JPH11137212A - Beauty culture composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a beauty culture composition capable of preventing and reducing wrinkles slackness or the like caused by aging of skin from not only the outside but also the inside and maintaining smooth and moist beautiful skin and useful for cosmetics or the like by including a specific amide-based compound therein. SOLUTION: This beauty culture composition contains preferably 0.1-10 wt.% compound represented by the formula (X is H or SO3 H) such as L-glutamic γ-monoethylamide (theanine) or L-glutamic γ-sulfoethylamide (glutaurine). The beauty culture composition further preferably contains collagen in an amount of 0.1-1 pt.wt. based on 1 pt.wt. glutamylamide compound and is preferably a cosmetic type or a food and drink type.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition, and more particularly to a cosmetic composition and / or a food and beverage type cosmetic composition having an excellent cosmetic effect. According to the present invention, an excellent skin effect such as improvement of wrinkles is exerted, so that it is possible to produce a cosmetic or a beauty beverage that maintains the skin swelling and exerts the effect not only from the outside but also from the inside of the body. it can.

[0002]

2. Description of the Related Art Conventionally, wrinkles and sagging have been regarded as a major problem in skin cosmetics, along with spots and freckles. Wrinkling and sagging are changes in the appearance of skin aging, which has been described as an irreversible phenomenon that reliably progresses with aging. The effects of skin dryness and ultraviolet rays have spurred the phenomenon and have become a major factor that further exacerbates the phenomenon. The cause of wrinkles and sagging is the qualitative and quantity of extracellular matrix due to internal factors caused by metabolic changes accompanying aging and aging of fibroblasts and external factors caused by accumulation of damage due to ultraviolet rays, active oxygen, etc. But these mechanisms are intricately intertwined,
There is still no definitive solution to the solution.

[0003]

SUMMARY OF THE INVENTION In view of the above-mentioned circumstances, the present inventors have newly developed a cosmetic composition which can achieve the constant maintenance of the skin.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and when a glutamylamide compound is blended in cosmetics and beauty drinks, a stronger skin effect can be obtained. This led to the completion of the present invention based on this finding.

[0005] That is, the present invention is a beautiful skin composition comprising a compound represented by the following general formula (I). The present composition is very excellent in that it has an excellent skin effect, but is particularly characterized in that the skin effect is exhibited not only for external use but also for internal use.

[0006]

Embedded image

Hereinafter, the present invention will be described in detail. As described above, wrinkles and sagging of the skin are phenomena caused by intricately entangled external or internal factors, and it has been difficult to elucidate the mechanism.

The present inventors focused on the homeostasis-preserving action, cell-proliferation-promoting action, and skin-color-improving action of glutamylamide compounds, and conducted various screenings on a large number of compounds, their derivatives, and related compounds. , A compound (I) having a strong beautiful skin effect. Further, as a result of further investigation, a very useful new finding that the compound (I) has a strong skin beautiful effect even when applied externally to the skin or when orally administered by oral administration has been obtained.

As is clear from the test examples described later, these compounds have an excellent homeostasis-maintaining effect, and furthermore, the fibroblasts of the skin which affect the change of the extracellular matrix which is the basis of wrinkles and sagging Has the effect of promoting cell proliferation, if this is used in cosmetics, and beauty foods and drinks,
Excellent skin effect from outside and inside.

Next, test examples are given for the homeostasis-maintaining effect and the cell growth-promoting effect of the compound of the present invention.

(Test Example 1) (Homeostasis maintaining effect) A test animal was a 5-week-old female guinea pig (Crj: Hartley, SPF, body weight 300 to 3).
50 g) was purchased and used for the experiment after one week of preliminary breeding. The breeding conditions were as follows: a breeding room set at 22 ± 1 ° C., a humidity of 55 ± 10%, a ventilation frequency of 20 times / hour, a lighting time of 12 hours / day (lights on at 6:00 am, lights off at 6:00 pm), and a metal cage ( (15 × 30 × 17 cm). As a feed, a solid feed RC4 (Oriental Yeast Co., Ltd.) was used, and drinking water was freely ingested from public tap water using a water bottle.

[0013] Guinea pigs were subjected to stress by ^three- group guinea pigs and overcrowded for 7 days (capacity per animal: 1700 cm ³ ). Theanine 2000mg for a total of 10 days from 3 days before the start of stress loading to 7 days of stress loading
/ Kg and glutaurine 1000 mg / kg were administered daily. Here, theanine is represented by X in the general formula (I).
= -H (L-glutamic acid-γ-monoethylamide), and glutaurine is a compound of the formula (I) where X = —SO ₃ H (L-glutamic acid-γ-
Sulfonic acid ethylamide).

The day before the administration, the guinea pig was shaved, and the skin was measured on the last day with a colorimeter (Minolta CR-300). The obtained results are shown in Table 1 below and FIG.

[0014]

[Table 1]

As is clear from the results shown in Table 1 and FIG. 1, the administration of theanine and glutaurine maintained almost the same color as in normal times even when stress was applied. In Table 1 and FIG. 1, the b * value is a yellow color, the L * value is lightness, and the a * value is redness. In addition, this test method and criteria are as follows:
7 (Heisei 9).

(Test Example 2) (Effect of promoting fibroblast proliferation)
The cells were cultured in an Eagle MEM medium supplemented with 0% fetal calf serum, and each of theanine and glutaurine was added in an amount of 100 μg / g.
ml and 300 μg / ml. After culturing for 96 hours, the cells were collected and the number of cells was counted. As a result, as shown in FIG. 2, it was confirmed that theanine and glutaurine have a fibroblast proliferation promoting effect.

As is clear from the above, the glutamylamide compound according to the present invention not only has an excellent skin effect, but theanine is an amino acid contained in tea leaves and has been approved for use as a food additive. And
Since glutaurine is a biological component separated from bovine organ extract, its safety is extremely high.
Each of these compounds was administered to rats at 1000 per day.
Oral administration of mg / kg or more showed no acute toxicity, and no abnormalities such as redness were observed at all even when applied to the outer skin of shaved guinea pigs. ), Cosmetic compositions and food and drink types.

Furthermore, it is well compatible with extenders, auxiliaries, and other cosmetic or food bases, and can be easily commercialized. When the glutamylamide compound as the active ingredient of the present invention is blended with a cosmetic base or food base, these may be used alone or in combination. In addition, vitamins (vitamin C, vitamin E), It may be used together with an oxidizing agent (hypotaurin, thiotaurine), a protein (collagen, albumin, etc.) and the like. In this case, for example,
When used in combination with theanine and vitamin C, the combination of the two types with different mechanisms of action will result in better skin effect. Further, by additionally using collagen (0.01 part per 1 part of glutamylamide compound)
10 to 10 parts, preferably 0.1 to 1 part), and any type of composition such as cosmetics and food / beverage can provide an excellent skin effect.

These are used as cosmetics and beauty foods and drinks, but are not limited by the base used. Therefore, animal and vegetable fats and oils, higher alcohols, glycols, surfactants, pigments, fragrances, stabilizers and other components generally used as cosmetic bases can be used freely. In addition, other ingredients such as seasonings, sour agents, sweeteners, coloring agents, preservatives, antioxidants, flavoring agents, collagen, and the like, which are used as food bases as beauty foods and drinks, can be freely used. And various types of beauty foods and drinks such as cosmetic tablets, cosmetic candies, cosmetic gums, cosmetic capsules and the like.
The blending of the active ingredient according to the present invention is not particularly limited because there is no problem in the safety of the active ingredient, but it is usually 0.01 to 20%, preferably 0.1 to 0.2%.
It is desirable to mix 1 to 10%. Further, as an adjusting method, a conventional method in the art can be appropriately used.

When the present composition is used as a cosmetic, the method of use is not different from that of ordinary cosmetics.
What is necessary is just to apply three times. Such a method is sufficiently effective, and no side effects or toxicity is observed.

Examples are described below, but these examples are not intended to limit the present invention, but to show concretely.

[0022]

Example 1: Lotion A lotion was prepared according to the following formulation. 1. Glycerin 5.0% 2. 2. Propylene glycol 4.0% Oleyl alcohol 0.1% 4. 4. Polyoxyethylene sorbitan monolaurate 1.0% 5. Polyoxyethylene lauryl ether 0.5% 6. Ethanol 10.0% 7. Theanine 3.0% 8. Thiotaurine 1.0% 10. Pantethein-S-calcium sulfonate 1.0% Fragrance 0.1% 11. Preservative appropriate amount 12. Purified water 74.3%

[0023]

Example 2: Cream A cream was prepared according to the following formulation. 1. MGS-B 1.2 2. BB-5 0.6 3. BB-20 1.2 4. Bees Wax Gold 3.0 5. GM-18S 1.0 6. Bacyl alcohol 18.0 7. CIO 5.0 8.1.3-BG 0.1 9. Methyl paraben 0.1 10. Propylparaben 0.1 11. Sodium dehydroacetate 0.1 12. Glutaurine 3.0 13. Hipotaurine 2.0 14. Collagen 2.0 15. Purified water 62.6 Production method: 1 to 10 was heated and dissolved at 85 ° C.
5 and heated to 90 ° C., and the mixture was stirred vigorously with a homomixer. The stirring was loosened from about 75 ° C., and the stirring was stopped at 30 to 35 ° C.

[0024]

Example 3 Beverage-1 A beverage was prepared according to the following formulation. 1. 1. Theanine 1000 mg 2. Fructose glucose solution 20000 mg 3. 200 mg of citric acid Collagen 200mg5. 5. Vitamin C 100mg 6. Inositol 50 mg 7. Nicotinamide 20 mg Vitamin B1 sulfate 5 mg 9. Vitamin B2 phosphate 5 mg 10. Vitamin B6 5 mg 11. 11. Caffeine anhydrous 50mg Flavor 150mg 13. Suitable amount of sweetener Production method: 1 to 13 was dissolved in 160 ml of distilled water, distilled water was added to make the total amount 200 ml, filtered, aseptically filled in a brown bottle, and then heat-sterilized to produce a beverage.

[0025]

Example 4: Beverage-2 A beverage was prepared according to the following formulation. 1. 1. Glutaurine 500 mg 2. Fructose glucose solution 20000 mg 3. Citric acid 120 mg Collagen 200mg5. 5. Vitamin C 100mg Vitamin B1 sulfate 5 mg 7. 7. Vitamin B2 phosphate 5mg Vitamin B6 5 mg 9. 10. Caffeine anhydrous 50mg Flavor 150 mg 11. Sodium carbonate 200 mg 12. Suitable amount of sweetener Production method: 1 to 12 was dissolved in 160 ml of distilled water, distilled water was added to make the total amount 200 ml, filtered, aseptically filled in a brown bottle, and sterilized by heating to produce a beverage.

[0026]

Example 5: Drink preparation-1 A drink preparation was prepared according to the following formulation. 1. 1. Theanine 1000 mg 2. Thiotaurine 1000 mg Royal jelly 200mg 4. Collagen 200mg5. 5. Inositol 50 mg 6. Nicotinamide 20 mg 7. Vitamin B1 sulfate 5 mg Vitamin B2 phosphate 5 mg 9. Vitamin B6 5 mg 10. 50 mg of anhydrous caffeine Production method: 1 to 10 were dissolved in 80 ml of distilled water, distilled water was added to make the total amount 100 ml, filtered, aseptically filled in a brown bottle, and sterilized by heating to produce a drink.

[0027]

Example 6: Drink preparation-2 A drink preparation was prepared according to the following formulation. 1. 1. Theanine 1000 mg 2. Pantethein-S-calcium sulfonate 500 mg Royal jelly 200mg 4. Collagen 200mg5. 5. Inositol 50 mg 6. Nicotinamide 20 mg 7. Vitamin B1 sulfate 5 mg Vitamin B2 phosphate 5 mg 9. Vitamin B6 5 mg 10. 50 mg of anhydrous caffeine Production method: 1 to 10 were dissolved in 80 ml of distilled water, distilled water was added to make the total amount 100 ml, filtered, aseptically filled in a brown bottle, and sterilized by heating to produce a drink.

[0028]

Example 7: Drinks-3 Drinks were prepared according to the following formulation. 1. 1. Theanine 1000 mg 2. Hypotaurine 1000 mg Royal jelly 200mg 4. Collagen 200mg5. 5. Inositol 50 mg 6. Nicotinamide 20 mg 7. Vitamin B1 sulfate 5 mg Vitamin B2 phosphate 5 mg 9. Vitamin B6 5 mg 10. 50 mg of anhydrous caffeine Production method: 1 to 10 was dissolved in 80 ml of distilled water, distilled water was added to make the total amount 100 ml, filtered, aseptically filled in a brown bottle, and sterilized by heating to produce a drink.

[0029]

Example 8: Drinks-4 Drinks were prepared according to the following formulation. 1. 1. Glutaurine 500 mg 2. Hypotaurine 1000 mg Royal jelly 200mg 4. Collagen 200mg5. 5. Inositol 50 mg 6. Nicotinamide 20 mg 7. Vitamin B1 sulfate 5 mg Vitamin B2 phosphate 5 mg 9. Vitamin B6 5 mg 10. 10. Caffeine anhydrous 50 mg 200 mg of sodium carbonate Production method: 1 to 11 were dissolved in distilled water (80 ml), distilled water was added to make the total amount 100 ml, filtered, aseptically filled in a brown bottle, and heat-sterilized to produce a drink.

[0030]

Example 9: Drink Preparations 5 A drink preparation was prepared according to the following formulation. 1. 1. Glutaurine 500 mg 2. Taurine 1000 mg Royal jelly 200mg 4. Collagen 200mg5. 5. Inositol 50 mg 6. Nicotinamide 20 mg 7. Vitamin B1 sulfate 5 mg Vitamin B2 phosphate 5 mg 9. Vitamin B6 5 mg 10. 10. Caffeine anhydrous 50 mg 200 mg of sodium carbonate Production method: 1 to 11 were dissolved in distilled water (80 ml), distilled water was added to make the total amount 100 ml, filtered, aseptically filled in a brown bottle, and heat-sterilized to produce a drink.

[0031]

Example 10: Drinks 6 A drink was prepared according to the following formulation. 1. 1. Glutaurine 500 mg 2. Pantethein-S-calcium sulfonate 500 mg Royal jelly 200mg 4. Collagen 200mg5. 5. Inositol 50 mg 6. Nicotinamide 20 mg 7. Vitamin B1 sulfate 5 mg Vitamin B2 phosphate 5 mg 9. Vitamin B6 5 mg 10. 50 mg of anhydrous caffeine Production method: 1 to 10 was dissolved in 80 ml of distilled water, distilled water was added to make the total amount 100 ml, filtered, aseptically filled in a brown bottle, and sterilized by heating to produce a drink.

[0032]

Example 11: Drinks 7 A drink was prepared according to the following formulation. 1. 1. Theanine 1000 mg 2. 500 mg of collagen Vitamin C 500mg 4. Royal jelly 200mg5. 5. Inositol 50 mg 6. Nicotinamide 20 mg 7. Barley extract 20mg Vitamin E acetate 20 mg 9. Vitamin B1 sulfate 5 mg 10. Vitamin B2 phosphate 5 mg 11. Vitamin B6 5 mg 12. 12. Chondroitin sulfate sodium 50 mg 50 mg of anhydrous caffeine Production method: 1 to 13 were dissolved in 80 ml of distilled water, distilled water was added to make the total amount 100 ml, filtered, filled aseptically in a brown bottle, and sterilized by heating to produce a drink.

[0033]

Example 12: Capsules A cosmetic capsule was prepared according to the following formulation. 1. 1. Theanine 50 parts by weight 20 parts by weight of purified calcium carbonate 3. Lactose 178 parts by weight Magnesium stearate 2 parts by weight Manufacturing methods: 1 to 4 were mixed, and the resulting mixture was filled into one capsule in 250 mg portions to prepare a cosmetic capsule containing 50 mg theanine in one capsule.

[0034]

According to the present invention, wrinkles and sagging caused by aging of the skin can be prevented and improved not only from the outside of the skin but also from the inside thereof, and a smooth and moist beautiful skin can be maintained.

[Brief description of the drawings]

FIG. 1 shows the homeostasis effect exerted by the present invention.

FIG. 2 shows the effect of promoting fibroblast proliferation exerted by the present invention.

Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/48 A23L 2/00 F

Claims (6)

[Claims] 1. A cosmetic composition comprising a compound represented by the following general formula (I): Embedded image 2. The compound represented by the general formula (I) is L-
2. The cosmetic composition according to claim 1, which is glutamic acid- [gamma] -monoethylamide (theanine) or L-glutamic acid- [gamma] -sulfonic acid ethylamide (glutaurine). 3. The cosmetic composition according to claim 1, further comprising collagen. 4. The cosmetic composition according to claim 1, wherein the composition is a cosmetic type and / or a food and drink type. 5. The cosmetic composition of claim 4, wherein said composition is a skin cosmetic. 6. The food or beverage type composition according to claim 4, wherein the composition is a beauty drink.