JPH08119829A - External medicine for skin - Google Patents

Abstract

PURPOSE: To provide an external medicince for skin which can prevent skin inflammation drying and shows excellent amelioration against xerosis or symptoms corresponding thereto, so called dry skin. CONSTITUTION: This external medicine for skin comprises (a) perilla oil and (b) one or more selected from glycyrrhizic acid, glycyrrhetinic acid, phosphoric acid, hydrogenated phospholipids, cholesterol and derivative therefrom and their salts, beefsteak plant extract, Huttaynia cordata extract, strawberry geranium extract, maltitol, sorbitol and mannitol.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin, and more particularly to dry skin which can prevent skin irritation, dryness, etc., and exhibits dry skin diseases and skin symptoms similar thereto. The present invention relates to a skin external preparation exhibiting excellent effects.

[0002]

2. Description of the Related Art Conventionally, allantoin is used as a medicinal component that has been used to prevent skin irritation, dryness, etc.
Aloe extract, placenta extract, ginseng extract, hyaluronic acid, collagen, amino acids and the like are known. However, a skin external preparation containing these drug components cannot obtain a sufficient effect, and development of a skin external preparation having more excellent action has been desired.

On the other hand, perilla oil contains a large amount of α-linolenic acid, which is one of the ω-3 polyunsaturated fatty acids, and when applied to the skin, it has the effect of moisturizing and preventing the skin from becoming bulky. Are known. Also, this α-linolenic acid is
It is metabolized in the body to eicosapentaenoic acid and docosahexaenoic acid. These ω-3 polyunsaturated fatty acids are currently found to have an anti-cancer effect and an effect of reducing the production of leukotrienes that cause allergic reactions,
It is getting attention.

[0004]

DISCLOSURE OF THE INVENTION The present inventors have focused on the above-mentioned action of perilla oil and blended it into a skin external preparation, particularly a skin external preparation having an improving effect on skin inflammation, dryness and the like. Tried. However, the effect of improving skin irritation, dryness, etc. when the sesame oil is blended alone is not sufficient, and due to the influence of other bases etc., the inherent effect of this may not be fully exerted. It was the reality.

Further, there is a limit to the action and effect when the perilla oil is blended at a high concentration for the purpose of obtaining a higher effect.
On the contrary, there is also a problem that due to the generation of the unique color and odor of these compounds themselves, there are restrictions on the amount of formulation, formulation, etc. in terms of products.

[0006]

In view of the above circumstances, the inventors of the present invention have conducted earnest studies to sufficiently bring out the action of perilla oil. As a result, they have found that, by combining these with a specific compound, excellent effects of improving skin inflammation, dryness and the like are exhibited stably and synergistically, and the present invention has been completed.

That is, the present invention provides the components (a) and (b)
Component (a) Perilla oil (b) Glycyrrhizic acid, glycyrrhetinic acid, phospholipids, hydrogenated phospholipids, cholesterol and its derivatives and salts thereof, perilla extract, Dokudami extract, Yukinoshita extract, maltitol, sorbitol, mannitol An external preparation for skin containing one or more selected from the following.

In the present invention, the sesame oil which is the component (a) that is essential is the sesame oil Perilla fru.
tescens Britton var. Japan
ica Hara and other homologous plants (Lamiaceae) extracted by a method usually used,
The method is not particularly limited. Further, it also includes a composition in which α-linolenic acid as a main component is further concentrated to increase the content, or an oil and fat composition prepared by mixing these other components.

The perilla oil may be blended as it is with the external preparation for skin of the present invention, or may be further refined by steam distillation, activated carbon treatment, acid clay treatment or the like.

The content of perilla oil in the cosmetic of the present invention is 0.0001 to 10% by weight (hereinafter simply referred to as "%"), and more preferably 0.01 to 5%.
If the content is less than 0.0001%, a sufficient effect may not be obtained, and if the content exceeds 10%, no further increase in the effect is seen, and rather, coloring and odor are generated. Also, depending on the dosage form, problems such as precipitation may occur on the product side.

On the other hand, the other essential component (b) in the present invention is glycyrrhizic acid, glycyrrhetinic acid,
One or more selected from phospholipids, hydrogenated phospholipids, cholesterol and its derivatives and salts thereof, perilla extract, dokudami extract, yukinoshita extract, maltitol, sorbitol, mannitol.

These components (b) are components that have been conventionally compounded in external preparations for skin, and the origin and acquisition method thereof are not particularly limited, and generally commercially available ones can be used.

Content of the above-mentioned specific components in the external preparation for skin of the present invention (as an extract is a dry solid form).
00001 to 10%, more preferably 0.001
~ 3%. The content of these specific components is 0.0000
If it is less than 1%, a sufficient effect may not be obtained, and if it exceeds 10%, no further increase in effect may be seen, which may adversely affect the formulation. .

Further, the external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, an aqueous component, a powder, a surfactant, which is used in ordinary external preparations for skin, within a range that does not impair the effects of the present invention.
Oil agents, humectants, alcohols, pH adjusters, preservatives, pigments, antioxidants, ultraviolet absorbers, thickeners, fragrances, cosmetic ingredients and the like can be appropriately added as necessary.

The external preparation for skin of the present invention comprises (a) component and (b)
In addition to cosmetics such as emulsions, creams, lotions, beauty essences, cleansing, packs, detergents, foundations, etc., they can be mixed with the ingredients and produced according to a conventional method, as well as dispersions, ointments, creams, liquids for external use. And the like, and quasi-drugs.

[0016]

EXAMPLES The present invention will be further described with reference to examples, but the present invention is not limited thereto.

Example 1 Emulsion An emulsion was prepared by the following formulation and production method. Each of the obtained emulsions was evaluated by a carrageen footpad edema inhibition test.

(Prescription)

[Table 1]

(Production Method) A. Ingredients (6), (8)-(12) and (16) are mixed by heating and kept at 70 ° C. B. Components (1) to (5), (7) and (13), (1
4) is heated and mixed, and kept at 70 ° C. C. The above B is added to the above A and mixed, (15) is added to uniformly emulsify, and the mixture is cooled to 30 ° C. to obtain an emulsion.

(Evaluation) Carrageenin footpad edema suppression test: 6 to 7 weeks old of Vista
1 group of 10 r-type male rats was subcutaneously injected into the rat hind footpad with a 1% carrageenin physiological saline solution as an inflammatory agent to cause edema. 2 hours after carrageenin injection and immediately after injection 1 ml each was applied, and the footpad volume was measured 4 hours after the injection of carrageenin, and the edema inhibition rate relative to the control group was determined.

Table 2 shows the results of the carrageenin footpad edema inhibition test.

[0022]

[Table 2]

As is clear from the results shown in Table 2, 1 to 4 of the products of the present invention in which perilla oil and dipotassium glycyrrhizinate, perilla extract, and Yukinoshita extract were used in combination were 1 to 5 of the comparative products in which they were blended alone. Compared with the above, it shows a remarkable edema inhibitory action and has an excellent anti-inflammatory effect.

Example 2 Emulsion An emulsion was prepared by the following formulation and production method. The obtained emulsions were evaluated by a rough skin improvement test.

(Prescription)

[Table 3]

(Production Method) A. The components (6), (8) to (10) and (14) are mixed by heating and kept at 70 ° C. B. Components (1) to (5), (7) and (11), (1
2) is mixed by heating and kept at 70 ° C. C. The above B is added to the above A and mixed, (13) is added to uniformly emulsify, and the emulsion is obtained by cooling to 30 ° C.

(Evaluation) Rough skin improvement test: A panel of 10 healthy persons aged 24 to 40 was used to photograph the skin condition before experimental rough skin was induced with a microscopic camera, and the score was calculated according to the following criteria. It was Experimental rough skin, ether on the flexion of the upper arm,
It was caused by treatment with a mixed solution of acetone (1: 1). Further, thereafter, the test emulsion was applied twice daily in the morning and at night for 7 days, and the skin condition score was obtained 3, 5 and 7 days after the induction of rough skin.

(Reference) Score 1 The skin groove is not clear, and many exfoliations of the keratin are observed. 2 The skin groove is slightly unclear, and exfoliation of the keratin is observed. 3 Defects are visible but shallow or unidirectional. 4 Skin groove is recognized and it is somewhat mesh-like. 5 Ridges arranged in a mesh pattern are recognized.

Table 4 shows the results of the rough skin improvement test.

[0030]

[Table 4]

As is clear from the results shown in Table 4, the products 5 and 6 of the present invention in which the perilla oil was used in combination with maltitol and hydrogenated soybean phospholipid did not contain the comparative products 6 to 8 in which each of them was blended alone, and these products Compared with Comparative product 9, it shows a remarkable effect of improving skin roughness, and it is understood that there is an excellent effect.

Example 3: Emulsion An emulsion was prepared by the following formulation and production method. The skin-cleansing effect of the obtained emulsion was evaluated.

(Prescription) Invention product 1 (as shown in Example 1) Invention product 6 (as shown in Example 2) Comparative product 1 (as shown in Example 1) Comparative product 2 (as shown in Example 1) Comparative product 3 (as shown in Example 1)

(Production method) As described in Example 1 or Example 2, respectively.

(Evaluation) Skin beautification test: A panel of 15 women aged 25 to 56, whose skin on the face was recognized to be dry skin, was tested twice daily in the morning and evening for 8 weeks, and an appropriate amount of test was conducted after washing the face. Instructed to apply the emulsion to the face. The effect of coating was evaluated according to the criteria below.

(Standard) Evaluation The dryness of the skin was remarkably improved, and the skin became moist and shiny. Remarkable effect The dryness of the skin was improved and the skin became moisturized. Somewhat effective Dryness of the skin is less noticeable. Disabled Same as before use.

The results of the skin beautifying effect test are shown in Table 5.

[0038]

[Table 5]

As is clear from the results shown in Table 5, the products 1 and 2 of the present invention in which perilla oil, dipotassium glycyrrhizinate, and hydrogenated soybean phospholipid were used in combination were compared with Comparative products 1 to 3 in which each of them was blended alone. It shows a remarkable improvement effect on dry skin, and it can be seen that there is an excellent effect.

Example 4: Lotion A lotion was obtained by the following formulation and the following production method. The lotion of the present invention had an excellent effect of improving skin irritation and dryness.

(Formulation) (% by weight) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene sorbitan 1.2 Monolauric acid ester (20EO) (4) ) Ethyl alcohol 8.0 (5) Perilla oil 0.01 (6) Perilla extract (Note) 3.0 (7) Preservative 0.2 (8) Perfume 0.1 (9) Purified water Remaining amount (Note) ) Nikko Chemicals

(Production Method) A. (3) to (5), (7) and (8) are mixed and dissolved. B. (1)-(2), (6) and (9) are mixed and dissolved. C. The above A and B are mixed and made uniform to obtain a lotion.

Example 5: Pack A pack was obtained by the following formulation and the following production method. The pack of the present invention had an excellent effect of improving skin irritation and dryness.

(Formulation) (wt%) (1) Polyvinyl alcohol 20.0 (2) Glycerin 5.0 (3) Kaolin 6.0 (4) Sorbitol (Note) 0.01 (5) Ethyl alcohol 20.0 (6) Perilla oil 0.05 (7) Preservative 0.2 (8) Perfume 0.1 (9) Purified water balance (Note) Wako Pure Chemical Industries

(Production Method) A. The components (1) to (4) and (9) are mixed, heated to 70 ° C. and stirred. B. Mix components (5)-(8). C. The above B is added to the above A, mixed and cooled to obtain a pack.

Example 6 Cleaning Agent A cleaning agent was obtained by the following formulation and the following production method. The cleansing agent of the present invention had an excellent effect of improving skin irritation and dryness.

(Formulation) (% by weight) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) Oleyl alcohol 1.5 (6) Purified lanolin 1.0 (7) Perfume 0.1 (8) Preservative 0.2 (9) Glycerin 18.0 (10) Potassium hydroxide 6.0 (11) Perilla oil 0.5 (12) Stearyl glycyrrhetinate (Note) 0.05 (13) Purified water Remaining amount (Note) Maruzen Pharmaceutical Co., Ltd.

(Production Method) A. Mixing components (9)-(10) and (13), 70
Heat to ° C. B. Components (1) to (6), (8), (11) and (1
2) are mixed and heated to 70 ° C. C. The above B is added to the above A, and the temperature is maintained at 70 ° C. for a while, and after the saponification reaction is completed, it is cooled to 50 ° C., (7) is added, and cooled to obtain a cleaning agent.

[0049]

INDUSTRIAL APPLICABILITY The external preparation for skin of the present invention can prevent skin irritation, dryness and the like, and exhibits an excellent improving effect on so-called dry skin which shows dryness disease and symptoms similar thereto. is there. that's all

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A61K 7/00 G 7/48 31/045 9455-4C 31/575 31/705 AGA 35/78 ABE Q 8217-4C ADA C 8217-4C 38/00 // (A61K 35/78 31: 045) (A61K 35/78 31: 705)

Claims (1)

[Claims] 1. Components (a) and (b) (a) Perilla oil (b) Glycyrrhizic acid, glycyrrhetinic acid, phospholipids, hydrogenated phospholipids, cholesterol and its derivatives, and salts thereof, perilla extract, Dokudami A skin external preparation characterized by containing one or more selected from the group consisting of extract, Yukinoshita extract, maltitol, sorbitol and mannitol.