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JPS53122489A - Cancer diagnosis apparatus by fluorescent polarization photometric microscope - Google Patents

Cancer diagnosis apparatus by fluorescent polarization photometric microscope

Info

Publication number
JPS53122489A
JPS53122489A JP3620077A JP3620077A JPS53122489A JP S53122489 A JPS53122489 A JP S53122489A JP 3620077 A JP3620077 A JP 3620077A JP 3620077 A JP3620077 A JP 3620077A JP S53122489 A JPS53122489 A JP S53122489A
Authority
JP
Japan
Prior art keywords
diagnosis apparatus
cancer diagnosis
fluorescent polarization
photometric
microscope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3620077A
Other languages
Japanese (ja)
Other versions
JPS5913697B2 (en
Inventor
Ichiro Sawamura
Yasuhiro Nakamura
Takeshi Yonekubo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Optical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Optical Co Ltd filed Critical Olympus Optical Co Ltd
Priority to JP52036200A priority Critical patent/JPS5913697B2/en
Priority to DE19782813317 priority patent/DE2813317A1/en
Publication of JPS53122489A publication Critical patent/JPS53122489A/en
Publication of JPS5913697B2 publication Critical patent/JPS5913697B2/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

PURPOSE: To automatically diagnose whether cancer or not by applying polarized exitation light to the specimen comprising separating only the lymphocytes from the blood of the person to be examined and mixing cancer protein therein to produce fluorescence and processing electrically the degree of polarization of the fluorescence.
COPYRIGHT: (C)1978,JPO&Japio
JP52036200A 1977-04-01 1977-04-01 Cancer diagnostic equipment using a fluorescent polarization photometric microscope Expired JPS5913697B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP52036200A JPS5913697B2 (en) 1977-04-01 1977-04-01 Cancer diagnostic equipment using a fluorescent polarization photometric microscope
DE19782813317 DE2813317A1 (en) 1977-04-01 1978-03-28 Cancer diagnosis device with direct indication - uses photometric polarisation microscope and fluorescent light reception and analysis system giving stabilised measurements

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52036200A JPS5913697B2 (en) 1977-04-01 1977-04-01 Cancer diagnostic equipment using a fluorescent polarization photometric microscope

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP69885A Division JPS60166845A (en) 1985-01-07 1985-01-07 Diagnosis of cancer

Publications (2)

Publication Number Publication Date
JPS53122489A true JPS53122489A (en) 1978-10-25
JPS5913697B2 JPS5913697B2 (en) 1984-03-31

Family

ID=12463082

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52036200A Expired JPS5913697B2 (en) 1977-04-01 1977-04-01 Cancer diagnostic equipment using a fluorescent polarization photometric microscope

Country Status (2)

Country Link
JP (1) JPS5913697B2 (en)
DE (1) DE2813317A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60420A (en) * 1983-06-17 1985-01-05 Olympus Optical Co Ltd Fluorescence microphotometric device
US7289205B2 (en) 2003-09-19 2007-10-30 The General Hospital Corporation Fluorescence polarization imaging devices and methods
US7627363B2 (en) 2003-03-18 2009-12-01 The General Hospital Corporation Polarized light imaging devices and methods

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4592361A (en) * 1982-06-28 1986-06-03 The Johns Hopkins University Electro-optical device and method for monitoring instantaneous singlet oxygen concentration produced during photoradiation using pulsed excitation and time domain signal processing
AU562556B2 (en) * 1982-06-28 1987-06-11 Johns Hopkins University, The Electro-optical device for monitoring instantaneous singlet oxygen concentration produced during the treatment of cancer by means of photochemotherapy
AT387860B (en) * 1985-09-16 1989-03-28 Optical Sensing Technology METHOD AND DEVICE FOR TUMOR DIAGNOSIS BY MEANS OF SERA
DE102011018725A1 (en) * 2011-04-20 2012-10-25 Carl Zeiss Jena Gmbh Optical arrangement with luminometer for detecting luminescence of samples, has emission filter formed as absorbent color filter without reflective layer, particularly without dichroic layers, where emission filter is arranged in beam path

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60420A (en) * 1983-06-17 1985-01-05 Olympus Optical Co Ltd Fluorescence microphotometric device
US7627363B2 (en) 2003-03-18 2009-12-01 The General Hospital Corporation Polarized light imaging devices and methods
US7289205B2 (en) 2003-09-19 2007-10-30 The General Hospital Corporation Fluorescence polarization imaging devices and methods
US7564550B2 (en) 2003-09-19 2009-07-21 The General Hospital Corporation Fluorescence polarization imaging devices and methods
US8139211B2 (en) 2003-09-19 2012-03-20 The General Hospital Corporation Fluorescence polarization imaging device and method

Also Published As

Publication number Publication date
DE2813317A1 (en) 1978-10-05
JPS5913697B2 (en) 1984-03-31

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