JPS63305874A - Living body material and its preparation - Google Patents
Living body material and its preparationInfo
- Publication number
- JPS63305874A JPS63305874A JP62140624A JP14062487A JPS63305874A JP S63305874 A JPS63305874 A JP S63305874A JP 62140624 A JP62140624 A JP 62140624A JP 14062487 A JP14062487 A JP 14062487A JP S63305874 A JPS63305874 A JP S63305874A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyapatite
- porous body
- bone
- pyrophosphate
- tricalcium phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 title claims 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 25
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 25
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 24
- 239000000919 ceramic Substances 0.000 claims abstract description 18
- 235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 13
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 11
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 11
- 229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 11
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 11
- 235000011180 diphosphates Nutrition 0.000 claims abstract description 10
- 239000002002 slurry Substances 0.000 claims abstract description 8
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims description 9
- 229940048084 pyrophosphate Drugs 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000012620 biological material Substances 0.000 claims description 4
- 229940005657 pyrophosphoric acid Drugs 0.000 claims description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 3
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 238000010304 firing Methods 0.000 description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 2
- 235000019798 tripotassium phosphate Nutrition 0.000 description 2
- 206010000372 Accident at work Diseases 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- RCUAPGYXYWSYKO-UHFFFAOYSA-J barium(2+);phosphonato phosphate Chemical compound [Ba+2].[Ba+2].[O-]P([O-])(=O)OP([O-])([O-])=O RCUAPGYXYWSYKO-UHFFFAOYSA-J 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- XZTWHWHGBBCSMX-UHFFFAOYSA-J dimagnesium;phosphonato phosphate Chemical compound [Mg+2].[Mg+2].[O-]P([O-])(=O)OP([O-])([O-])=O XZTWHWHGBBCSMX-UHFFFAOYSA-J 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- QGKBPWOLFJRLKE-UHFFFAOYSA-J distrontium;phosphonato phosphate Chemical compound [Sr+2].[Sr+2].[O-]P([O-])(=O)OP([O-])([O-])=O QGKBPWOLFJRLKE-UHFFFAOYSA-J 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229940098424 potassium pyrophosphate Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- OMSYGYSPFZQFFP-UHFFFAOYSA-J zinc pyrophosphate Chemical compound [Zn+2].[Zn+2].[O-]P([O-])(=O)OP([O-])([O-])=O OMSYGYSPFZQFFP-UHFFFAOYSA-J 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
Ａ、産業上の利用分野
この発明は外科医療の分野において骨の欠損部を補填す
る生体材料とその製造方法に関する。DETAILED DESCRIPTION OF THE INVENTION A. Field of Industrial Application This invention relates to a biomaterial for filling bone defects in the field of surgery and a method for producing the same.
Ｂ９発明の概要
この発明は生体材料とその製造方法において、ハイドロ
キシアパタイトから成る多孔体の表面にピロリン酸部材
を付着させてリン酸三カルノウムから成る層を形成して
骨補綴用多孔体セラミックスを得るようにしたことによ
り、
新生骨の遺骨を促進させるとともに機械的強度を向上さ
せることができろようにしたものである。B9 Summary of the Invention This invention relates to a biomaterial and a method for producing the same, in which a porous ceramic for bone prosthesis is obtained by attaching a pyrophosphate member to the surface of a porous body made of hydroxyapatite to form a layer made of tricarnoum phosphate. By doing so, it is possible to promote the formation of new bone and improve mechanical strength.
Ｃ１従来の技術
外科の分野では、骨部にガン等の疾患が生じたとき、そ
の患部を切除したり、あるいは交通事故、労働災害等に
より骨を損傷した場合、切除した個所に患者の健全な部
分の骨の一部を切り出し補填する方法がとられている。C1 Conventional technology In the field of surgery, when a disease such as cancer occurs in a bone, the affected area is removed, or when a bone is damaged due to a traffic accident, industrial accident, etc. The method used is to cut out part of the bone and replace it.
Ｄ３発明が解決しようとする問題点
近年、上記のように患者の骨を切り取らずにすむ骨代用
品として、骨欠損部補填セラミックスが開発されてきて
いる。このものは骨の増生進入が容易な空間を有し、生
体内で為害性のない多孔体セラミックスである。この多
孔体セラミックスは上記のような特徴を持っているけれ
ども新生骨の遺骨を促進させるまでには至っていないと
ともに、機械的強度も手術時の取扱いにおいても慎重を
要した。D3 Problems to be Solved by the Invention In recent years, ceramics for filling bone defects have been developed as bone substitutes that do not require cutting out the patient's bone as described above. This is a porous ceramic that has a space where bone growth can easily enter and is not harmful in vivo. Although this porous ceramic has the above-mentioned characteristics, it does not go so far as to promote the formation of new bone, and its mechanical strength requires careful handling during surgery.
Ｅ１問題点を解決するための手段
この発明の第１発明はハイドロキシアパタイトから成る
多孔体の表面にピロリン酸部材を付着させて、３次元的
に連続した空隙を持つとともに空隙の径が２０〜６０μ
ｍ１空孔率が５０％以上のリン酸三カルシウムから成る
層が形成された骨補綴用多孔体セラミックスを得るよう
にしたものである。Means for Solving Problem E1 The first invention of the present invention is to attach a pyrophosphoric acid member to the surface of a porous body made of hydroxyapatite, so that it has three-dimensionally continuous voids and the diameter of the voids is 20 to 60 μm.
The present invention provides a porous ceramic for bone prosthesis in which a layer of tricalcium phosphate having an m1 porosity of 50% or more is formed.
第２発明はハイドロキシアパタイトから成る多孔体の表
面にピロリン酸部材のスラリーを付着させた後、９００
℃から１３００℃の温度で一定時間焼成してハイドロキ
シアパタイト表面にリン酸三カルシウムから成る層を有
する骨補綴用多孔体セラミックスを製造するようにした
ものである。In the second invention, after attaching a slurry of a pyrophosphate member to the surface of a porous body made of hydroxyapatite,
A porous ceramic for bone prosthesis having a layer of tricalcium phosphate on the surface of hydroxyapatite is produced by firing at a temperature of 1300° C. for a certain period of time.
Ｆ１作用
ハイドロキシアパタイトから成る多孔体の表面にピロリ
ン酸部材を付着させて焼成してハイドロキシアパタイト
表面にリン酸三カルシウムから成る層を有する骨補綴用
多孔体セラミックスの焼結体に形成した。A pyrophosphate member was attached to the surface of a porous body made of F1-acting hydroxyapatite and fired to form a porous ceramic sintered body for bone prosthesis having a layer of tricalcium phosphate on the surface of the hydroxyapatite.
このため、ハイドロキシアパタイトより破壊靭性値の大
きなリン酸三カルシウムで覆われるため新生骨の遺骨が
促進されかつ機械的強度が向上する。Therefore, since it is covered with tricalcium phosphate, which has a higher fracture toughness value than hydroxyapatite, the formation of new bone is promoted and the mechanical strength is improved.
Ｇ、実施例 以下図面を参照してこの発明の一実施例を説明する。G. Example An embodiment of the present invention will be described below with reference to the drawings.
図において、ＨＡＰはハイドロキシアパタイトで、この
ハイドロキシアパタイトＨＡＰを用いて多孔体を製造す
る。この多孔体の製造には種々あるが、その１つの方法
は例えばウレタンフオームのスポンジにハイドロキシア
パタイトＨＡＰのスラリーを浸み込ませ、乾燥させた後
、１０００〜１３００℃の温度で焼成することにより得
る。In the figure, HAP is hydroxyapatite, and a porous body is manufactured using this hydroxyapatite HAP. There are various ways to manufacture this porous body, but one method is to impregnate a urethane foam sponge with a slurry of hydroxyapatite HAP, dry it, and then bake it at a temperature of 1000 to 1300°C. .
上記のようにして得られたハイドロキシアパタイトＨＡ
Ｐから成る多孔体の表面にピロリン酸カルシウムスラリ
ーを付着させた後、乾燥させ、９００〜１３００°Ｃ（
好ましくは１０００〜１１７０°Ｃ）で１０〜６０分間
焼成させる。この焼成によりハイドロキシアパタイトＨ
ＡＰの表面がリン酸三カルシウムＴＣＰで覆われ、かつ
ＴＣＰから成る層ＬＡＹを有する骨補綴用多孔体セラミ
ックスに形成される。Hydroxyapatite HA obtained as above
After adhering calcium pyrophosphate slurry to the surface of a porous body made of P, it was dried and heated at 900 to 1300°C (
It is preferably baked at a temperature of 1000 to 1170°C for 10 to 60 minutes. By this firing, hydroxyapatite H
The surface of the AP is covered with tricalcium phosphate TCP and is formed into a porous ceramic for bone prosthesis having a layer LAY made of TCP.
なお、ピロリン酸カルシウムスラリーの濃度が高いと多
孔体の空隙を埋めてしまうため、スラリー濃度を調製す
る必要がある。また、ピロリン酸カルンウムの他に、ピ
ロリン酸マグネシウム、ピロリン酸バリウム、ピロリン
酸ストロンチウム、ピロリン酸ナトリウム、ピロリン酸
カリウムやピロリン酸亜鉛等、これらのうち一種を用い
たスラリーをハイドロキシアパタイト多孔体に付着させ
るようにしてもよい。Note that if the concentration of the calcium pyrophosphate slurry is high, it will fill the voids in the porous body, so it is necessary to adjust the slurry concentration. In addition to carunium pyrophosphate, a slurry containing one of these, such as magnesium pyrophosphate, barium pyrophosphate, strontium pyrophosphate, sodium pyrophosphate, potassium pyrophosphate, and zinc pyrophosphate, is adhered to the hydroxyapatite porous material. You can do it like this.
Ｈ発明の効果
以上性へたように、この発明によれば、ハイドロキシア
パタイトから成る多孔体の表面にピロリン酸部材を付着
させてハイドロキシアパタイト表面にリン酸三カリウム
から成る層を形成した骨補綴用多孔体セラミックスを得
るようにしたので、新生骨の遺骨を促進させるとともに
機械的強度を向上させる多孔体セラミックスが得られる
。これにより手術時の取扱いが容易になる。また、骨補
綴用多孔体セラミックスの製造方法においてもピロリン
酸部材をハイドロキシアパタイトから成る多孔体に付着
させ、焼成させるだけでの簡単な方法で、新生骨の遺骨
の促進及び機械的強度の向上が図れる多孔体セラミック
スが製造することができる。According to the present invention, a pyrophosphate member is attached to the surface of a porous body made of hydroxyapatite to form a layer made of tripotassium phosphate on the surface of the hydroxyapatite. Since a porous ceramic is obtained, a porous ceramic that promotes the formation of new bone and improves mechanical strength can be obtained. This facilitates handling during surgery. In addition, in the manufacturing method of porous ceramics for bone prosthesis, it is possible to promote new bone formation and improve mechanical strength by simply attaching a pyrophosphate member to a porous body made of hydroxyapatite and firing it. It is possible to produce porous ceramics that can be used in various ways.
図面はこの発明の一実施例を示す骨補綴用多孔体セラミ
ックスの拡大図である。
ＨＡＰ・・・ハイドロキシアパタイト、ＬＡＹ・・・リ
ン酸三カリウムからなる層。The drawing is an enlarged view of a porous ceramic for bone prosthesis showing one embodiment of the present invention. HAP: hydroxyapatite, LAY: layer consisting of tripotassium phosphate.
Claims (2)
ピロリン酸部材を付着させて、３次元的に連続した空隙
を持つとともに空隙の径が２０〜６０μｍ、空孔率が５
０％以上のリン酸三カルシウムから成る層が形成された
骨補綴用多孔体セラミックスを得るようにしたことを特
徴とする生体材料。(1) A pyrophosphoric acid member is attached to the surface of a porous body made of hydroxyapatite, so that it has three-dimensionally continuous voids, the diameter of the voids is 20 to 60 μm, and the porosity is 5.
A biomaterial characterized in that it provides a porous ceramic for bone prosthesis in which a layer consisting of 0% or more tricalcium phosphate is formed.
ピロリン酸部材のスラリーを付着させた後、９００℃か
ら１３００℃の温度で一定時間焼成してハイドロキシア
パタイト表面にリン酸三カルシウムから成る層を有する
骨補綴用多孔体セラミックスを製造するようにしたこと
を特徴とする生体材料の製造方法。(2) After attaching a slurry of pyrophosphate material to the surface of a porous body made of hydroxyapatite, it is fired at a temperature of 900°C to 1300°C for a certain period of time to form a bone with a layer made of tricalcium phosphate on the hydroxyapatite surface. A method for producing a biomaterial, characterized in that it produces a porous ceramic for prosthesis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62140624A JPS63305874A (en) | 1987-06-04 | 1987-06-04 | Living body material and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62140624A JPS63305874A (en) | 1987-06-04 | 1987-06-04 | Living body material and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63305874A true JPS63305874A (en) | 1988-12-13 |
Family
ID=15273031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62140624A Pending JPS63305874A (en) | 1987-06-04 | 1987-06-04 | Living body material and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63305874A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001049327A3 (en) * | 2000-01-03 | 2002-01-03 | Versitech Ltd | Bioactive and osteoprorotic bone cement |
| JP2011251920A (en) * | 2010-06-01 | 2011-12-15 | Ube Industries Ltd | Method for producing n-vinylamide, and apatite used therein |
-
1987
- 1987-06-04 JP JP62140624A patent/JPS63305874A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001049327A3 (en) * | 2000-01-03 | 2002-01-03 | Versitech Ltd | Bioactive and osteoprorotic bone cement |
| US6593394B1 (en) | 2000-01-03 | 2003-07-15 | Prosperous Kingdom Limited | Bioactive and osteoporotic bone cement |
| JP2011251920A (en) * | 2010-06-01 | 2011-12-15 | Ube Industries Ltd | Method for producing n-vinylamide, and apatite used therein |
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