JPH0466205B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a form of administration for preventive treatment or emergency treatment using a drug that acts locally in the oral cavity and pharyngeal cavity or on the gums to exert its effect. It is. Such local treatment is carried out by brushing or spraying the drug, soaking it with a drug, or sucking a tablet or the like.

The therapeutic effectiveness of such treatments depends on the extent to which the form in which the drug is presented allows the active substance to remain concentrated at the site of action. Medications and solutions applied with a brush are diluted by saliva within a short time and moved away from the site of action. Furthermore, the saliva solution is diluted by saliva, making it difficult for the patient to keep the solution in the oral cavity for a long period of time. On the other hand, tablets and the like take time to disintegrate in the oral cavity and release the drug only slowly, but in this case they have the disadvantage that only the amount of drug carried to the site of action by saliva is effective. have.

The object of the present invention is to eliminate the above-mentioned disadvantages, to achieve as long a contact time at the site of action as possible, to be suitable for both liquid and solid drugs, to release the active substance as uniformly as possible and without irritation; It is an object of the present invention to provide a drug form in which only physiologically neutral auxiliary substances are used, in particular auxiliary substances that do not have a caries-promoting effect, such as sugars or stimulants.

The aim of the invention is to provide a simple drug form in which the mixture of active substance and auxiliary substance has a high adhesion to the mucous membranes for as long a contact time as possible.

The object of the invention was achieved by containing the active substance in dispersed or dissolved form in a gelatin gel and processing this gelatin gel in a known manner into soft gelatin capsules. The soft gelatin capsules thus produced are sucked or chewed.

Methods for producing soft gelatin capsules have been known for some time, for example in K. Voigt, published by Chemie Publishing House.
"Lehrbuch der phamazeutischen" written by
Pages 232-235 of "Technology" (Pharmaceutical Engineering Textbook)
It is written on the page. In contrast to conventional production techniques, in this case the gelatin band is cast as thick as possible in order to increase the wall thickness of the capsule.

In addition, the capsule has a gas core to give the molded product a certain degree of flexibility, so it feels better against the teeth, and the capsule is less likely to break even when the teeth touch it lightly, making it more effective in the oral cavity. The effective time of the substance increases. The gelatin material used usually has a composition similar to that of common soft gelatin capsules. Nevertheless, the selection of the qualitative composition of the gelatin capsule has important implications. This is because gelatin capsules quickly soften when licked or chewed.
This is because it must be something that will only collapse slowly. When a gelatin material is selected in this manner, the adhesive properties of gelatin allow it to be distributed within the oral cavity and adhere to the oral mucosa, but remain in contact with the oral mucosa for as long as possible.

It has surprisingly been found that the aforementioned effects can be achieved with known compositions of gelatin capsules, which are commonly used for soft gelatin capsules.

Another advantage of the invention is that a range of active substances, such as ethereal oils or astringent tinctures, can be dissolved within the gelatin material, so that the active substances become dispersed in molecular form and act. It is.

Next, one embodiment of the present invention will be described, but this embodiment does not limit the present invention.

100.0 whose composition is 46.00% gelatin, 17,23% glycerin and 36.77% water, temperature 70℃
While stirring, 1.07 kg of a 24.3% aqueous solution of preservative and 1.07 kg of sweetener were added to ℃ kg of melted gelatin.
5.04Kg of 22.8% aqueous solution, 0.65Kg of ether oil mixture
Kg, 1.02 Kg of astringent tincture mixture, and 0.08 Kg of 62.5% aqueous dispersion of colorant or mixed colorant are added.

To produce the soft gelatin capsules of the present invention, a sheera rotary die process is used.
A 1032.0 mg compact is punched out. To stabilize the shape, 0.32 ml of nitrogen is filled into the capsule. The capsules are dried within 2-3 days to a final weight of 660.0 mg.

Claims (1)

[Scope of Claims] 1. A soft gelatin capsule for use as a medicine for the oral cavity and pharyngeal cavity, the soft gelatin capsule containing the active substance in the wall in a dispersed or dissolved state, and the core containing only a gas. A soft gelatin capsule characterized by containing no gelatin. 2. The gelatin material according to claim 1, wherein the gelatin material consists of 40% to 50% gelatin, 20% to 30% glycerin and 20% to 30% water in order to obtain high adhesion to mucous membranes. Soft gelatin capsule.