JPH06145037A - Skin external preparation - Google Patents

Abstract

PURPOSE:To obtain a skin external preparation, capable of imparting moderate moistness and tenseness to the skin, simultaneously remarkably improved in touch of use and excellent in stability. CONSTITUTION:This skin external preparation comprises (A) 0.01-30wt.%, preferably 0.05-20wt.% one or two or more selected from the group consisting of amino acids, derivatives thereof and urea and (B) 0.01-30wt.%, preferably 0.05-20wt.% trehalose. Natural amino acids (e.g. glycine or serine), acidic amino acids (e.g. aspartic acid or glutamine) and basic amino acids (e.g. arginine or lysine) are cited as the amino acid and acylsarcosines, acyl-beta-alanines, glutathione, etc., are cited as the derivatives of the amino acids.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention provides an external preparation for skin having excellent stability, which has the effects of imparting proper "moisturization" and "swelling" to the skin.

[0002]

2. Description of the Related Art Generally, the water content of stratum corneum is 10 to 15%.
It is said that the condition containing is healthy skin. If it contains too much water, it becomes dull, and if it is too small, it becomes dull, so in order to solve this, external skin preparations such as lotion, cream and emulsion are used.
In these external preparations for skin, moisturizing agents such as organic acids such as sodium lactate, glycerin, 1,3-butylene glycol, propylene glycol and the like have an affinity for the skin,
It is used in a relatively large amount (3-10%) from the point of use.
In addition, amino acids and urea are used in the hope that they will restore hydration to the aged and hardened epidermis.

[0003]

However, especially in the external preparation for skin which appeals a rich feeling, there is a tendency that the above moisturizer is blended in an extremely large amount, which causes a sticky feeling on the skin. In addition, when these skin external preparations containing moisturizers are used under low humidity, the humidity of the outside air is low, so water is absorbed from the skin to the skin external preparations containing moisturizers, which causes the skin to dry. In some cases. On the other hand, the skin external preparation containing an amino acid does not have the drawbacks as in the case of adding the above moisturizing agent, but has a problem of odor change over time. Urea has a problem not only in smell but also in stability over time.

[0004]

Means for Solving the Problems In view of the above circumstances, the present inventors have conducted extensive studies and as a result, have found that trehalose and one or more selected from the group consisting of amino acids, amino acid derivatives and urea. It has been found that the compounded external preparation for skin is excellent in stability, gives proper "moisturization" and "swelling" to the skin, and is also excellent in the effect of remarkably improving the feeling of use, and thus completed the present invention. That is, the present invention provides an external preparation for skin, which comprises trehalose and one or more selected from the group consisting of amino acids, amino acid derivatives and urea.

The structure of the present invention will be described in detail below. Amino acids used in the present invention include glycine, serine, cystine, alanine, threonine, cysteine, valine,
Phenylalanine, methionine, leucine, tyrosine,
Examples thereof include neutral amino acids such as proline, isoleucine, tryptophan and hydroxyproline, acidic amino acids such as aspartic acid, asparagine, glutamine and glutamic acid, and basic amino acids such as arginine, histidine and lysine. Further, the amino acid derivative, acyl sarcosine and a salt thereof, acyl glutamic acid and a salt thereof, acyl-β-alanine and a salt thereof, glutathione, pyrrolidone carboxylic acid and a salt thereof, and the like, glutatin,
Examples include oligopeptides such as carnosine, gramcygin S, tyrosidine A, and tyrosidine B. Urea is generally used in cosmetics. The external preparation for skin of the present invention is appropriately selected and blended with one or more of these.

The amount of the amino acid, amino acid derivative or urea used in the present invention is 0.01% in the skin external preparation of the present invention.
-30% by weight, preferably 0.05-20% by weight. If the blending amount is less than 0.01%, the moisturizing effect on the skin is weak, and conversely
Even if it is added in an amount of 30% or more, the effect cannot be expected to increase, and it tends to be difficult to improve the daily stability of urea and amino acids.

The trehalose according to the present invention is a disaccharide in which two D-glucoses are bound, and there are three binding modes, α, α-, α, β-, β, β-, which are natural. To
The α, α-bonding mode, which is widely recognized, is common.

The amount of trehalose used in the present invention is 0.01 to 30% by weight, preferably 0.05 to 20% by weight, based on the total amount of the external preparation for skin.

In addition to the above-mentioned essential constituents, the external preparation for skin of the present invention may optionally contain other components usually used in external preparations for skin such as pharmaceuticals and cosmetics, such as edetic acid,
Sequestering agents such as di-, tri- or tetra-sodium, sodium citrate and sodium metaphosphate, butyl hydroxytoluene (BHT), propyl gallate, tocopherol and other antioxidants, surfactants, UV absorbers, fragrances, water , Lower alcohols such as ethanol and isopropanol, thickeners, colorants, powders, drugs, organic acids such as citric acid and malic acid, and inorganic acids such as phosphoric acid. Of course, these components must be used within a qualitative and quantitative range that does not impair the effects of the present invention.

The dosage form of the external preparation for skin of the present invention is arbitrary,
Solution system, solubilization system, emulsion system, powder dispersion system, water-two-layer system,
Any formulation such as water-oil-powder three-layer system may be used.
Further, the application of the external preparation for skin of the present invention is also arbitrary, and it can be used for external preparations for facial and body such as lotion, emulsion, cream and pack.

[0011]

The external preparation for skin of the present invention has excellent stability,
It is an external preparation for the skin, which imparts proper "moisturization" and "swelling" to the skin and remarkably improves the feeling of use.

[0012]

EXAMPLES Next, the present invention will be specifically described with reference to Examples and Comparative Examples. The present invention is not limited to this. The blending amount is% by weight.

Example 1 Lotion A lotion was prepared by a conventional method according to the following formulation. Ethanol 8.0 1,3-Butylene glycol 5.0 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.8 Trehalose 0.1 Sodium pyrrolidonecarboxylate 0.5 Pullulan 0.05 Jojoba oil 0.5 Caustic potassium 0.015 EDTA-3Na 0.01 Fragrance 0.1 Deionized water remaining

Example 2 Cream A cream was produced by a conventional method according to the following formulation. 1,3-Butylene glycol 3.0 Polyethylene glycol 4000 1.0 Glycerin 2.0 Squalane 20.0 Vaseline 5.0 Cetostearyl alcohol 3.0 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.5 Glyceryl monostearate 1.5 Trehalose 20.0 Urea 3.0 Sodium lactate 2.0 Xanthan gum (Keltrol product Name) 0.05 Methylparaben 0.1 Ethylparaben 0.2 Caustic potassium 0.01 EDTA-3Na 0.01 Perfume 0.2 Ion-exchanged water Remaining amount

Example 3 Emulsion An emulsion was prepared by a conventional method according to the following formulation. Glycerin 2.0 Squalane 5.0 Vaseline 1.0 Cetostearyl alcohol 0.3 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.5 Glyceryl monooleate 1.5 Trehalose 10.0 Sodium polyacrylate 0.03 Ethylparaben 0.2 Aspartic acid 10.0 Caustic potassium 0.1 EDTA-3Na 0.03 Perfume 0.2 Deionized water Remaining amount

Example 4 Pack A pack was manufactured by a conventional method according to the following formulation. Polyethylene glycol 4000 3.0 Ethanol 10.0 Trehalose 15.0 Polyvinyl alcohol 10.0 Olive oil 3.0 Lactic acid 1.0 Glutamic acid 10.0 Carboxymethylcellulose 0.07 Methylparaben 0.1 Ethylparaben 0.1 Caustic potassium 0.02 EDTA-3Na 0.01 Fragrance 0.1 Ion-exchanged water Remaining amount

Comparative Example 1 Lotion A cosmetic lotion was prepared in the same manner as in Example 1. Ethanol 8.0 1,3-Butylene glycol 5.0 Polyoxyethylene glycol 5.0 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.8 Sodium pyrrolidonecarboxylate 0.5 Pullulan 0.05 Jojoba oil 0.5 Caustic potassium 0.015 EDTA-3Na 0.01 Perfume 0.1 Deionized water remaining amount

Comparative Example 2 Cream A cream was prepared in the same manner as in Example 2. 1,3-Butylene glycol 3.0 Polyethylene glycol 4000 1.0 Glycerin 2.0 Squalane 20.0 Vaseline 5.0 Cetostearyl alcohol 3.0 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.5 Glyceryl monostearate 1.5 Urea 3.0 Sodium lactate 2.0 Xanthan gum 0.05 Methylparaben 0.1 Ethylparaben 0.2 Caustic potash 0.01 EDTA-3Na 0.01 Fragrance 0.2 Ion-exchanged water Remaining amount

Comparative Example 3 Emulsion The same procedure as in Example 3 was repeated. Glycerin 2.0 Squalane 5.0 Vaseline 1.0 Cetostearyl alcohol 0.3 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.5 Glyceryl monooleate 1.5 Sodium polyacrylate 0.03 Ethylparaben 0.2 Aspartic acid 10.0 Caustic potassium 0.1 EDTA-3Na 0.03 Perfume 0.2 Deionized water remaining

Comparative Example 4 Pack A pack was prepared as in Example 4. Polyethylene glycol 4000 3.0 Ethanol 10.0 Polyvinyl alcohol 10.0 Olive oil 3.0 Lactic acid 1.0 Glutamic acid 10.0 Carboxymethylcellulose 0.07 Methylparaben 0.1 Ethylparaben 0.1 Caustic potassium 0.02 EDTA-3Na 0.01 Perfume 0.1 Ion-exchanged water Remaining amount

The effect of the external preparation for skin according to the present invention was confirmed by a use test. In the use test, 30 women were divided into 3 groups, and each panel was used. The first group contains the lotions of Example 1 and Comparative Example 1, the second group contains the creams of Example 2 and Comparative Example 2, and the third group contains the lotions of Example 3 and Comparative Example 3. Apply the formulations of Examples and Comparative Examples to the right and left halves of the face after washing twice daily in the morning and evening, respectively, for a suitable amount of 2 weeks, and moisturize the skin, firm the skin, and moisturize the next morning. The effectiveness of each item was judged. The results are shown in Tables 1 to 3. For stability, odor and coloration after 1 week were evaluated. Judgment is extremely good ・ ・ ・ ◎◎ Good ・ ・ ・ ・ ・ ・ ○ Somewhat unstable ・ ・ ・ ・ ・ ・ △ Unstable ・ ・ ・ ・ ・ ・ ・ ・It is indicated by x.

[0022]

[Table 1]

[0023]

[Table 2]

[0024]

[Table 3]

As shown in Tables 1 to 3, the external preparation for skin of the present invention was excellent in the moisture of the skin, the firmness of the skin, the moisture of the skin in the next morning, and the stability.

Claims (1)

[Claims] 1. A skin external preparation containing one or more kinds selected from the group consisting of amino acids, amino acid derivatives and urea, and trehalose.