JPH07165571A - Disinfecting composition - Google Patents

Abstract

PURPOSE:To obtain a quick-drying disinfecting composition, having a sufficient germicidal activity without causing hand roughening or stickiness and causing no hand roughening even in the case of a high frequency of use. CONSTITUTION:This disinfecting composition contains a lower alcohol, a cationic germicide and a wetting agent, further blended with a cyclic or a chain silicone expressed by the formula [(CH3)2SiO]n or HO-[CH3)2SiO]n-H [(n) is 2-6] and/or a polyhydric alcohol ester of a fatty acid having 0.22-0.85 IOB.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a disinfecting composition for medical use which is suitable for disinfecting fingers and hands, and is free from rough skin.

[0002]

2. Description of the Related Art Nosocomial infections in hospitals have become popular in newspapers nowadays, so that prevention of nosocomial infections has become an important issue for medical staff, comparable to the treatment of patients' diseases. Nosocomial infections in hospitals have been reported to be transmitted to another patient via a doctor or a nurse, and must be completely treated after treatment or care of one patient and before treatment of another. You must disinfect your hands. Therefore, various kinds of quick-drying disinfectants containing ethanol for disinfection as a main component have been studied and marketed recently. Examples of quick-drying disinfectants include ethanol solutions such as benzalkonium chloride and chlorhexidine gluconate. Benzalkonium chloride and chlorhexidine gluconate are added to the disinfectant ethanol in a proportion of 0.1 to 4%. Is prepared. However, if a solution containing ethanol at a high concentration of 76.9 to 81.4 v / v%, such as disinfecting ethanol, is used every time the patient changes, it causes rough hands. Therefore, despite the need for disinfection,
Often not used frequently. The roughened hands are in a vicious circle where many bacteria are attached to the fingers, which easily causes secondary infection. Therefore, it is conceivable to add an emollient agent that protects the skin to an antiseptic solution containing ethanol as a main component to prevent rough skin (Japanese Patent Laid-Open No. 57-171).
65305, JP-A-1-132515, JP-B-4-33226, JP-B5-63446, etc.). However, it has been reported that adding emollients only causes the fingers to become sticky and hinders work, and that the effects of fungicides such as benzalkonium chloride and chlorhexidine gluconate, which have been added for the purpose of sterilization, are reduced. ing. Thus, it is a disinfecting composition that can be safely used by medical staff and nurses who have to disinfect their fingers many times daily to prevent nosocomial infections, and has sufficient sterilizing power and rough hands. The present situation is that a quick-drying disinfecting composition free of stickiness has not been obtained.
The present invention has been made to solve the above problems, the object is to have a sufficient sterilizing power, and quick-drying without rough hands and stickiness, in the case of frequent use. Another object of the present invention is to provide a disinfecting composition that does not cause rough hands.

[0003]

Means for Solving the Problems The present inventors have been investigating an emollient agent which does not reduce the bactericidal activity of a cationic bactericide such as benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, etc. It has been found that the combination of polar oil and cyclic or chain silicone does not cause rough hands or stickiness and gives a silky feeling after use, thus completing the present invention. That is,
The disinfecting composition of the present invention is a disinfecting composition containing a lower alcohol, a cationic disinfectant and a wetting agent, and has the following formula:

[0004]

Embedded image [(CH ₃ ) ₂ SiO] _n or HO-
_{[(CH 3) 2 SiO]} n -H

(Wherein n represents an integer of 2 to 6) and a cyclic or chain silicone and / or IOB
Of 0.22 to 0.85 of polyhydric alcohol fatty acid ester (provided that the fatty acid may be linear or branched)
Is further compounded. The disinfecting composition here is not limited to finger disinfection, but refers to a disinfecting composition that can be widely used in medical care and at home, such as skin during surgery and skin of patients, medical instruments and the like.

As the cationic bactericide to be added to the disinfecting composition of the present invention, C _{8 to} C ₁₈ benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, alkylisoquinolinium bromide, C ₈ to C ₂₄ alkyltrimethylammonium chloride, N-cocoyl-L-arginine ethyl ester DL pyrrolidonecarboxylate represented by the following chemical structural formula (hereinafter abbreviated as CAE):

[0007]

[Chemical 3]

(In the above formula, RCO-represents a coconut oil fatty acid residue.) And the like, and one or two of these can be mentioned.
More than one species are selected and used. The cationic disinfectant compounded in the disinfecting composition of the present invention has no problem as long as it is within the range of the concentration of the usual disinfectant used, and is 0.02 to 4 w / v%, preferably 0 from the solubility of the disinfectant. .05 to 0.5 w / v%
If it is good.

The lower alcohol to be added to the composition of the present invention is preferably ethanol or isopropyl alcohol. In ethanol, the blending amount is preferably 76.9 to 81.4 v / v% from the viewpoint of its sterilizing power, but 50 to 9
Any 9 v / v% ethanol solution can be used. Isopropyl alcohol 0.5 ~ to enhance the bactericidal effect
It is also possible to mix 5 v / v%.

The wetting agent used in the present invention is a polyhydric alcohol such as polyethylene glycol, glycerin, diglycerin, propylene glycol, butylene glycol, erythritol, dipropylene glycol, sorbitol, maltitol, pyrrolidone carboxylic acid, lactic acid. Examples thereof include sodium and urea. Of these, one or more selected from the group consisting of polyethylene glycol, glycerin, propylene glycol, butylene glycol, erythritol, dipropylene glycol and sorbitol are particularly preferable. The wetting agent content is 0.1 to 3.0% by weight, preferably 0.2 to
1.5% by weight is suitable. If it is less than 0.1% by weight, it is not enough to prevent rough hands, and if it exceeds 3.0% by weight, stickiness cannot be prevented.

Next, the cyclic or chain silicone represented by the above formula 1 and the polyhydric alcohol fatty acid ester having an IOB of 0.22 to 0.85 are all sticky when a wetting agent is added in a predetermined amount or more. It is formulated to further reduce water vaporization and prevent evaporation of water from the skin. Among them, cyclic or chain silicone and IOB
When a polyhydric alcohol fatty acid ester of 0.22 to 0.85 is used together, it is particularly not sticky and has a dry feel, and is excellent in the effect of preventing rough hands due to a lower alcohol.

IOB incorporated into the disinfecting composition of the present invention
Examples of the polyhydric alcohol fatty acid ester having 0.22 to 0.85 include propylene glycol fatty acid ester having 9 to 15 total carbon atoms, glycerin fatty acid diester having 15 to 27 total carbon atoms, and 21 to 39 total carbon atoms. Examples thereof include glycerin fatty acid triester, sorbitan fatty acid ester having 12 to 18 carbon atoms, pentaerythritol fatty acid triester having 23 to 41 carbon atoms, and pentaerythritol fatty acid tetraester having 29 to 53 carbon atoms. These can be used alone or as an arbitrary mixture. Of these, glycerin fatty acid triesters (triglycerides) having a total carbon number of 21 to 39 are preferable. Examples of such triglycerides include Panacet 875 (manufactured by NOF CORPORATION), Tristar S-
Medium chain fatty acid triglycerides such as 810 (manufactured by Nikko Chemicals Co., Ltd.), vegetable oils such as olive oil, soybean oil, sesame oil, safflower oil and corn oil, RA-G-308.
(Glyceryl tri-2-ethylhexanoate) synthetic oil and the like can be mentioned. Of these, particularly preferred is RA-G-3.
It is 08. The amount of the polyhydric alcohol fatty acid ester having an IOB of 0.22 to 0.85 is 0.2 to 5.0% by weight,
It is preferably 0.5 to 3.0% by weight. The compounding amount is
If it is less than 2% by weight, the stickiness is not improved, and if it exceeds 5.0% by weight, the stability of the formulation is deteriorated and it feels oily in terms of usability, which is not preferable.

The cyclic or chain silicone compounded in the disinfecting composition of the present invention is represented by the above formula 1, which effectively suppresses the stickiness of the composition immediately after drying with a small amount, and is polar. Unlike oil, it volatilizes and does not remain on the skin forever, so it is the most suitable adjuster for usability. The blending amount is suitably 0.1 to 2.0% by weight. If the blending amount is less than 0.1% by weight, the stickiness is not improved, and if it exceeds 2.0% by weight, the "slickness" peculiar to silicone appears at the time of use and the stability of the preparation is deteriorated, which is not preferable. . If n = 7 or more in the above formula 1, the cyclic or chain silicone is unfavorable because the compatibility with ethanol for disinfection becomes poor, and if n = 1 or less, the action of suppressing the stickiness of glycerin is lost.

The total amount of polyhydric alcohol fatty acid ester having cyclic or chain silicone and / or IOB of 0.22 to 0.85 is preferably 0.1 to 5.0% by weight, and the most stable amount is within this range. And good usability. Further, the compounding ratio of the wetting agent and the cyclic or chain silicone and / or polyhydric alcohol fatty acid ester is such that the wetting agent 1 is 0.5 to 2.0 of the cyclic or chain silicone and / or polyhydric alcohol fatty acid ester. The (weight ratio) is suitable, and the most usability (point of stickiness) is best within this range.

Other formulations which can be contained in the disinfecting composition of the present invention include, for example, glycyrrhizic acid or its derivative, vitamin E, vitamin E acetate,
Examples thereof include agents such as vitamin B ₆ and water-soluble polymers such as xanthan gum, dextrin, hydroxyethyl cellulose, hydroxymethyl cellulose, methyl cellulose, carrageenan and carboxymethyl cellulose.

[0016]

EXAMPLES Examples of the present invention will be described in detail below, but the present invention is not limited thereto. Unless otherwise specified,% in the examples is% by weight. Examples 1-5, Comparative Examples 1-3 benzalkonium chloride 0.2% and CAE 0.02%
As a representative component as a wetting agent, a polyhydric alcohol fatty acid ester and a cyclic or chain silicone, which is uniformly soluble in an ethanol solution for disinfection, glycerin, triglyceride (triglyceryl tri-2-ethylhexanoate),
Cyclic silicone (decamethylcyclotetrasiloxane) and chain silicone (methylpolysiloxane, 2c
s, n = 3) was selected, and the effect of preventing rough hands, the slimy feeling during use, the stickiness after drying and the moist feeling after drying were evaluated in a use test of 20 people in a combination in which the concentration of each component was changed. . The evaluation was performed by taking the average value of 20 people based on the following evaluation points.

Evaluation point 3: Very good 2: Good 1: Normal 0: Poor Table 1 and Table 2 show the compounding ratio of each composition and the evaluation results.

[0018]

[Table 1] ──────────────────────────────── Comparative Example Examples Ingredients ──────── ───────── 1 2 3 1 2 ──────────────────────────────── Ethanol 75.0 75.0 75.0 75.0 75.0 Chlorhexidine gluconate − − − − − Benzalkonium chloride 0.2 0.2 0.2 0.2 0.2 CAE 0.02 0.02 0.02 0.02 0.02 Glycerin − − 1.0 1.0 1.0 Chain silicone − − − − − Cyclic silicone − − − − 0.2 Triglyceride − 0.5 − 0.5 0.3 Lactic acid − − − − − Purified water 24.78 24.28 23.78 23.28 23.28 ──────────────────────────────── In use Sliminess 1.5 1.2 1.6 1.1 1.7 Stickiness after drying 1.9 1.7 0.8 1.6 1.9 Moisture after drying 0.7 1.0 1.0 1.8 2.3 ───────────── ─────────────────── Hand roughening prevention effect 0.7 1.6 1.4 2.4 2.4 ──────────────────────── ─────────

[0019]

[Table 2] ──────────────────────────────── Example Ingredients ─────────── ──────── 3 4 5 6 7 ──────────────────────────────── Ethanol 75.0 75.0 75.0 75.0 75.0 Chlorhexidine gluconate − − − − 0.2 Benzalkonium chloride 0.2 0.2 0.2 0.2 − CAE 0.02 0.02 0.02 0.02 0.02 Glycerin 2.0 1.0 2.0 1.0 1.0 Chain silicone − − − − 0.2 Cyclic silicone 0.2 0.5 2.0 0.2 − Triglyceride 0.3 0.3 3.0 − 0.3 Lactic acid − − − − 0.05 Purified water 22.28 22.98 17.78 23.58 23.23 ──────────────────────────────── Feeling 1.7 1.2 0.6 1.7 1.7 Stickiness after drying 1.4 1.8 0.7 0.8 1.9 Moisture after drying 2.4 2.0 2.0 1.7 2.3 ─────────────── ───────────────── Hand roughening prevention effect 2.5 2.5 2.7 2.2 2.5 ───────────────────────── ───────

Next, the composition of Example 2 and Comparative Examples 1 and 2 which are compositions close to those conventionally commercially available
The time course change (minute) of the conductance (μS) of the skin when the finger was disinfected with the composition of Example 1 and dried (Sample 1 on the forearm 25 cm ² at 25 ° C. and 50% humidity) was measured.
00 ml was applied and Sukicon 200 (Japan IB Co., Ltd.
S) was used to measure the conductance of each sample. ). The result is shown in FIG. Skin conductance correlates with water retention. Therefore, it was found that the disinfecting composition of the present invention has a large water content on the skin and retains the water for a long time after application.

EXAMPLE 8 Sorbitol was added as a typical component of a wetting agent, a polyhydric alcohol fatty acid ester and a cyclic or chain silicone, which was uniformly soluble in a disinfecting ethanol solution containing chlorhexidine gluconate 0.25%, and sorbitol at 1.0 w / v%, triglyceride (triglyceryl tri-2-ethylhexanoate) 0.
3w / v%, cyclic silicone (decamethylcyclotetrasiloxane) 0.2w / v%, and C as a bactericide
A mixture containing AE 0.02 w / v% was prepared, and the bactericidal effect was confirmed on the skin. The bactericidal effect was confirmed as follows.

Staphylococcus aureus
FDA 209P) is cultured in a liquid broth medium at 37 ° C. for 20 hours, and serially diluted 2000 times with sterile physiological saline. 0.1 ml of this liquid (containing about 10 ⁵ cfu of bacteria)
Is poured into a glass cup (cylindrical shape) having a diameter of 3 cm which is in close contact with the skin, and it is applied to the skin surface with a sterilized glass rod and naturally dried. After drying, add the disinfecting composition prepared in advance to 2
Pour it into a ml glass cup and bring it into sufficient contact with the surface of the skin with a sterilized glass rod, and after 1 minute, add 0.1% of this disinfectant composition.
ml was pipetted and added to 100 ml of SCDLP medium, which was cultured at 37 ° C for 48 hours and smeared on Vogel Johnson agar medium, and the presence or absence of Staphylococcus aureus was confirmed. Although the presence was confirmed, the pre-inoculated Staphylococcus aureus was not confirmed, so it was confirmed that the bacteria were killed. The SCDLP medium used for the recovery of the bacteria contained lecithin and polysorbate 80, and it was devised so that the activity of chlorhexidine gluconate was reduced and diluted with 100 ml so that the growth inhibition would not occur.

Example 9 Glycerin, triglyceride (as a typical component of a wetting agent, a polyhydric alcohol fatty acid ester and a cyclic or chain silicone, which is uniformly soluble in a disinfecting ethanol solution containing 0.1% benzalkonium chloride, Triglyceryl tri-2-ethylhexanoate) and cyclic silicone (decamethylcyclotetrasiloxane) are selected, and the concentration of each component is 1.0 w / v% glycerin, 0.3 w / v% triglyceride, and 0. 2 w / v%
The anti-stickiness effect and the sterilization effect in the above combination were confirmed on the fingers.

Staphylococcus aureus
FDA 209P) was cultured in a liquid broth medium at 37 ° C. for 20 hours, and serially diluted 200 times with sterile physiological saline.
Similarly, Pseudomonas aeruginosa is cultured and diluted. 1 ml (each containing about 10 ⁶ / ml of bacteria) of this diluted solution is picked up by fingers, rubbed evenly, and naturally dried. After drying, 2 ml of the disinfecting composition prepared in advance is rubbed evenly on the fingers. After drying, put a sterile rubber glove on your hand and pour 50 ml of LP diluted solution (made by Daigo) kept at 37 ° C into it. Knead the glove for 1 minute after binding the wrist with rubber so that the LP diluted solution does not leak. The contaminated bacteria were collected. Confirmation of bacteria is SCDLP medium and LP
It carried out using the diluent. As a blank test, 50 ml of sterile physiological saline solution was used instead of the disinfecting composition. 2 ml of the disinfecting composition was picked up by fingers, and the stickiness after evenly rubbing was also evaluated. Table 3 shows the results for each panel when performed by 5 persons. In addition, less than 5 (<5) in the number of bacteria after disinfection in the table indicates that the number was not detected by measuring the number of bacteria.

[0025]

[Table 3]

Example 10 Glycerin 1.5 w / as a typical component of a wetting agent, polyhydric alcohol fatty acid ester and cyclic or chain silicone, which is uniformly soluble in a disinfecting ethanol solution containing 0.2% of chlorhexidine gluconate. v%, triglyceride (triglyceryl tri-2-ethylhexanoate) 0.
35 w / v% and 0.3 w / v% of cyclic silicone (decamethylcyclotetrasiloxane) were prepared, and the effect of preventing rough hands when continuously used was confirmed on the skin. 2 ml of the prepared composition for disinfection is rubbed evenly on the fingers and dried. The same operation was repeated 12 times every 10 minutes. This was carried out by 10 people for 5 consecutive days, and the rough condition of the hand was self-evaluated. Table 4 shows the results for each panel at that time.
Shown in. The evaluation method is the same as in Example 1.

[0027]

[Table 4]

Comparative Example 4 (Example using silicone other than cyclic or chain silicone of the present invention) A disinfecting composition was prepared by the following formulation. Ethanol 75.0 wt% Benzalkonium chloride 0.2 CAE 0.02 1,3-butylene glycol 1.0 Methylphenyl polysiloxane 0.2 Isopropyl myristate (IPM) 0.3 Purified water 23.28 Obtained In terms of usability, since silicone was not volatile in terms of usability, the usability of the silicone and IPM combined was great, and the film had a filmy feel on the hands, and was too smooth.

[0029]

As described above, since the disinfecting composition of the present invention has sufficient bactericidal power and is free from rough hands and stickiness, it can be safely used by medical staff and nurses who frequently use it. It is possible.

[Brief description of drawings]

FIG. 1 is a diagram showing changes in conductance with time when a disinfecting composition according to the present invention is applied to a hand, as compared with a case of a disinfecting composition according to a conventional example.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Office reference number FI technical display area A61K 47/44 Z

Claims (7)

[Claims] 1. A disinfecting composition containing a lower alcohol, a cationic bactericide, and a wetting agent, which has the following formula: ## STR1 ## [(CH ₃ ) ₂ SiO] _n or HO--
_{[(CH 3) 2 SiO]} n -H ( wherein, n represents an integer of 2-6.) Cyclic or chain silicone and / or IOB represented by the polyvalent 0.22 to 0.85 A disinfecting composition, further comprising an alcohol fatty acid ester (however, the fatty acid may be linear or branched). 2. The wetting agent is one or more selected from the group consisting of polyethylene glycol, glycerin, diglycerin, propylene glycol, butylene glycol, erythritol, dipropylene glycol and sorbitol. Disinfecting composition. 3. The disinfecting composition according to claim 1, wherein the compounding amount of the cyclic or chain silicone is 0.1 to 2.0% by weight. 4. A polyhydric alcohol fatty acid ester having an IOB of 0.22 to 0.85 is one of triglycerides or two.
The disinfecting composition according to claim 1, which is one or more kinds. 5. A compounding amount of a polyhydric alcohol fatty acid ester having an IOB of 0.22 to 0.85 is 0.2 to 5.0% by weight.
The disinfecting composition according to any one of claims 1 to 4. 6. The total amount of polyhydric alcohol fatty acid ester having cyclic or chain silicone and / or IOB of 0.22 to 0.85 is 0.1 to 5.0% by weight. The disinfecting composition according to any one. 7. The compounding ratio of the wetting agent to the cyclic or chain silicone and / or polyhydric alcohol fatty acid ester is 0.5 to 1 of the cyclic or chain silicone and / or polyhydric alcohol fatty acid ester to the wetting agent. 2.0
It is (weight ratio), The disinfecting composition in any one of Claims 1-6.