JPS595110A - Composition for oral cavity - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a stable oral composition containing extracts of plants of the Lamiaceae family, such as sage and rosemary.

Extracts of plants of the Lamiaceae family, such as sage and rosemary, are blended into oral compositions such as toothpaste to provide effects such as suppressing bad breath, and especially when used in combination with sodium alkyl sulfate and monoglyceride laurate, They use each other synergistically to exhibit excellent antibacterial activity specifically against Fusibacterium nucleatum (Japanese Patent Application No. 139075/1983, 1
No. 39076). However, when an extract of a Lamiaceae plant is blended into an oral composition, there are problems with its storage stability.
If stored for a long period of time, the effect may not be fully exhibited.

The present inventors have conducted various studies to solve the above-mentioned problems. As a result, by setting the pH of the oral composition to an acidic range, more preferably 6.6 or less, it has been found that The present invention was based on the discovery that the deactivation of plant extracts is suppressed and the storage stability of oral compositions containing this extract as an active ingredient is improved.

The present invention will be explained in more detail below.

The present invention is a composition in which an extract of a plant of the Lamiaceae family is blended into an oral composition such as a toothpaste, a liquid toothpaste, a mouthwash, etc., and the pH of the oral composition is adjusted to an acidic range. Reed is a more stable extract of a plant belonging to the Lamiaceae family than K.

In this case, the raw materials used to obtain extracts of plants of the Labiatae family, such as sage and rosemary, include powders of plants of the Labiata family, such as sage and rosemary; residues of oil extracted from these plants by steam distillation, etc. Essential oil collection residue; or sage, rosemary, and other plants of the Lamiaceae family are used as solvents such as ethyl ether, ethylene chloride, dioxane, acetone, lower alcohols such as ethanol and methanol, ethyl acetate, cyclogylene glycol, glycerin, and water. Oleoresin and its extraction residue obtained by extracting Lamiaceae plants such as sage and rosemary with n-hexane, petroleum ether, ligroin, cyclohexane,
Carbon tetrachloride, chloroform, dichloromethane, 1.2-
Those selected from oleoresins obtained by extraction with non-polar solvents such as dichloroethane, toluene, and benzene, and their extraction residues are used. When obtaining an extract of Lamiaceae plants from these raw materials, one of these raw materials
The species or two or more species are extracted with a polar solvent and/or a non-polar solvent (the solvents listed above can be used), and the extract (extract liquid or the solvent is distilled off from it). (7) collected. In the present invention, this extract can be used as it is, but the steam distillation residue obtained by subjecting this extract to a steam distillation treatment, or the steam distillation residue obtained by subjecting this extract or the steam distillation residue to activated carbon, diatomaceous earth, acid clay, etc. The extract treated with an adsorbent and the residue obtained by steam distillation after treating the extract with an adsorbent can also be suitably used as extracts of plants belonging to the Lamiaceae family. As the extraction method, a known method may be used, for example, a method such as digesting a dried powder of a Lamiaceae plant in a solvent may be used. In this case, the solvent is preferably an organic solvent, and an organic solvent extract obtained by extracting the raw material with an organic solvent is more effective.

In the present invention, as the extract of the Lamiaceae plant, one type obtained by the above-mentioned method may be used, or two or more types may be used in combination.

In addition, the amount of extracts of Lamiaceae plants such as sage and rosemary added to the oral composition is 000005% (by weight) of the total amount.
%, hereinafter the same) to 5%, particularly preferably 0.005 to 2%.

As other components of the present invention, appropriate components are used depending on the type of oral composition. For example, in the case of toothpaste, dibasic calcium phosphate dihydrate and anhydrous salt, calcium carbonate, calcium pyrophosphate, calcium sulfate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum hydroxide, Abrasives such as aluminum oxide and resin (compounding amount usually 20-60
Ch), Cal? Binder such as oxymethylcellulose, hydroxyethylcellulose, alginate, caradanan, gum arabic, polyvinyl alcohol (0.3~5qIy
), thickeners such as polyethylene glycol, sorbitol, glycerin, propylene glycol (10-70 g)
In addition, sodium alkyl sulfate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N-acyl glutamate, lauryl jetanolamide are added as necessary. , a foaming agent (0 to 5%) such as sucrose fatty acid ester is blended. Furthermore, Beno mother-dento,
Fragrances such as essential oils such as suiamint, fragrance materials such as l-menthol, calden, oilnol, anethole, etc.
Cullin sodium, stevioside, neohesiridylzohydrochalcone, glycyrrhizin, perillartin, p
- Ingredients such as sweeteners such as methoxycinnamic aldehyde and thaumatin, and preservatives may also be blended.

In addition, in the present invention, in addition to extracts of plants of the Lamiaceae family such as sage and rosemary, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine or its salts, sorbic acid, alexidine, hinokitiol,
Cetyl birizonium chloride, alkylglycine, alkyldiaminoethylglycine salt, allantoin, ε-
Aminocaproic acid, tranexamic acid, azulene, vitamin E1 sodium monofluorophosphate, sodium fluoride, stannous fluoride, water-soluble mono- or di-phosphate,
Active ingredients such as quaternary ammonium compounds and sodium chloride can also be blended.Of the above-mentioned ingredients, alkyl sulfur, sodium acid, or monoglyceride laurate can be combined with extracts of plants of the Lamiaceae family, such as sage and rosemary. When used together, they act synergistically against Fusibacterium sufreatum and exhibit high antibacterial activity, so sodium caprylic sulfate, sodium lauryl sulfate,
Sodium myristyl sulfate, sodium alkyl sulfate having an alkyl group of 8 to 18 carbon atoms, such as sodium myristyl sulfate or sodium rimityl sulfate, is added to the total by 0.1 to 5 parts, especially 0.5 to 3 parts, or lauric acid monoglyceride is added. o, oo
It is preferable to mix t to 10 t, especially 0.01 to 3 t.

The oral composition of the present invention is prepared by blending appropriate ingredients depending on the type of composition in addition to the extract of the Lamiaceae plant. Preferably, it is prepared to have a pH of 6.6 or less, thereby suppressing the deactivation of the extract of the Lamiaceae plant,
The storage stability of the composition can be improved. On the other hand, if the pH of the oral composition is 7 or higher, the extract of the Lamiaceae plant will be severely deactivated, making it impossible to achieve the object of the present invention.

The method for adjusting the pH of the oral composition to an acidic range is not particularly limited. When insoluble sodium metaphosphate, rum, calcium pyrophosphate, or silica is used alone as an abrasive, the composition can be made acidic as it is. In addition, organic acids and their salts such as citric acid, tartaric acid, malic acid, malonic acid, maleic acid, succinic acid, acetic acid, and phosphonic acid, acidic substances such as phosphoric acid and its salts, sulfuric acid, hydrochloric acid, and stannous fluoride. By blending, it is also possible to adjust the acidic range.

Thus, in the oral composition in the acidic range, the extract of the Lamiaceae plant is stably retained for a long period of time, and its effects are effectively exhibited over a long period of time.

Next, a production example of the Lamiaceae plant used in the present invention will be shown.

[Manufacturing example]

100.019 ml of dry sage powder and 300 m of methanol
1 was added, and the mixture was refluxed for 1 hour on a water bath at 70 to s o 'C' with a condenser attached. Then, the methanol fraction was separated by furnace,
Fresh methanol was added to the residue, and the same reflux was repeated twice, resulting in a total of three extraction operations.

The methanol extract was concentrated under reduced pressure to obtain a dark green 4-
27.4 g of stock was obtained.

4 ta, o-, e-mari dry powder 30I! 150 m/m of methanol was added to the mixture, and the mixture was refluxed for 1 hour on a water bath at 70 to 80°C with a condenser attached. Thereafter, the same procedure as in the case of sage was carried out to obtain 7.3 g of a dark greenish brown solid.

Other solvents were operated in the same manner as above to obtain various extracts of sage and rosemary.

Table 1 shows the extraction results.

Table 1 below shows examples and comparative examples to specifically explain the present invention.

[Examples 1 to 3. Comparative Examples 1 to 3] Toothpastes with the following formulations were prepared at various pH levels by adjusting the pH as shown in Table 2.

prescription Abrasive (silica) 40.0%.

Propylene glycol 2.0 glycerin
25.0 Carboxymethyl cellulose 1.0 Fragrance
1. .

Rosemary extract A6 o,,os Saccharin 0.1 Sodium lauryl sulfate 1.5 100.0% Next, immediately after preparing the above toothpaste and at 50°C for 1 month and 5
The effectiveness (stability) of the rosemary extract after storage at 0°C for 2 months was evaluated by the following deodorization rate measurement method. The results are shown in Table 2.

Deodorization rate measurement method ■ Put Tris-HCl buffer 1.51 and sample (toothpaste) IIi into a test tube with a capacity of about 23 m4.

■ Add 1 ppm of methyl mercaptan CH3SH to this.
Add 0.5 ml of the solution, cap the tube and stir for 1 minute.

■ Next, keep this test tube at 37°C for 6 minutes.

■ Inject 5 wl of air into the test tube and stir for 30 seconds.

■ Collect 5 ml of headspace gas in a test tube.

■ Inject this into a gas chromatograph and show the integral count of the methyl mercagutan peak.

■ Obtain the deodorization rate using the following formula.

Deodorization rate = -925 x 100 CHC: CH3SH integral count of toothpaste immediately after preparation S: CI of sample toothpaste (38H% minute count Table 2) According to the results in Table 2, toothpaste whose pH is in the acidic region is found to stably retain rosemary extract.

[Example 4] Toothpaste propylene glycol 2.0 tin lupit (60 liquid) 30.0 caldexymethyl cellulose 1.0 dibasic calcium phosphate dihydrate 45.0 sodium phosphate
0.5 fragrance 1.0
Rosemary extract Afi 0.15 Saccharin 0.1 Sodium lauryl sulfate 1.5 ioo, ochi After storage at 40°C for 3 months pI (6,74〃 Deodorization rate 65chi [Example 5] Toothpaste propylene glycol 2 .5 Tiglycerin 26.0 Carrageenan
1.0 Dibasic calcium phosphate 40.0
Tartaric acid 0.1 titanium oxide
5.0 fragrance
1.0 Rosemary extract A9 0.2
5 Satucalin 0.1 Lauryl diethanolamide 1.2100.0% pH after storage at 40℃ for 3 months 6.43 Deodorization rate after storage at 40℃ for 3 months 70chi [Example 6
] Toothpaste Pro Gylene Glycol 2.0 Thisolbit (60% liquid) 15.0 Glycerin
10.0 Caldexymethylcellulose
0.9 Dibasic calcium phosphate dihydrate 42
,0 citric acid 0,1 fragrance
1.0 Rosemary extract AIO0.05 Satucalin 01 Sodium lauryl sulfate 1,5100.1 p) I after storage at 40°C for 3 months 6.50
Deodorization rate: 52% [Example 7] Toothpaste propylene glycol 2,5 thisorbitol (
60% liquid) aO,O carboxymethyl cellulose 1.0 dibasic calcium phosphate dihydrate
20.0 Silica 10
．． 0 titanium oxide 5.0 fragrance
1.0 Rosemary extract 47 0.25 Saccharin
o, i Sodium lauryl sulfate
pH 6.71 after storage for 3 months at 40°C. [Example 8] Propylene glycol toothpaste 20 Thisolbit solution (60%) 32.0 cal? Oxymethylcellulose 1.2 Dibasic calcium phosphate
Dihydrate salt 30.0 Insoluble sodium metaphosphate
10.0 fragrance
1. Op-summary extract A6 0
．． 1 Sacchulin o, i Sodium lauryl sulfate 1.0100.0% PH 6.40 after storage for 3 months at 40°C Deodorization rate 61 [Example 9] Toothpaste propylene glycol 2.0% glycerin
25.0 Caldexymethyl cellulose 1.0 Insoluble sodium metaphosphate 4
5.0 Chlorhexidine hydrochloride o, ooi
Fragrance 1.0 Sage extract A5 0.15 Saccharin
0.1 Sodium lauryl sulfate 1.5100.0
% pl after storage at 40°C for -3 months (4,91〃
Deodorization rate 64 [Example 10] Toothpaste Propylene Glycol 2.0% Sorbit (60% liquid) 28.0 Caldexymethyl cellulose 1.1 Calcium birophosphate
45.0 Fragrance 1.
0 boiled sage extract 10,1 saccharin 0.1 sodium lauryl sulfate 1,5100.0 h after storage at 40°C for 3 months p) 1 5.811
Deodorization rate 63 t [Example 11] Toothpaste propylene glycol 2.5 tiglycerin 25.0 caldexymethylcellulose 1.07 li
25.0 Fragrance 1.0 Sage Extract A4 0.15 Saccharin
0.11 Sodium lauryl sulfate
1.0100.0% pH after storage at 40°C for 3 months 〃 Deodorization rate 62㎜ [Example 12] Mouth rinse ethanol 1.0 Tiglycerin 1.0 Polyoxyethylene ethylene hardened castor oil Rust conductor 0 .60-Zumary extract A6
0.15 Satukarin 0
．． 05 Fragrance 0.2Na
H2PO40.5 100.0chi After storage at 40℃ for 3 months opa 5.0〃
Deodorization rate 72%

Claims (1)

[Claims] 1. Contains an extract of a plant belonging to the Lamiaceae family, and contains p.
An oral composition characterized in that H is in an acidic range. 2. The oral composition according to claim 1, which has a pH of 6.6 or less. 3. The oral composition according to claim 1, wherein the Lamiaceae plant is sage or rosemary.