JPH05301821A - Medicated cosmetic - Google Patents

Abstract

(57) [Summary] [Purpose] To provide a cosmeceutical product which is less irritating to the skin or scalp, exhibits a sufficient effect of preventing itching and dandruff, and has excellent sustainability of the effect. [Structure] The cosmeceutical composition of the present invention contains a crude drug extract component having an antibacterial effect in a buffer solution containing an organic acid and an organic acid salt.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmeceutical composition, and more particularly to a cosmeceutical composition which is applied to the skin and scalp to prevent the occurrence of itching and dandruff.

[0002]

BACKGROUND OF THE INVENTION Itching, dandruff, etc. of the skin or scalp is caused by bacteria or the like present in the skin or scalp to decompose sebum or the like to give a decomposed product or a metabolite. And the irritation of the skin or scalp by metabolites. Therefore, it has been attempted to prevent the growth of the above-mentioned bacteria by a suitable drug having an antibacterial effect, reduce the decomposition products and metabolites of sebum by the above-mentioned bacteria, and prevent itching of the skin or scalp, dandruff, etc. As an anti-dandruff agent having an antibacterial effect, one containing an essential oil of a plant or a solvent extract is known (see JP-A-59-88412, etc.).

However, although the above anti-dandruff agent has an antibacterial effect, its effect is insufficient.
Moreover, the effect was lacking in sustainability. Also,
Ordinary antibacterial agents include itching of the skin or scalp as described above,
When used in a large amount for the purpose of preventing dandruff and the like, the skin or scalp was strongly irritated and was not practical.

Therefore, it is an object of the present invention to provide a cosmeceutical which has less irritation to the skin or scalp, exhibits a sufficient effect of preventing itching and dandruff, and is excellent in the sustainability of the effect.

[0005]

Means for Solving the Problems The present inventors have found that a cosmeceutical composition in which a crude drug extract component having an antibacterial effect is combined with a buffer solution of an organic acid and an organic acid salt achieves the above object. That is, the present invention has been reached. That is, the present invention provides a cosmeceutical containing a crude drug extract having an antibacterial effect in a buffer solution containing an organic acid and an organic acid salt.

The cosmeceutical composition of the present invention will be described in detail below. The organic acid contained in the cosmeceutical of the present invention,
For example, straight chain fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid; oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid,
Dicarboxylic acids such as phthalic acid, isophthalic acid and terephthalic acid; acidic amino acids such as glutamic acid and aspartic acid;
Glycolic acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, malic acid, tartaric acid, citric acid, salicylic acid (o, m, p), gallic acid,
Oxyacids such as mandelic acid, tropic acid, ascorbic acid, gluconic acid; cinnamic acid, benzoic acid, phenylacetic acid, nicotinic acid, kainic acid, sorbic acid, pyrrolidonecarboxylic acid, trimellitic acid, benzenesulfonic acid, toluenesulfonic acid, etc. Is mentioned. The organic acid salt contained in the cosmeceutical of the present invention includes salts of the above organic acids, preferably acetic acid, citric acid, lactic acid, and alkali metal salts thereof, and the like, lactic acid or sodium lactate, and These combinations are particularly preferable.

The above-mentioned organic acid and organic acid salt mainly exhibit functions such as an antibacterial effect, a moisturizing effect and a buffering effect in the cosmeceutical of the present invention, and the content thereof (the above-mentioned organic acid and organic acid). The total content of salts) is preferably 0.01 to 25.0% by weight, and more preferably 0.10 to 10.0% by weight in the total composition of the cosmeceutical of the present invention.
The liquidity of the cosmeceutical of the present invention varies depending on the galenical extract component contained, the purpose of use and the like, but it is usually preferably in the range of pH 3 to 7, particularly pH 4 to 6. The buffer capacity of the above-mentioned buffer solution is 20 to 20 at pH 4.0 to 6.0.
It is preferably 200 mM.

The crude drug which is a raw material for the crude drug extract component contained in the cosmeceutical of the present invention is not particularly limited as long as the extract component has an antibacterial effect, but it is not limited thereto. Cloves, nutmeg, oak, aloe, ginger, ginkgo, pomegranate, safflower,
Mint, perilla, pearl oyster, neat grass, goldfish,
Preferred examples thereof include kujin, gennosho, salamander, sycamore, loquat, juniper, peach, kokinoshita, forsythia, shirakanha, hops, lavender, lemon, sucrose, and the like, and clove, green tea and sucrose are particularly preferable.

The above-mentioned crude drug extract component is extracted from the above crude drug by a conventional method and is not limited to the extraction method. For example, in the case of a clove extract, the following (extraction of clove extract) is shown. It can be obtained by various extraction methods. (Extraction of clove extract) Japanese Pharmacopoeia Clove was dried and finely chopped into 10 kg, and 50 V / V% ethanol (a cosmetic raw material standard, prepared with absolute ethanol and purified water) was added and immersed for 24 hours, Extraction is obtained by pressing and separating.

In the cosmeceutical composition of the present invention, the crude drug extract component suppresses the growth of bacteria causing itching and dandruff in the presence of the organic acid and the organic acid salt, and the content thereof is: The content of the cosmeceutical composition of the present invention is preferably 0.001 to 25.0% by weight, and more preferably 0.005 to 5.0% by weight.

The cosmeceutical of the present invention is usually used by containing the above essential components in water and an aqueous solvent such as ethanol. The above-mentioned aqueous solvent is preferably a lower alcohol, and the content of the lower alcohol in the cosmeceutical of the present invention is 30 to 80% by weight, more preferably 40 to 60% by weight. In the cosmeceutical composition of the present invention, in addition to the above essential components, components contained in ordinary cosmetics, for example, oily bases, emollients, gelling agents, various emulsifiers, fragrances, parahydroxybenzoic acid esters, etc. Antiseptics, antioxidants such as butylhydroxyanisole, coloring agents such as dyes, wetting agents such as propylene glycol, film agents, thickeners, blood circulation promoters, vitamins and the like can be appropriately added.

The cosmeceutical of the present invention can be produced in the same manner as ordinary cosmetics. For example, lotion, emulsion,
Hair lotion, hair tonic, hair liquid,
Used as shampoo, conditioner, hair restorer, hair restorer, etc.,
It is used by filling it into a container together with a propellant such as pressurized carbon dioxide gas as necessary.

[0013]

EXAMPLES Examples of the cosmeceutical of the present invention will be given below.
The present invention will be specifically described.

Example 1 A cosmeceutical of the present invention having the following formulation was prepared. (Component) (wt%)-Ethanol 60-Lactic acid / sodium lactate 4.5 / 1.6-Clove extract 0.1-Fragrance 0.3-Liquid paraffin 2.0-Polyoxyethylene (20) cetyl ether 0.1. 5 ・ Purified water Balance

Example 2 A cosmeceutical (misted hair lotion) of the present invention having the following formulation was prepared. (Component) (wt%)-Ethanol 40-Citric acid / sodium citrate 2.5 / 1.0-Ougon extract 2.0-Polyoxyethylene hydrogenated castor oil 0.1-Fragrance 0.1-Purified water Balance Above Stock solution 70% LPG / DME (50/50) 30%
Was added and the container was sealed in a pressure container.

Comparative Example 1 A cosmeceutical composition having the following formulation was prepared. (Component) (wt%)-Ethanol 60-Clove extract 0.01-Fragrance 0.3-Liquid paraffin 2.0-Polyoxyethylene (20) cetyl ether 0.5-Purified water Balance (Comparative Example 2) The following formulation To prepare the cosmeceutical of the present invention. (Component) (wt%)-Ethanol 60-Lactic acid / sodium lactate 4.5 / 1.6-Fragrance 0.3-Liquid paraffin 2.0-Polyoxyethylene (20) cetyl ether 0.5-Purified water Balance

(Test Example 1) With respect to the cosmeceutical preparations prepared in the above Examples and Comparative Examples, the number of aerobic bacteria on the scalp was measured by the following [Measurement Method], and the itching prevention effect by the half head was measured. The average value (number of panelists n = 5) of the panelists' determination according to the following [criteria] was used for the determination. The results are shown in [Table 1] and [Table 2] below. [Measurement method] A prescribed amount of the prepared medicated cosmetic was directly applied to the scalp. After application to the scalp, physiological saline was used at predetermined intervals and extraction was performed using a glass cup having an inner diameter of 2 cm ² .
The obtained extract was cultured in SCD medium at 37 ° C. for 48 hours, and the number of bacteria was measured.

[0018]

[Table 1]

[0019]

[Table 2]

[0020]

EFFECT OF THE INVENTION The cosmeceutical of the present invention has little irritation to the skin or scalp, exhibits a sufficient effect of preventing itching and dandruff, and is excellent in the sustainability of the effect.

Claims (1)

[Claims] 1. In a buffer solution containing an organic acid and an organic acid salt,
A cosmeceutical containing a crude drug extract having an antibacterial effect.