JPS572220A - Production of interferon - Google Patents
Production of interferonInfo
- Publication number
- JPS572220A JPS572220A JP7669080A JP7669080A JPS572220A JP S572220 A JPS572220 A JP S572220A JP 7669080 A JP7669080 A JP 7669080A JP 7669080 A JP7669080 A JP 7669080A JP S572220 A JPS572220 A JP S572220A
- Authority
- JP
- Japan
- Prior art keywords
- poly
- interferon
- microcarrier
- acid
- inducer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000014150 Interferons Human genes 0.000 title abstract 4
- 108010050904 Interferons Proteins 0.000 title abstract 4
- 229940079322 interferon Drugs 0.000 title abstract 4
- 239000002253 acid Substances 0.000 abstract 4
- 210000004102 animal cell Anatomy 0.000 abstract 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
- 239000000411 inducer Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 229920002307 Dextran Polymers 0.000 abstract 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- -1 diethylaminoethyl groups Chemical group 0.000 abstract 1
- 239000002799 interferon inducing agent Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE: To obtain interferon in high yield, by stimulating an animal cell grown on a microcarrier having positively charged chemical residues with an inducer consisting of polyriboinosinic acid (poly I) and polyribocytidylic acid (poly C) in a specific proportion.
CONSTITUTION: An animal cell, e.g. human dipolid cell, grown on a microcarrier, e.g. a crosslinked dextran microcarrier having diethylaminoethyl groups, having positively charged chemical residues is stimulated with an interferon inducer consisting of a polyriboinosinic acid (poly I) and polyribocytidylic acid (poly C) as constituents to produce interferon. In the process, the inducer is used in a range in which the molar fraction of the hypoxanthine base in the poly I over that of the cytosine base in the poly C, particularly I/C=1.1W1.3. The production of the interferon reaches 2.7 times that in the case of the conventional I/C=1.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7669080A JPS572220A (en) | 1980-06-09 | 1980-06-09 | Production of interferon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7669080A JPS572220A (en) | 1980-06-09 | 1980-06-09 | Production of interferon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS572220A true JPS572220A (en) | 1982-01-07 |
| JPS641119B2 JPS641119B2 (en) | 1989-01-10 |
Family
ID=13612453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7669080A Granted JPS572220A (en) | 1980-06-09 | 1980-06-09 | Production of interferon |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS572220A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59179095A (en) * | 1983-03-29 | 1984-10-11 | Yamasa Shoyu Co Ltd | Production of interferon |
| JPS61163763A (en) * | 1985-01-14 | 1986-07-24 | Fujitsu Ltd | Carrier wave recovery system |
| WO2006131023A1 (en) * | 2005-06-08 | 2006-12-14 | Newbiomed Pika Pte Ltd | Polyinosinic acid-polycytidylic acid-based adjuvant |
| US8303966B2 (en) | 2006-01-13 | 2012-11-06 | Yisheng Biopharma (Singapore) Pte. Ltd. | Immunogenic substances comprising a polyinosinic acid—polycytidilic acid based adjuvant |
| US12097254B2 (en) | 2014-12-23 | 2024-09-24 | Yisheng Biopharma (Singapore) Pte Ltd | Rabies composition comprising PIKA adjuvant |
-
1980
- 1980-06-09 JP JP7669080A patent/JPS572220A/en active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59179095A (en) * | 1983-03-29 | 1984-10-11 | Yamasa Shoyu Co Ltd | Production of interferon |
| JPS61163763A (en) * | 1985-01-14 | 1986-07-24 | Fujitsu Ltd | Carrier wave recovery system |
| WO2006131023A1 (en) * | 2005-06-08 | 2006-12-14 | Newbiomed Pika Pte Ltd | Polyinosinic acid-polycytidylic acid-based adjuvant |
| US7838017B2 (en) | 2005-06-08 | 2010-11-23 | Newbiomed Pika Pte Ltd | Polyinosinic acid-polycytidylic acid-based adjuvant |
| US8303965B2 (en) | 2005-06-08 | 2012-11-06 | Yisheng Biopharma (Singapore) Pte. Ltd. | Polyinosinic acid-polycytidylic acid-based adjuvant |
| US8303966B2 (en) | 2006-01-13 | 2012-11-06 | Yisheng Biopharma (Singapore) Pte. Ltd. | Immunogenic substances comprising a polyinosinic acid—polycytidilic acid based adjuvant |
| US12097254B2 (en) | 2014-12-23 | 2024-09-24 | Yisheng Biopharma (Singapore) Pte Ltd | Rabies composition comprising PIKA adjuvant |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS641119B2 (en) | 1989-01-10 |
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