JPH08301322A - Lid for sealing the opening - Google Patents

Abstract

(57) [Summary] [Purpose] When the chip is pushed up with the container opening sealed, the resistance when inserting and withdrawing is small, making it easy to use and highly compatible with automatic sampling equipment. A lid for sealing a part is provided. The lid of the present invention is made of a resin film, and the film has a non-linear half cut capable of forming a chip insertion opening having a two-dimensional expansion, and the half cut portion is a container opening portion. Has a size that does not protrude from the inner periphery of the film, and the half cut has a strength such that when the chip is pierced into the film, the chip ruptures by a force smaller than the force required for the chip to pierce and penetrate the film. are doing.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a lid for sealing an opening of a bottomed cylindrical container such as a blood dispensing tube so that a specimen such as blood for analysis, which is the content, can be collected. More particularly, the present invention relates to a lid for sealing an opening, which facilitates insertion and removal of a chip when collecting a sample.

[0002]

2. Description of the Related Art Blood tests are widely performed in hospitals, test centers and the like. This is because it is possible to understand the human body condition such as the blood type, white blood cell amount, cholesterol amount, blood glucose level, etc. by the blood test, and it is possible to judge the human health condition from these values. is there.
In addition, it is possible to know whether or not the person is infected with a pathogenic bacterium or virus that causes diseases such as hepatitis and AIDS by a blood test.

In the case of performing such a blood test, the collected blood is divided into aliquots by a predetermined amount corresponding to the test item, and different tests are performed on the blood divided into the aliquots. It is common.

Dispensing pipes used in such inspections are made of glass or plastic, and in recent years, plastic pipes are often used. The dispensing pipes have a diameter of about 10 mm and a deep depth. There are various sizes and shapes including a test tube-like container having a size of about 80 mm.

Generally, blood collected from a patient is divided into the above-mentioned dispensing tubes. Then, in the opening of the dispensing tube where the blood was divided, put a resin lid of a size that can be fitted into the opening of the dispensing tube molded by a method such as injection molding, and after transferring to the inspection department, The lid is removed, and a hollow needle-shaped sample collection device called a chip is inserted into the blood in the dispensing tube, and a required amount of blood is taken up for testing. Humans may perform the entire inspection process,
Recently, many analyzers that automatically perform the process of sucking blood by a chip and subsequent processes have been used.

By the way, the present inventor has previously used a resin film (for example, uniaxially stretched PP) that can penetrate and penetrate a hollow needle-shaped body as an alternative to a lid body that is used by fitting.
(Japanese Patent Application No. 7-5421) has been proposed (Japanese Patent Application No. 7-5421) in which a film-like cover for sealing an opening is formed by laminating an easy-peel heat-sealing layer on one surface. This film-shaped opening sealing lid is different from the lid used by fitting,
The contents do not leak even if the container falls over, so the sample can be taken out by piercing the chip without removing the lid, and it is also possible to easily remove the lid and take out the whole sample, Moreover, it is inexpensive even if it is disposable.

However, in order to make the above film-like lid easier to use, the piercing resistance of the chip should be further reduced. In particular, in order to improve the adaptability to the automatic sampling device, it is necessary to improve the sticking property of the chip. That is, when the chip is pierced into the lid body by the automatic sampling device and then pierced deep into the container, the sensor of the device detects the piercing resistance of the lid body added to the chip, and the chip does not enter the predetermined opening. The machine may be stopped by mistakenly recognizing that the smooth sampling may be hindered.

Further, when the chip pierced by the film-shaped lid is pulled out, pull-out resistance of the lid is added to the chip, so that the lid that seals the opening with the chip and the sealed sample collection There is also a problem that the container for use is lifted. Therefore, it is desirable that not only the chip stab resistance but also the pullout resistance be as small as possible.

[0009]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and is a film-like lid used for a specimen collecting container such as a blood dispensing tube, which has a puncture resistance. It is an object of the present invention to provide a lid for sealing an opening, which has a low (insertion resistance) and a pulling resistance and is easy to use and has high compatibility with an automatic sampling device.

[0010]

In order to achieve the above object, in the present invention, an opening sealing lid is (1) an opening sealing lid made of a resin film, comprising: ) The resin film contains a circular shape or a non-linear half cut having a start point and an end point, and (3) a region surrounded by the line of the circular half cut or the non-linear half. A region surrounded by a cut line and a virtual straight line connecting the start point and the end point has a size that does not protrude from a region surrounded by the inner circumference of the opening to be sealed, (4)
The half-cut is any position within a region surrounded by the line of the circular-shaped half-cut or a region surrounded by the non-linear half-cut line and a virtual straight line connecting the start point and the end point. When the chip is pierced, the chip has such strength that it breaks with a force smaller than the force required for piercing and penetrating the resin film.

Preferably, an area surrounded by the half-cut line of the circular shape or an area surrounded by the non-linear half-cut line and a virtual straight line connecting the start point and the end point, The chip has the same shape and size as the cross section at the height of the opening of the chip that has entered the opening to be sealed and reached the deepest entry position, or the cross section does not protrude. Configured to have

As another preferred limitation, the resin film is a synthetic resin film that curls with the sealing surface side facing inward. As still another preferred limitation, the resin film is a single layer or a composite film composed of a rigid plastic film or having a rigid plastic film layer, and the rigid plastic film forming the single layer or the composite film is the rigid plastic film. When a 25 mm wide test piece made of a plastic film is folded into a loop with a diameter of 20 mm, this is 10 mm.
The load required for crushing to the width was 50 mg or more.

[0013]

The opening sealing lid of the present invention is made of a synthetic resin film and has a circular shape (for example, a circle, a triangle, etc.) or a non-linear shape having a start point and an end point (for example, an arc curve, a polygonal line, etc.). Since the half cut is included, the chip insertion opening having a two-dimensional spread can be formed by breaking the half cut.

Further, a region surrounded by the circle-shaped half-cut line or a region surrounded by the non-linear half-cut line and a virtual straight line connecting the start point and the end point (hereinafter referred to as "half-cut portion"). Has a size that does not protrude from the region surrounded by the inner circumference of the container opening to be sealed, and therefore, when sealing the container opening with the lid of the present invention. The half cut can be sealed in a state in which the half cut is located above the container opening and does not protrude from the inner circumference of the opening.

Further, the half-cut provided on the lid of the present invention is such that, when the tip is pushed to any position in the half-cut portion, the tip pierces and penetrates the resin film which is the main body of the lid. It has the strength to break with a force smaller than the required force.

Therefore, using the lid of the present invention, the container opening is sealed with the half-cut portion of the lid just above the container opening and not protruding from the inner circumference of the opening.
Then, when the tip is pierced at any position within the half-cut portion at the tip of the tip, a large tip insertion opening having a two-dimensional spread is formed before the tip pierces the lid and penetrates, Low resistance when inserting the chip.

In the present invention, preferably, the half-cut portion has the same shape as the cross-section at the height of the container opening of the chip in a state where it reaches the deepest entry position of the container to be sealed. -The size should be such that the cross section does not protrude.

When the half-cut portion is made sufficiently large in this way, when the tip is pushed into the lid of the present invention, the half-cut is caused by the tapering tip that is entering the container, and the half-cut is the container opening of the tip. As it breaks to a size equal to or larger than the cross-section at the height of the part, the insertion resistance applied to the chip from the lid becomes smaller and smaller.

When the half cut portion is made sufficiently large in this way, the resistance (resistance during extraction) applied to the chip from the lid when the chip is pulled out from the container is also very small. That is, when the area is made sufficiently large, the breakage of the half cut progresses and the tip insertion opening expands as the tip enters, as described above,
The force of the lid that pushes the tip to be pulled out laterally is usually only a weak force exerted by a highly mobile fragment. Even if the tip entry position is displaced from the center of the opening and is located along the half-cut line, the strong force that the half-cut cut surface pushes the side surface of the tip is only applied from one direction. . Therefore, the resistance at the time of extraction does not increase as the lid or container is lifted.

In the present invention, when a resin film that curls with the sealing surface side facing inward is used as the resin film that is the main body of the lid body, the fractured end of the half-cut is in a direction that does not deviate from the chip entry direction. Warping, and moreover,
Since the movable fragment that grows as the chip moves in will curl in a direction that does not oppose the direction in which the chip moves in, the force of the lid body that pushes the inserted chip laterally becomes even smaller.

Therefore, when such a resin film is used, the resistance when the chip is inserted and the resistance when the chip is pulled out can be further reduced. In the present invention, when the resin film which is the main body of the lid is a single layer or a composite film having a rigid plastic film having a strength of at least a certain test value as described above, the opening is sealed. When the tip is pushed against the stopped lid, the lid is difficult to stretch, so the pressing force of the tip is concentrated on the half-cut portion without being absorbed by the lid. Therefore, the breakability of the half cut is improved, and the resistance when the chip is inserted can be reduced.

[0022]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in more detail below with reference to embodiments, but before that, the contents of the drawings will be described first.

FIG. 1A shows an example (10) of the lid of the present invention.
FIG. 1B is a plan view showing 1), and FIG. 1B is a cross-sectional view of the same lid. The lid 101 is a single-layer resin film 1
The adhesive layer 15 is laminated on the sealing surface side, and the circular half cut 2 having a circular shape is put on the surface opposite to the sealing surface. The area surrounded by the line of the circular half cut 2, that is, the half cut portion 6
Has a size which does not protrude from the inner circumference of the container opening to be sealed, which is indicated by an imaginary line 8, and which has reached the deepest entry position in the container indicated by an imaginary line 7. The cross section of the chip at the height of the container opening has a size that does not protrude. And the half cut 2 is the half cut portion 6
When the chip is struck to any position inside, the chip has a strength to be broken by a force smaller than a force necessary for piercing and penetrating the resin film 1, and a chip insertion opening can be formed. it can.

FIG. 2 is a perspective view showing a state in which the opening of the container is sealed by the lid 101 of FIG. When the container opening is sealed using the lid of the present invention, the half cut portion 6 of the lid is thus positioned just above the container opening and does not protrude from the inner circumference of the opening. Is sealed.

FIGS. 3A to 3D show a lid 101 of FIG.
It is explanatory drawing which shows a mode that it fracture | ruptures. In FIG. 3 (a), the tip 9 descends onto the container opening sealed by the lid 101 of the present invention, and in FIG. 3 (b), the tip of the tip 9 reaches an arbitrary position within the half cut portion and the lid is closed. Start pushing the body 101. At this time, the lid body is slightly stretched by the force of the tip. Next, in FIG. 3 (c), as the tip 9 descends, the force with which the tip pushes the lid gradually increases, but before the tip becomes stronger enough to pierce and penetrate the lid, half force is applied. The cut begins to break. Then, a chip insertion opening having a two-dimensional spread is formed.

Further, in FIG. 3D, the tip 9 enters deep inside the container, the tip of the tip reaches the inside of the specimen, and sucks up the specimen 11. Half-cut portion 6 of lid 101
Is a cross section taken at the height of the container opening of the chip in the state where it reaches the deepest entry position in the container, that is, an AA cross section in FIG. 3D, and an imaginary line in FIG. The cross section indicated by 7 has a size that does not protrude. For this reason,
When the tapered tip enters, the tip insertion opening is gradually expanded, and the half cut 2 is larger than the cross section of the tip at the height of the container opening. It gradually breaks. Therefore, the tip insertion opening is enlarged by the entry of the tip. Further, the force of the lid body that pushes the tip 9 laterally when pulling out the tip that has reached the deepest part in the container is usually only a weak force applied from the highly movable fragment 14.

FIG. 4A shows another example (1) of the lid of the present invention.
02), and FIG. 4B is a cross-sectional view of the same lid. The lid 102 is made of a resin film 1 having a multi-layer structure, a heat-sealing resin layer is laminated on the sealing surface side surface, and an adhesive layer is not laminated. The half cut 2 is a U-shaped member that belongs to a non-linear linear shape having a start point and an end point, and is placed on the sealing surface side surface of the lid body. The area surrounded by the line of the U-shaped half-cut 2 and the virtual straight line 5 connecting the start point 3 to the end point 4, that is, the half-cut portion 6, is the container opening portion to be sealed indicated by the virtual line 8. The size is such that it does not protrude from the inner circumference, and the cross-section does not protrude at the height of the container opening of the chip in the state where it reaches the deepest entry position in the container indicated by imaginary line 7. have. Then, the half cut 2 has a strength such that when the chip is pushed to any position in the half cut portion 6, the chip is broken by a force smaller than a force required for the chip to pierce and penetrate the resin film 1. Therefore, the tip insertion port can be formed.

FIG. 5 shows another example (10) of the lid of the present invention.
It is explanatory drawing which shows 3). The lid 103 uses a resin film that curls with the sealing surface side as the inner side, as the resin film that is the main body of the lid, so that the breaking end 12 of the half cut does not deviate from the direction in which the chip 9 enters. On the other hand, the movable fragment 14 that grows in size as the chip enters advances curls in a direction that does not counteract the approach direction of the chip 9. Therefore, the force of the lid body that pushes the inserted tip in the lateral direction is further reduced, and the resistance when the tip is inserted and the resistance when the tip is pulled out are further reduced.

FIGS. 6A to 6C are explanatory views showing another example (104) of the lid of the present invention. This lid 104
Uses a rigid single-layer plastic film or a composite film formed by laminating rigid plastic layers as the resin film that is the main body of the lid. In FIG. 6 (a), the chip 9 descends onto the container opening sealed by the lid 104, and in FIG. 6 (b), the tip of the chip 9 reaches an arbitrary position within the half-cut portion to remove the lid 104. Start pushing. At this time, since the lid body 104 has a hard plastic layer, the lid body 104 hardly stretches even if it is pushed by the tip of the chip. Then, in FIG. 6 (c), as the tip 9 descends, the force with which the tip pushes the lid gradually becomes stronger, but this force is not absorbed by the lid that hardly extends and the half cut portion is not absorbed. , Which results in the half-cut breaking more easily.

The present invention will be described in detail below with reference to the above-mentioned drawings. The lid of the present invention is made of a resin film,
The resin film contains a non-linear half cut that can form a chip insertion opening with a two-dimensional spread,
The half cut portion has a size that does not protrude from the inner circumference of the container opening, and the half cut is smaller than the force required for the chip to pierce and penetrate the film when the chip is pierced into the film. It has the strength to break by force.

The resin film 1 which is the main body of the lid is shown in FIG.
It may be a single layer film like the lid 101 shown in FIG. 4 or a composite film like the lid 102 shown in FIG. The thickness of the resin film is not particularly limited,
Usually, it is about 10 to 150 μm. The material of the resin film is not particularly limited, and examples thereof include polyethylene terephthalate (PET), polyethylene naphthalate (PEN),
Polyester resins such as polybutylene terephthalate (PBT), high density polyethylene (HDPE), medium density polyethylene (MDPE), low density polyethylene (LDP)
E), linear low density polyethylene (LLDPE), polypropylene (PP), cyclic olefin copolymer (CO
C) and other olefin resins, polystyrene (P
S), polycarbonate (PC), nylon (Ny),
Examples thereof include polyphenylene sulfone (PPS) and polyvinyl chloride (PVC).

As the resin film, the lid 1 shown in FIG. 5 is used.
It is preferable to use a resin film that curls with the sealing surface side facing inward as shown in No. 03. As a method for producing such a curling film, it is possible to use a film having different heat shrinkage rates.
Examples thereof include a method of laminating different kinds of synthetic resins, a method of laminating two resin films in a state where a strong tension is applied to one film, and the like. For example, when polyester and polyolefin are laminated by an extrusion coating method or a coextrusion coating method, a polyolefin usually has a higher heat shrinkage rate than polyester, so that a film that curls with the polyolefin layer side inside can be formed. In addition, when a stretched polypropylene film (OPP) and an unstretched polypropylene film (CPP) are dry laminated by applying a strong tension to CPP, a film that curls with the CPP layer side inside is formed.

Further, as the resin film, it is also preferable to use a single layer film made of a rigid plastic film or a composite film formed by laminating rigid plastic layers like the lid 104 shown in FIG. When the latter composite film is used, the breakability of the half cut can be further improved by inserting a half cut that penetrates the rigid plastic layer into the composite film.

Here, the rigid plastic film or rigid plastic layer refers to a material exhibiting a strain (rigidity) strength of a certain value or more by the loop stiffness test described below. That is, in the loop stiffness test according to the present invention, as shown in FIGS. 8 (a) to 8 (d), the test piece film 50 having a width (l ₁ ) of 25 mm was 62.
Two clamps 51, 51 spaced 8 mm apart (l ₂ ).
And clamps the two clamps close to each other to close the gap, and the test piece forms a loop having a diameter (l ₃ ) of 20 mm. Then, the weight applied to the indenter 52 when the loop is pressed vertically from the apex by the indenter 52 and contracted to a width (l ₄ ) of 10 mm is taken as a loop stiffness test test value. The stiff plastic film or stiff plastic layer of the present invention comprises:
This test value is preferably 50 mg or more. As an apparatus for performing this test, for example,
A loop stiffener tester manufactured by Toyo Seiki Co., Ltd. can be exemplified.

Examples of the material for forming the rigid plastic film or rigid plastic layer as described above include polyethylene terephthalate (PET), polyethylene naphthalate (PEN), polybutylene terephthalate (P).
Examples thereof include BT), cyclic olefin copolymer (COC), polystyrene (PS), polycarbonate (PC), polyphenylene sulfone (PPS), and polyvinyl chloride (PVC).

The half cut 2 is a lid 101 shown in FIG.
You can put it on the surface opposite to the sealing surface like
You may put in a sealing surface like the lid body 102 shown in FIG. When the resin film is a composite film, it may be included in the intermediate layer.

The shape of the half cut 2 is not particularly limited as long as the chip insertion opening having a two-dimensional expansion is formed by the break of the half cut, and may be a circular shape as shown in FIG. However, it may be a non-linear linear shape having a start point and an end point as shown in FIG. In the present invention, the circular shape means a two-dimensional shape drawn by a single line without branching. As such a circular shape, for example, in addition to the circle shown in FIG. 1A, a triangle, a quadrangle, a star shape and the like can be exemplified. On the other hand, examples of the non-linear linear shape having the start point and the end point include the U-shape shown in FIG. 4A, an arc-shaped curve, a polygonal line and the like. However, since there are variations in the tip entry position into the container opening, the tip end is not always pushed to the center of the half-cut portion 6, and it is preferable that the tip insertion opening be formed as large as possible. The half cut is preferably circular.

In the present invention, the half-cut portion 6 means the area surrounded by the line of the half-cut 2 as shown in FIG. 1 (a) when the half-cut has a circular shape, and the half-cut is the starting point. In the case of a non-linear linear shape having an end point, the line of the half cut 2 and the starting point 3-
It means a region surrounded by a virtual straight line 5 connecting the end points 4. The half cut portion 6 needs to have a size that does not protrude from the inner circumference of the container opening to be sealed, which is indicated by an imaginary line 8. If the half-cut portion 6 is large enough to protrude from the inner circumference of the container opening, the periphery of the half-cut of the lid body will adhere to the wall surface of the container, and the half-cut will not break.

The half-cut portion 6 has the same shape and size as the cross-section at the height of the opening of the chip in the state of entering the container opening and reaching the deepest entry position, or the cross-section. It is preferable that the surface has a size that does not protrude. The cross section of the chip is A in FIG.
FIG. 1A is a cross-sectional view taken along the line A in FIG.
Also, in FIG. 4A, it is shown by a virtual line 7. By making the half-cut portion 6 sufficiently large in this way, the resistance when the chip is inserted and the resistance when the chip is pulled out can be made smaller.

The half-cut 2 has a force smaller than the force required for the chip to pierce and penetrate the resin film 1 which is the main body of the lid when the chip is pushed to any position in the half-cut portion 6. It is necessary to break by. The film thickness of the half-cut portion is a major factor controlling the breaking strength. This thickness should be set in consideration of the material of the resin film and the force applied to the lid from the chip trying to enter the container, but it is usually 1 to 35 μm, preferably 3 to 30 μm.
Set to the range of. If this thickness is less than 1 μm, pinholes may occur, while if it exceeds 35 μm, the chip may bend when it is struck.

Examples of the method of inserting the half cut 2 into the resin film 1 include a method of inserting with a metal blade or the like, and a method of heating and evaporating a specific synthetic resin layer with a laser or the like to insert. The former is suitable when the resin film is relatively thick or made of a single material, and the latter is suitable when the resin film is thin and a plurality of synthetic resin layers having different laser absorption wavelengths are laminated. ing. In the latter case, it is necessary to irradiate a laser having a wavelength that can be absorbed by the resin layer to be half-cut.
For example, for polyethylene terephthalate (PET), polyvinylidene chloride (PVDC), nylon (Ny), etc., 10.6 μm (943 cm ⁻¹ ) is suitable,
A CO ₂ laser is generally used to emit this wavelength.

As a method of fixing the lid of the present invention to the opening to be sealed, for example, a method of physically fixing with an adhesive tape or a method of adhering with a pressure sensitive adhesive or a heat sealing material can be exemplified. However, the latter is preferable from the viewpoint of productivity and cost. Therefore, the sealing surface of the lid of the present invention has a structure shown in FIG.
As shown in (b), the adhesive layer 15 may be laminated if necessary. Also, instead of laminating the adhesive layer 15,
As shown in FIG. 4B, a composite film having a heat-sealing synthetic resin layer on the sealing surface side may be used as the resin film 1. It should be noted that it is preferable to adopt an adhesive layer or a heat sealable synthetic resin layer having an easy peeling property. When these layers have an easy peel property, it becomes easy to manually peel off the lid material from the container opening and sample the contents.

The pressure-sensitive adhesive depends on the material of the resin film or the container to be sealed, but is, for example, chloroprene-based, polyisobutylene-based, polyisoprene-based, polyacrylic acid ester-based, polyvinyl ether-based, butadiene-based, styrene. Butadiene rubber-based, butyl rubber-based, natural rubber, recycled rubber and the like can be used.

The heat-sealant having an easy peel property depends on the material of the resin film and the container to be sealed, but is, for example, vinyl acetate type, hydrochloric acid / vinyl acetate type, vinyl chloride type, acrylic type (PMA, MMA, EMA, E
AA), polyester-based, EVA-based, PVA-based, polyolefin-based, modified polyolefin-based (maleic acid-modified polyethylene, chlorinated polypropylene, etc.), urethane-based, urethane-modified polyester-based, partially urethane-modified polyester-based, polyether-based, A modified ether type polyester system or the like can be used.

The above-mentioned pressure-sensitive adhesives and heat-sealing agents can be used in various forms, for example, water-based, solvent-based, hot melt type, emulsion type and the like. The easy-peel heat sealing agent usually has a softening temperature of 80 ° C. or higher and an adhesive strength of 50 to 300 gf / 15.
The composition and the like are adjusted so as to be mm. Further, a tackifier such as petroleum resin may be blended in order to adjust the heat sealability.

The easy-peel heat-sealing agent used is usually selected in accordance with the material constituting the resin film to which it is applied and the material adhered to this material. Therefore, when the container is formed of plastic such as polypropylene (PP) or polyethylene (PE) or glass, a material that can adhere these materials to the lid is selected. For example, when an α-olefin (co) polymer such as polyethylene or polypropylene is used as the resin film as the base material, MC-3800 (manufactured by Mitsubishi Petrochemical Co., Ltd.) is used as this easy peel heat sealant. ), AD-345 (Toyo Motor Co., Ltd.)
It is preferable to use an olefin-based easy-peel heat sealant such as PEG, and when a resin having a polar group such as polyethylene terephthalate is used as the base material, for example, PES-330SK (Toa Synthetic Chemical Industry Co., Ltd. It is preferable to use a polyester-based easy peel heat sealant such as)).

The coating amount of the easy peel heat seal layer is usually 1 to 15 g / m ² , preferably ^{2 to} 10 g / m ² .
Within the range of m ² . This easy peel heat seal layer can be formed by applying the above easy peel heat seal agent to the sealing surface side of the resin film by a known coating method such as gravure reverse coater or gravure coater. it can.

Further, the lid of the present invention may be provided with a printing layer for describing the usage method and notes. When the container opening is sealed using the lid of the present invention, as shown in FIG. 2, the half cut portion 6 of the lid is located right above the container opening and does not protrude from the inner circumference of the opening. The opening is sealed in this state. Such a sealing operation may be performed manually or by an automatic machine. However, since the lid body of the present invention has high compatibility with an automatic sampling device, it is preferable to perform a series of operations from sealing operation to sampling consistently by an automatic machine.

The lid of the present invention is, for example, an actual fair 4-36.
It can be used as a sealing film used in a test tube opening sealing device as described in Japanese Patent No. 25. With reference to FIG. 7, the opening-sealing lid 105 of the present invention is usually wound in a roll in the form of a film. Then, first, the film pull-out device 29 of the film tensioning mechanism 25 is operated to operate the film feeding device 28.
The end portion of the film-shaped lid 105 is picked up and pulled out.
At this time, the sample collecting container 10 specified as the dispensing tube in FIG. 7 is being conveyed along the conveying path 22 and is stopped at the first position. The pulled-out film-like lid 105 of the present invention is horizontally stretched on the opening 10a of the stopped sample collecting container 10.

Next, with the pressing plate 31 and the receiving plate 32,
The film-like lid body 105 of the present invention is sandwiched from both upper and lower surfaces. At this time, the film-like lid 105 of the present invention is laterally cut by the cutting blade 35 attached to the pressing plate 31 in the vicinity of the supply port of the film supply device 28. The film-shaped lid 105 cut in this manner is in a state in which the peripheral portion thereof is held by the film contact mechanism 30.

Next, the film contact mechanism 30 descends with the peripheral portion of the cut lid 105 held. When the film contact mechanism 30 descends to a predetermined level, the central portion of the lid body 105 contacts the opening 10a of the sample collecting container. After the lid 105 comes into contact with the opening 10 a in this way, the lid 105 is released from the pressing plate 31 and the receiving plate 32. At the same time, the cylinder 44, which is interlocked with the cylinder 42 of the film coating mechanism 40 via the piston shaft 43, descends and fits into the upper end of the sample collecting container 10. The peripheral portion of the lid body 105 is narrowed down by the cylindrical body 44, and the lid body 105 is placed along the outer peripheral surface of the specimen collecting container 10. In the state in which the opening 10a is covered with the film piece that is the lid 105 of the present invention as described above, the sample collecting container 10 advances in the transport path and is provided with a film welding mechanism (not shown). Stop at stop position 2. Sample collection container 10 stopped at the second position
The film welding mechanism descends from above and heats and presses the lid body 105 onto the peripheral portion of the opening 10a of the specimen collecting container.

In this way, the container for sample collection having the lid of the present invention welded to the opening is sent to the analyzer equipped with the chip, the chip is pushed into the lid, the chip is inserted into the container, and the container is The specimens inside are collected and analyzed.

Next, an experimental example will be shown. Experimental Example 1 A stretched polypropylene (OPP) film having a thickness of 30 μm was used as a resin film, and a metal blade having a diameter of 9 mm was used to form a 9 m diameter film on the surface of the film opposite to the sealing surface.
A m-shaped half cut with a depth of 15 μm was placed, and a PVA-based heat-sealing agent was applied to the sealing surface side of the film by a gravure coating method (application amount: 4 g / m ² ) to produce a lid of the present invention.

Next, the lid is placed in the opening of a polypropylene dispensing tube (inner diameter 10 mm, depth 80 mm) containing 1 ml of blood, and the sealing temperature is 140 ° C. and the sealing time is 1
Second, heat sealing was performed under the conditions of a sealing pressure of 3 kg / cm ² .

After sealing, the dispensing tube was held in the hand and shaken for a few seconds, and then laid aside for 10 seconds, but no blood leaked. In addition, when a tip with a diameter of 1 mm and a maximum diameter of 4 mm in the range that passes through the dispensing tube opening when the tip of the tip penetrates deepest into the dispensing tube is pushed into the half-cut portion of the lid, The half cut was broken. further,
The dispensing tube did not lift even when the tip was removed after sucking the blood in the dispensing tube with the tip.

Table 1 summarizes the material of the resin film, the thickness thereof, the leakage of blood when laid on its side, the puncture property, and the presence or absence of lifting of the dispensing tube. Experimental Example 2 In Experimental Example 1, a thickness of 30 was used instead of the OPP film.
Using a polyethylene polyethylene terephthalate (OPET) film with a thickness of μm, apply a polyester heat seal agent instead of the PVA heat seal agent (coating amount 5 g / m ² ).
A lid of the present invention was manufactured and tested in the same manner except that the above was performed. The results are shown in Table 1.

Experimental Example 3 A high impact type polystyrene (HIPS) sheet having a thickness of 100 μm was used as a resin film, and a 9 mm diameter circular and 90 μm deep was formed on the surface of the film opposite to the sealing surface by a metal blade having a diameter of 9 mm. Half-cut, and then apply a butadiene-based adhesive on the sealing surface side of the film by the gravure coating method (application amount 8 g /
m ² ) to produce the lid of the present invention. Next, 1 ml of blood
Place the above lid on the opening of a polypropylene dispensing tube (inner diameter 10 mm, depth 80 mm) containing
It was crimped at kg / cm ² . Then, the test was conducted in the same manner as in Experimental Example 1. The results are shown in Table 1.

Experimental Example 4 In Experimental Example 1, a cyclic polyolefin copolymer (COC) and polyethylene (PE) were used instead of the OPP film.
Co-extrusion film (COC layer: 100 μm, PE
Layer: 10 μm) was used, and the same operation was performed except that a half cut was placed on the COC layer side. The results are shown in Table 1.

Experimental Example 5 As a resin film, a 12 μm thick stretched polyethylene terephthalate (OPET) film was coated with a polyester anchor coating agent (AC) at a rate of 1 g / m ² , and then polyethylene (PE) was extrusion coated. Obtained film (OPET layer: 12 μm, AC layer: 1 μm, P
E layer: 13 μm) was used. 10.6 on this film
When the donut shape was irradiated with CO ₂ laser light having a wavelength of μm (943 cm ² ), only the OPET layer was evaporated and a circular half cut with an inner diameter of 9 mm, a width of 0.3 mm and a depth of 12 μm was formed. After inserting the half cut, the PE layer side was coated with the heat seal layer by the same operation as in Experimental Example 1, and the test was conducted. The results are shown in Table 1.

Experimental Example 6 In Experimental Example 5, a thickness of 1 was used instead of the extruded film.
2 μm stretched polyethylene terephthalate (OPET)
A film (OPET layer: 12 μm, AC layer: 1 μm, obtained by dry-laminating a polypropylene (PP) film having a thickness of 15 μm after applying a polyester-based anchor coating agent (AC) at a rate of 1 g / m ^{2 on} the film. P
A lid of the present invention was produced and tested in the same manner except that P layer: 15 μm) was used. The results are shown in Table 1.

Experimental Example 7 As a resin film, OPET / AC used in Experimental Example 5 was used.
/ PE Film obtained by applying polyester anchor coating agent (AC) to the OPET side of the extruded film at a rate of 1 g / m ² and then dry laminating a high impact type polystyrene (HIPS) sheet having a thickness of 100 μm (HIPS layer: 100 μm, AC layer: 1 μm
m, OPET layer: 12 μm, AC layer: 1 μm, PE layer:
13 μm) was used to make a circular cut with a diameter of 9 mm and a depth of 110 μm on the surface of the HIPS layer side of this film by a metal blade with a diameter of 9 mm, and a PVA heat seal agent was applied to the PE layer side by a gravure coating method. (Coating amount: 4 g / m ² ) to produce the lid of the present invention.
This lid was heat-sealed to the opening of the dispensing tube, and thereafter, the same test as in Experimental Example 1 was conducted. The results are shown in Table 1.

Comparative Example 1 A lid was manufactured and tested in the same manner as in Experimental Example 1 except that the half cut was not provided. In the case of this lid, the tip pierced and penetrated, but the dispensing tube was also lifted up when the tip was removed. The results are shown in Table 1.

Comparative Example 2 A lid was manufactured and tested in the same manner as in Experimental Example 3 except that the half cut was not added. In the case of this lid, when the chip was pushed up, the tip of the chip was bent and the chip could not be pierced. The results are shown in Table 1.

Comparative Example 3 A lid was manufactured and tested in the same manner as in Experimental Example 5 except that the half cut was omitted. In the case of this lid, the tip pierced and penetrated, but the dispensing tube was also lifted up when the tip was removed. The results are shown in Table 1.

[0065]

[Table 1] Note 1… ○: Insertion or piercing of the chip is possible. ×: Insertion or piercing of the chip is impossible.

Note 2 ∘: The dispensing tube cannot be lifted. ×: The dispensing tube is lifted.

[0067]

When the chip is pushed into the opening of the container sealed with the lid of the present invention, the half cut is broken with a force smaller than the force required for the chip to pierce and penetrate the lid, resulting in a two-dimensional shape. A large chip insertion opening having a uniform spread is formed in the lid. Therefore, since the tip can be easily inserted and the sample can be sucked up without receiving excessive resistance during insertion into the container opening where the lid is not removed, labor for sampling can be saved. It is also possible to prevent misidentification of sensors in the automatic sampling device.

Furthermore, since the lid of the present invention has a small resistance during withdrawal, it is possible to prevent the container from being lifted when the chip is withdrawn, and it is possible to ensure a smooth sampling operation.

[Brief description of drawings]

FIG. 1 (a) is a plan view showing an example of a lid body of the present invention. FIG. 1B is a cross-sectional view of the same lid.

FIG. 2 is a perspective view showing a state in which the container opening is sealed by the lid of the present invention.

FIG. 3 is an explanatory diagram showing a state in which a half cut is broken and a chip enters a container. 3 (a) shows a state in which the tip is descending, FIG. 3 (b) shows a state in which the tip of the tip starts to push the lid, and FIG. 3 (c) shows a state in which the half cut starts to break, FIG. 3D shows a state in which the tip has reached the deepest entry position.

FIG. 4 (a) is a plan view showing another example of the lid body of the present invention. FIG.4 (b) is a cross-sectional view of the same lid.

FIG. 5 is an explanatory view showing another example of the lid body of the present invention.

FIG. 6 is an explanatory view showing another example of the lid body of the present invention.
FIG. 6A shows a state where the chip is descending.
FIG. 6B shows a state in which the tip of the chip starts to push the lid, and FIG. 6C shows a state in which the half cut starts to break.

FIG. 7 is a diagram showing an example of an apparatus for sealing the opening of a specimen collecting container using the lid of the present invention.

8A to 8D are explanatory views showing a series of operation procedures of a loop stiffness test.

[Explanation of symbols]

1 ... Resin film 2 ... Half cut 3 ... Start point 4 ... End point 5 ... Virtual line connecting start point and end point 6 ... Half cut part 7 ... Cross section at opening height of chip reaching deepest entry position 8 ... Container Inner circumference of opening 9 ... Chip 10 ... Specimen collecting container 11 ... Specimen 12 ... Breaking end 13 ... Fracture surface 14 ... Fragment 15 ... Adhesive layer 22 ... Conveying path 28 ... Film supply device 30 ... Film contact mechanism 31 ... Pressing plate 32 ... Receiving plate 35 ... Cutting blade 44 ... Cylindrical body 50 ... Test piece 51 ... Clamp 52 ... Indenter l1 ... Width of test piece l2 ... Distance between clamps l3 ... Loop diameter l4 ... When crushed Loop width

Claims (4)

[Claims] 1. A lid body for sealing an opening, which comprises (1) a resin film, and (2) the resin film has a circular shape or a non-linear half cut having a start point and an end point. (3) The area surrounded by the half-cut line of the circular shape or the area surrounded by the non-linear half-cut line and the virtual straight line connecting the start point and the end point,
(4) The half cut has a size that does not protrude from an area surrounded by the inner circumference of the opening to be sealed, and (4) the area surrounded by the line of the half-cut of the winding shape or the non-linear shape. When the chip is struck at any position within the area surrounded by the half-cut line and the virtual straight line connecting the start point and the end point, the force required for the chip to pierce and penetrate the resin film A lid for opening closure, which has a strength to be broken by a small force. 2. A region surrounded by the circular-shaped half-cut line or a region surrounded by the non-linear half-cut line and a virtual straight line connecting the start point and the end point is sealed. Has the same shape and size as the cross-section at the height of the opening of the chip in the state of entering the deepest entry position after entering from the opening, or the cross-section has a size that does not protrude. The opening sealing lid according to claim 1. 3. The opening sealing lid according to claim 1, wherein the resin film is a synthetic resin film that curls with the sealing surface side facing inward. 4. The resin film is a single layer or a composite film made of a rigid plastic film or having a rigid plastic film layer, and the rigid plastic film constituting the single layer or the composite film is the rigid plastic film. When a test piece with a width of 25 mm is bent into a loop with a diameter of 20 mm, the load required to crush it to a width of 10 mm is 50 mg.
The opening sealing lid according to claim 1, which is the above.