JPH0692841A - Production of aerosol composition - Google Patents

Abstract

PURPOSE:To provide the production process of aerosol which keeps homogeneity even after long-range storage, hardly causes phase separation, can take out the homogeneous content without shaking every on use and induces no skin defatting and skin irritation. CONSTITUTION:The objective composition is composed of a solution comprising (A) 30 to 85wt.% of the oil component or a combination thereof with the alcohol component and (B) 15 to 70wt.% of water and (C) dimethyl ether. The amounts of the solution and dimethyl ether are set to 2 to 60 pts.wt. and 40 to 98 pts.wt. based on 100 pts.wt. of the total, and (A) and (B) are mixed at first and, then (C) is admixed.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a method for producing an aerosol composition. More specifically, for example, cosmetics, pharmaceuticals,
The present invention relates to a method for producing an aerosol composition which can be suitably used for quasi drugs.

[0002]

2. Description of the Related Art Conventionally, cosmetics have been blended with synthetic oils such as fatty acid esters and silicone oils, and oil components such as vegetable oils and animal oils for the purpose of imparting permeability and luster to the skin and improving the feeling of use. . Further, an oil component such as glycol salicylate, dl-α-tocopheryl acetate, 1-menthol, and dl-camphor is blended as a medicinal component in a drug or quasi drug.

However, when an aerosol composition is prepared by mixing a propellant such as liquefied petroleum gas with these oil component and alcohol component, there is a problem that the skin is degreased when applied to the skin. In order to prevent this, it is preferable to add water, but there is a problem that oil components and the like are separated from each other.

As a method for stabilizing a composition containing such an oil component or alcohol component and water in a uniform state, a surfactant is added to form a water-in-oil emulsion or an oil-in-water emulsion. The method is known.

However, emulsions containing a surfactant have problems such as stickiness during use and great irritation to the skin. Further, in order to use as an aerosol, a propellant such as liquefied petroleum gas is added to the emulsion. The blended aerosol composition may cause the contents to separate into layers when stored for a long period of time, and it may be necessary to sufficiently shake each time before use. There is a problem that it is difficult to apply the same amount uniformly.

[0006]

DISCLOSURE OF THE INVENTION The present invention has been made in view of the above-mentioned prior art, and has no degreasing or skin irritation to the skin, moreover does not easily cause layer separation, and does not shake each time it is used. It is also an object of the present invention to provide a method for producing an aerosol composition in which the contents having a uniform and desired composition can be taken out as they are.

[0007]

Means for Solving the Problems That is, the present invention relates to (A) an oil component, or a stock solution comprising 30 to 85% by weight of an oil component and an alcohol component and (B) 15 to 70% by weight of water, and (C) dimethyl ether. The ratio of the stock solution is 2 to 60 parts by weight and the ratio of dimethyl ether is 40 to 98 parts by weight with respect to 100 parts by weight of the total amount of the stock solution and dimethyl ether, and the components (A) and (B) are mixed. Then, the present invention relates to a method for producing an aerosol composition, which comprises mixing the component (C).

[0008]

According to the production method of the present invention, by mixing dimethyl ether at a specific blending ratio with a stock solution consisting of an oil component in a specific blending ratio, or an oil component and an alcohol component, and water, a stock solution stage is obtained. An aerosol composition is obtained in which an oil component that is layer-separated from each other, or an oil component and an alcohol component, and water are homogeneously dissolved in dimethyl ether.

In the method for producing the aerosol composition of the present invention, a stock solution comprising the components (A) and (B) described below is used.

The component (A) is an oil component or an oil component and an alcohol component.

The oil component is a component for imparting skin permeability and luster, improving the feeling of use, and imparting a pharmacological action, and as long as it can be used for such purpose. Although not particularly limited, such oil components include fatty acid esters, silicone oils, oil-soluble pharmacologically active substances,
It is preferably at least one selected from the group consisting of vegetable oils and animal oils.

Specific examples of the oil component include isopropyl myristate, myristyl myristate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, ethyl linoleate, isopropyl linoleate, diisopropyl adipate, diisopropyl sebacate, Fatty acid esters such as diethyl sebacate; silicone oils such as methylphenylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane; dl-camphor, 1-menthol, glycol salicylate, methyl salicylate, dl-α-tocopherol acetate. Eucalyptus oil, diet,
Oil-soluble pharmacologically active substances such as lidocaine, crotamiton, diphenhydramine and vitamin oil; olive oil, almond oil, jojoba oil, peanut oil, castor oil, coconut oil, palm oil, safflower oil, sunflower oil, cottonseed oil, avocado oil, camellia oil , Corn oil, wheat germ oil, rice bran oil, cacao butter, sesame oil, evening primrose oil, safflower oil, southern oil, soybean oil, rapeseed oil, carnauba wax, macadamian nut oil, apricot kernel oil, grape seed oil and other vegetable oils; lanolin and Examples include animal oils such as lanolin derivatives, turtle oil, mink oil, beeswax, squalene, squalane, pristane, and egg yolk oil, which may be used alone or in combination with 2
It is used as a mixture of two or more species.

The alcohol component is a component for diluting an oil component having a high viscosity, and when two or more oil components are used, they are uniformly mixed and dissolved. There is no particular limitation as long as it can be used for.

Specific examples of the alcohol component include, for example, ethanol and isopropanol,
Ethanol may be a commonly used one, and undenatured ethanol, various denatured ethanol and the like can be used. These may be used alone or in admixture of two or more.

When the alcohol component contains a large amount of water, layer separation occurs. Therefore, the alcohol component preferably has a concentration of 90% or more, particularly 95% or more.

The blending amount of the alcohol component in the component (A) is 3000 with respect to 100 parts of the oil component (parts by weight, the same applies hereinafter).
It is preferably not more than 1000 parts, especially not more than 1000 parts.
When the content of the alcohol component exceeds 3000 parts, the effect of using the oil component tends to be insufficiently exhibited.

The content of the component (A) in the stock solution is 30 to 85% by weight, preferably 40 to 80% by weight. When the content of the component (A) is less than 30% by weight, the obtained aerosol composition becomes easy to separate, and when it exceeds 85% by weight, the aerosol composition is applied to the skin. When this happens, degreasing of the skin is likely to occur.

The water as the component (B) is a component for preventing degreasing of the skin when the aerosol composition is applied to the skin, and such water is not particularly limited. For example, distilled water, Purified water such as ion-exchanged water can be used.

The content of the component (B) in the stock solution is 15 to 70% by weight, preferably 20 to 60% by weight. When the blending amount of the component (B) is less than 15% by weight, degreasing of the skin is likely to occur when the obtained aerosol composition is applied to the skin, and when it exceeds 70% by weight. The aerosol composition becomes easy to separate.

The stock solution used in the present invention contains various active ingredients in addition to the components (A) and (B).
A solvent or the like can be appropriately selected and used according to the application within a range not impairing the object of the present invention.

Specific examples of the active ingredients include, for example, astringent active ingredients, hair spray active ingredients, baby oil active ingredients, nail protection active ingredients, antiperspirant active ingredients,
Hair tonic active ingredient, after-shave lotion active ingredient, hand lotion active ingredient, suntan lotion active ingredient, body lotion active ingredient, anti-itch active ingredient, anti-inflammatory analgesic active ingredient, hair restorer active ingredient, bactericide active ingredient, fragrance, etc. .

When the above-mentioned active ingredient is used, the amount of the active ingredient blended in the stock solution varies depending on the kind of the active ingredient, but it is adjusted so that the effect due to the blending of the active ingredient can be sufficiently exhibited. It is preferable. If the blending amount is too large, compatibility with a propellant and the like,
Since the stability tends to decrease, it is desirable to adjust the concentration to preferably about 15% by weight or less, more preferably about 10% by weight or less.

Specific examples of the solvent include propylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, glycerin, 1,
Examples include polyhydric alcohols such as 3-butylene glycol.

When the above-mentioned solvent is used, it is desirable to adjust the content of the solvent in the stock solution to be preferably about 20% by weight or less, more preferably about 15% by weight or less.

In the present invention, dimethyl ether ((C) component) is used as a propellant.

Total amount of the stock solution and dimethyl ether 10
The ratio of undiluted solution to 0 parts is 2-60 parts, especially 10-
The ratio of dimethyl ether is 40 to 98 parts, especially 50 to 90 parts. When the ratio of dimethyl ether to the total amount of the undiluted solution and dimethyl ether is 100 parts is less than 40 parts, the undiluted solution and dimethyl ether are separated into two layers, and a uniform aerosol composition cannot be obtained. If it exceeds, the amount of the undiluted solution becomes too small to achieve the object of the present invention, and the amount of dimethyl ether becomes relatively large, which is not preferable in terms of safety.

In the present invention, in addition to the above-mentioned dimethyl ether, F12, F114, F134a as a propellant can be used.
And the like, liquefied petroleum gas (a mixture of propane, i-butane, n-butane, etc.) and the like can be used.

Components other than these dimethyl ethers used as a propellant can be used in place of the oil component, water, alcohol component and a part of dimethyl ether as long as the undiluted solution and the propellant are not separated into two layers. It is preferable to use 20% by weight or less, especially 10% by weight or less of the total amount of the oil component, water, alcohol component and dimethyl ether that can be used in order to obtain a composition capable of exhibiting desired properties.

In the production method of the present invention, the component (A) and the component (B) constituting the stock solution are divided into two steps, and the aerosol pressure-resistant container is sequentially filled, and the components are mixed.
An aerosol composition is obtained by filling and mixing a propellant which is the component (C) in this.

As the aerosol pressure-resistant container, a conventionally used one can be used, and the aerosol composition obtained as described above has an internal pressure of 2 at 25 ° C.
It is preferable to adjust the pressure so as to be 6 kg / cm ² · G, especially 3 to 5 kg / cm ² · G.

When the component (A) is composed of an oil component and an alcohol component, it is usually sufficient that they are uniformly mixed in advance and then mixed with the component (B).

When the above-mentioned active ingredients and solvents are used, they may be added in advance to the component (A) or the component (B) and mixed, and the components (A) and (B) may be mixed. The components may be mixed and then added and mixed.
When dimethyl ether and a propellant other than dimethyl ether are used in combination, it is preferable that the propellant other than dimethyl ether is mixed with dimethyl ether in advance and then mixed with the stock solution.

The aerosol composition obtained by the production method of the present invention is homogeneous even when stored for a long period of time, layer separation is unlikely to occur, and the content of a uniform composition can be taken out as it is without shaking each time it is used. In addition, since the degreasing and skin irritation of the skin is small, it can be suitably used in a wide range of fields such as cosmetics, pharmaceuticals, and quasi-drugs.

Next, the method for producing the aerosol composition of the present invention will be described in more detail based on examples, but the present invention is not limited to these examples.

Example 1 As component (A), 5 parts of isopropyl myristate and
30 parts of 99% ethanol and purified water as component (B)
Using 15 parts, aerosol pressure resistant container (full volume: 200 ml)
Then, the components (A) and (B) are charged in this order and mixed, and then 50 parts of dimethyl ether is added as the component (C).
It was lightly agitated and dissolved to obtain an aerosol composition as a hair spray for polishing. The internal pressure at this time is 25 ° C
Adjusted to 3.8kg / cm ² · G.

The state of the stock solution before the preparation of the aerosol composition and the state one day after the preparation of the obtained aerosol composition were visually inspected, and the appearance was examined. However, no layer separation was observed in the obtained composition, and a uniform solution was obtained. Also,
After leaving this composition at room temperature for 30 days, the state of the composition was examined in the same manner as above, and it was found that a uniform state was maintained.

When the obtained aerosol composition was sprayed on the hair and its glossing effect was examined, the sprayed portion of the aerosol composition had a glossy hair state as compared with the other portions, and the aerosol composition It has been found that the objects have an excellent polish effect.

The characteristics of the obtained aerosol composition are familiar to the hair, sticky feeling, degreasing of the skin,
For skin irritation, 5 g of the aerosol composition was sprayed on the heads (hair) of 50 randomly selected panelists of men and women,
Each was evaluated according to the following evaluation criteria.

(Evaluation Criteria) (a) Familiarity with Hair A: More than 40 people felt that they were familiar. B: 30 to 39 people felt familiar. C: 20 to 29 people felt familiar. D: 10 to 19 people felt familiar. E: Only 9 people or less felt familiar.

(B) Sticky feeling A: 9 or less people felt that there was sticky feeling. B: 10 to 19 people felt that it was sticky. C: 20 to 29 people felt that it was sticky. D: 30 to 39 people felt that it was sticky. E: More than 40 people felt sticky.

(C) Degreasing of skin A: 9 or less people felt that the skin was degreased. B: 10 to 19 people felt that the skin was degreased. C: 20 to 29 people felt that the skin was degreased. D: 30 to 39 people felt that the skin was degreased. E: More than 40 people felt that the skin was degreased.

(D) Skin irritation A: 9 or less people felt irritation on the skin. B: 10 to 19 people felt irritation on the skin. C: 20 to 29 people felt irritation on the skin. D: 30 to 39 people felt irritation on the skin. E: More than 40 people felt irritation on the skin.

Table 1 shows the state of the stock solution before the preparation of the aerosol composition, the state of the obtained aerosol composition and the results of the monitor test of each property.

Examples 2 to 5 and Comparative Examples 1 to 4 An aerosol composition was prepared in the same manner as in Example 1 except that the compounding amounts of the components were changed as shown in Table 1.
Similarly to the above, the state of the stock solution before the preparation of the aerosol composition and the state of the obtained aerosol composition were observed, and a monitor test of each characteristic was performed. The results are shown in Table 1.

The aerosol compositions of Examples 2 to 5 had the same excellent lustering effect as those of Example 1.

Example 6 Using 4.5 parts of glycol salicylate as the component (A), 11 parts of 1-menthol and 12.5 parts of 95% 8-acetylated sucrose denatured ethanol, and 12 parts of purified water as the component (B), for aerosol In a pressure resistant container (full volume: 200 ml),
After filling the components (A) and (B) in this order and mixing,
60 parts of dimethyl ether was charged as the component (C), and the mixture was lightly agitated and dissolved to obtain an aerosol composition as an anti-inflammatory analgesic. The internal pressure at this time was adjusted to 3.8 kg / cm ² · G at 25 ° C.

The state of the stock solution before the preparation of the aerosol composition and the state of the obtained aerosol composition were observed in the same manner as in Example 1. The results are shown in Table 2.

Next, the obtained aerosol composition was sprayed on the inflamed part of the upper arm to examine its anti-inflammatory and analgesic effect. As a result, it was found that the inflammation subsided and the aerosol composition had the anti-inflammatory and analgesic effect.

The characteristics of the obtained aerosol composition are familiar to the skin, sticky feeling, degreasing of the skin,
For skin irritation, 5 g of the aerosol composition was sprayed onto the upper arm of 50 randomly selected male and female panelists, and the same evaluation criteria as in Example 1 were used (however, the evaluation criteria for familiarity with the skin are familiar with the above hair). (Same as the evaluation standard of 1). The results are shown in Table 2.

Example 7 An aerosol composition was prepared in the same manner as in Example 6 except that the compounding amounts of the respective components were changed as shown in Table 2.
Similarly to the above, the state of the stock solution before the preparation of the aerosol composition and the state of the obtained aerosol composition were observed, and a monitor test of each characteristic was performed. The results are shown in Table 2.

The aerosol composition of Example 6 was prepared.
It also had an anti-inflammatory and analgesic effect.

[0052]

[Table 1]

[0053]

[Table 2]

As is clear from the results shown in Tables 1 and 2, the aerosol composition obtained by the production method of the present invention does not cause layer separation even when it is stored for a long period of time, and is well known. It is clear that it has excellent physical properties such as a sticky feeling, no degreasing of the skin, and no skin irritation.

[0055]

EFFECTS OF THE INVENTION According to the production method of the present invention, the contents are homogeneous even when stored for a long period of time, layer separation hardly occurs, and the contents having a uniform composition can be taken out as they are without shaking each time they are used. It is possible to obtain an aerosol composition which has no skin degreasing or skin irritation and can be suitably used in a wide range of fields such as cosmetics, pharmaceuticals, and quasi drugs.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display location A61K 7/06 8615-4C 7/48 9051-4C

Claims (3)

[Claims] 1. A stock solution comprising (A) an oil component, or 30 to 85% by weight of an oil component and an alcohol component and (B) 15 to 70% by weight of water, and (C) dimethyl ether. The ratio of the undiluted solution to the total amount of 100 parts by weight is 2 to 60 parts by weight, the ratio of dimethyl ether is 40 to 98 parts by weight, and the component (A) and the component (B) are mixed, and then the component (C) is added thereto. A method for producing an aerosol composition, which comprises mixing the components. 2. The method for producing an aerosol composition according to claim 1, wherein the oil component is at least one selected from the group consisting of fatty acid esters, silicone oils, oil-soluble pharmacologically active substances, vegetable oils and animal oils. 3. The method for producing an aerosol composition according to claim 1, wherein the alcohol component is ethanol and / or isopropanol.