JPH06285158A - Heavy-duty blood plasma / blood collection device - Google Patents

Abstract

(57) [Summary] [Purpose] The anticoagulant injection during blood collection is controlled continuously according to the blood collection volume, and at the time of blood return, the air from the blood bag into the blood flow path and into the membrane plasma separator To prevent the contamination of the device and further simplify the entire device. [Means] A second connecting pipe 63 is connected to one inlet / outlet port of a membrane plasma separator 64, a third continuous pipe 65 is connected to the other inlet / outlet port, and a fourth connecting pipe 67 is connected to a plasma outlet port. Detection means 4a, 4b, 4c are provided. Second connecting pipe 6
3 is a first connecting pipe 61 communicating with an anticoagulant storage bag 62.
, And the injection amount of the anticoagulant at the time of blood collection is controlled by the roller pump 11. When the blood is returned from the blood bag 66, it is provided with control means for leaving a small amount of blood due to air-mixing in the bag.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a conventional depressurization-type blood collecting machine, which is provided with a pressurizing function in a storing portion of a blood bag so as not only to collect blood but also to return blood. The present invention relates to a heavy-duty plasma / blood sampling combined device in which a set amount of plasma is separated and collected by a membrane plasma separator.

[0002]

2. Description of the Related Art A conventional blood plasma collecting apparatus has been developed for the purpose of using it exclusively for blood plasma collecting. For example, when performing blood collecting on a business trip using a blood donation car, etc. It is necessary to transport both the dedicated device and the whole blood collection device and use the device properly according to the donor's condition.In a small blood donation vehicle, plasma collection or whole blood collection is required due to the location of the device. In some cases, they were forced to donate blood only, and they often felt inconvenient to use. Therefore, in recent years, we improved the decompression-type whole blood blood sampling device so that the decompression box can be pressurized and not only blood can be collected but also blood can be returned through a membrane plasma separator for whole blood collection and plasma collection. There has been proposed a device that can be used in common (for example, Japanese Patent Laid-Open No. 2-98365).

However, in the above-mentioned device, the anticoagulant has a mechanism in which the amount of the anticoagulant is limited by the resistance of the flow path so that the anticoagulant is injected at a constant ratio with respect to the blood volume. Although the required amount of anticoagulant is placed in a bag with a limited capacity and no further injection is performed, it is not possible to keep the anticoagulant ratio constant at all times depending on the negative pressure state of the blood circuit. In many cases, it is difficult or necessary amount is not injected, and as a result, there is a problem that hemolysis of blood and thrombus formation in a membrane plasma separator and a blood circuit including a puncture needle are caused.

In addition, when the whole blood collection machine is improved to add a function to collect blood plasma, if the positional relationship between the blood bag and the inlet of the blood is not taken into consideration, for example, the inlet will be If it is horizontal or higher than the blood bag, air bubbles in the bag may be mixed in the blood circuit, and it will be mixed inside the membrane plasma separator, which will have a significant adverse effect on the performance of the membrane. Could also cause air bubbles in the donor.

Further, in the above-mentioned device, since the whole amount of blood (including anticoagulant) in the blood bag is returned, when the blood bag is returned to a positive pressure and returned, the air-membrane is formed after the return of blood. However, there is a problem in that air bubbles remain in the membrane when mixed in the blood plasma separator, and a poor flow occurs at the next blood collection.
In addition, air mixed in the circuit may enter the blood donor. Furthermore, since the concentrated red blood cells returned after plasma separation have high viscosity and high resistance, if the concentrated red blood cells remain in the blood line, the blood (whole blood) at the time of blood collection will not flow to the smooths and the blood collection time There is a problem that it takes. Furthermore, since the above-mentioned device is provided with a separate connecting tube dedicated to blood collection, the structure of the disposable set is complicated, the handling becomes complicated, the number of control clamps increases, and priming operation is required.

The present invention, in a combined blood plasma and blood sampling apparatus, makes it possible to continuously control the injection of an anticoagulant at the time of blood sampling according to the amount of blood collected, and to change the blood flow path from the blood bag when returning blood. The purpose is to prevent air bubbles from entering the inside. Further, the present invention, in the above-mentioned plasma collection and blood collection apparatus, prevents air-mixing from the blood bag to the membrane plasma separator at the time of blood return, and simplifies the entire apparatus by sharing the line for blood collection and blood return. It is an object of the present invention to solve the above-mentioned problems, and further, it is possible to use two types of plasma collecting apparatus and blood collecting apparatus in one unit.

[0007]

The present invention provides at least a puncture needle for puncturing a blood donor, an anticoagulant storage bag connected to the puncture needle via a first connecting tube, and a puncture needle for the puncture needle. Membrane-type plasma separation means connected via two connecting tubes, a blood bag connected to the plasma separation means via a third connecting tube, and a blood bag connected to the plasma separating means via a fourth connecting tube. A disposable instrument part including a plasma bag, a means for accommodating at least the blood bag, for decompressing / pressurizing the blood bag from the outside, a means for detecting the weight of the plasma bag, and an intermediate part of the first connecting pipe. What is claimed is: 1. A heavy-duty blood plasma / blood collection combined use apparatus, which is used by combining an anticoagulant delivery means provided and a control section, wherein at least one or more of the means described in (1) to (4) below are provided. Weighted plasma collection / collection To provide a sharing device. (1) A means for sequentially controlling the means for transferring the anticoagulant according to a signal from the means for detecting the weight of the blood bag, and (2) a blood bag storage unit having means for decompressing / pressurizing the blood bag. In (3), a means for inclining the blood bag so that the connection site side of the blood bag with the third connecting pipe becomes relatively lowest when pressurizing, (3) a blood collection amount set value in the blood bag during blood collection Means for collecting a large amount of blood and controlling so as to leave a blood volume of an amount capable of preventing air from being mixed in the blood bag when returning blood, (4) closing the fourth connecting pipe at the end of blood returning, The means (1) for filling the blood in the blood bag into the plasma separating means and the second connecting pipe, said means (1) is a conveying means for electrically varying the injection amount of the anticoagulant, and a means for reducing / pressurizing the blood bag. The weight of the blood bag inside the storage box A measuring means such as a load cell capable of detecting continuously or in a short time period of about 0.5 to 10 seconds is provided, and the conveying means for the anticoagulant is controlled on the basis of a signal from the measuring means, so that an optimum condition is always obtained. It is a means of collecting blood at an anticoagulant ratio. Further, the means (2) is provided with a blood bag receiving blood in the storage box, and is basically based on a position where the blood receiving is horizontal, and means for controlling the inclination thereof is provided to provide a blood bag and an inlet of the blood bag. Is a means for inclining the tray 5 ° to 90 ° so that the inflow port is located at the lower part so that air bubbles are not mixed in the blood channel.

[0008]

According to the above-mentioned means for injecting the anticoagulant, the anticoagulant is infused in a necessary and sufficient amount according to the amount of blood collected, which causes problems such as hemolysis and blood clotting. Solve. By using the above-mentioned means for controlling the inclination of the blood bag, bubbles are not mixed in the blood flow path, the safety to the blood donor is significantly improved, and the performance of the membrane plasma separator is further hindered. Nothing happens, and safe and comfortable plasma collection can be performed. According to the above-mentioned means, when the blood in the blood bag is returned, a small amount of blood remains in the blood bag, so that the air in the blood bag flows out, and the connecting pipe, the plasma separator, etc. It is possible to prevent it from being mixed in with and to increase safety. After separating the plasma, when the fourth connecting pipe is closed to return a predetermined amount of excess blood in the blood bag, the concentrated red blood cell residual portion is replaced with whole blood.

[0009]

Embodiments of the present invention will now be described with reference to the accompanying drawings. FIG. 1 is an overall view of a main body device according to the present invention, showing a blood bag storage box 1 and a disposable device for blood collection, blood return, and plasma collection that is erected on the rear part of the blood bag storage box 1. The support part 2 is provided. A holder part 3 of the membrane plasma separator is provided on the front surface of the support part 2,
A bubble detecting means 4a is provided, and a plasma bag supporting hook portion 5 and an anticoagulant storage bag supporting hook portion 7 are provided above the supporting portion. Plasma bag support hook 5
Is connected to a weight measuring means 6 such as a load cell.
The bubble detecting means 4a is an ultrasonic sensor here, but may be an optical sensor.

A blood line clamp 8 and a plasma line clamp 9 are provided at the lower end of the front surface of the support portion 2, and a whole blood stopper-12 is provided at the upper end of the blood bag storage box 1. These clamps 8 and 9 and stopper-12
Is a solenoid type open / close clamp here. The whole blood stopper 12 can be forcibly opened by a release lever 19 on the side of the blood bag storage box 1. In addition, a cuff pressure adjuster 17 for adjusting the pressure of the tourniquet 55 (see FIG. 3) wound around the donor's arm on one side surface of the support 2, and a decompression force adjustment in the blood bag storage box 1 A tool 18 is provided, and a roller pump 11 and a pressure adjusting tool (not shown) in the blood bag storage box 1 are provided on the other side surface portion.

The blood bag storage box 1 has an opening / closing lid 13 on the upper surface, and the inside has a sealed structure. The open / close lid 13 is locked by the lock member 13a in the closed state. The inside of the blood bag storage box 1 can be switched to a negative pressure state or a pressurized state by a pressurizing / depressurizing means (not shown). The pressurizing / depressurizing unit is composed of an air supply / exhaust pump, a ventilation pipe, a pressurizing / depressurizing switching valve, etc., and the pressure of negative pressure / positive pressure can be changed according to the blood collecting state such as the blood vessel thickness of the donor. There is. The blood bag storage box 1 has a power switch 20 on the front bottom.

Inside the blood bag storage box 1, a blood bag tray 14 (see FIG. 2), a swinging means 52 (see FIG. 3) for the blood bag tray, and a blood bag weight measuring means 15 (see FIG. 3). ), A swing angle detecting means 54 (see FIG. 3), and the like. The bag plate swinging means 52 is a drive motor.
It is composed of a rotary cam, a rotary cam, and a bracket that moves up and down by the rotary cam, and swings in the range of 10 to 40 rpm. Although the blood bag weight measuring unit 15 is specifically a load cell, it may be an electromagnetic balance, a capacitance type balance, or the like. The blood bag plate swinging means 52, the blood bag weight measuring means 15, the swing angle detecting means 54, etc. are disclosed in Japanese Patent Application No. 63-298168 and Japanese Patent Application No. 2-9.
No. 9896, Japanese Patent Application No. 2-49182, Japanese Patent Application No. 2-19
Since it has been specifically proposed by the present applicant in Japanese Patent No. 3878, detailed description thereof will be omitted.

FIG. 2 is a conceptual diagram of the system of the present invention. The disposable instrument includes a puncture needle 60 that punctures a blood vessel of a blood donor, an anticoagulant storage bag 62 that is connected to the puncture needle 60 via a first connecting tube 61, a membrane plasma separator 64, and
A second connecting pipe 63 that connects one blood inlet / outlet of the membrane plasma separator 64 and the puncture needle 60, and a blood bag connected to the other blood inlet / outlet of the membrane plasma separator 64 via a third connecting pipe 65. 66 and a plasma bag 68 connected to the plasma outlet of the membrane plasma separator 64 via a fourth connecting pipe 67.

The anticoagulant storage bag 62 contains ACD liquid,
Contains an anticoagulant such as CPD solution and sodium citrate. A plastic connecting needle 61a is provided at the tip of the first connecting pipe 61, and a drip chamber-
61b is provided. A drip chamber-63a is provided below the membrane plasma separator 64 of the second connecting pipe 63. The drip chamber-63a removes blood clots and air bubbles contained in blood passing through the chamber, and a mesh filter is provided inside the chamber.

Bubble detecting means 4b, 4a are provided above the membrane plasma separator 64 and below the drip chamber-63a. The bubble detecting means 4a is for preventing the blood cells from being mixed when blood cells are returned and injecting the bubbles to the donor. If the bubbles are detected, the blood line clamp 8 is activated to close the second connecting pipe 63. To do. Also, the bubble detection means 4
b is a component of the plasma separator 64, the second connecting pipe 63, the drip chamber 63a, the fourth connecting pipe 67, etc.
The presence / absence of black is detected.

The plasma separated by the membrane plasma separator 64 is transferred to and stored in the plasma bag 68 via the fourth connecting pipe 67. For some reason, the plasma leaks to the hollow fiber membrane portion, or When hemolysis occurs, a hemolysis detector 4c is provided to detect it.

The membrane plasma separator 64 is a bundle of a large number of hollow fiber membranes such as polyvinyl alcohol, polyethylene, polypropylene and polysulfone membrane. When blood is flown into the hollow fiber membrane at a predetermined pressure, the hollow fiber membranes are hollow fibers. The plasma component is separated and collected outside the membrane through the membrane pores of the membrane. The blood bag 66 is empty before use, but may be filled with a small amount of the above-mentioned anticoagulant if necessary.

Anticoagulant storage bag 62, blood bag 6
6, plasma bag 68, each connecting pipe 61, 63, 65, 67
The drip chambers 61b, 63a and the like are made of soft synthetic resin such as soft vinyl chloride resin.

FIG. 3 shows the internal pressure control of the blood bag storage box 1, the swing control of the blood bag tray 14, the open / close control of the clamps 8 and 9, the stopper 12, and the roller pump 1.
FIG. 3 is a circuit block diagram for centrally controlling rotation control of No. 1 and the like by a microcomputer 50. Microcomputer 5
Setting conditions such as the amount of collected blood and the amount of collected plasma input by various switches of the operation panel 16 are input to the 0 input port section and stored in the memory 50b. The memory 50b is preferably a non-volatile memory.

The input port of the microcomputer 50 is also
The plasma bag weight detecting means 6 and the air bubble detecting means 4 are provided in the upper portion.
a, external information from the cuff pressure adjusting means 17 and internal information of the blood bag storage box 1, that is, the blood bag weight detecting means 15, the pressure detecting means 53, the swing angle detecting means 54, the blood circuit internal pressure detecting means 80, and the like. The detection signal is input.

CPU 50a of the micro computer 50
Then, the stored information stored in the memory 50b is read, the external information described above and the internal information of the blood bag storage box 1 are read, and the data is read according to a predetermined program.
Data calculation processing is performed. The calculation result is sent via the output port to the reducing / pressurizing means 51 of the blood bag storage box 1,
The rocking means 52, the blood line clamp 8, the plasma line clamp 9, the whole blood stopper 12, the roller pump 11, the tourniquet 55, and the like are output to the drive units, and interlocked control is performed.

Next, an operation example and an operation example in the plasma collection mode of the present invention will be described. The power switch 20 is turned on to enter the operation standby state. At this time, the blood line clamp 8, the plasma line clamp 9, and the whole blood stopper-12 are opened from closed.

Next, the disposable device for collecting blood, returning blood, and collecting plasma is attached to the main body device. That is, FIGS.
As shown in FIG. 5, the holder 3 of the apparatus main body support 2 holds the membrane plasma separator 64, and the hook 5 holds the plasma bag 68.
And the anticoagulant storage bag 62 is hung on the hook portion 7. The blood bag 66 is placed on the plate 14 of the blood bag storage box 1. At this time, the plate 14 is set so as to be automatically inclined sufficiently upward so as to move to the bottom of the blood bag 66 even if air flows into the blood bag 66.

The second connecting pipe 63 is a drip chamber-6.
The lower part of 3a is passed through the bubble detecting means 4a and the blood line clamp 8. In addition, the third connecting pipe 65 passes through the whole blood stopper-12 near the blood bag 66 and the plasma line clamp 9 through the middle of the fourth connecting pipe 67.

After that, the first connecting pipe 61 is filled with an anticoagulant, and then the opening / closing lid 13 of the blood bag storage box 1 is closed and locked by the lock member 13a. Thereafter, if there is no change in the setting mode of the previous operation, a blood donor is punctured and a start switch (not shown) is pressed to start the blood collecting operation. When changing the setting mode, it can be changed by the predetermined switch of the operation panel 16.

The blood collection amount set value is 100 to 6 depending on the donor.
It can be changed between 99 g. The amount of remaining blood collected is set by the air in the blood bag 66 when returning blood from the blood bag 66.
It is the amount of blood left in the blood bag 66 to prevent mixing, and can be changed between 0 and 99 g.

The tare amount and then the anticoagulant ratio are set.
The anticoagulant ratio is the injection ratio of the anticoagulant with respect to the amount of blood collected, and is usually 1/12 or 1/16. The amount of blood plasma collected is usually set to 450 g, but 200 to 69
It can be set in the range of 9 g.

After setting the above mode, when the start switch is pressed, the blood collecting operation is started, the inside of the blood bag storage box 1 is in a negative pressure state, and blood is collected from the donor by the blood bag 6.
A predetermined amount is stored in 6. At this time, the blood bag plate 14
By rocking, the blood and the anticoagulant can be mixed sufficiently. After that, the operation returns to blood return, and the blood bag storage box 1 is switched to the positive pressure state. By this pressurization, the blood in the blood bag 66 is pushed out, and while the plasma components are separated and collected in the plasma bag 68 by the membrane plasma separator 64, the concentrated red blood cells are returned to the donor at the same time.

The blood collecting operation and the blood returning operation are repeated for several cycles until the amount of plasma stored in the plasma bag 68 reaches a predetermined weight, with one cycle of blood collecting and blood returning. The standard number of cycles is 3 cycles for 400 ml of blood sampling mode and 6 cycles for 200 ml, and the blood sampling amount is calculated and controlled by the CPU 50a for each cycle.

A small amount of blood is left so that the air in the blood bag 66 is not transferred to the donor even if the set blood collection amount is returned at the time of collecting blood plasma. If this amount is as small as possible, it will take less time, but the blood bag capacity,
It changes depending on the inclination angle of the blood bag plate 14 or the like.

A limit switch (not shown), a pressure sensor, or other means is installed in contact with the drip chamber-section 63a or the second connecting pipe 63 or the third connecting pipe 65, and the circuit parts change according to the internal pressure. It may be used to confirm depressurization and pressurization by a means for detecting the occurrence of depressurization.

Next, an operation example will be described. When the start switch is pressed, the blood collecting operation is started and the plasma line clamp 9 is closed. Further, the pressurization of the tourniquet is started, and at the same time, the pressure reducing means 51 depressurizes the blood bag storage box 1.

When the inside of the blood bag storage box 1 is in a negative pressure state, the blood of the donor is drawn from the puncture needle 60 to the second connecting pipe 63, the drip chamber 63a, and the membrane plasma separator 6.
4, stored in the blood bag 66 via the third connecting pipe 65. Further, during blood collection, the detection operation of the bubble detection means 4a is stopped.

When the blood collecting operation is started, the roller pump 1
1 rotates, and the anticoagulant in the anticoagulant storage bag 62 is first
It is supplied to the second connecting pipe 63 through the connecting pipe 61, and is mixed in the collected blood. The roller pump 11 supplies a sufficient amount of the anticoagulant at the initial stage of blood collection, so that a fixed amount of the anticoagulant is delivered, and then the rotation speed is controlled according to the weight increase rate of the blood bag 66. A set amount of anticoagulant is delivered to blood bag 66.

The blood bag plate 14 of the blood bag storage box 1 is periodically rocked in the vertical direction by the plate rocking means 52 during the blood collecting operation, and the blood in the blood bag 66 and the anticoagulant are collected. Are mixed by stirring. The weight of the blood bag 66 is measured by the blood bag weight measuring means 15.

When the blood bag weight approaches the set blood collection amount,
The swing of the plate 14 automatically stops, and when the set blood collection amount is reached, the roller pump 11, the pressure cuff, etc. automatically stop, and the blood line clamp 8 is closed to end the blood collection operation. To do.

The device of the present invention releases the reduced pressure once when it is determined that the blood flow rate is low, such as when the blood vessel of the donor is sucked into the needle tip of the puncture needle 60 due to negative pressure during blood collection, and the device is excellent. It has the function of automatically controlling the pressure to ensure blood flow. During the blood collecting operation, the blood collecting speed is calculated from the change in the weight of the blood bag within a predetermined time, and the rotation of the roller pump 11 is controlled in response to the blood collecting speed. The blood collection rate is also displayed on the blood flow rate display section (not shown). When the blood collection rate becomes abnormal, the blood line clamp 8 is closed and an alarm signal is output at the same time.

If, for example, the blood vessel of the donor is thin and the current decompression force is too strong, the blood vessel will be crushed and the blood collection speed will be slowed or blood will not be collected. In this case, the decompression force is reduced by the decompression force adjuster 18 of the main body device. Or it can be done automatically. As a method thereof, for example, when the weight measurement value by the blood bag weight measuring means is extremely slow as compared with usual, the tube diameter of the pressure reducing path is selected to automatically adjust the degree of pressure reduction. As a result, blood flow can be secured and blood can be collected.

When the blood collecting operation described above is completed, the blood returning operation is automatically started. When the blood collecting operation is stopped, the roller pump 11 and the pumps of the tourniquet 55 stop. Then, the inside of the blood bag storage box 1 is pressurized. As a result, the blood in the blood bag 66 is pushed out, and the third connecting pipe 6
5. Plasma and blood cells are separated by the membrane plasma separator 64, and the blood cell components are returned to the donor through the drip chamber-63a, the second connecting tube 63, and the puncture needle 60.

When the blood bag storage box 1 is pressurized, the plasma line clamp 9 is opened. Membrane Plasma Separator 64
Since positive pressure is applied to blood flowing inside the hollow fiber membrane, the plasma component is separated through the hollow fiber membrane. The separated plasma component passes through the fourth connecting pipe 67 and is stored in the plasma bag 68.

The weight of the blood bag 66 depends on the set residual blood volume (0 to 0).
(Selection within the range of 99 g), the blood line clamp 8 is closed and the pressurization in the blood bag storage box 1 is stopped. After that, the pressure is switched to the depressurization, and the blood collection operation described above is repeated.

During the blood returning operation, the plasma bag 68 is measured by the plasma bag weight measuring means 6, and when the set plasma collection weight is reached, the plasma line clamp 9 is closed. Further, during the blood returning operation, the blood returning speed is calculated from the weight change of the blood bag 66 within a predetermined time. If the blood return rate is abnormal, it is displayed on the blood flow rate display section and an alarm is output. The pressure in the blood bag storage box 1 at the time of returning blood can also be adjusted by a pressing force adjusting tool (not shown) provided in the main body device.

At the end of blood return, the fourth connecting pipe 67 is closed by the plasma line clamp 9, and the blood collected in the blood bag 66 is filled in the plasma separating means 64 and the second connecting pipe 63. Blood collection in the next cycle is smoothly performed.
That is, if blood is simply returned, concentrated red blood cells with high viscosity remain in the plasma separation means 64 and the second connecting pipe 63, so that blood does not flow smoothly during blood collection in the next cycle, but the above-described operation is performed. As a result, the flow of whole blood at the time of blood sampling becomes smooth, and the blood sampling time can be shortened. Further, in the present invention, since blood collection and blood return are shared by the same connecting pipe, that is,
The disposable circuit is simple because it does not require a connecting tube for blood collection and blood return.

During the blood returning operation, the blood (concentrated red blood cells) that has passed through the drip chamber 63a by the bubble detecting means 4a.
The air bubbles inside are monitored, and when air exceeding a specified amount passes, all the clamps 8 and 9 and the stopper 12 are closed to stop the blood returning operation and at the same time an alarm is output. The roller pump 11 is stopped during the blood returning operation.

When the blood returning operation is in the final cycle, all the operations are completed on condition that the set plasma collection amount has been reached, and the blood line clamp 8 and the plasma line clamp 9 are closed. Finally, the blood bag 66 is put in the blood bag storage box 1
The blood remaining in the blood bag 66 is pushed out by hand so that the air in the blood bag 66 does not flow out. When the air passes through the drip chamber 63a, the connecting tube near the needle base of the puncture needle 60 is stopped by a kochher, and the puncture needle 60 is removed from the blood donor. It should be noted that this blood returning operation can be automatically performed by applying pressure.

Next, the case of the whole blood sampling mode will be described. Whole blood collection refers to a conventional blood collection method. Regarding the specific method in the whole blood sampling mode, as described above,
Blood bag rocking means, blood bag weight measuring means, rocking angle detecting means, etc. are disclosed in Japanese Patent Application No. Sho 63-298168 and Japanese Patent Application No.
99896, Japanese Patent Application No. 2-49182, Japanese Patent Application No. 2-
Since it was proposed by the present applicant in No. 193878, etc., its details are omitted. At the time of collecting whole blood, the weight of the blood bag is measured under reduced pressure in the blood bag storage box while swinging the blood bag loading. Details are slightly different. That is, since the final weight is a problem in whole blood collection, when it is almost full, the bag loading is stopped horizontally and weighed, but in the blood collection at the time of plasma collection, the blood collection amount does not require precision, and it is sufficient to understand the outline. So there is no need to stop horizontally. It is sufficient that the amount of plasma collected in the plasma bag is accurate.

[0047]

According to the present invention as described above, (1) According to the means for injecting the anticoagulant, the anticoagulant is infused in a necessary and sufficient amount according to the amount of blood collected. This will solve problems such as hemolysis and blood clotting. (2) By using the means for controlling the inclination of the blood bag, bubbles are not mixed in the blood flow path, the safety to the blood donor is significantly improved, and the performance of the membrane plasma separator is impaired. It is also possible to collect plasma safely and comfortably. (3) In a device for collecting a set amount of plasma with a membrane plasma separator during the blood returning operation by repeatedly collecting and returning blood in the blood bag by decompressing / pressurizing the inside of the blood bag storage box. Since the set amount of blood is allowed to remain in the blood bag when returning the blood, it is possible to prevent the air in the blood bag from flowing out and being mixed into the connecting pipe, the plasma separator, etc. Coagulation due to air contact can be prevented. (4) In addition, by collecting blood in excess of the set blood collection amount in the blood bag, and returning blood, by returning excess blood with the fourth connecting tube of the membrane plasma separator closed, Since the remaining concentrated red blood cells in the downstream portion of the separator are replaced with whole blood, the blood flow for the next blood collection operation becomes smooth, and the blood collection time can be shortened. (5) Furthermore, by controlling the clamp operation, the blood flow path for blood collection and blood return can be shared by the same blood line, so the configuration of the disposable device for blood collection, blood return, and plasma collection is simplified. And can be handled easily.

[Brief description of drawings]

FIG. 1 is an overall perspective view of a heavy-duty plasma / blood sampling combined device of the present invention.

FIG. 2 is a system conceptual diagram of the apparatus for combined use of heavy-duty blood plasma collection and blood collection of the present invention.

FIG. 3 is a block diagram of a control circuit unit of the combined weight-type blood plasma and blood sampling apparatus of the present invention.

[Explanation of sign]

 1 Blood Bag Storage Boxes 4a, 4b Air Bubble Detection Means 4c Hemolysis Detection Means 6 Plasma Bag Weight Measuring Means 8 Blood Line Clamps 9 Plasma Line Clamps 11 Roller Pumps 12 Whole Blood Stoppers 13 Blood Bag Storage Box Open / Close Lids 14 Blood Bags Plate 15 Blood bag weight measuring device 16 Operation panel 17 Cuff pressure adjusting device 18 Decompression force adjusting device 50 Microcomputer 52 Blood bag plate swinging device 55 Blood tourniquet 60 Puncture needle 61 First connecting pipe 62 Anticoagulant Storage bag 63 Second connection pipe 63a Drip chamber-64 Membrane-type plasma separator 65 Third connection pipe 66 Blood bag 67 Fourth connection pipe 68 Plasma bag

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yuji Kitazawa 5 shares of 75 Osamu Osamu Foundry, Sarahaku City, Nagano Prefecture Chiyoda Manufacturing Co., Ltd. (72) Inventor Kiyokazu Iijima 5 shares of 75 Osamu Osamu Foundry House in Kodaira, Nagano Prefecture Ceremony Company Chiyoda Manufacturing (72) Inventor Shun Ishihara 354-2 Kashima, Maeda, Fuji City, Shizuoka Prefecture Asahi Medical Co., Ltd.

Claims (1)

[Claims] 1. A puncture needle that is punctured by at least a donor, an anticoagulant storage bag that is connected to the puncture needle through a first connecting tube, and a puncture needle that is connected to the puncturing needle through a second connecting tube. Membrane-type plasma separation means, a blood bag connected to the plasma separation means via a third connecting pipe, and a fourth plasma separation means.
A disposable instrument portion including a plasma bag connected via a connecting tube; a means for accommodating at least the blood bag, for depressurizing / pressurizing the blood bag from the outside, means for detecting the weight of the plasma bag, A heavy-duty blood plasma / blood collection combined-use device that uses a combination of an anticoagulant delivery means provided in the middle of the first connecting pipe and a control unit, the means being described in at least the following (1) to (4): Among these, a heavy-duty plasma / blood sampling combined device having one or more means. (1) A means for sequentially controlling the means for transferring the anticoagulant in accordance with a signal from the means for detecting the weight of the blood bag, (2) A blood bag storage section having depressurizing / pressurizing means for the blood bag In (3), a means for inclining the blood bag so that the connection site side of the blood bag with the third connecting pipe is relatively lowest at the time of pressurization, (3) From the blood collection amount set value in the blood bag at the time of blood collection Means for collecting a large amount of blood and controlling so as to leave a sufficient blood volume in the blood bag at the time of returning blood (4) Closing the fourth connecting pipe at the end of blood returning, Means for filling the blood in the blood bag into the plasma separating means and the second connecting pipe.