JPH06121820A - Drug container with communication means - Google Patents

Abstract

(57) [Summary] [Object] To provide a drug container with a communicating means that is easy to operate, hassle-free, has a small number of parts, and that can be aseptically mixed with a solution. A drug container with a communicating means according to the present invention comprises a container body 1 and a rubber stopper 2 for closing an opening 11 of the container body 1.
And the rubber stopper 2 has the chemical liquid passage 23 closed by the closing body 3, and the communication means 4 is slidable and airtight on the outer wall of the container body 1. And is protected by the cover member 5. When the rubber stopper of the dissolution liquid container is applied to the puncture needle 411 of the communication means 4 and pushed down, the closing body 3 is moved by the push rod 412 of the communication means 4 to the communication portion 22 in which the slit 25 is formed, and the dissolution liquid container. The rubber stopper of the puncture needle 41
Since it is pierced by 1, the medicine container and the solution container are communicated with each other via the communication pipe 41.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a drug container. More specifically, dry drugs such as powdered preparations, freeze-dried preparations, and solid preparations and their dissolved solutions are stored in a separated state, and the dried drug and the dissolved solutions are aseptically mixed in a container immediately before use. , A drug container with a communicating means for supplying as a liquid drug.

[0002]

2. Description of the Related Art Conventionally, in medical institutions such as hospitals, a dried drug contained in a drug container such as a vial is dissolved in distilled water, a saline solution, a solution such as glucose solution (including other drug solutions), and then an intravenous injection is made. It is used for In order to easily use in such a case, the vial containing the dry drug is connected in series to the flexible container containing the solution,
An infusion container has been proposed in which a rubber needle of both containers is pierced by a puncture needle (referred to as a double-ended needle) having puncture portions at both ends of a hollow needle at the time of use so that these two containers can be aseptically communicated with each other. Table 61-501129, Japanese Patent Laid-Open No. 2-12
77 gazette, Jitsukai 63-135642 gazette, etc.).

The one disclosed in Japanese Patent Publication No. 61-501129 is that in which a capsule containing a drug container and a flexible container containing a solution are connected by a tube, which is provided in the tube. The medicine container and the flexible container are communicated with each other by the communication means so that the medicine and the solution are aseptically mixed. In addition, JP-A-2-1277
What is disclosed in the publication is that the capsule containing the drug container is connected to the mouth of the dissolution liquid container at its connecting portion, and the connecting means having the connecting sequence regulating means is interposed on the connecting portion side of the capsule. In, after the drug container is pierced by the communication means, the dissolution liquid container is pierced and the two containers are communicated, and the drug and the dissolution liquid are aseptically mixed,
The one disclosed in Japanese Utility Model Laid-Open No. 63-135642 is a cylindrical support ring that is detachably attached to the sealing portion at the mouth of the solution container, and a double-ended needle is attached to this support ring so that it can slide up and down. In addition, when the double-ended needle is slid downward, the lower needle body punctures the seal portion at the mouth of the dissolution liquid container.

[0004]

Among the above-mentioned conventional infusion containers, the one disclosed in Japanese Utility Model Laid-Open No. 63-135642 is an infusion container with a communicating means, and a vial which is a general distribution form of dry chemicals. It includes the one that is captured and integrated as it is. Further, those disclosed in Japanese Patent Publication No. 61-501129 and Japanese Patent Application Laid-Open No. 2-1277 are:
All of them are vials, which are a general distribution form of dry chemicals, and are integrated as they are, and in that sense, they are highly versatile. However, the special table Sho 61-501129
The infusion container of Japanese Patent Publication has a large number of parts, and it takes time to fold the breaking member by hand to open the passage. It has the drawback of being time consuming, and it is also difficult to achieve this.
The infusion container of -1277 is considerably improved in comparison with the infusion container of JP-A-61-501129 in respect of prevention of contamination of internal medicine and simplification of communication between the medicine container and the dissolution container. However, there are drawbacks in that the parts such as the communication order regulating means are complicated and the number of parts is large as a whole.
The infusion container of JP-A-3-135642 has a small number of parts and is relatively easy to operate, but requires a relatively large force for communication. After mixing the drug and the solution, the support ring and the double-ended needle are removed to dissolve the solution. Since it is necessary to invert the container and connect an infusion set etc. to the seal part at the mouth of the dissolution liquid container after removing the double-ended needle, it takes time and labor for operation, and there is a risk that the mixed drug solution will leak when the double-ended needle is removed. There is
It has drawbacks such as

The present invention has been made in view of the above circumstances, and is an improvement over the conventional drug container, which is easy to operate, hassle-free, has a small number of parts, and is aseptically mixed with a solution. An object of the present invention is to provide a drug container with a communicating means that can be used.

[0006]

In order to solve the above problems, the present invention provides a bottomed cylindrical container body having a reduced diameter mouth portion, a rubber stopper for closing the mouth portion of the container body, and A drug container comprising a communication means attached to a mouth or a body of a container body, wherein the rubber stopper is composed of an upper closed part and a lower communication part and has a drug solution passage extending along a central axis thereof. However, the chemical liquid passage of the closing part is closed by the closing body,
A groove or slit is formed in the liquid medicine passage of the communication portion so that the liquid medicine passage opens when the closing body moves, and the communication means has a vertically extending liquid medicine passage and an upper puncture needle. And a communication pipe composed of a lower push rod and the communication pipe supported by a partition wall separating the communication pipe from above and below, and the outer wall of the container body was slidably and airtightly attached to the mouth or body of the container body. A drug container with a communicating means is used which is composed of a supporting member, and a cover member which protects the communicating pipe is airtightly attached to the supporting member.

[0007]

According to the above construction, when the cover member is removed from the communicating means and the puncture needle on the upper part of the communicating tube is applied with the rubber stopper at the mouth of the dissolving liquid container and pushed down, the closing body is closed. It is pushed by the push rod to move from the closed portion of the rubber stopper to the communication portion, and the inside of the container main body and the chemical liquid passage of the communication pipe communicate with each other through the groove (or slit) formed in the chemical liquid passage of the communication portion. On the other hand, the mouth rubber plug of the drug container is pierced by the puncture needle of the communication tube, and the inside of the drug container communicates with the drug solution passage of the communication tube, so that the drug container communicates with the dissolution liquid container through the communication tube. .

[0008]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, a medicine container with a communicating means of the present invention will be described with reference to the drawings. 1 is a cross-sectional view of a drug container with a communicating means according to an embodiment of the present invention, and FIG. 2 is a cross-sectional view of the drug container shown in FIG. 1 taken along line XX. As shown in FIGS. 1 and 2, the drug container with the communicating means of the present invention is a container body 1
And a rubber stopper 2 for closing the opening 11 of the container body 1 and a communication means 4 attached to the container body 1,
The rubber stopper 2 has a chemical liquid passage 23 closed by a closing body 3, and the communication means 4 is slidably and airtightly attached to the outer wall of the container body 1 and is protected by a cover member 5.

Unlike a normal rubber stopper, the rubber stopper 2 for closing the mouth portion 11 of the container body 1 usually made of glass has a chemical liquid passage 23 passing through it along its central axis,
It is composed of an upper closed portion 21 and a lower communication portion 22.
The chemical liquid passage 23 of the closing portion 21 is closed by the closing body 3, and the chemical liquid passage 23 of the communicating portion 22 is formed with a groove (not shown) or a slit 25. The grooves (or slits 25) are formed so that the chemical liquid passages 23 are opened when the closing body 3 moves to this portion, and usually two to four grooves are formed. Chemical liquid passage 2 of communication section 22
In accordance with the shape of the closing body 3, the bulge 2 as shown in FIG.
4 may be formed. Incidentally, 6 is a caulking member 6 made of aluminum or the like, and the rubber stopper 2 is the mouth portion 11 of the container body 1.
It is used to firmly fix the rubber stopper 2 to the mouth portion 11 by crimping the flange 26 of the closing portion 21 to the mouth portion 11 after being plugged. Further, as a material for forming the rubber plug 2,
Generally, butyl rubber, butadiene rubber, styrene-butadiene rubber, isoprene rubber and the like are used.

The closing body 3 for closing the chemical liquid passage 23 of the rubber stopper 2 has an outer shape larger than the inner diameter of the chemical liquid passage 23, and is usually formed of glass or synthetic resin in a spherical or columnar shape. The forming material is not particularly limited as long as it has a smooth surface and chemical resistance.

The communication means 4 includes a communication pipe 41 and a partition wall 42.
The support member 43 is supported through the support member 43, and is normally integrally formed of a synthetic resin such as polypropylene, ABS resin, or polycarbonate.
A cover member 5 for protecting 1 is airtightly attached.

The communicating tube 41 usually has one or two vertically running drug solution passages 413, and is composed of an upper puncture needle 411 and a lower push rod 412. A partition wall 42 that divides the communication pipe 41 into upper and lower portions is provided in the middle portion thereof, and the communication pipe 41 is connected to and supported by the support member 43 by the partition wall 42.

The partition member 42 is connected to the upper portion of the support member 43, and an O-ring 44 is provided as a seal member which is close to the lower end of the lower skirt portion 431 and seals the body portion 12 of the container body 1. It is installed. A male coupling means such as a male screw 433 is provided near the upper end of the cover member 5 so as to be coupled with a female coupling means formed on the skirt portion 52 of the cover member 5, such as a female screw 51. There is. In addition, an annular protrusion 432 or a plurality of hemispherical protrusions (not shown) is provided in the middle thereof.
Is formed to prevent the communication means 4 from being inadvertently moved toward the container body 1. The material for forming the cover member 5 is not particularly limited, but polyethylene, polypropylene, polyester, etc. are preferable. Further, 45 is a packing for sealing between the upper end of the support member 43 and the cover member 5.

[0014]

As is apparent from what has been described above, by adopting the drug container with the communicating means of the present invention, the aseptic mixing operation with the solution is easy and does not require much labor. Since the number of parts is small, the quality of the product is stable, and the manufacturing cost is low, so that it is possible to inexpensively provide a high-quality drug container with a communication means. You can get advantages such as.

[Brief description of drawings]

FIG. 1 is a cross-sectional view of a drug container with a communicating means according to an embodiment of the present invention.

FIG. 2 is a cross-sectional view taken along line XX of the drug container shown in FIG.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Container main body 2 Rubber stopper 21 Closing part 22 Communication part 23 Chemical liquid passage 25 Slit 3 Closing body 4 Communication means 41 Communication pipe 411 Puncture needle 412 Push rod 413 Chemical liquid passage 42 Partition wall 43 Support member 5 Cover member 6 Caulking member

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[Procedure amendment]

[Submission date] December 10, 1992

[Procedure Amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0007

[Correction method] Change

[Correction content]

[0007]

According to the above construction, when the cover member is removed from the communicating means and the puncture needle on the upper part of the communicating tube is applied with the rubber stopper at the mouth of the dissolving liquid container and pushed down, the closing body is closed. It is pushed by the push rod to move from the closed portion of the rubber stopper to the communication portion, and the inside of the container main body and the chemical liquid passage of the communication pipe communicate with each other through the groove (or slit) formed in the chemical liquid passage of the communication portion. On the other hand, mouth rubber stopper of the solvent vessel is pierced by the puncture needle of the communication pipe, the liquid medicine passage communicates with the interior tube of the solvent vessel is communicated, medicament container and solvent container through the communication pipe Communicate.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Toshihiro Kikuchi 3-9-3 Honjo Nishi, Kita-ku, Osaka City

Claims (3)

[Claims] 1. A medicine comprising a bottomed cylindrical container body having a reduced diameter mouth part, a rubber stopper for closing the mouth part of the container body, and a communication means attached to the mouth part or the body part of the container body. In the container, the rubber stopper is composed of an upper closed portion and a lower communication portion, and has a liquid medicine passage that penetrates along a central axis thereof, and the liquid medicine passage of the closed portion is closed by a closing body,
A groove or slit is formed in the liquid medicine passage of the communication portion so that the liquid medicine passage opens when the closing body moves, and the communication means has a vertically extending liquid medicine passage and an upper puncture needle. And a communication pipe composed of a lower push rod and the communication pipe supported by a partition wall separating the communication pipe from above and below, and the outer wall of the container body was slidably and airtightly attached to the mouth or body of the container body. A drug container with a communication means, comprising a support member, and a cover member for protecting the communication pipe, which is airtightly attached to the support member. 2. The medicine container according to claim 1, wherein the closing body is a spherical closing body. 3. The drug container according to claim 1, wherein the communication pipe protection member is a cap.