JPH08301730A - Hair growing agent - Google Patents

Abstract

PURPOSE: To obtain a hair growing agent and testosteron-5α-reductase inhibitor. CONSTITUTION: This hair growing agent contains one or two or more extracts or aromatic compound fractions selected from Plantaginis Herba, Cistanchis Herba and CHOROGI. Whole grass of Plantagoasiatica L., whole grass or tuber of Cistanchesalsa (C. A. MEY) G. BECK and whole grass or tubuer of Stachyssieboldii MIQ., or their analog plants can be also each used as Plantaginis Herba, Cistanchis Herba and CHOROGI. The formulation of the hair growing agent includes e.g. hair tonic, hair lotion, hair cream, hair conditioner, hair gel, hair mist, hair foam, shampoo, rinse, etc.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair growth agent and a testosterone-5α-reductase inhibitor. The hair restorer in the present invention is used for the purpose of preventing hair loss and promoting hair growth and hair growth.

[0002]

2. Description of the Related Art Heretofore, hair growth agents containing blood circulation promoters, cell activating agents, vitamins, and antiandrogen agents as active ingredients have been known for the purpose of treating and improving male pattern baldness and alopecia areata. There is. However, there are still many unclear points about the mechanism of hair loss and hair growth, and sufficient therapeutic and improving effects have not been obtained. Also testosterone-
5α-reductase inhibitors are effective for alopecia and diseases involving male hormones such as acne, but no sufficient inhibitors have been obtained. On the other hand, a solvent-extracted extract of Chazenshi is known as a testosterone-5α-reductase inhibitor (JP-A-60-146829).

[0003]

Therefore, the development of an excellent active ingredient for preventing hair loss, promoting hair growth and hair growth, and
Its application to a hair restorer is desired. Further, development of an excellent testosterone-5α-reductase inhibitor is also desired. Chazenchi is a seed of psyllium Plantago asiatica L., but its testosterone-5α-reductase inhibitory action was not sufficient.

[0004]

In view of such circumstances, the present inventor has examined the hair-growth effect for many natural products, and as a result,
1 selected from Chazensou, Nijuju and Chorogi
It was found that one or more extracts or aromatic compound fractions have strong testosterone-5α-reductase inhibitory action and hair growth effect, and completed the present invention.

[0005] The Chamesou, Cistanche salsa, and Chologi used in the present invention are Plantago asiatica, respectively.
Whole plant of L. (Plantago asiatica L.) or above ground, whole plant of Cistanche salsa (CAMEY.) G. BECK (Stachys sie)
Whole plants, above-ground parts, tubers, etc. of boldii MIQ. (stachys sybordi MIQ.), but plants of the same genus may be used. Commercially available products can be used for these plants. Chazensou has the same origin as Chazenshi but its parts are different, and its use as a folk medicine is also different (Primary color Japanese and Chinese medicine pictorial book (above), Tsuneo Namba, nursery company). In addition, it has been reported that the contained components are also different, and the phenylpropanoid glycoside, planta majoside, which is contained in a few percent by dry weight of Chasenzo, is hardly found in Chazenshi (Pharmaceutical Journal, 110 (6 ), 453-45
6 (1990)).

The extract of the present invention can be obtained, for example, by extracting the above-mentioned plant material with water or a water-soluble solvent such as ethanol, methanol, 1,3-butylene glycol, propylene glycol or the like alone or in a mixed solution. . The extraction may be performed at room temperature or with heating. When chlorophyll and oil-soluble components are contained, they may be removed by partition extraction with chloroform, hexane or the like. Further, a dried product obtained by removing the solvent by freeze-drying or the like may be used, or a state containing the solvent may be used.

The aromatic compound fraction used in the present invention can be obtained, for example, as follows. Synthetic adsorbent obtained by swelling an extract dissolved in water or a low-concentration alcohol (ethanol, methanol, etc.) aqueous solution with water or a low-concentration alcohol aqueous solution, preferably an aromatic synthetic adsorbent by a column method or a batch method. Adsorb by a conventional method such as a method. After washing with water or a low-concentration alcohol aqueous solution to remove non-adsorbed components, the synthetic adsorbent is treated with a solution having an alcohol concentration higher than that during adsorption to elute aromatic compounds (fractions). . The synthetic adsorbent used in the present invention is not particularly limited as long as it is a synthetic adsorbent that adsorbs an aromatic compound, but is preferably an aromatic synthetic adsorbent that selectively adsorbs an aromatic compound, such as Pharmacia. Sephadex LH-20 manufactured by Mitsubishi Kasei, Diaion HP-20 manufactured by Mitsubishi Kasei, MCI gel CHP20P, and Sepa beads SP850. Further, the aromatic compound fraction can also be obtained by partition extraction, for example, it can be obtained by dissolving the extract in water and then partition extraction with ethyl acetate, n-butanol, or the like. The solution of the obtained aromatic compound fraction may be used as it is or after being concentrated, or the solvent may be distilled off or freeze-dried.

The amount of the extract or the aromatic compound fraction in the entire composition of the hair restorer of the present invention may be 0.001 to 10% by weight (hereinafter simply referred to as%), and more preferably 0.01 to 5%. is there. If it is less than 0.001%, the desired effect of the present invention is not sufficient, while if it exceeds the upper limit, the improvement of the effect commensurate with the increase cannot be expected.

Further, the hair restorer of the present invention does not impair the effects of the present invention with the extract or the aromatic compound fraction thereof, and if necessary, other additives and other agents conventionally used as a hair restorer. It can be appropriately blended within the range. Examples of the additive include hinokitiol, benzalkonium chloride, hexachlorophene, antibacterial agents such as undecylenic acid, cooling agents such as menthol, higher fatty acids, higher alcohols, surfactants, fragrances, antioxidants, ethanol, and refinement. Examples include water and moisturizers. In addition, examples of other agents commonly used as a hair-growing agent include cembly extract, vasodilator such as acetylcholine derivative, swelltinogen, vitamin E nicotinic acid ester, capsicum tincture, and carrot carrot. these
One kind or two or more kinds can be used.

The form of the hair restorer of the present invention is not limited as long as it can be used as an external preparation. For example, hair tonic, hair lotion, hair cream, hair conditioner, hair gel, hair mist, hair. Examples include foams, shampoos, rinses, and the like.

[0011]

EXAMPLES Next, the production method of the extract and the aromatic compound fraction used in the present invention or the method for formulating the hair-growth agent of the present invention will be specifically described according to typical production examples and examples. The invention is not limited to this. Production Example-1 Cholorgi Extract and Aromatic Compound Fraction 1.5 L of methanol was added to 1 kg (fresh weight) of crushed Cholorgi, followed by extraction at 60 ° C. for 1 hour. After filtration, methanol was distilled off and freeze-dried to obtain 122 g of Cholorgi extract. This extract
Sephadex LH-2 in which 100 g of water-soluble fraction was swollen with water
It was subjected to 0 column chromatography (column: 5 × 50 cm, flow rate: 100 ml / hr). After washing with 3 L of water, 2
The adsorbed component was eluted with L 50% aqueous methanol solution. Methanol in the obtained eluate was distilled off and then freeze-dried to obtain 15 g of an aromatic compound fraction.

Production Example-2 Chorogi Extract and Aromatic Compound Fraction 1.5 L of ethanol was added to 1 kg (fresh weight) of crushed Chologi, and the mixture was extracted at 60 ° C. for 1 hour. After filtration, ethanol was distilled off and freeze-dried to obtain 100 g of Cholorgi extract. This extract
Column chromatography of Diaion HP-20 swollen with 80 g of water-soluble fraction (column: 5 × 50 cm, flow rate: 10
0 ml / hr). After washing with 3 L of water, the components adsorbed with 2 L of ethanol were eluted and concentrated to dryness to obtain 10 g of an aromatic compound fraction.

Production Example-3 Cholorgi Extract 1.5 kg of 1,3-butylene glycol (1,3-BG) was added to 1 kg (raw weight) of crushed Cholorgi, and the mixture was extracted at room temperature for 1 week.
It was filtered to obtain 2.3 kg of Choriogi extract.

Production Example-4 Chazensou Extract and Fraction of Aromatic Compound To 500 g of Chazensou of the Japanese Pharmacopoeia, 5 L of methanol was added, and the mixture was extracted at room temperature for 1 week. After filtration, 4 L of methanol was added to the residue and the same extraction was performed. The obtained extracts were combined and concentrated to dryness to obtain 89.8 g of a Chamesou extract. 50 g of this extract
Was dissolved in 200 ml of water, and then distributed and extracted three times with 400 ml of chloroform to remove chlorophyll and the like. The aqueous layer was subjected to column chromatography on Sephadex LH-20 swollen with water (column: 5 × 50 cm, flow rate: 100 ml / hr). Three
After washing with L of water, the adsorbed component was eluted with 50% aqueous methanol solution, the methanol was distilled off, and the residue was freeze-dried to obtain 5 g of an aromatic compound fraction.

Production Example-5 Chazensou Extract and Fraction of Aromatic Compound 5L of water was added to 500 g of the Japanese Chasanthus and extracted at 85 to 90 ° C. for 1 hour. After filtration, 2 L of water was added to the residue for washing and filtration. Combine the resulting filtrates (Chanthanthus extract),
It was subjected to column chromatography of DIAION HP-20 swollen with water (column: 5 × 50 cm, flow rate: 100 ml / hr). After washing with 3 L of a 20% aqueous methanol solution, the components adsorbed with a 50% aqueous methanol solution were eluted, the methanol was distilled off and freeze-dried to obtain 8.5 g of an aromatic compound fraction.

Production Example-6 Chazensou Extract 1 kg of a 100% chlorophyll of the Japanese Pharmacopoeia was added with 1 kg of a 50% aqueous solution of 1,3-butylene glycol, and the mixture was extracted at room temperature for 1 week.

Production Example-7 Cistanche salsa extract and aromatic compound fraction To 500 g of Cistanche salsa, 4 L of methanol was added and extracted for 1 week at room temperature. After filtration, 4 L of methanol was added to the residue and the same extraction was performed. The obtained extracts are combined and concentrated to dryness,
203.2 g of the Radix Notoginseng extract was obtained. The water-soluble fraction of 100 g of this extract was divided into two and swollen with water to separate Sephadex.
LH-20 column chromatography (column: 5 x 50 cm,
Flow rate: 100 ml / hr). After washing with 3 L of water, 30
% L of ethanol solution to elute the adsorbed components,
900 ml of an aromatic compound fraction was obtained.

Production Example-8 Cistanche salsa extract and aromatic compound fraction 4 g of ethanol was added to 500 g of Cistanche salsa and extracted for 1 week at room temperature. After filtration, 4 L of ethanol was added to the residue and the same extraction was performed. The obtained extracts are combined and concentrated to dryness,
150 g of the Radix Notoginseng extract was obtained. A water-soluble fraction of 100 g of this extract was adsorbed by a batch method on 1 L of Sepa beads SP850 swollen with water. After washing with 3 L of water, the adsorbed components were eluted with 1 L of a 30% aqueous ethanol solution to obtain 900 ml of an aromatic compound fraction.

Production Example-9 Cistanche salsa extract 100 g of Cistanche salsa, 1 kg of 1,3-butylene glycol 50
% Aqueous solution was added, and the mixture was extracted at room temperature for 1 week, and then filtered to obtain 1 kg of salamander extract.

Example-1 Hair lotion 1. Stearic acid 5.0 parts 2. Cetyl alcohol 5.0 3. Liquid paraffin 2.0 4. Glycerin monostearate 1.3 5. Sorbitan monooleate 1.5 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. Chorogi extract 0.2 8. Glycerin 6.0 9. Preservative proper amount 10. Purified water 78.2 [Production method] Components 1 to 7 and components 8 to 10 at 70 to 75 ° C, respectively
After heating and dissolving, add components 8-7 to components 1-7 to emulsify and cool to 30 ° C to make a hair lotion.

Example-2 Hair tonic 1.95% ethanol 60.0 parts 2. Cholorgi extract 2.0 3. Glycerin 2.0 4. Purified water 36.0 [Production Method] Cholorgi extract is dissolved in ethanol, glycerin and purified water are added, and the mixture is sufficiently stirred. Mix to make a hair tonic.

Example-3 Shampoo 1. Alkyl sulfate triethanolamine 18.0 parts 2. Lauric acid diethanolamide 3.0 3. Cholorgi extract 0.1 4. Methylcellulose 0.5 5. Purified water 77.0 6. Fragrance [Producing method] Component 4 After melting 5 evenly, add components 1 and 3, heat and dissolve at 70-75 ° C, then add component 2,
While cooling, add ingredient 6 and cool to 30 ° C to make a shampoo.

Example-4 Rinse 1. Jojoba oil 0.01 parts 2. Behenyl alcohol 3.0 3.1, 3-butylene glycol 5.0 4. Distearyl dimethylammonium chloride (75%) 8.0 5. Cholorgi extract 0.1 6. Citric acid 0.05 7. Perfume Proper amount 8. Add purified water to make 100 [Production method] Ingredients 1-8 are dissolved at 60 ° C, stirred and cooled to 30 ° C to rinse.

Example-5 Hair lotion 1. Stearic acid 5.0 parts 2. Cetyl alcohol 5.0 3. Liquid paraffin 2.0 4. Glycerin monostearate 1.3 5. Sorbitan monooleate 1.5 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. Chamesou extract 0.2 8. Glycerin 6.0 9. Preservative proper amount 10. Purified water 78.2 [Production method] Components 1 to 7 and components 8 to 10 at 70 to 75 ° C, respectively
After heating and dissolving, add components 8-7 to components 1-7 to emulsify and cool to 30 ° C to make a hair lotion.

Example-6 Hair Tonic 1.95% Ethanol 60.0 parts 2. Chazen extract 2.0 3. Glycerin 2.0 4. Purified water 36.0 [Production Method] The Chazen Sodium extract is dissolved in ethanol, glycerin and purified water are added, and the mixture is thoroughly stirred. Mix to make a hair tonic.

Example-7 Shampoo 1. Alkyl sulfate triethanolamine 18.0 parts 2. Lauric acid diethanolamide 3.0 3. Chasen extract 0.1 4. Methylcellulose 0.5 5. Purified water 77.0 6. Perfume [Producing method] Component 4 After melting 5 evenly, add components 1 and 3, heat and dissolve at 70-75 ° C, then add component 2,
While cooling, add ingredient 6 and cool to 30 ° C to make a shampoo.

Example-8 Rinse 1. Jojoba oil 0.01 parts 2. Behenyl alcohol 3.0 3.1, 3-butylene glycol 5.0 4. Distearyl dimethylammonium chloride (75%) 8.0 5. Chamomile extract 0.1 6. Citric acid 0.05 7. Perfume Proper amount 8. Add purified water to make 100 [Production method] Ingredients 1-8 are dissolved at 60 ° C, stirred and cooled to 30 ° C to rinse.

Example-9 Hair lotion 1. Stearic acid 5.0 parts 2. Cetyl alcohol 5.0 3. Liquid paraffin 2.0 4. Glycerin monostearate 1.3 5. Sorbitan monooleate 1.5 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. Cistanche salsa extract 0.2 8. Glycerin 6.0 9. Preservative proper amount 10. Purified water 78.2 [Production method] Components 1 to 7 and components 8 to 10 at 70 to 75 ° C, respectively
After heating and dissolving, add components 8-7 to components 1-7 to emulsify and cool to 30 ° C to make a hair lotion.

Example-10 Hair Tonic 1.95% Ethanol 60.0 parts 2. Cistanche salsa extract 2.0 3. Glycerin 2.0 4. Purified water 36.0 [Production method] The communis radix extract was dissolved in ethanol, glycerin and purified water were added, and the mixture was thoroughly stirred. Mix to make a hair tonic.

Example-11 Shampoo 1. Triethanolamine alkylsulfate 18.0 parts 2. Lauric acid diethanolamide 3.0 3. Cistanche salsa extract 0.1 4. Methylcellulose 0.5 5. Purified water 77.0 6. Perfume [Production method] Component 4 After melting 5 evenly, add components 1 and 3, heat and dissolve at 70-75 ° C, then add component 2,
While cooling, add ingredient 6 and cool to 30 ° C to make a shampoo.

Example-12 Rinse 1. Jojoba oil 0.01 parts 2. Behenyl alcohol 3.0 3.1, 3-butylene glycol 5.0 4. Distearyl dimethyl ammonium chloride (75%) 8.0 5. Cistanche salsa extract 0.1 6. Citric acid 0.05 7. Perfume Proper amount 8. Add purified water to make 100 [Production method] Ingredients 1-8 are dissolved at 60 ° C, stirred and cooled to 30 ° C to rinse.

Example-13 Hair lotion 1. Stearic acid 5.0 parts 2. Cetyl alcohol 5.0 3. Liquid paraffin 2.0 4. Glycerin monostearate 1.3 5. Sorbitan monooleate 1.5 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. Chorogi aromatic compound fraction 0.2 8. Glycerin 6.0 9. Preservative proper amount 10. Purified water 78.2 [Production method] Components 1 to 7 and components 8 to 10 at 70 to 75 ° C, respectively
After heating and dissolving, add components 8-7 to components 1-7 to emulsify and cool to 30 ° C to make a hair lotion.

Example-14 Hair Tonic 1.95% Ethanol 60.0 parts 2. Chologi aromatic compound fraction 2.0 3. Glycerin 2.0 4. Purified water 36.0 [Production Method] The chologi aromatic compound fraction was dissolved in ethanol to give glycerin. , Purified water is added, and the mixture is thoroughly stirred to give a hair tonic.

Example-15 Shampoo 1. Triethanolamine alkylsulfate 18.0 parts 2. Lauric acid diethanolamide 3.0 3. Chorogi aromatic compound fraction 0.1 4. Methylcellulose 0.5 5. Purified water 77.0 6. Perfume [Producing method] After uniformly melting Component 5 in Component 4, add Components 1 and 3, heat and dissolve at 70-75 ° C, and then add Component 2,
While cooling, add ingredient 6 and cool to 30 ° C to make a shampoo.

Example-16 Rinse 1. Jojoba oil 0.01 parts 2. Behenyl alcohol 3.0 3.1, 3-butylene glycol 5.0 4. Distearyl dimethyl ammonium chloride (75%) 8.0 5. Chorogi aromatic compound fraction 0.1 6. Acid 0.05 7. Perfume Proper amount 8. Add purified water to make 100 [Production Method] Dissolve components 1 to 8 at 60 ° C, stir and cool to 30 ° C to rinse.

Example-17 Hair Lotion 1. Stearic acid 5.0 parts 2. Cetyl alcohol 5.0 3. Liquid paraffin 2.0 4. Glycerin monostearate 1.3 5. Sorbitan monooleate 1.5 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. Chazensou aromatic compound fraction 0.2 8. Glycerin 6.0 9. Preservative proper amount 10. Purified water 78.2 [Production method] Components 1 to 7 and components 8 to 10 at 70 to 75 ° C, respectively
After heating and dissolving, add components 8-7 to components 1-7 to emulsify and cool to 30 ° C to make a hair lotion.

Example-18 Hair Tonic 1.95% Ethanol 60.0 parts 2. Chazensou aromatic compound fraction 2.0 3. Glycerin 2.0 4. Purified water 36.0 [Production Method] Chazensou aromatic compound fraction was dissolved in ethanol to give glycerin. , Purified water is added, and the mixture is thoroughly stirred to give a hair tonic.

Example-19 Shampoo 1. Triethanolamine alkylsulfate 18.0 parts 2. Lauric acid diethanolamide 3.0 3. Chasenzo aromatic compound fraction 0.1 4. Methylcellulose 0.5 5. Purified water 77.0 6. Perfume suitable amount [Production method] After uniformly melting Component 5 in Component 4, add Components 1 and 3, heat and dissolve at 70-75 ° C, and then add Component 2,
While cooling, add ingredient 6 and cool to 30 ° C to make a shampoo.

Example-20 Rinse 1. Jojoba oil 0.01 part 2. Behenyl alcohol 3.0 3.1, 3-butylene glycol 5.0 4. Distearyl dimethylammonium chloride (75%) 8.0 5. Chasenzo aromatic compound fraction 0.1 6. Quench Acid 0.05 7. Perfume Proper amount 8. Add purified water to make 100 [Production Method] Dissolve components 1 to 8 at 60 ° C, stir and cool to 30 ° C to rinse.

Example-21 Hair Lotion 1. Stearic acid 5.0 parts 2. Cetyl alcohol 5.0 3. Liquid paraffin 2.0 4. Glycerin monostearate 1.3 5. Sorbitan monooleate 1.5 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. Nijuju Aromatic Compound Fraction 0.2 8. Glycerin 6.0 9. Preservative Appropriate amount 10. Purified water 78.2 [Preparation] Components 1 to 7 and Components 8 to 10 at 70 to 75 ° C, respectively.
After heating and dissolving, add components 8-7 to components 1-7 to emulsify and cool to 30 ° C to make a hair lotion.

Example-22 Hair Tonic 1.95% ethanol 60.0 parts 2. Cistanche aromatic compound fraction 2.0 3. Glycerin 2.0 4. Purified water 36.0 [Production method] Cistanche aromatic compound fraction was dissolved in ethanol to give glycerin. , Purified water is added, and the mixture is thoroughly stirred to give a hair tonic.

Example-23 Shampoo 1. Triethanolamine alkylsulfate 18.0 parts 2. Lauric acid diethanolamide 3.0 3. Fragrance aromatic compound fraction 0.1 4. Methylcellulose 0.5 5. Purified water 77.0 6. Perfume proper amount [Production method] After uniformly melting Component 5 in Component 4, add Components 1 and 3, heat and dissolve at 70-75 ° C, and then add Component 2,
While cooling, add ingredient 6 and cool to 30 ° C to make a shampoo.

Example-24 Rinse 1. Jojoba oil 0.01 parts 2. Behenyl alcohol 3.0 3.1, 3-butylene glycol 5.0 4. Distearyl dimethylammonium chloride (75%) 8.0 5. Cistanche aromatic compound fraction 0.1 6. Quench Acid 0.05 7. Perfume Proper amount 8. Add purified water to make 100 [Production Method] Dissolve components 1 to 8 at 60 ° C, stir and cool to 30 ° C to rinse.

[0044]

INDUSTRIAL APPLICABILITY The hair-growing agent of the present invention has an excellent hair-growing effect and is effective for many alopecia including androgenetic alopecia and senile alopecia. Also, the testosterone of the present invention
-5α-reductase inhibitor is an excellent testosterone-5
Since it has an α-reductase inhibitory effect, it can be used as a hair restorer, acne remedy, and the like.

[0045]

EXPERIMENTAL EXAMPLE Next, an experimental example will be given in order to explain the effect of the present invention in detail. Experimental Example-1 Testosterone-5α-reductase activity inhibition test The testosterone-5α-reductase was extracted from the liver of an SD male rat (7 weeks old) and measured under the following reaction system conditions. Testosterone (final concentration 187.7μ
M) was dissolved with 10 drops of propylene glycol and then Tris-
Add 5 ml of hydrochloric acid buffer (pH 7.2), then sample and NADPH
5 mg and 2 ml of testosterone-5α-reductase were sequentially added, and the mixture was reacted at 37 ° C for 30 minutes. After the reaction, methylene chloride is added to stop the reaction, and the whole is extracted with 50 ml of methylene chloride. Then, the methylene chloride layer was distilled off under reduced pressure,
The reaction amount was measured by gas chromatography. (Conditions of gas chromatography: column OV-17 2m; column temperature 250 ° C; detector FID) Inhibition rate: The sample without addition was used as a control, and the reaction rate of the control was regarded as 100% (inhibition rate 0%), The reaction rate including the sample is calculated to obtain the inhibition rate. The formula is as follows. a: peak area of testosterone (control) b: peak area of dehydrotestosterone and androstanediol (control) a ': peak area of testosterone (sample addition) b': peak area of dehydrotestosterone and androstanediol (sample addition) In addition, since dehydrotestosterone is further metabolized to produce androstanediol, testosterone-
The peak area (amount) of the 5α-reductase metabolite was also included (calculated) in the calculation including androstanediol.
The results are summarized in Table 1. Margin below

[0046]

[Table 1]

Experimental Example-2 Hair Growth Effect on Mice The back hairs of 3-week-old ICR male mice were carefully shaved and shaved so as not to damage the skin.
One group of animals, 80% ethanol solution containing 2% of extract or aromatic compound fraction in one group, and 80% ethanol solution as control in another group twice a day About 0.5 ml each was applied. The judgment is made by measuring the area where regenerated hair is observed in the shaving part,
The regeneration rate was calculated according to the following formula.

[0048]

[Table 2]

[0049]

[Table 3] Margin below

[0050]

[Table 4]

Tables 2, 3 and 4 show the results of obtaining the regeneration rate in each group on the 23rd, 25th, 27th, 28th, 29th and 30th days after the start of application of the sample. As shown in Fig. 5, the extract of Chochogi, Chardella, and Cistanche salsa and the aromatic compound fractions significantly accelerated hair regrowth and showed a remarkable hair growth promoting effect when compared with the control.

Experimental Example-3 Hair Growth Effect on Human To 15 men suffering from hair loss, a hair tonic (choline extract) (preparation example-1) and an aromatic compound fraction (preparation example-2) were added respectively. Example-2, Example-14)
Was applied once daily for 3 months, the former was effective for 6 people, slightly effective for 6 people, and the latter was effective for 6 people, slightly effective for 7 people. And no abnormality was found on the skin. In addition, a Chamesou extract (Production Example-5), an aromatic compound fraction (Production Example-4), a salmonella extract (Production Example-7), and an aromatic compound fraction (Production Example-8) were added, respectively. Hair tonic (Example-6, Example-18, Example-10,
Example-22) was also subjected to a usage test in the same manner.
An excellent hair-growth effect was seen.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A61K 35/78 AED A61K 35/78 AEDC

Claims (4)

[Claims] 1. A hair restorer containing one or more kinds of extracts selected from peanut perilla, syringa, and cholorgi. 2. A hair restorer containing an aromatic compound fraction of one or more kinds of extracts selected from peanut perilla, syringa, and cholorgi. 3. A testosterone-5α-reductase inhibitor, which comprises one or more kinds of extracts selected from peanut perilla, syringa, and cholorgi. 4. Testosterone-5, which contains an aromatic compound fraction of one or more kinds of extracts selected from peanut perilla, pearl syrup, and cholorgi.
α-reductase inhibitor.