JPH06100427A - Agent for preventing chapped skin - Google Patents

Abstract

PURPOSE:To provide a chap-preventing agent having strong antioxidation action, effective in suppressing hyaluronidase activity to stabilize hyaluronic acid, preventing chapped skin and wrinkle, keeping the springiness of the skin and improving the luster of the skin when used as a component of a cosmetic. CONSTITUTION:A chap-preventing agent containing a solvent extract of AIGYOKUSHI (fruit of Ficus awkeotsuang). Although water or an hydrophilic organic solvent can be used as the extraction solvent, water and/or ethanol are preferable because the extract is used as a cosmetic raw material. Cosmetics having various forms can be prepared by adding other cosmetic raw materials such as liquid oil, solid oil, activator, humectant and medicine to the extract.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a highly safe skin roughening preventive agent.

[0002]

There are various possible causes of rough skin, one of which is oxidation of lipids. At present, butylhydroxyanthony (BHA) and butylhydroxytoluene (BH) are mainly used as antioxidants.
T), vitamin E and its derivatives. BHA and BHT
Is a synthetic product. As a general common sense nowadays, there is a harsh criticism regarding the use of synthetic products because there is no guarantee of safety through long-term use, and the use is being severely regulated even by actual legal regulations. In addition, vitamin E and its derivatives have a weak antioxidant action, and a substance that is a natural product and has a strong antioxidant action is desired.

Hyaluronic acid is also considered to be involved in rough skin. Hyaluronidase is an enzyme that is widely distributed in the living body and is also present in the skin. As its name implies, it decomposes hyaluronic acid. Hyaluronic acid is a linear polymer polysaccharide in which β-D-N-acetylglucosamine and β-D-glucuronic acid are alternately bonded, and is a glycosaminoglucan that widely exists in connective tissues of mammals along with chondroitin sulfate and the like. It is a kind.

As a function of hyaluronic acid in connective tissues, water is retained in the intercellular spaces, and a jelly-like matrix is formed in the tissues to retain cells, and the lubricity and flexibility of the skin are maintained. It is believed to prevent external forces (mechanical disorders) and bacterial infections. It is said that hyaluronic acid in the skin decreases with age, resulting in aging such as wrinkles and roughness. Therefore, suppressing the activity of hyaluronidase, which decomposes this, stabilizes the stability of hyaluronic acid used in the formulation and the stability of hyaluronic acid in the formulation after application to the skin and hyaluronic acid present in the skin. It is thought to contribute. Hyaluronidase is also known as an inflammatory enzyme, and it is known that suppressing the activity suppresses inflammation and also suppresses allergies.

[0005] Aitama is a dried fruit of a plant whose scientific name is Ficus awkeotsuang Makino and whose Japanese name is Kanten itabi. The place of origin is altitude of 1000-200 mainly in southern Taiwan
It is a tall tree that grows naturally at 0 m, and can be put in water in Taiwan.
It is used as a soft drink with added sugar. Furthermore, the present inventors have found that they have a whitening effect, a moisturizing effect, and the like.

[0006]

SUMMARY OF THE INVENTION An object of the present invention is to find a substance having a strong skin roughening preventive action among natural substances which have been confirmed to be safe for the human body, and provide it as a raw material for cosmetics.

[0007]

[Means for Solving the Problems] In order to solve the above-mentioned problems, the present inventors have screened and investigated plants that have been used for food for many years and have been confirmed to be safe for the human body. I examined what is useful as. As a result, they have found that love eggs are very effective as a rough skin preventive agent.

That is, the present invention is a skin roughening preventive agent containing a solvent extract of love eggs.

As a method of using the egg, it is extracted with water or a hydrophilic organic solvent such as ethanol, methanol or acetone. However, since it is extraction of cosmetic raw materials, it is natural that extraction with water, ethanol or a mixed solvent thereof is preferable. In some cases, a polyhydric alcohol such as glycerin, 1,3 butylene glycol, propylene glycol or the like or a mixed liquid of polyhydric alcohol and water can be used for extraction. Further, freeze-drying and using it as powder is also effective depending on the method of use.

This substance is used as a raw material for other cosmetics, for example, liquid oils such as squalane and jojoba oil, solid oils such as beeswax and cetyl alcohol, various activators, moisturizing agents such as glycerin and 1,3 butylene glycol, and various agents. It can be added to adjust various dosage forms of cosmetics. For example, a lotion, a cream, a milky lotion, a pack, or the like may be used depending on the purpose.

[0011]

EXAMPLE An example of an actual usage will be described below, but the present invention is not limited to this example. Examples of the extract of love eggs used in the present invention are shown below.

(Example 1) 3 seeds (dried product) of love eggs
300 ml of 75% ethanol was added to 0 g and left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 2) Lotion Olive oil 0.5 75% ethanol extract of Example 1 0.5 Polyoxyethylene (20 E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60 E.O.) Hydrogenated castor oil 2.0 Ethanol 10.0 1.0% sodium hyaluronate aqueous solution 5.0 Purified water 80.0

(Example 3) Cream A Squalane 20.0 Olive oil 2.0 Mink oil 1.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan monostearate 2 .0 75% ethanol extract of Example 1 1.0 B Purified water 47.9 Polyoxyethylene (20 E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60 E.O.) hydrogenated castor oil 1. 0 Glycerin 5.0 1.0% sodium hyaluronate aqueous solution 5.0 Methyl paraoxybenzoate 0.1 A and B were respectively weighed, heated to 70 ° C., and A was gradually added to B with stirring. , Stirring slowly, 30
Cooled to ° C.

(Antioxidant test) The following test solutions were prepared in 50 ml test tubes with screw caps. Specimen 5 mg 2% ethanol solution of linoleic acid 10 ml 0.1M, pH 7.0 phosphate buffer 10 ml purified water 5 ml This is left in a thermostat bath at 50 ° C while being shielded from light. It was measured before it was placed in a constant temperature bath and every few days. Test solution 0.12
5 ml, 12.25 ml of 75% ethanol and 0.125 ml of 30% ammonium thiocyanate were added and stirred for 3 minutes, after which 0.125 ml of 0.02N ferrous chloride 3.5% HCl aqueous solution was added and stirred for 3 minutes. Wavelength after leaving 500nm
The absorbance was measured with. The cell length is 10 mm, and the control cell has the test solution replaced with water.

[0016]

[Table 1]

(Hyaluronidase activity inhibition test) (Test method) 0.4% sodium hyaluronate 0.1M
(PH 6.0) Weigh 6 g of phosphate buffer solution, and
After standing in a constant temperature water bath at ℃ for 5 minutes, 0.1 wt / v% aqueous solution of the above Example 1 (freeze-dried product) (if it is difficult to dissolve, add ethanol and dissolve, then add purified water and evaporate Was added to 1.0 wt / v%) and 1.0 ml was added and stirred, and 0.01% hyaluronidase (manufactured by Sigma Beef Testicle, Type I-S) was added.
1 ml of 0.1 M (pH 6.0) phosphate buffer solution was added and immediately stirred, and 6 g was placed in an Ostwald viscometer placed in a constant temperature water bath at 37 ° C. The viscosity was measured after 1 minute, 5 minutes, 10 minutes, 20 minutes, and 40 minutes. As a control, pure water was added instead of the sample solution and the same measurement was performed.
In this test, the final concentration of the sample is 0.0125%. 1
The results are shown in Table 2 as an index, with the viscosity after 100 minutes being 100.

[0018]

[Table 2]

(Use test) The faces of 6 women were divided into right and left, the lotion of Example 2 and the cream of Example 3 were used on one side, and the other side was used as Comparative Example 1 as Example 2. A lotion in which the extract of Example 3 was replaced with water and a cream of Comparative Example 2 in which the extract of Example 3 was replaced with water were used, and a questionnaire was conducted 3 months later.

The judgment criteria are as follows, and the results of the questionnaire are summarized in Table 3 below. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is good −1 Comparative example is good −2 Comparative example Is very good -3

[0021]

[Table 3]

[0022]

The solvent extract of love egg of the present invention has a strong antioxidative effect and a strong inhibitory effect on hyaluronidase activity. Therefore, when incorporated as a cosmetic, it prevents rough skin, prevents wrinkles and gives a moist feeling. Furthermore, it maintains the elasticity of the skin and improves the luster of the skin. Since it has been used as a soft drink for many years, its safety to human skin is guaranteed.

Claims (1)

[Claims] 1. A skin roughness inhibitor containing a solvent extract of love eggs.