JPH0788294B2 - Cosmetics - Google Patents

Description

Description: FIELD OF THE INVENTION The present invention relates to a cosmetic composition which activates skin cell functions and exerts a remarkable effect on skin protection and beautification, which is excellent in skin penetration of an active ingredient and has low stickiness.

BACKGROUND OF THE INVENTION Conventionally, an extract obtained from the skin of Randum domesticus camber barduke or Randium domesticus camouflage bar balancer and its specific component are 5α-
It is known that it inhibits the activity of reductase and is effective for the prevention and treatment of androgenetic alopecia, acne vulgaris, seborrhea, dandruff and the like, which are involved in male hormones (Japanese Patent Laid-Open Publication No. Sho.
See 60-243020).

Such an effect is caused by activation of cells by increasing energy production of skin cells due to inhibition of 5α-reductase activity. Therefore, if the extract or the like is added as a base, a cosmetic effective for regenerating and maintaining live skin by preventing and treating various skin diseases involving male hormones can be obtained. Be expected.

However, when a cosmetic containing the extract or the like as a base is applied to the skin, it is extremely sticky and unsuitable for use in a cosmetic requiring a refreshing feeling.
The skin permeability of the extract or the like is insufficient, and no one showing a satisfactory effect has been obtained. Therefore, there is a demand for a formulation that alleviates the sticky feeling upon application to the skin and enhances the skin permeability of the extract or the like.

The inventors of the present invention are eager to obtain a cosmetic that improves the above drawbacks, does not have a sticky feeling upon application, and has excellent skin protection and beautification with enhanced skin penetration of the active ingredient. As a result of the examination, by using the crude extract and / or its specific component in combination with a phospholipid,
It was found that a cosmetic having good characteristics can be obtained,
The present invention has been completed.

DISCLOSURE OF THE INVENTION The present invention provides one or two or more phospholipids in an amount of 0.01 to 3% by weight based on the total amount of cosmetics, and Randium domesticus Jack Burduke (hereinafter referred to as Duke) or Randium domesticus camouflage. Jack Barlancer (hereinafter,
0.01 to 3% by weight based on the total amount of cosmetics of crude extract obtained from pericarp of lancea) and one or more of its components, randic acid, randioside and derivatives thereof. The present invention provides a cosmetic characterized by being blended.

The cosmetic of the present invention does not have a sticky feeling when applied, and has excellent skin permeability of the active ingredient. When applied to the skin, the skin cell function is activated to exert a remarkable effect on protection and beautification of the skin. .

The phospholipid to be added to the cosmetic of the present invention is a major lipid that constitutes various membrane systems of cells, and is also contained in serum lipids, egg yolk, etc., and its constituent components lead to glycerophospholipids and sphingophospholipids. being classified. Examples of the glycerophospholipid include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, diphosphatidylglycerol, plasmalogen, and ether lipid, and examples of the sphingolipid include sphingomyelin. The phospholipid is blended in an amount of 0.01 to 3% by weight, preferably 0.05 to 1% by weight, based on the total amount of the cosmetic. If the blending amount is less than 0.01% by weight, a sufficient effect cannot be obtained, and if it is more than 3% by weight, it may be difficult to dissolve in the base material.

The crude extract obtained from the skin of Duke or Lansa, which is incorporated into the cosmetic of the present invention, the method for extracting, separating and purifying randic acid and landioside and the structure thereof are known (for example, JP-A-60-243020). No.),
It can be obtained commercially. As the derivative, a salt of randic acid (for example, sodium salt, disodium salt, etc.) ester (for example, a mole alkyl ester having 2 to 12 carbon atoms, a dialkyl ester having 2 to 12 carbon atoms),
Examples thereof include salts of landioside (for example, sodium salt, potassium salt, etc.), esters (for example, mol alkyl ester having 2 to 12 carbon atoms, etc.), and can be produced by a conventional method. The crude extract, landic acid, landioside and their derivatives are 0.01 to 3% by weight, preferably 0.
It is blended from 05 to 1% by weight. If the blending amount is less than 0.01% by weight, a sufficient drug effect cannot be obtained, and if it is more than 3% by weight, it may be difficult to dissolve it in the base.

Further, in the cosmetic of the present invention, a suitable polyhydric alcohol, an oily component, an ultraviolet absorber, an antioxidant, an antiseptic, a bactericide, a drug, a fragrance, a dye, etc. are added in a range not impairing the properties thereof, if necessary. May be added in.

The cosmetics of the present invention can be produced according to a conventional method, such as solution system, emulsion system, powder dispersion system, basic cosmetics such as lotion, emulsion, cream, pack, foundation, make-up and shampoo, hair art, hair. It may be a usual dosage form for hair makeup such as liquid, hair treatment, and hair spray.

EXAMPLES Next, the present invention will be described in more detail with reference to Examples.

Example 1 lotion At room temperature, B was added to A, mixed and solubilized, and then filtered to produce a lotion.

Example 2 Hair Treatment With stirring, A was heated to 75 ° C. and dissolved. B heated to about 75 ° C. was added to the obtained solution, and the mixture was sufficiently stirred and then cooled to produce a hair treatment.

Example 3 Face-wash cream With stirring, Component A was heated to about 75 ° C. and dissolved. Component B heated to about 75 ° C. was added to the obtained solution with stirring, thoroughly mixed and then cooled to produce a face cleansing cream.

Example 4 Oily cream With stirring, Component A was heated to about 75 ° C. and dissolved. Component B heated to about 75 ° C. was added to the obtained solution with stirring, mixed well and cooled to produce an oily cream.

Example 5 Shampoo Ingredients wt% Langic acid 1.0 Hydrogenated lecithin 3.0 Alkylsulfate triethanolamine 10.0 Coconut oil fatty acid diethanolamide 5.0 Propylene glycol 5.0 Ethylene glycol distearate 2.0 Urea 0.5 Preservative and fragrance Trace amount of ion-exchanged water Shampoo was manufactured according to a conventional method.

Example 6 Rinsing component wt% Duke extract 3.0 Phosphatidylethanolamine 0.3 Phosphatidylglycerol 0.3 Diphosphatidylglycerol 0.3 Plasmalogen 0.1 Propylene glycol 4.0 Liquid paraffin 3.0 Sorbitan monooleate 2.0 Cetyltrimethylammonium chloride 1.5 Cetanol 1.0 Polyvinylpyrrolidone 1.0 Monooleic acid Polyoxyethylene (20E.O.) sorbitan 0.2 Preservative and fragrance Trace amount of ion-exchanged water An appropriate amount of the above formulation was used to prepare a rinse according to a conventional method.

Example 7 Soap constituent% by weight Langic acid 3.0 Egg yolk lecithin 3.0 Soap substrate 50.0 Denatured alcohol 20.0 Concentrated glycerin 5.0 Dipotassium glycyrrhizinate 0.2 Disodium edetate 0.02 Perfume 1.0 Ion-exchanged water Producing soap according to a conventional method according to the above formulation. did.

Example 8 Scalprotion component wt% Duke extract 10.0 Soy lecithin 0.5 95 ° Brucine denatured alcohol 60.0 Concentrated glycerin 5.0 Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0 Fragrance 0.5 Ion-exchanged water Skull protions were manufactured according to the method.

Example 9 Hairnic component weight% Landic acid 0.3 Phosphatidylserine 0.1 Phosphatidylglycerol 0.1 99% Denatured alcohol 15.0 POE / POP cetyl ether 3.0 POE / POP decyl tetradecyl ether 1.0 l-menthol 0.5 Fragrance 0.5 Ion-exchanged water Was manufactured according to a conventional method.

Example 10 Moisture pack component% by weight Duke extract 5.0 Hydrogenated lecithin 1.0 Isopropyl myristate 15.0 Liquid paraffin 10.0 Stearic acid 6.0 Maltitol 5.0 Propylene glycol 5.0 Glycerin monostearate 3.0 Stearyl alcohol Polyoxyethylene (20E.O .) Stearyl alcohol 3.0 Polyoxysorbitan monostearate (20E.O.) 2.0 Preservative and perfume Trace amount of ion-exchanged water An appropriate amount of the above formulation was used to produce a moisture pack according to a conventional method.

Example 11 Moisture Cream Composition Weight% Landic Acid 0.5 Phosphatidylinositol 0.1 Diphosphatidylglycerol 0.05 Isopropyl palmitate 4.0 Stearic acid 4.0 Squalane 3.0 Propylene glycol 3.0 1,3-Butylene glycol 3.0 Methylpolysiloxane 2.0 Glycerin monostearate 1.0 Myristyl myristate 1.0 Preservative and fragrance Trace amount of ion-exchanged water An appropriate amount of the above formulation was used to produce a moisture cream according to a conventional method.

Example 12 Hair Treatment Component A and component B were each uniformly dissolved at about 75 ° C. Then, after adding component B to component A with stirring,
Cooled to produce a hair treatment.

Example 13 Pomade Component Weight% Landic Acid 0.5 Soybean Lecithin 1.0 Hydrogenated Castor Oil 49.0 Wood Wax 19.3 Liquid Paraffin 15.0 Vaseline 10.0 Olive Oil 5.0 Sorbitol 0.2 The above ingredients are dissolved at about 75 ° C., then cooled with stirring. Produced Pomade.

Example 14 Hair cream Component A and component B were each uniformly dissolved at about 80 ° C. Then, after adding component A to component B with stirring,
Cooled to produce a hair cream.

Example 15 Liquid hair styling ingredient% by weight 20% Duke skin rough extract (ethanol solution) 5.0 Sphingomyelin 2.0 Ethanol 50.0 Polyoxypropylene butyl ether 10.0 Glycerin 2.0 Hyaluronic acid 0.01 Fragrance 0.3 Purified water A liquid hair styling product was produced.

Example 16 Skin lotion component% by weight Sodium radicate 0.1 Phosphatidylserine 0.1 Ethyl alcohol 20.0 Glycerin 3.0 Pentaerythritol 2.0 Polyoxyethylene hydrogenated castor oil 0.5 Lactic acid 0.3 Fragrance 0.1 Preservative Trace amount of purified water Water was produced.

Example 17 Emulsion Component A and component B were uniformly dissolved at about 70 ° C. Then, after adding component A to component B with stirring,
After cooling, component C was added to produce an emulsion.

Example 18 Antiperspirant Ingredient A was uniformly dispersed, placed in a pressure-resistant can and then sealed, and ingredient B was filled to produce an antiperspirant.

Example 19 After-shave lotion composition% by weight 20% Duke skin crude extract (ethanol solution) 1.5 egg yolk lecithin 0.4 ethanol 40.0 1,3-butylene glycol 1.0 polyoxyethylene cetyl ether 0.6 polyoxyethylene silicon derivative 0.1 sodium hyaluronate 0.05 fragrance 0.3 Purified water An aftershoe lotion was produced by an ordinary method using the above components in an appropriate amount.

Example 20 Sunscreen cosmetics Component A and component B were each uniformly dissolved at about 75 ° C. Then, after adding component A to component B with stirring,
After cooling, a sunscreen cosmetic was manufactured.

Example 21 Hair nourishment component% by weight Duke extract 1.0 Phosphatidylinositol 1.0 Ethanol 50.0 Polyoxyethylene hydrogenated castor oil 2.0 Sodium pyrrolidonecarboxylate 1.0 Assemblage extract 0.2 Hinokitiol 0.1 Pyridoxine hydrochloride 0.1 Acetate d1-α-tocopherol 0.01 Perfume 0.3 Purified water An appropriate amount of the above ingredients was dissolved by stirring uniformly to produce a hair nourishing agent.

Next, except that soybean lecithin was not added, the above-mentioned Example 1 was used.
Comparative Example 1 (lotion) was produced in the same manner as in. Then,
Divide 20 female panel members with similar skin quality into 2 groups, 1
The lotion of Example 1 was applied to one group, and the lotion of Control Example 1 was applied to the other group twice a day for 2 months, and after 2 months, the feeling of use and the degree of skin function improvement were evaluated by sensory evaluation. I let myself declare it.
The results are shown in Table 1. The numbers in the table are the number of panel members who made the corresponding evaluations.

As shown in Table 1, by using soybean lecithin, which is one of phospholipids, in combination with landic acid, it is possible to reduce the stickiness and improve the skin function caused by the increased skin permeability of radisic acid. A remarkable effect was recognized.

Furthermore, except that the egg yolk lecithin was not added,
Comparative Example 2 (hair treatment) was produced in the same manner as in. Then, 30 male panel members with androgenetic alopecia associated with dandruff were divided into two groups, one group was treated with the hair treatment of Example 2 and the other group was treated with the hair treatment of Control Example 2 for 3 months. Apply to the scalp twice a day, massage it,
After 3 months, the feeling of use, hair loss and the occurrence of dandruff were evaluated. The results are shown in Table 2. The numbers in the table are the number of panel members who made the corresponding evaluations.

As shown in Table 2, the combined use of egg yolk lecithin, which is one of the phospholipids, alleviates the sticky feeling caused by the combination of randic acid and Duke's skin crude extract, and the skin of randic acid and Duke's crude extract. A remarkable effect was observed in reducing hair loss and improving dandruff symptoms due to increased permeability.

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Yasuhiro Nogawa 13-10-107 Tonomachi, Takatsuki City, Osaka (56) References JP-A-60-243020 (JP, A) JP-A-60-94903 (JP, A) JP-A-55-47608 (JP, A) JP-A-57-179109 (JP, A)

Claims (1)

[Claims] 1. One or more phospholipids, obtained in an amount of 0.01 to 3% by weight based on the total amount of cosmetics, and from the skin of Randum domesticus jack barduke or Randium domesticus jack bar balancer. A cosmetic, comprising 0.01 to 3% by weight of the crude extract, one or more of its components, radinic acid, landioside and derivatives thereof, as radisic acid with respect to the total amount of the cosmetic.