JPH07173078A - Antipruritic composition - Google Patents

Abstract

(57) [Summary] [Object] To provide an antipruritic composition which is fast-acting and has an excellent antipruritic effect. [Structure] Contains an antipruritic component and calcium hydrogen phosphate having a particle size of 0.01 to 1.0 mm, and exerts a strong antipruritic effect by rubbing the affected area with a hand or a finger at the time of application, and does not damage the skin. An antipruritic composition characterized by the following:

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antipruritic composition, and more particularly to an antipruritic composition which, when applied to the skin, provides a rapid and strong antipruritic effect.

[0002]

2. Description of the Related Art When it is bitten by insects such as mosquitoes, severe itching occurs. As conventional antipruritic drugs corresponding thereto, creams, liquids and aqueous gels containing antihistamines, local anesthetics and skin stimulants are used.

[0003]

However, in order for these drugs to exert an antipruritic effect, the drugs must penetrate the skin to reach the site of action, and it takes a long time to develop the action. Therefore, in practice, there is almost no antipruritic effect, and the itching cannot be covered and the skin is scratched and the skin condition is deteriorated.

[0004]

[Means for Solving the Problems] In order to remedy this drawback, the present inventors have conducted various studies on antipruritic compositions containing powders and granules, and as a result, the type, size, shape and hardness of the granules have been investigated. The present invention has been completed based on the finding that is strongly affected by the antipruritic effect, and that it exerts a strong antipruritic effect when a specific powder or granular material is used.

That is, in the present invention, the antipruritic component and the particle size are 0.0
The antipruritic composition is characterized by containing 1 to 1.0 mm of calcium hydrogen phosphate. The components of the present invention will be described in more detail below.

Calcium hydrogen phosphate used in the present invention is a powdery material in the shape of a square having a hardness that does not disintegrate by coating or rubbing with hands, fingers, etc.
It is necessary to be 1.0 mm, and a particularly preferable particle size is 0.15 to 0.5 mm. If it is smaller than this, a sufficient antipruritic effect cannot be obtained, and if it is larger than this, the usability is unfavorable. In addition, the powder or granular material should not damage the skin even if it is rubbed on the affected area with the hands or fingers at the time of application. Its content is 0.5 to 15% by weight based on the whole antipruritic composition.
Is preferable, and particularly preferably 3 to 10% by weight.

The antipruritic ingredients used in the present invention include various steroid agents such as hydrocortisone acetate, dexamethasone acetate, and prednisolone acetate, non-stedoid anti-inflammatory agents such as indomethacin, ibuprofen, bufexamac, dibucaine hydrochloride, lidocaine, amino. Local anesthetics such as sodium benzoate, diphenhydramine hydrochloride,
Chlorpheniramine maleate, antihistamines such as isothipendyl hydrochloride, chlorhexidine hydrochloride, decalinium chloride, bactericides such as isopropylmethylphenol, capsicum tincture, dl-menthol, dl-camphor,
Examples include skin irritants such as methyl salicylate, other compounds having anti-inflammatory action such as allantoin, glycyrrhetinic acid and dipotassium glycyrrhizinate, and compounds having antipruritic action such as crotamiton. These may be used alone or in combination of two or more, and the compounding amount thereof is preferably 0.01 to 10% by weight based on the whole antipruritic composition.

Further, the antipruritic composition of the present invention may contain, in addition to the above components, additives generally used for external preparations. Examples of such components include surfactants such as polyoxyethylene hydrogenated castor oil, alcohols such as ethanol and isopropyl alcohol, propylene glycol, dipropylene glycol, polypropylene glycol, butylene glycol, ethylene glycol, polyethylene glycol, glycerin. Polyhydric alcohols such as, gelling agents such as carboxyvinyl polymers, ammonia water, neutralizing agents such as diisopropanolamine, pH adjusting agents such as phosphates, citrates, phosphites, acetates, etc. Antioxidants such as dibutylhydroxytoluene and butylhydroxyanisole, preservatives such as methyl paraoxybenzoate and propyl paraoxybenzoate, perfumes and water are included.

The antipruritic composition of the present invention can be used in various external preparations such as creams, gels and liquids.

[0010]

The antipruritic composition of the present invention has a specific particle size,
It contains hard and shaped powders, and exerts a strong antipruritic effect by rubbing it on the affected area with hands or fingers at the time of application, and does not damage the skin.

[0011]

EXAMPLES The present invention will be described in more detail below with reference to examples.

EXAMPLE 1 0.34 parts by weight of dibucaine hydrochloride, 1 part by weight of diphenhydramine, 3.5 parts by weight of dl-menthol and dl were added to a mixed solution of 41.4 parts by weight of ethanol and 2 parts by weight of polyoxyethylene hydrogenated castor oil. -2 parts by weight of camphor was added and dissolved. This was added to a liquid in which 1.5 parts by weight of carboxyvinyl polymer was dispersed in 27.3 parts by weight of water, and the mixture was stirred and mixed,
A solution prepared by diluting 1.0 part by weight of diisopropanolamine with 10 parts by weight of water was gradually added to neutralize. Then, 10 parts by weight of calcium hydrogen phosphate having an average particle diameter of 0.25 mm was added to obtain an antipruritic composition.

Example 2 0.75 parts by weight of isothibenzyl hydrochloride, 0.3 parts by weight of dibucaine hydrochloride, 0.1 part by weight of decarinium chloride, 1.5 parts by weight of aqueous ammonia, 1 part by weight of dl-menthol and 2 of dl-camphor. Parts by weight are dissolved in 35 parts by weight of ethanol, and 0.4 parts by weight of carboxyvinyl polymer is added to 48.
It was added to the liquid mixed and dispersed in 95 parts by weight and stirred and mixed.
10 parts by weight of calcium hydrogen phosphate having an average particle diameter of 0.25 mm was added thereto to obtain an antipruritic composition.

Comparative Examples 1 and 2 The antipruritic compositions prepared by removing calcium hydrogen phosphate from Examples 1 and 2 were designated as Comparative Examples 1 and 2, respectively.

Test Example 1 Five healthy adult women were used as test subjects, and the transepidermal water loss of the forearm (hereinafter abbreviated as TWL) was evaluated by an evaporation meter EP.
It was measured using -10 (manufactured by Servo Med). Example 1
After applying each of Comparative Examples 1 and 2 for 2 minutes, the applied part was washed with water. The results of measuring the TWL before coating and after 60 minutes after coating are shown in FIG.

As a result, the TW of Example 1 and Comparative Example 1
L was similar, and it was confirmed that the antipruritic composition containing the powdery particles of calcium hydrogen phosphate of the present invention does not damage the skin.

Test Example 2 Five healthy adult men were used as subjects, and the back of the hand had a diameter of 5 mm.
Wearing rubber gloves with a hole, a hand was put into a cage containing a mosquito (adult Aedes albopictus female adult) and one mosquito sucked blood. After blood-sucking, the hands were removed from the cage, the gloves were removed, and when the itch became score 3, 30 μl of the antipruritic composition of Examples 1 and 2 and Comparative Examples 1 and 2 was applied and massaged onto the affected area for about 2 minutes. . After application, the degree of itching was self-determined at regular intervals. Table 1 shows the criteria for itching.
The results are shown in Table 2.

[0018]

[Table 1]

[0019]

[Table 2]

From these results, it was confirmed that the antipruritic agent of the present invention quickly removes itch.

[Brief description of drawings]

It shows the measurement results of transepidermal water loss (TWL) of the forearm.

FIG. 1 shows the results of measurement of transepidermal water loss using an evaporation meter EP-10 after the compositions obtained in Example 1 and Comparative Example 1 were applied and washed on the forearm.

Claims (1)

[Claims] 1. An antipruritic component and a particle size of 0.01 to 1.0 mm
2. An antipruritic composition comprising the calcium hydrogen phosphate according to claim 1.