purifying apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61226200A JPS6382671A (en) | 1986-09-26 | 1986-09-26 | Blood purifying apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6382671A true JPS6382671A (en) | 1988-04-13 |
Family
ID=16841455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61226200A Pending JPS6382671A (en) | 1986-09-26 | 1986-09-26 | Blood purifying apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6382671A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004512873A (en) * | 2000-10-30 | 2004-04-30 | ネフロス・インコーポレーテッド | Two-stage diafiltration method and apparatus |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6129361A (en) * | 1984-05-08 | 1986-02-10 | フレセニウス・ア−ゲ− | Blood dialytic apparatus |
| JPS6194662A (en) * | 1984-10-16 | 1986-05-13 | 旭メデイカル株式会社 | Asceptic water filled serum separator and its production |
| JPS61143073A (en) * | 1984-12-13 | 1986-06-30 | ザルトリウス・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | disposable filter |
-
1986
- 1986-09-26 JP JP61226200A patent/JPS6382671A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6129361A (en) * | 1984-05-08 | 1986-02-10 | フレセニウス・ア−ゲ− | Blood dialytic apparatus |
| JPS6194662A (en) * | 1984-10-16 | 1986-05-13 | 旭メデイカル株式会社 | Asceptic water filled serum separator and its production |
| JPS61143073A (en) * | 1984-12-13 | 1986-06-30 | ザルトリウス・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | disposable filter |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004512873A (en) * | 2000-10-30 | 2004-04-30 | ネフロス・インコーポレーテッド | Two-stage diafiltration method and apparatus |
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