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JPH0747090A - 多層移植片 - Google Patents

多層移植片

Info

Publication number
JPH0747090A
JPH0747090A JP6024931A JP2493194A JPH0747090A JP H0747090 A JPH0747090 A JP H0747090A JP 6024931 A JP6024931 A JP 6024931A JP 2493194 A JP2493194 A JP 2493194A JP H0747090 A JPH0747090 A JP H0747090A
Authority
JP
Japan
Prior art keywords
fleece
porosity
layer
implant
mesh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6024931A
Other languages
English (en)
Other versions
JP3565890B2 (ja
Inventor
Lothar Schilder
ロター・シルダー
Hermann Dahlke
ヘルマン・ダールケ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethicon Inc
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc filed Critical Ethicon Inc
Publication of JPH0747090A publication Critical patent/JPH0747090A/ja
Application granted granted Critical
Publication of JP3565890B2 publication Critical patent/JP3565890B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A61F2002/0068—Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0051—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

(57)【要約】 【目的】 多層移植片。 【構成】 多層移植片には少なくとも２層備わってお
り、これらの少なくとも２層は異なる間隙率を有してい
る。例えば織ったか或は編んだメッシュの片側または両
側に、多孔質のフリース層を完全には或は部分的に与え
ることができる。この間隙率はフリース層内で変化して
いてもよい。この多層移植片の１層はまたフィルムで構
成されていてもよい。再吸収性を示す物質および再吸収
性を示さない物質が材料として考えられる。

Description

【発明の詳細な説明】
【０００１】
【産業上の利用分野】本発明は多層移植片に関する。
【０００２】
【従来の技術】手術を行っている間に通常の均質移植片
が体の中に移植されている。もしこれらが多孔質材料か
或は再吸収性を示す材料を含んでいる場合、組織が成長
してそれらの孔の中に入るか或は治癒過程中の移植片の
場所に入り込むことで、新しい組織構造体を生じる。空
洞またはガイディング（guiding）構造を有する非再吸
収性移植片を用いると、この非再吸収性移植片は完全な
再生を可能にしないことから、特定点における生理学的
な細胞の増加がちょうど良く生じない可能性がある。従
って、非晶質で無秩序な新しい組織が生じる傾向を示
し、瘢痕化と収縮が生じる。その結果として、組織の強
度が不適当になる可能性があり、そしてこれは更に、も
し移植片が再吸収性を示さないことからある程度の機械
的安定性を保証している材料で出来ている場合、合併症
がもたらされ得る。従って、その移植片と体自身の組織
との組み合わせが示す自然発生的な生物学的機能は、そ
の元の健康な組織が示すそれに相当しなくなる。
【０００３】
【発明が解決しようとする課題】本発明の目的は、組織
再生の異なる段階における組織の成長値および速度に選
択的および差別的影響を与える移植片を提供することに
ある。
【０００４】
【課題を解決するための手段】この目的は、請求項１の
特徴を示す多層移植片を用いることによって達成され
る。
【０００５】すなわち、本発明に従う多層移植片には少
なくとも２層備わっており、これらの少なくとも２層は
異なる間隙率を有している。従って、この移植片の構造
は、この移植片が移植されている体内の組織再生過程に
特異的に適合することが可能であり、そして望まれてい
る、組織が成長して中に入り込むこと（growing-in）が
調節され得る。例えば、急成長する細胞単位は、その移
植片の一方の側から、大きな孔を有する層の中に速く進
行して入って行くことができる一方、もう一方の側で
は、有意な間隙率を有していない層、例えばフィルムに
よって、細胞の入り込みが完全に防止され得る。本発明
に従う移植片に備わっているいくつかの層は、種々の再
吸収性を示す材料および再吸収性を示さない材料を含ん
でいてもよく、これらは今度は、異なる速度で劣化し得
る。この移植片に備わっている個々の層の材料、間隙
率、厚さおよび寸法、並びにこの層の順序および全体的
な形状を適切に選択したならば、この移植片が新しい組
織を生じさせる刺激は、阻害影響を示さず、治癒過程に
選択的に適合し得るものであり、その結果として、促進
された秩序ある組織増殖がもたらされる。
【０００６】与えられた手術中に移植される本発明に従
う移植片の構成および外部形状は、従って、置き代える
べき元の組織構造体の種類および形状を基としており、
従って場合場合で異なっている。個々の層が有する材料
および構造に関する適切な選択を通して、本発明に従う
移植片をその与えられた生物学的条件に適合させること
ができ、その結果として、その新しく生じてくる組織は
再び分化し（高い値）、そして好適な場合として、元の
健康な組織と同じ秩序ある構造を示すようになる。
【０００７】本発明に従う多層移植片の好適な変形にお
いて、織ったか或は編んだメッシュ（格子）の一つの側
に、多孔質フリース（fleece）層を完全にか或は部分的
に与える。このフリース層が示す間隙率は、２００Ｐａ
の入り口圧力、５０ｃｍ2の試験表面積および１ｍｍの
試験厚を用いて測定して１００から１０００Ｌ／（ｍ2
秒）気体流量の範囲にある。このような構成を用いる場
合、このメッシュは、粗い間隙率を有する層を形成して
おり、これを貫通して組織が実質的に妨げられないで成
長する。他方、この組織の増殖速度は、該フリース層が
示す間隙率によって調節され得る。従って、この組織
は、小さい間隙率を有する材料よりも大きな間隙率を有
する材料の中により迅速に成長して入り込む傾向を示
す。このメッシュおよびフリース層は、再吸収性を示す
材料か或は再吸収性を示さない材料を含んでいてもよ
い。例えば、このフリース層が再吸収性を示すがそのメ
ッシュが再吸収性を示さない場合、このメッシュは、あ
る期間経った後、その体内で単にその移植片の構成要素
のままであり、必要に応じて、永久的な追加的物理安定
性を保証し得る。
【０００８】別の好適な変形において、織ったか或は編
んだメッシュの両側に、多孔質フリース層を完全にか或
は部分的に与え、そしてこれらの２つのフリース層は異
なる間隙率を有していてもよい。これらのフリース層は
また、異なる形状または輪郭を有していてもよい。この
間隙率はまた、１つのフリース層内で変化していてもよ
い。本発明に従う多層移植片は、これらの変数を適切に
適合させることにより、与えられた使用に適したように
選択的に調製され得る。
【０００９】別のデザインの本発明に従う多層移植片を
用いることで、このメッシュを完全にか或は部分的に占
めている多孔質フリース層を、織ったか或は編んだメッ
シュの１つの側に位置させる一方、もう一方の側に、１
０から５０μｍの厚さを有するフィルムを配置する。上
記フィルムにより、その隣接する組織への誤った成長が
防止されると共に接着性が低下する、と言うのは、この
組織の細胞は、そのフィルムが備わっている移植片のそ
の側からは、この移植片の中に入り込むことができない
からである。このフィルムが再吸収性を示す場合、この
効果が継続するのは一定期間のみである。しかしなが
ら、これは、特定の環境下では、急速に成長する細胞単
位がその移植片の中に入り込むのを防止するに充分であ
り、その間に、もう一方の側から、ゆっくりと成長する
細胞単位がその多孔質フリース層の中に成長して入り込
むが、これにそのフィルムが備わっていない場合、それ
らがそうするのを、その進んで来る急成長する細胞単位
が妨げる。
【００１０】フィルムが備わっている本発明に従う他の
多層移植片構造もまた可能である。従って、織ったか或
は編んだメッシュの片側または両側にフィルムを完全に
か或は部分的に与えることができる。少なくとも１つの
フリース層が備わっている移植片を用いる場合、これら
のフリース層の１つをフィルムで完全にか或は部分的に
コートすることができる。さもなければ、上記移植片
は、上に挙げた構造の１つを有していてもよい、即ちメ
ッシュを含んでいてもよい。二者択一的に、単に２つの
層、即ちフィルム、即ち小さいか或は有意でない間隙率
を有する層とフリース層とが含まれている変形もまた考
えられ得る。
【００１１】本発明に従う多層移植片が有する個々の層
は、各々、再吸収性を示すか或は再吸収性を示さない材
料で出来ていてもよい。これは、メッシュ、フリース層
またはフィルムに適用される。再吸収性を示す材料とし
て適切なものは、例えば好適にはポリグラクチン（Poly
glactin）、ポリジオキサノン（Polydioxanone）または
ポリグレカプロン２５（Poliglecaprone 25）であるか
或はこれらの材料の組み合わせである。
【００１２】ポリプロピレンまたはポリエステルが非再
吸収性材料として用いられ得る。
【００１３】図を用いて説明する下記の実施例は、本発
明に従う多層移植片の種々の可能な構造を示すものであ
る。
【００１４】ここに示す図は下記の通りである。
【００１５】図１は、本発明に従う多層移植片の第一変
形を示している。織ったか或は編んだメッシュ（格子）
１２の片側に、１０００Ｌ／ｍ2秒の間隙率を有するフ
リース１１を与える。このメッシュ１２のもう一方の側
に、間隙率が１００Ｌ／ｍ2秒のフリース１３を存在さ
せる。５０ｃｍ2の試験表面積と１ｍｍの試験厚を有す
るフリース層を２００Ｐａの入り口圧力で気体に暴露し
たとき生じる気体通過を、間隙率の尺度として与える。
【００１６】図２に示す具体例の場合、その上方のフリ
ース層は、異なる間隙率を有する２つのゾーンを有して
いる。ゾーン２１は、１０００Ｌ／ｍ2秒の間隙率を有
するフリースで出来ており、一方ゾーン２２は、より低
い間隙率である２００Ｌ／ｍ2秒を有するフリースを含
んでいる。２つのゾーン２４（８００Ｌ／ｍ2秒の間隙
率）および２５（３００Ｌ／ｍ2秒の間隙率）を有する
フリース層を、メッシュ２３のもう一方の側に配置す
る。この移植片をその与えられた条件に適合させるのを
最適にする目的で、ゾーン２２と２５の輪郭が異なって
いる点を注意する必要がある。
【００１７】図３は、均質なフリース３１、中間層とし
てメッシュ３２、およびフィルム３３で出来ている多層
移植片を示している。
【００１８】図４は、上の層に再び、異なる間隙率を有
するフリースで出来ている２つのゾーン、即ち周辺ゾー
ン４１（１００Ｌ／ｍ2秒の間隙率）と中心ゾーン４２
（５００Ｌ／ｍ2秒の間隙率）が備わっている多層移植
片を示している。織ったか或は編んだメッシュ４３が中
間層として働く。このメッシュ４３のもう一方の側にフ
ィルム４４が位置している。
【００１９】図５の移植片は、単に１枚のメッシュ５１
とそれの上に配置されているフィルム５２とで出来てい
る。従って、これは極端な場合を示している、と言うの
は、これは、非常に大きな間隙率を有する１つの層（メ
ッシュ５１）を含んでいる一方、もう１つの層（フィル
ム５２）はわずかに小さい間隙率を有している。
【００２０】図６は、図５の変形を若干修飾したもので
ある。ここでは、フィルム６２がメッシュ６１の一部の
みで覆われている。
【００２１】図７に示す変形には安定化用メッシュが含
まれていない。この移植片は、単に、１０００Ｌ／ｍ2
秒の間隙率を有するフリース７１とフィルム７２とで出
来ている。上記変形は、例えば歯周症の治療を行う時、
その歯近くの骨領域のための再吸収性移植片として適切
である。フィルム７２をその歯肉側に置くようにその移
植片を位置させると、これによって、急成長する歯肉が
その骨領域に入り込むのが有効に防止される。従って、
この骨物質は、成長してそのフリース７１の中に入り込
むに充分な時間を有している。このようにして、健全な
骨領域が再び作られる。
【００２２】図８に示す変形は、図７のそれに類似して
いる。ここでは、フリース層に２つのゾーンが備わって
いる、即ち１０００Ｌ／ｍ2秒の間隙率を有するフリー
スで出来ているゾーン８１と、５００Ｌ／ｍ2秒の間隙
率を有するフリースで出来ているゾーン８２が含まれて
いる。このフリース層の１つの側はフィルム８３で覆わ
れている。
【００２３】図９は、中間層として与えられているメッ
シュ９３が再び含まれている変形を示している。このメ
ッシュ９３の１つの側は、１００Ｌ／ｍ2秒の間隙率を
有するフリース９２であり、これはフィルム９１で覆わ
れている。メッシュ９３のもう一方の側には、５００Ｌ
／ｍ2秒の間隙率を有するフリース９４が配置されてお
り、これには最終フィルム９５が備わっている。
【００２４】図１０は、本発明に従う複雑な構造を有す
る多層移植片を示している。メッシュ１０４が支持体と
して働いている。このメッシュ１０４の上側に、間隙率
が２００Ｌ／ｍ2秒のフリースで出来ている外部ゾーン
１０２と間隙率が１００Ｌ／ｍ2秒のフリースが備わっ
ている内部ゾーン１０３とで出来ている、フリース層が
存在している。この内部ゾーン１０３の一部はフィルム
１０１で覆われている。このメッシュ１０４の下側に
は、ゾーン１０５（２５０Ｌ／ｍ2秒の間隙率）と１０
６（１５０Ｌ／ｍ2秒の間隙率）が備わっているフリー
ス層が配置されている。このゾーン１０６の一部はフィ
ルム１０７で覆われている。
【００２５】簡潔さの目的で、これらの図に示す多層移
植片は、長方形の基本的形状を有していると共に、それ
らのフリース層は一定した厚さを有している。しかしな
がら、与えられた用途では、この移植片の基本的構成、
個々の層の材料および間隙率、並びに層の厚さおよび移
植片の全体的形状などを、その条件に適合させる。
【００２６】本発明に従う多層移植片が有する個々の層
を互いに結合させる目的で、例えば、異なる融点を有す
る材料を隣接層として用いることが可能であり、この移
植片の製造中に、これを、より低い融点を有する材料の
融点よりも高い温度であるが融点が高い方の材料の融点
よりも低い温度に加熱すると、これらの層の１つが溶融
してその隣接層と結合する。再吸収性を示す材料、好適
にはポリジオキサノンおよびポリグラクチンで作成した
移植片の成分は、ドイツ特許第38 30 005 C1号に記述さ
れている。
【００２７】異なる融点を有する２つの層の間に、より
低い融点を有する材料から作成したフィルムを位置させ
て加熱する結果として、このフィルムを溶融させて多孔
性を示すようにさせると共に上記２つの層を互いに結合
させることも可能である。このようにして、例えば、再
吸収性を示さない材料から作成したメッシュと、より低
い融点を有する再吸収性を示す材料から作成した多孔質
フリース層とを互いに連結させることができる。
【００２８】本発明の特徴および態様は以下のとうりで
ある。
【００２９】１． 少なくとも２つの層が備わってお
り、これらの少なくとも２つが異なる間隙率を有するこ
とを特徴とする多層移植片。
【００３０】２． ２００Ｐａの入り口圧力、５０ｃｍ
2の試験表面積および１ｍｍの試験厚で測定して１００
から１０００Ｌ／（ｍ2秒）気体流量の範囲にある間隙
率を有する多孔質フリース層を、織ったか或は編んだメ
ッシュの１つの側に完全にか或は部分的に与えることを
特徴とする第１項記載の多層移植片。
【００３１】３． ２００Ｐａの入り口圧力、５０ｃｍ
2の試験表面積および１ｍｍの試験厚で測定して１００
から１０００Ｌ／（ｍ2秒）気体流量の範囲にある間隙
率を有する多孔質フリース層を、織ったか或は編んだメ
ッシュの両側に完全にか或は部分的に与えることを特徴
とする第１項記載の多層移植片。
【００３２】４． 該２つのフリース層が異なる間隙率
を有していることを特徴とする第３項記載の多層移植
片。
【００３３】５． ２００Ｐａの入り口圧力、５０ｃｍ
2の試験表面積および１ｍｍの試験厚で測定して１００
から１０００Ｌ／（ｍ2秒）気体流量の範囲にある間隙
率を有する多孔質フリース層を、織ったか或は編んだメ
ッシュの１つの側に完全にか或は部分的に与え、そして
もう一方の側に、１０から５０μｍの範囲の厚さを有す
るフィルムを完全にか或は部分的に与えることを特徴と
する第１項記載の多層移植片。
【００３４】６． 該フリース層の少なくとも１層内で
該間隙率が変化していることを特徴とする第２から５項
の１項記載多層移植片。
【００３５】７． １０から５０μｍの範囲の厚さを有
するフィルムを、織ったか或は編んだメッシュの片側ま
たは両側に完全にか或は部分的に与えることを特徴とす
る第１項記載の多層移植片。
【００３６】８． フリース層を少なくとも１層含んで
おりそして該フリース層の少なくとも１層がフィルムで
完全にか或は部分的にコートされていることを特徴とす
る第１から５項の１項記載多層移植片。
【００３７】９． 該層の少なくとも１層が再吸収性を
示すことを特徴とする第１から８項の１項記載多層移植
片。
【００３８】１０． 該層の少なくとも１層が再吸収性
を示さないことを特徴とする第１から８項の１項記載多
層移植片。
【００３９】１１． 再吸収性を示す材料としてポリグ
ラクチン９１０、ポリジオキサノン、ポリグレカプロン
２５またはそれらの組み合わせを用いることを特徴とす
る第９項記載の多層移植片。
【００４０】１２． 再吸収性を示さない材料としてポ
リプロピレンまたはポリエステルを用いることを特徴と
する第１０項記載の多層移植片。
【図面の簡単な説明】
【図１】１枚のメッシュと２枚のフリース層とで出来て
いる多層移植片の分解図である。
【図２】１枚のメッシュと、変化した間隙率を有する２
枚のフリース層とで出来ている多層移植片の分解図であ
る。
【図３】１枚のメッシュと、１枚のフリースと、１枚の
フィルムとで出来ている多層移植片の分解図である。
【図４】１枚のメッシュと、変化した間隙率を有する１
枚のフリースと、１枚のフィルムとで出来ている多層移
植片の分解図である。
【図５】１枚のメッシュと１枚のフィルムとで出来てい
る多層移植片の分解図である。
【図６】１枚のメッシュと、このメッシュの表面よりも
小さい表面を有する１枚のフィルムとで出来ている多層
移植片の分解図である。
【図７】１枚のフリースと１枚のフィルムとで出来てい
る多層移植片の分解図である。
【図８】変化した間隙率を有する１枚のフリースと１枚
のフィルムとで出来ている多層移植片の分解図である。
【図９】１枚のメッシュと、各々に１枚のフィルムがコ
ートされている２枚のフリース層とで出来ている多層移
植片の分解図である。
【図１０】１枚のメッシュと、変化した間隙率を有する
２枚のフリース層が含まれており、各フリース層の一部
領域が１枚のフィルムでコートされている多層移植片の
分解図である。
【符号の説明】
１１ フリース １２ メッシュ １３ フリース ２１ 特定の間隙率を有するゾーン ２２ ２１と間隙率の異なるゾーン

Claims (2)

    【特許請求の範囲】
  1. 【請求項１】 少なくとも２つの層が備わっており、こ
    れらの少なくとも２つが異なる間隙率を有することを特
    徴とする多層移植片。
  2. 【請求項２】 ２００Ｐａの入り口圧力、５０ｃｍ2の
    試験表面積および１ｍｍの試験厚で測定して１００から
    １０００Ｌ／（ｍ2秒）気体流量の範囲にある間隙率を
    有する多孔質フリース層を、織ったか或は編んだメッシ
    ュの１つの側或は両側に完全にか或は部分的に与えるこ
    とを特徴とする請求項１記載の多層移植片。
JP02493194A 1993-01-28 1994-01-28 多層移植片 Expired - Lifetime JP3565890B2 (ja)

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GR (1) GR1002613B (ja)

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JP2015516838A (ja) * 2012-03-28 2015-06-18 エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ． 複数の材料で構成された組織厚さコンペンセーター

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AU666600B2 (en) 1996-02-15
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US5686090A (en) 1997-11-11
BR9400359A (pt) 1994-08-16
AU5477194A (en) 1994-08-04
JP3565890B2 (ja) 2004-09-15

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