JPH0672838A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a novel cosmetic containing the water-soluble extract of coconut fruits as an active ingredient, simultaneously having a beautifully whitening action, an antiinflammatory action and a water retention which are highly stable, and preferable also on safety. CONSTITUTION:Coconut fruits are ground and then extracted with water or with the water and a water-soluble solvent under heating, and the extract is concentrated. The cosmetic simultaneously having a beautifully whitening action, an inflammatory action and a water-retaining force contains the concentrated extract as a raw material. The base material is used as a raw material to provide the cosmetic such as a beauty water, a cream, an emulsion, a shampoo. a foundation, a lip cream, a lip stick. etc. The water-soluble extract of the coconut fruits is preferably used in an amount of 0.1-5.0wt.% based on the total amount of the cosmetic.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a novel cosmetic. More specifically, the present invention relates to a cosmetic having a whitening effect, an anti-inflammatory effect, and a water retention ability, which contains a water-soluble extract of coconut palm fruit as an active ingredient.

[0002]

BACKGROUND OF THE INVENTION Although there are some unclear points regarding the mechanism of skin spots, freckles, etc., melanin pigments are generally formed due to hormonal abnormalities and ultraviolet rays from the sun, and this is due to the fact that the It is thought that it will be abnormally deposited. For the treatment of such stains and freckles, a substance that inhibits the thyrodinase activity present in the skin and suppresses melanin production, for example, a method in which a large amount of vitamin C is administered, glutathione is an ointment, and cream is used. , A lotion or the like and locally applying it.
In Europe and America, hydroquinone preparations are used as medicines.

On the other hand, the skin is irritated by various skin stimuli, for example, the action of ultraviolet rays, and those which suppress these inflammations are anti-inflammatory agents, and as ingredients for cosmetics, aloe, loofah, etc. Plant extract, glycyrrhizin,
Zinc white or the like is used.

Further, if the water content in the stratum corneum of the skin decreases, it may cause rough skin. Glycerin, 1,3-butylene glycol, propylene glycol, hyaluronic acid and the like are used as moisturizing agents in order to give an appropriate water content to the stratum corneum.

[0005]

[Problems to be Solved by the Invention] Vitamin C contains heat,
It has poor stability over time with respect to light, and causes discoloration and odor particularly in systems containing water. On the other hand, the use of hydroquinone type is limited because of its safety problems such as skin irritation and allergenicity. Further, there is a problem in terms of stability because it is easily oxidized by air. Thiol-based compounds such as glutathione and cysteine have a strong offensive odor and are easily oxidized and their effects are slow. In addition, 2-mercaptoethylamine salt, N- (2-mercaptoethyl) dimethylamine salt and the like are known to decolorize the skin of black guinea pigs, but since white spots easily occur after decolorization, they are generally used. Absent.

On the other hand, there are various components having a whitening action, an anti-inflammatory action and a moisturizing action, as described above, but in order to produce a cosmetic having these effects, a plurality of these components are respectively added. There are many things to be noted such as the stability of the product, which must be added.

[0007] In view of the above situation, the inventors of the present invention have conducted extensive studies and found that a cosmetic containing a water-soluble extract of coconut palm fruit as an active ingredient has good whitening action, anti-inflammatory action and water retention ability. The present invention has been completed and the present invention has been completed.

[0008]

The present invention is a cosmetic containing a water-soluble extract of coconut palm fruit as an active ingredient.

The coconut palm used in the present invention is a genus of Palmae clogs (Arenga engleri), which is an evergreen shrub and is usually less than 2 m in height. Many trunks are dark brown. The leaves are 2-3 m long, the surface is dark green and shiny, and the back is whitish. The leaflets are 70 cm long and 4 cm wide.
A blackish brown leaf sheath network is densely formed at the base of the petiole. Male and female flowers of the same strain bloom one month earlier than female flowers. The flower cover is yellow and the length is about 2c.
m, the fruits are berries, ripe red, spherical, and slightly less than 2 cm in diameter. The seeds are black and about 1 cm long. (Heibonsha Terasaki Botanical Encyclopedia, Ryukichi Terasaki)

The water-soluble solvent used in the present invention is water or a water-soluble solvent such as water, alcohols (methanol, ethanol, 1,3-butylene glycol, propylene glycol, etc.). ), Acetone and the like. Moreover, the extraction of the fruit of the plant of the present invention may be carried out by using one or a mixture of two or more of these water-soluble solvents. Further, it may be one extracted by heating or one extracted at room temperature. If necessary, it can be concentrated or diluted and used as a cosmetic raw material.

The cosmetics of the present invention contain oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters and metals as long as the effect of the water-soluble extract of coconut palm is not impaired. Soaps, surfactants and the like can be blended as raw materials.

Examples of cosmetics produced from these base materials as raw materials include lotion, cream, emulsion, shampoo, foundation, lip cream, lipstick and the like.

The amount of the water-soluble extract of coconut palm fruit used in the cosmetic of the present invention is 0.01 to 10% by weight, based on the total amount of the cosmetic, as solid content obtained by distilling off the solvent. It is preferable to add 0.1 to 5.0% by weight. If it is less than 0.01% by weight, no sufficient effect can be expected, and if it exceeds 10% by weight, the effect is not enhanced and it is uneconomical.

Regarding the method of addition, it may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0015]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto. The parts shown in the examples are parts by weight, and% is% by weight.

Example 1 Coconut palm fruit (500 g) was shredded, heat-extracted with 500 ml of water twice for 2 hours each time, and further concentrated by vacuum freeze-drying to obtain 10 g of extract (containing solids of 99% or more). Got

Example 2 60 g of dried coconut palm fruit was crushed, heat-extracted with 600 ml of a water-ethanol mixed solution (1: 1) for 5 hours, and further concentrated to obtain 5 g of the extract (solid content of 50%). (Including things).

Example 3 60 g of dried coconut palm fruit was crushed, 300 ml of ethanol was added, and the mixture was allowed to stand at room temperature for 1 month. 5g of extract by further concentration (including 99% or more solids)
Got

Example 4 60 g of dried coconut palm fruit was crushed and propanoed.
The mixture was heated and extracted twice with 600 ml each for 2 hours, and further concentrated to obtain 3 g of an extract (containing 70% of solid matter).

Example-5 Lotion (1) Hot water extract of coconut palm fruit (99% as a solid) 5.0 parts (2) Glycerin 2.0 (3) Ethyl alcohol 7.0 (4) Methyl paraoxybenzoate 0.05 (5) Polyoxyethylene (20) Lauryl ether 0.5 (6) Citric acid 0.01 (7) Sodium citrate 0.1 (8) Perfume 0.1 (9) The components (2) to (4) having a total amount of 100 are mixed with purified water and dissolved. Separately, the components (1) and (5) to (8) are mixed and dissolved. Then, both are mixed and filtered through a Tetoron cloth (300 mesh) to obtain a product.

Example-6 Cream (1) Hot water extract of coconut palm fruit (99% as solid) 2.0 parts (2) Squalane 5.5 (3) Olive oil 3.0 (4) Stearic acid 2 0.0 (5) Beeswax 2.0 (6) Octyldodecyl myristate 3.5 (7) Polyoxyethylene (20) Cetyl ether 3.0 (8) Behenyl alcohol 1.5 (9) Glycerin monostearate 2.5 (10) 1,3-Butylene glycol 8.5 (11) Methyl paraoxybenzoate 0.2 (12) Ethyl paraoxybenzoate 0.05 (13) Perfume 0.1 (14) Total amount to 100 with purified water. The components (2) to (9) are dissolved by heating and mixed, and the mixture is kept at 70 ° C. to obtain an oil phase. Ingredients (1) and (10) to (12) are heated and dissolved in ingredient 14 and mixed, and the mixture is kept at 75 ° C to form an aqueous phase.
The aqueous phase is added to the oil phase to emulsify, component (13) is added, and the mixture is stirred and cooled to 30 ° C. to obtain a product.

Example-7 Emulsion (1) Ethanol extract of coconut palm fruit (99% as solid content) 1.0 (2) Squalane 5.0 (3) Olive oil 5.0 (4) Jojoba oil 5.0 (5) Cetyl alcohol 1.5 (6) Glycerin monostearate 2.0 (7) Polyoxyethylene (20) cetyl ether 3.0 (8) Polyoxyethylene (20) sorbitan monooleate 2.0 (9 ) Dipropylene glycol 1.0 (10) Glycerin 2.0 (11) Perfume 0.1 (12) Methyl paraoxybenzoate 0.2 (13) Total amount to 100 with purified water Components (2) to (8) ) Is melted by heating and mixed, and the mixture is kept at 70 ° C. to obtain an oil phase. Components (1), (9), (10), (1
2) is dissolved in the component (13) by heating and mixed, and the mixture is kept at 75 ° C. to form an aqueous phase. The aqueous phase is added to the oil phase to emulsify and disperse, and the component (11) is added and stirred to cool to 30 ° C. to obtain a product.

Example-8 Pack (1) Propylene Glycol Extract of Coconut Palm Fruit (20% as Solid) 3.0 parts (2) Polyvinyl Alcohol 11.5 (3) 1,3-Butylene Glycol 2.5 (4) Polyoxyethylene (40) Hydrogenated castor oil 1.0 (5) Ethyl alcohol 7.0 (6) Methyl paraoxybenzoate 0.2 (7) Perfume 0.05 (8) The total amount is 100 with purified water. The components (1) to (8) are dissolved by heating at 75 ℃, 30 ℃
Cool down to product.

[0024]

EFFECTS OF THE INVENTION A cosmetic containing the water-soluble extract of coconut palm of the present invention as an active ingredient has a highly stable whitening action, an anti-inflammatory action and a water retention ability, and is also preferable in terms of safety. Is. Hereinafter, the effects of the present invention will be described with reference to experimental examples.

[Experimental Example] Efficacy Test Example 1 Whitening Action To examine the inhibitory action on tyrosinase activity, 0.1
The tyrosinase activity inhibitory ability of the 5% aqueous solution was measured before and after the incubation at 37 ° C. for 2 weeks. As a comparative example, ascorbic acid, loofah water, and hot water extract of loofah fruits, which have been conventionally used as cosmetics, were similarly tested. The sample used was the extract obtained in Example 1. The hot water extract of loofah (comparative example) was prepared by extracting 10 g of the dried product with hot water (95 ° C, 3 hours, 30 hours).
(0 ml), the filtrate was lyophilized in vacuo.

Measurement of tyrosinase activity inhibitory action: 1 ml of L-tyrosine solution (0.3 mg / ml), 1 ml of Max Bain's buffer (pH 6.8), and 0.15% aqueous solution of the sample in a test tube Add 0.9 ml to 37
Incubated for 10 minutes in a constant temperature water bath at ℃. 0.1 ml of an aqueous solution of tyrosinase (1 mg / ml) was added thereto, well stirred, incubated at 37 ° C. for 12 minutes, set in a spectrophotometer, and the absorbance at 475 nm was measured. On the other hand, the same absorbance measurement was performed using distilled water instead of the above sample as a blank, and the tyrosinase activity inhibition rate of each sample was calculated from the following formula. In the formula, A means the absorbance when each sample was added, and B means the absorbance of the blank. Inhibition rate (%) = (1−A / B) × 100

The results of these tests are shown in Table 1. As is clear from Table 1, the water-soluble extract of coconut palm fruit obtained in Example-1 has a more remarkable thyrodinase activity inhibitory activity than loofah water and hot water extract of loofah. It is recognized that the product has a good thermostability and has a stronger tyrosinase activity inhibitory effect than that of vitamin C after standing for 2 weeks at 37 ° C. In addition, in these stability tests, no odor or discoloration was observed in the water-soluble extract of coconut palm fruit. Furthermore, when the water-soluble extracts of coconut palm fruits obtained in Examples 2 to 4 were tested in the same manner,
It was found that they showed equally good tyrosinase activity inhibitory activity. (Below margin)

[0028]

[Table 1] Tyrosinase activity inhibition ────────────────────────── Sample concentration Activity inhibition rate (%) (%) ───── ────── Before heating ────────────────────────── Example-1 0.15 60 60 Vitamin C 0 15 95 26 Loofah water 0.15 95 9 Loofah 0.15 32 32 Hot water extract ───────────────────────────

Efficacy test example 2 Anti-inflammatory effect In order to investigate the anti-inflammatory effect, a sample of 0.01%, 0.1
% And 1.0% of each aqueous solution, a histamine release inhibition test was carried out. As a comparative example, hot water extracts of loofah water and Kitia aloe, which have been conventionally used in cosmetics, were similarly tested. The water-soluble extract of coconut palm, loofah water and hot water extract of loofah are the same as those used in Experimental Example 1.

Histamine release inhibition test; Male Spraqu according to the report of Hirai et al. (Biopharmaceutical Journal, 37 , 374, 1983.).
The histamine release inhibitory effect on mast cells collected from the abdominal cavity of e-Dawley rats (200 to 450 g) was measured. Ie 4 ppm compound 48/80
The inhibitory effect on histamine release by A. was determined as the release inhibition rate (%).

The results are shown in Table 2. From these results, the hot water extract of the fruit of the coconut palm obtained in Example-1 has a remarkable histamine release inhibitory action as compared with the hot water extract of loofah water and Kitia aloe, and also has an excellent anti-inflammatory action. I found that. Further, when the water-soluble extract of the fruit of the coconut palm obtained in Examples 2 to 4 was tested in the same manner, it was found that it showed a good anti-inflammatory action.

[0032]

[Table 2] Histamine release inhibitory effect ────────────────────────── Sample concentration Histamine (%) Release inhibitory rate (%) ──── ────────────────────── Example-1 1.0 100 0.1 99 0.01 0.01 65 loofah water 1.0 65 0.1 23 23. 01 13 Kitta aloe 1.0 80 Hot water extract 0.1 61 0.01 35 35 ───────────────────────────

Efficacy Test Example 3 Moisturizing Effect The moisture evaporation inhibition rate was measured for samples 0.5 and 7.0% aqueous solutions. For comparison, glycerin, which has been conventionally used as a moisturizer in cosmetics, was similarly tested using distilled water as a blank. The hot water extract obtained in Example-1 was used as the sample.

Method for measuring water vapor evaporation inhibition rate: 2 ml of each sample solution is placed in a standard bottle and allowed to stand at a temperature of 25 ° C. and a relative humidity of 50%. After standing for 4 days, the water evaporation amount of each sample solution was measured, and the water evaporation rate was calculated from the following equation. In the formula, A means the water evaporation amount of each sample, and B means the water evaporation amount of the blank (distilled water). Rejection rate (%) = (1-A / B) × 100

The results of these tests are shown in Table 3. As is clear from the results, the hot water extract obtained in Example-1 of the present invention was found to have a water evaporation inhibition rate similar to that of glycerin, and to be excellent in water retention.

[0036]

[Table 3] Moisture evaporation inhibition rate ─────────────────────────── Sample Sample concentration (%) Moisture evaporation inhibition rate (%) ── ───────────────────────── Example-1 0.5 5.0 7.0 31.5 Glycerin 0.5 5.0 7. 0 32.8 ────────────────────────────

Efficacy Test Example 4 Usage Test A usage test was carried out using 30 healthy subjects. As the samples, the cosmetics of Examples 5 and 6 were used, and the weight% of the water-soluble extract of coconut palm fruit was changed. A UV-B lamp (TOSHIBA FL-20SE) was used to irradiate the site of 2 cm square on the inner side of the forearm of the subject with ultraviolet rays having an intensity of ³ mw / cm ² for 1 minute. Each sample was applied to each site twice daily in the morning and evening for 3 days, and then the effect of suppressing inflammation was surveyed and evaluated. The effect of suppressing pigmentation after one month of use and the moist feeling of the skin are also questioned.
An evaluation was performed by conducting a survey. Incidentally, one of the sites irradiated with ultraviolet rays was a control in which nothing was applied. The evaluation criteria of the questionnaire were based on the following, and evaluated in comparison with the control. (Judgment Criteria) Valid ◎ Slightly Valid ○ Almost Invalid △ Invalid × (Margins below)

[0038]

[Table 4-1] Questionnaire results on the effect of suppressing inflammation (Below margin)

[0039] (Below margin)

[0040]

[Table 4-3] Results of questionnaire on skin moisturization

From the results shown in Table 4, it can be seen that the cosmetics used in the present invention exhibit a remarkable effect of suppressing inflammation and pigmentation after sunburn, and also exhibit a good effect on the moist feeling of the skin.

Efficacy Test Example 5 Safety Test In order to clarify the safety of the water-soluble extract of coconut palm fruit of the present invention, a primary irritation test for humans was conducted by an occlusive patch test. That is, the fin chamber
Using EPITEST, 30 healthy people were occluded on the flexed side of the forearm for 48 hours, and after removal of the patch test plaster, the average value of the judgments made 1 hour, 24 hours, and 48 hours later. It was judged using. As the sample, the water extract obtained in Example 1 was used, and the coating concentration was 10% (W / W) aqueous solution.
Distilled water was used as a control. As a result of the determination, no erythema was observed in the water extract of coconut palm fruit, while a slight erythema was observed in 5 of the distilled water as a control. From these results, it was confirmed that the water-soluble extract of coconut palm has extremely low primary irritation and is highly safe to the skin. Also,
The water-soluble extracts of coconut palm fruits obtained in Examples 2 to 4 were also tested in the same manner, and were found to be similarly highly safe to the skin.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Akio Monobe 2-130, Torimi-cho, Nishi-ku, Nagoya, Aichi Prefecture, Central Research Institute, Japan Menard Cosmetics Co., Ltd. (72) Iwa Fukunaga 2 Torimi-cho, Nishi-ku, Nagoya, Aichi Prefecture 130-chome, Central Research Institute, Japan Menard Cosmetics Co., Ltd.

Claims (1)

[Claims] 1. A cosmetic comprising a water-soluble extract of coconut palm fruit.