JPH07126149A - Cosmetic composition for beautifying and whitening - Google Patents

Abstract

PURPOSE:To obtain a safe cosmetic composition for beautifying and whitening having high effects. CONSTITUTION:The characteristic of this cosmetic composition for beautifying and whitening comprises an extract of at least one galenical of the group of GAIYO (Artemisiae Argyi Folium), SANSONIN (Zizyphi Spinosi Semen.), SHUROYO (a leaf of Trachycarpus wagnerianus), SEIMOKKO (a root of Vladimiria berardioides, Vladimiria forrestii and Vladimiria edulis), SOKYO (a fruit of Gleditsia sinensis Lam.), TAISO (Zizyphi Inermi Fructus), HAKUSENPI (the root bark of Dictamnus dasycarpus), BYAKUREN (a root of Ampelopsis japonica Makino), HAKUMOKUJI (a fruit body of Tremella fuciformis), MOKKA (Chaenomeles Fructus), IKURININ (Prunus Japonicae Semen), KYONIN (Armeniacae Semen), SEKINANYO (a dried leaf of Photinia serrulata Lindl.), HAKKYO (a stem and a leaf of Lactuca scariola), KAISHUNSHI (a branch, a leaf and a fruit of Cotoneaster acutifolius), IRYOSAI (a root or the whole herb with the root of Potentilla chinensis), DOBAIMO (a tuber of Bolbostemma paniculatum), HIREN (the whole herb or a root of Carduus crispus L.), CHOREI (Fungus Umbellatus), CHOMOSAI (the whole herb of Salsola collina), NYUHAKUKOSEI (the dried whole herb of Anaphalis lacteal, KYUSETSUSHOBU (Rhizoma Anemone), TAISEIKON (a root of Clerodendron cyrtophyllum) and KARENTOSAI (the whole herb of Drymaria cordata) as an active ingredient. This extract is capable of remarkably suppressing the melanogenesis without manifesting cytotoxocity. Thereby, the cosmetic composition for beautifying and whitening containing at least one of the extracts is safe and has high beautfying and whitening effects.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition having an excellent whitening effect. More specifically, it is particularly effective in preventing or treating spots, freckles, etc., and has an excellent whitening effect. The present invention also relates to a safe and stable whitening cosmetic composition.

[0002]

2. Description of the Related Art Conventionally, hydroquinone and its glycosides, kojic acid and its derivatives, ascorbic acid and its derivatives, thiol compounds, extracts of various animals and plants, etc. for the purpose of preventing or treating spots, freckles, etc. A whitening cosmetic composition has been proposed in which is added as a whitening ingredient.

[0003]

However, these cosmetics have various problems, and there is a problem in practical use. For example, hydroquinone as a whitening component has a safety problem, and the polarity of hydroquinone glycosides, kojic acid and its derivatives, ascorbic acid and its derivatives, etc. is too high to be used as a blending component of cosmetics. There is a problem.

Further, thiol compounds such as glutathione and cysteine still have a problem in stability after compounding, and compounding of animal and plant extracts such as placenta extract and aloe extract is known. , Its whitening effect was not satisfactory.

[0005]

[Means for Solving the Problems] In order to find a substance having an excellent whitening effect, the present inventors screened various plants using a melanin production suppression test using a mouse B16 melanoma strain as an index. It was as a result,
Known as herbal medicines, Ginseng, Sansounin, Pleurotus, Gypsophila, Gypsophila, Ginseng, Chinese cabbage, Chinese cabbage, Mokka, Ikrinin, Kyounin, Sekinanyou, Hakukyo, Kaishunshii, Iryosai, Dubai, Hiren, Chorei, Kyokusai, Kyokusai, Chomokusai, Chomokui It was found that each of the extracts of Shobu, Taiseikon, and Current Japanese cabbage has a strong melanin production inhibitory effect, and that the extract has extremely weak cytotoxicity and is extremely effective as a whitening ingredient in cosmetics. Completed the invention.

That is, the present invention is based on
Pleurotus, Pleurotus, Gypsophila, Ganoderma lucidum, Pleurotus japonicus, Chinese cabbage, Chinese cabbage, Mokka, Ikrinin, Kyounin, Sekinanyou, Hakukyo, Kaishuenshi, Ilyosai, Duomo, Hiren, Chorei, Chomosai, Nukuakukousei, Kukusetsusho
There is provided a whitening cosmetic composition comprising an extract of at least one herbal medicine selected from the group consisting of Taiseikon and Current Japanese cabbage as an active ingredient.

In the present invention, the whitening cosmetic composition refers to a skin cosmetic composition which is effective in preventing or treating spots, freckles and the like, and is a quasi-drug lotion, emulsion, cream, pack. , External lotions such as soaps and other medicated cosmetics and pharmaceuticals such as lotions, emulsions, creams and ointments.

The herbal medicines used in the present invention have been accepted by human beings for a long time, and have no problem in terms of toxicity.

Regarding the herbal medicines used in the present invention, the medicinal effects shown in Tables 1 and 2 are described in the Chinese Medicine University Dictionary (Shogakukan) and the like, but these are effective as whitening agents. That is not known at all.

[0010]

[Table 1]

[0011]

[Table 2]

The solvent used when obtaining an extract from these crude drugs is not particularly limited as long as it is a solvent capable of effectively extracting the active ingredient, but water or acetone, methanol, ethanol, propanol and the like can be used. It is preferable to use an organic solvent miscible with water, such as a lower alcohol, or a mixed solution thereof, ethyl acetate or the like.

At the time of extraction, the above-mentioned crude drug on the market (produced in China, available from Chinese medicine dealer) can be directly extracted with a solvent, but in order to improve the extraction efficiency, these raw materials are finely cut. It is desirable to extract with a solvent. Extraction is 5 to 5g for 1g of finely cut raw material.
Using 100 ml, preferably 10-20 ml of solvent,
It is desirable to carry out the test at room temperature for 1 to 1 month, preferably 2 to 5 days, and 2 to 4 times.

Further, in order to increase the concentration of the active ingredient in the extract, the obtained extract is further subjected to means such as concentration, liquid-liquid partitioning, adsorption chromatography, normal phase or reverse phase chromatography, if desired. It is also possible to attach.

In the whitening cosmetic composition of the present invention, the extract obtained as described above can be used alone or as a mixture. In addition, components commonly used in cosmetics, for example, oily components, surfactants, ultraviolet absorbers, lower alcohols, preservatives, bactericides, coloring agents, powders, fragrances, water-soluble polymers, buffers, etc. It is prepared by appropriately blending it according to its dosage form and within a range that does not impair the effects of the present invention.

The amount of the above-mentioned extract compounded in the whitening cosmetic composition of the present invention is preferably determined in consideration of the melanin production-inhibiting action and the skin keratin permeability, but generally the above-mentioned extract is used. 0.01 to 50% by weight in terms of raw materials,
Preferably, it is about 0.1 to 20% by weight.

[0017]

It is not yet clear how the above-mentioned extract, which is the active ingredient of the present invention, acts to have a whitening effect. However, in the melanogenesis inhibition test using the mouse B16 melanoma strain, the above-mentioned extract strongly inhibits melanin production without showing cytotoxicity, and therefore, in any step from tyrosine to melanin production, this reaction It is expected that the

The present invention will be described in more detail with reference to examples.

【Example】

Example 1 Preparation of Guillaume Extract 10 g of cabbage was finely cut into 50% ethanol.
0 ml was added and the mixture was extracted at room temperature for 48 hours. After the solid matter was removed by filtration, the extracts were collected and concentrated under reduced pressure to remove the solution to obtain 22.2 mg of an extract.

Example 2 Preparation of Sansounin Extract 10g of Sansounin was finely cut and extracted with ethanol in the same manner as in Example 1 to obtain 9.8 mg of an extract.

Example 3 Preparation of Salamander extract 10 g of Salamander was finely cut and extracted with ethanol in the same manner as in Example 1 to obtain 14.3 mg of an extract.

Example 4 Melanin Production Inhibition Test The melanin production inhibition test was carried out in the following manner using mouse melanoma cells. First, 1 × 10 ⁵ B16 melanoma cells were seeded in a petri dish having a diameter of 60 mm containing 5 ml of Eagle's minimal nutrient medium containing 10% (V / V) fetal bovine serum, and 5% (V / V) carbon dioxide gas was added. The cells were cultured at 37 ° C. for 24 hours in a carbon dioxide incubator adjusted to 1. Next, a 50% ethanol-dissolved sample was added to this petri dish.
ml was added. After further culturing for 5 days under the same conditions, cells were collected by trypsin treatment, the degree of whitening thereof was visually evaluated, and at the same time, the change in cell mass volume was visually evaluated and used as an index of cytotoxicity.

According to this measuring method, in addition to the extract of Example 1, the extract of Example 2 and the extract of Example 3, euglenae, sycamore, turmeric, Chinese cabbage, Chinese cabbage,
According to the method of Examples 1 to 3 for each crude drug of Hakumokuji, Mokka, Ikrinin, Kyounin, Sekinanyou, Hakukyo, Kaishinshi, Ilyosai, Dubai Mo, Hiren, Chorei, Chomokusai, Nakuhakakusei, Kyusetsushobu, Taiseikon, and Current Usai The melanin production inhibition was measured for each of the extracted extracts. The results are shown in Table 3. The cytotoxicity is also shown in Table 3. None of the extracts of the present invention had cytotoxicity and exhibited a melanin production inhibitory effect sufficient for practical use (similar to the activity of arbutin 25 mM). Further, the extract of the present invention was stored at room temperature for 3 months and then evaluated for melanin production inhibition and cytotoxicity again, but similar results were obtained.
These results show that the extract of the present invention is a useful whitening ingredient having both excellent whitening effect, safety and stability.

[0023]

[Table 3]

Example 5 Production of whitening cream (1) [Formulation] A Extract of Example 1 0.05 g Purified water 5.50 g B 3-succinyloxyglycyrrhetinic acid dibasic sodium 0.05 g C squalane 10.00 g myristin Octyldodecyl acid 8.00 g Microcrystalline wax 4.00 g Behenyl alcohol 3.00 g Lipophilic glyceryl monostearate 2.50 g Polyoxyethylene sorbitan monostearate (20 EO) 2.50 g D 1,3-butylene glycol 10 2.00 g Methyl paraoxybenzoate 0.10 g Purified water 54.00 g E Fragrance 0.30 g

[Production Method] B was added to D heated to 80 to 85 ° C., and C which was heated and dissolved at 80 to 85 ° C. was added to this while stirring with a homomixer to uniformly emulsify. It was gradually cooled to about 50 ° C. at room temperature and E and A were added. The whitening cream was manufactured by further cooling to room temperature while continuing stirring. The cream thus produced had an excellent whitening effect.

Example 6 Production of Whitening Cream (2) [Formulation] A of Example 5 was replaced with A extract of Example 2 0.25 g, purified water 5.30 g, and the same procedure as Example 5. A whitening cream was produced.

Example 7 Production of Carmine Lotion [Formulation] A zinc oxide 1.30 g silicic acid anhydride 1.10 g talc 2.00 g red iron oxide 0.01 g polyoxyethylene stearic acid amide (4 EO) 0.05 g B Extract of Example 1 0.05 g Ethanol 5.55 g C Concentrated glycerin 3.00 g Camphor 0.10 g Methyl paraoxybenzoate 0.05 g Perfume 0.05 g D Purified water 86.74 g

[Production Method] About 60 g of D was added to A and uniformly dispersed with a homomixer to prepare a powder dispersion. A solution of B and C were added thereto, the rest of D was added, and the mixture was uniformly dispersed with a homomixer to produce a carmine lotion. The carmine lotion thus produced had a hot whitening effect and was excellent in whitening effect.

Example 8 Production of Whitening Ointment [Formulation] A Macrogol 4000 47.50 g Macrogol 400 47.50 g B Extract from Example 2 0.15 g Extract from Example 3 0.10 g Purified water 4.75 g

[Manufacturing Method] Macrogol 4000 and Macrogol 400 were heated to 65 ° C. in a water bath to dissolve, and uniformly mixed to prepare a Macrogol ointment base. B to this
The solution was mixed to produce a whitening ointment. The whitening ointment thus produced was excellent in whitening effect.

[0031]

[Effects of the Invention] Gayou, Sansonin, Shuroyou,
Peppermint, Gypsophila, Ginseng, Chinese cabbage, Chinese cabbage, Mokka, Ikrinin, Kyounin, Sekinanyou, Hakukyo, Kaishuenshi, Ilyosai, Dubai moth, Hiren, Chorei, Chomokusai, Nyakuakusei, Kyouseitsukonsyubu, each The substance significantly suppresses melanin production without showing cytotoxicity. Therefore, the cosmetic composition for whitening containing at least one of these extracts of the present invention is safe and has a high whitening effect.

Claims (1)

[Claims] [Claim 1] Gyoyou, Sansonin, Shiroyou, Seimokko, Soukyo, Thyroid, Hakusenpi, Byakuren, Hakumokuji, Mokka, Ikrinin, Kyounin, Sekinanyou, Hakukyo, Kaishuenshi, Iryosai, Dumo, Hiren, Chorei, Chocounensis, Chocounensis, Clams A cosmetic composition for whitening, comprising as an active ingredient an extract of at least one herbal medicine selected from the group consisting of Setsushobu, Taiseikon, and Current Saisai.