JPH09504286A - 発泡しうるゼラチンカプセル充填物 - Google Patents

発泡しうるゼラチンカプセル充填物

Info

Publication number: JPH09504286A
Authority: JP; Japan
Prior art keywords: carbonate; pharmaceutical product; alginic acid; alginate; oil
Prior art date: 1993-10-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP7512497A

Other languages

English (en)

Japanese (ja)

Inventor

キースサグデン

キースグレイムハッチソン

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Catalent Pharma Solutions Inc

Original Assignee

Catalent Pharma Solutions Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-29

Filing date

1994-10-28

Publication date

1997-04-28

1993-10-29 Priority claimed from GB939322314A external-priority patent/GB9322314D0/en

1994-10-28 Application filed by Catalent Pharma Solutions Inc filed Critical Catalent Pharma Solutions Inc

1997-04-28 Publication of JPH09504286A publication Critical patent/JPH09504286A/ja

Status Pending legal-status Critical Current

Links

239000007903 gelatin capsule Substances 0.000 title claims abstract description 10
235000010443 alginic acid Nutrition 0.000 claims abstract description 32
229920000615 alginic acid Polymers 0.000 claims abstract description 32
239000000203 mixture Substances 0.000 claims abstract description 22
239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 18
229940127557 pharmaceutical product Drugs 0.000 claims abstract description 18
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 16
229940072056 alginate Drugs 0.000 claims abstract description 16
239000000783 alginic acid Substances 0.000 claims abstract description 16
229960001126 alginic acid Drugs 0.000 claims abstract description 16
150000004781 alginic acids Chemical class 0.000 claims abstract description 16
239000000126 substance Substances 0.000 claims abstract description 16
239000007788 liquid Substances 0.000 claims abstract description 14
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 11
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 10
210000002784 stomach Anatomy 0.000 claims abstract description 10
208000021302 gastroesophageal reflux disease Diseases 0.000 claims abstract description 8
208000000689 peptic esophagitis Diseases 0.000 claims abstract description 8
229920002148 Gellan gum Polymers 0.000 claims abstract description 6
208000008469 Peptic Ulcer Diseases 0.000 claims abstract description 6
206010057969 Reflux gastritis Diseases 0.000 claims abstract description 6
229920001525 carrageenan Polymers 0.000 claims abstract description 6
208000011906 peptic ulcer disease Diseases 0.000 claims abstract description 6
229920001285 xanthan gum Polymers 0.000 claims abstract description 6
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims abstract description 5
230000002378 acidificating effect Effects 0.000 claims abstract description 5
235000010418 carrageenan Nutrition 0.000 claims abstract description 5
239000000679 carrageenan Substances 0.000 claims abstract description 5
229940113118 carrageenan Drugs 0.000 claims abstract description 5
235000010987 pectin Nutrition 0.000 claims abstract description 5
239000001814 pectin Substances 0.000 claims abstract description 5
229920001277 pectin Polymers 0.000 claims abstract description 5
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 5
229960000292 pectin Drugs 0.000 claims abstract description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 14
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 12
239000003981 vehicle Substances 0.000 claims description 12
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 11
239000003921 oil Substances 0.000 claims description 11
235000019198 oils Nutrition 0.000 claims description 11
238000000034 method Methods 0.000 claims description 10
-1 propylene glycol ester Chemical class 0.000 claims description 10
238000012360 testing method Methods 0.000 claims description 10
239000000463 material Substances 0.000 claims description 9
229910052782 aluminium Chemical group 0.000 claims description 7
229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 7
235000017557 sodium bicarbonate Nutrition 0.000 claims description 7
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 6
150000002500 ions Chemical class 0.000 claims description 6
239000011777 magnesium Substances 0.000 claims description 6
229910052749 magnesium Inorganic materials 0.000 claims description 6
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 6
239000001095 magnesium carbonate Substances 0.000 claims description 6
229910000021 magnesium carbonate Inorganic materials 0.000 claims description 6
229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
159000000007 calcium salts Chemical class 0.000 claims description 5
150000004649 carbonic acid derivatives Chemical class 0.000 claims description 5
235000019864 coconut oil Nutrition 0.000 claims description 5
239000003240 coconut oil Substances 0.000 claims description 5
229920000642 polymer Polymers 0.000 claims description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
229910019142 PO4 Inorganic materials 0.000 claims description 4
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
PPQREHKVAOVYBT-UHFFFAOYSA-H dialuminum;tricarbonate Chemical compound [Al+3].[Al+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PPQREHKVAOVYBT-UHFFFAOYSA-H 0.000 claims description 4
229920001223 polyethylene glycol Polymers 0.000 claims description 4
235000015497 potassium bicarbonate Nutrition 0.000 claims description 4
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 4
239000011734 sodium Substances 0.000 claims description 4
229910052708 sodium Inorganic materials 0.000 claims description 4
235000012424 soybean oil Nutrition 0.000 claims description 4
239000003549 soybean oil Substances 0.000 claims description 4
239000002562 thickening agent Substances 0.000 claims description 4
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 4
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 3
239000002202 Polyethylene glycol Substances 0.000 claims description 3
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
JIFPTBLGXRKRAO-UHFFFAOYSA-K aluminum;magnesium;hydroxide;sulfate Chemical compound [OH-].[Mg+2].[Al+3].[O-]S([O-])(=O)=O JIFPTBLGXRKRAO-UHFFFAOYSA-K 0.000 claims description 3
229960004018 magaldrate Drugs 0.000 claims description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
239000010452 phosphate Substances 0.000 claims description 3
229920000136 polysorbate Polymers 0.000 claims description 3
229960003975 potassium Drugs 0.000 claims description 3
239000011591 potassium Substances 0.000 claims description 3
229910052700 potassium Inorganic materials 0.000 claims description 3
239000011736 potassium bicarbonate Substances 0.000 claims description 3
229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 3
229940086066 potassium hydrogencarbonate Drugs 0.000 claims description 3
CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims description 2
229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 2
229920002582 Polyethylene Glycol 600 Polymers 0.000 claims description 2
229940118662 aluminum carbonate Drugs 0.000 claims description 2
DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 claims description 2
239000011575 calcium Substances 0.000 claims description 2
229910052791 calcium Inorganic materials 0.000 claims description 2
229910001424 calcium ion Inorganic materials 0.000 claims description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 2
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 2
RRPFCKLVOUENJB-UHFFFAOYSA-L disodium;2-aminoacetic acid;carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O.NCC(O)=O RRPFCKLVOUENJB-UHFFFAOYSA-L 0.000 claims description 2
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims description 2
229940093471 ethyl oleate Drugs 0.000 claims description 2
229940050410 gluconate Drugs 0.000 claims description 2
239000001087 glyceryl triacetate Substances 0.000 claims description 2
235000013773 glyceryl triacetate Nutrition 0.000 claims description 2
JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 2
229950008882 polysorbate Drugs 0.000 claims description 2
RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims description 2
239000004094 surface-active agent Substances 0.000 claims description 2
229940095064 tartrate Drugs 0.000 claims description 2
229960002622 triacetin Drugs 0.000 claims description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 2
230000000149 penetrating effect Effects 0.000 claims 2
235000021317 phosphate Nutrition 0.000 claims 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
PCRDIRUKXOTDNN-UHFFFAOYSA-K aluminum;sodium;carbonate;hydroxide Chemical compound [OH-].[Na+].[Al+3].[O-]C([O-])=O PCRDIRUKXOTDNN-UHFFFAOYSA-K 0.000 claims 1
125000005586 carbonic acid group Chemical group 0.000 claims 1
GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 claims 1
239000012213 gelatinous substance Substances 0.000 claims 1
150000003893 lactate salts Chemical class 0.000 claims 1
239000002480 mineral oil Substances 0.000 claims 1
235000010446 mineral oil Nutrition 0.000 claims 1
229940042472 mineral oil Drugs 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
229920000223 polyglycerol Polymers 0.000 claims 1
230000035515 penetration Effects 0.000 description 15
239000002775 capsule Substances 0.000 description 13
235000003599 food sweetener Nutrition 0.000 description 5
239000003205 fragrance Substances 0.000 description 5
239000003765 sweetening agent Substances 0.000 description 5
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 4
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
239000000499 gel Substances 0.000 description 4
235000010413 sodium alginate Nutrition 0.000 description 4
239000000661 sodium alginate Substances 0.000 description 4
229940005550 sodium alginate Drugs 0.000 description 4
LCWAOCHOPBSGMU-UHFFFAOYSA-J aluminum;magnesium;sodium;hydrogen carbonate;oxygen(2-);silicon;trihydroxide Chemical compound [OH-].[OH-].[OH-].[O-2].[Na+].[Mg+2].[Al+3].[Si].OC([O-])=O LCWAOCHOPBSGMU-UHFFFAOYSA-J 0.000 description 3
238000009472 formulation Methods 0.000 description 3
210000004211 gastric acid Anatomy 0.000 description 3
229940045140 gaviscon Drugs 0.000 description 3
150000003839 salts Chemical class 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
229910002012 Aerosil® Inorganic materials 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
229920001268 Cholestyramine Polymers 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
229940069428 antacid Drugs 0.000 description 2
239000003159 antacid agent Substances 0.000 description 2
230000001458 anti-acid effect Effects 0.000 description 2
239000003613 bile acid Substances 0.000 description 2
229940075614 colloidal silicon dioxide Drugs 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000005538 encapsulation Methods 0.000 description 2
210000003238 esophagus Anatomy 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
229940075507 glyceryl monostearate Drugs 0.000 description 2
239000008172 hydrogenated vegetable oil Substances 0.000 description 2
235000010445 lecithin Nutrition 0.000 description 2
239000000787 lecithin Substances 0.000 description 2
229940067606 lecithin Drugs 0.000 description 2
239000012669 liquid formulation Substances 0.000 description 2
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
229940068968 polysorbate 80 Drugs 0.000 description 2
229920000053 polysorbate 80 Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
230000008719 thickening Effects 0.000 description 2
VQJMAIZOEPPELO-KYGIZGOZSA-N (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-(2-hydroxy-5-methylhexan-2-yl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol hydrochloride Chemical compound Cl.CO[C@]12CC[C@@]3(C[C@@H]1C(C)(O)CCC(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 VQJMAIZOEPPELO-KYGIZGOZSA-N 0.000 description 1
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
235000006679 Mentha X verticillata Nutrition 0.000 description 1
235000002899 Mentha suaveolens Nutrition 0.000 description 1
235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
241001676573 Minium Species 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
LISYCWMGWAORRH-UHFFFAOYSA-N [Na].[Th] Chemical compound [Na].[Th] LISYCWMGWAORRH-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical group 0.000 description 1
229940024545 aluminum hydroxide Drugs 0.000 description 1
235000010407 ammonium alginate Nutrition 0.000 description 1
239000000728 ammonium alginate Substances 0.000 description 1
KPGABFJTMYCRHJ-YZOKENDUSA-N ammonium alginate Chemical compound [NH4+].[NH4+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O KPGABFJTMYCRHJ-YZOKENDUSA-N 0.000 description 1
235000013871 bee wax Nutrition 0.000 description 1
239000012166 beeswax Substances 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
229940037769 calcium carbonate 100 mg Drugs 0.000 description 1
229940016060 calcium carbonate 150 mg Drugs 0.000 description 1
229940016038 calcium carbonate 30 mg Drugs 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
125000005587 carbonate group Chemical group 0.000 description 1
NKCVNYJQLIWBHK-UHFFFAOYSA-N carbonodiperoxoic acid Chemical compound OOC(=O)OO NKCVNYJQLIWBHK-UHFFFAOYSA-N 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000001055 chewing effect Effects 0.000 description 1
238000004040 coloring Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
201000006549 dyspepsia Diseases 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000003925 fat Substances 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000006260 foam Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000007789 gas Substances 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
210000003736 gastrointestinal content Anatomy 0.000 description 1
235000010492 gellan gum Nutrition 0.000 description 1
239000000216 gellan gum Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
208000024798 heartburn Diseases 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000007774 longterm Effects 0.000 description 1
230000001050 lubricating effect Effects 0.000 description 1
235000014380 magnesium carbonate Nutrition 0.000 description 1
229940031958 magnesium carbonate hydroxide Drugs 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
239000011368 organic material Substances 0.000 description 1
238000012856 packing Methods 0.000 description 1
229940031625 pectin 300 mg Drugs 0.000 description 1
229920000379 polypropylene carbonate Polymers 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
235000011181 potassium carbonates Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000010992 reflux Methods 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
XHFLOLLMZOTPSM-UHFFFAOYSA-M sodium;hydrogen carbonate;hydrate Chemical compound [OH-].[Na+].OC(O)=O XHFLOLLMZOTPSM-UHFFFAOYSA-M 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
239000001993 wax Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus

Landscapes

Health & Medical Sciences (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

JP7512497A 1993-10-29 1994-10-28 発泡しうるゼラチンカプセル充填物 Pending JPH09504286A (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB9322314.7		1993-10-29
GB939322314A GB9322314D0 (en)	1993-10-29	1993-10-29	Foam generating capsules
GB9411350A GB2283171B (en)	1993-10-29	1994-06-07	Pharmaceutical products
GB9411350.3		1994-06-07
PCT/GB1994/002380 WO1995011668A1 (fr)	1993-10-29	1994-10-28	Substance a pouvoir moussant garnissant une gelule de gelatine

Publications (1)

Publication Number	Publication Date
JPH09504286A true JPH09504286A (ja)	1997-04-28

Family

ID=26303761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP7512497A Pending JPH09504286A (ja)	1993-10-29	1994-10-28	発泡しうるゼラチンカプセル充填物

Country Status (9)

Country	Link
EP (1)	EP0725626A1 (fr)
JP (1)	JPH09504286A (fr)
CN (1)	CN1133558A (fr)
AU (1)	AU8000494A (fr)
BR (1)	BR9407916A (fr)
CA (1)	CA2174777A1 (fr)
NO (1)	NO961638D0 (fr)
NZ (1)	NZ274901A (fr)
WO (1)	WO1995011668A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000169397A (ja) *	1998-12-03	2000-06-20	Otsuka Pharmaceut Factory Inc	ゲル化剤、経管栄養食品用ゲル化剤およびそれを含有する経管栄養食品
JP2009513657A (ja) *	2005-10-26	2009-04-02	バナーファーマキャプス，インコーポレイテッド	カプセル充墳物としての親油性ベヒクルに基づく二重制御された放出マトリクスシステム

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0103722D0 (sv) *	2001-10-30	2001-10-30	Astrazeneca Ab	Novel formulation
GB2384986B (en) *	2002-02-12	2004-01-07	Reckitt Benckiser Healthcare	Compositions for the treatment of disorders of the upper gastrointestinal tract
KR100919508B1 (ko) *	2007-08-14	2009-09-28	강원대학교산학협력단	매트릭스에 칼슘 카보네이트를 함유한 알지네이트 입자 및그 제조방법
GB0814376D0 (en) *	2008-08-06	2008-09-10	Reckitt Benckiser Healthcare	Formulation
JP2013525313A (ja) *	2010-04-23	2013-06-20	エス−バイオテックホールディングエーピーエス	胃酸を中和する固形医薬組成物
ITUB20156821A1 (it) *	2015-12-09	2017-06-09	Altergon Sa	CAPSULE DI GELATINA MOLLE A RILASCIO pH INDIPENDENTE
FR3071728B1 (fr) *	2017-09-29	2019-09-27	Laboratoires Arkopharma	Composition adaptee pour former un radeau gastrique gelifie
WO2019169137A1 (fr) *	2018-03-02	2019-09-06	Pharagen Llc	Formulations pour le traitement du reflux acide comprenant de l'alginate de sodium
CN110353271B (zh) *	2019-06-13	2022-07-22	陕西科技大学	一种抑制食道反流的特殊医学食品增稠组件及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH630257A5 (en) *	1975-03-17	1982-06-15	Hoffmann La Roche	Sustained release formulation
CH652025A5 (de) *	1981-09-14	1985-10-31	Hoffmann La Roche	Pharmazeutisches praeparat.
NL8902338A (nl) *	1988-09-20	1990-04-17	Glaxo Group Ltd	Farmaceutische preparaten.

1994
- 1994-10-28 CA CA 2174777 patent/CA2174777A1/fr not_active Abandoned
- 1994-10-28 NZ NZ27490194A patent/NZ274901A/en unknown
- 1994-10-28 AU AU80004/94A patent/AU8000494A/en not_active Abandoned
- 1994-10-28 EP EP94931124A patent/EP0725626A1/fr not_active Withdrawn
- 1994-10-28 CN CN 94193934 patent/CN1133558A/zh active Pending
- 1994-10-28 JP JP7512497A patent/JPH09504286A/ja active Pending
- 1994-10-28 WO PCT/GB1994/002380 patent/WO1995011668A1/fr not_active Ceased
- 1994-10-28 BR BR9407916A patent/BR9407916A/pt not_active Application Discontinuation
1996
- 1996-04-24 NO NO961638A patent/NO961638D0/no unknown

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000169397A (ja) *	1998-12-03	2000-06-20	Otsuka Pharmaceut Factory Inc	ゲル化剤、経管栄養食品用ゲル化剤およびそれを含有する経管栄養食品
JP2009513657A (ja) *	2005-10-26	2009-04-02	バナーファーマキャプス，インコーポレイテッド	カプセル充墳物としての親油性ベヒクルに基づく二重制御された放出マトリクスシステム

Also Published As

Publication number	Publication date
CA2174777A1 (fr)	1995-05-04
NO961638L (no)	1996-04-24
CN1133558A (zh)	1996-10-16
NZ274901A (en)	1997-03-24
NO961638D0 (no)	1996-04-24
EP0725626A1 (fr)	1996-08-14
BR9407916A (pt)	1996-11-26
AU8000494A (en)	1995-05-22
WO1995011668A1 (fr)	1995-05-04

Publication	Publication Date	Title
Sriamornsak et al.	2007	Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads
JP4184278B2 (ja)	2008-11-19	非ゼラチン系カプセル皮膜組成物及びそれを用いたカプセル
AU594148B2 (en)	1990-03-01	Gelatin-encapsulated controlled-release composition
JPH09504286A (ja)	1997-04-28	発泡しうるゼラチンカプセル充填物
WO1988007862A1 (fr)	1988-10-20	Composition anti-acide
JP2006505542A (ja)	2006-02-16	腸溶性調製物
EA019116B1 (ru)	2014-01-30	Жевательные капсулы
GB2283171A (en)	1995-05-03	Pharmaceutical product for treatment of reflux oesophagitis,gastritis or peptic ulceration
CA2633924A1 (fr)	2007-07-05	Formes pharmaceutiques resistantes au reflux gastrique
US5888540A (en)	1999-03-30	Pharmaceutical products
DE69423812T2 (de)	2000-09-07	Neue schwimmende Antacida-Zusammensetzungen
JP2001170137A (ja)	2001-06-26	硬質カプセル及びその製造方法
EP3642274A1 (fr)	2020-04-29	Composition auto-moussante en milieu acide et procédé de préparation
CA2175225C (fr)	2004-09-21	Substance a pouvoir moussant garnissant une gelule de gelatine
JP7416908B2 (ja)	2024-01-17	生体適合性材料
JP5746454B2 (ja)	2015-07-08	嗜好品
Chaturvedi et al.	2022	Formulation and development of sustained release of cefixime using floating oral In situ gelling system
RU2848477C2 (ru)	2025-10-20	Антацидный продукт в форме непроглатываемой жевательной резинки, способ его получения и применение
WO2010108494A1 (fr)	2010-09-30	Traitement de dyspepsie par alginate
EA047934B1 (ru)	2024-09-30	Новые комбинации и композиции сукральфата в альгинате и его применение в терапии
WO2022144825A1 (fr)	2022-07-07	Nouvelles combinaisons et compositions de sucralfate dans de l'alginate et leur utilisation en thérapie
WO2025061824A1 (fr)	2025-03-27	Compositions et methodes pour reduire l'appetit et/ou faciliter la perte de poids
Kanabar Vishvesh et al.	2015	Formulation and evaluation of raft forming sustained release Tablet containing ranitidine
FR3153240A1 (fr)	2025-03-28	Compositions et méthodes pour réduire l’appétit et/ou faciliter la perte de poids
EA049989B1 (ru)	2025-05-28	Комбинация и композиция сукральфата в альгинате и их применение в терапии

Legal Events

Date	Code	Title	Description
2005-02-15	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050215
2005-06-02	A601	Written request for extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050513
2005-06-27	A602	Written permission of extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20050627
2005-09-01	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050815
2007-10-02	A02	Decision of refusal	Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20071002

JPH09504286A - 発泡しうるゼラチンカプセル充填物 - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (5)

Publications (1)

Family

ID=26303761

Family Applications (1)

Country Status (9)

Cited By (2)

Families Citing this family (9)

Family Cites Families (3)

Cited By (2)

Also Published As

Similar Documents

Legal Events