JPH04186163A - Automatic analyzing device - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to a method for remedial treatment of abnormal specimens.
-455 Yes.

[Conventional technology]

Conventional devices had a memory storage function for only reaction process data, but did not have a function to recalculate using that data.

[Problem to be solved by the invention]

The above conventional technology had a function of storing only the measured results (○/NG) or only the reaction process data of a specific item in the memory, but in the case of an abnormal sample, the conditions had to be reset. There was a problem in that no consideration was given to the waste of specimen samples, reagents, and time during measurements.

The purpose of the present invention is to reset the conditions and recalculate based on the data of the reaction process, and furthermore, if a sample changes from abnormal to normal in the recalculation, it is determined by human judgment that it becomes normal. The purpose is to put a mark to let people know.

[Means to solve the problem]

In order to achieve the above object, a function is provided to constantly store reaction process data in a memory (RAM, FD, etc.).

In addition, in order to rescue abnormal samples, we have set up a function to reset the conditions and recalculate using reaction process data, and as a result of recalculation, samples that change from abnormal to normal are marked (
It has a function to add marks).

[Effect]

Data on the reaction process being measured is stored in memory (RAM).

FD, etc.), and can be called up on a display medium such as CR1" after the measurement is completed. In particular, data on the reaction process of a sample judged to be abnormal can be called up and recalculations can be performed by resetting the conditions. However, if a sample changes from abnormal to normal, it will be marked and later it will be possible to tell whether the judgment was made by the machine or by a human.By doing so, blood can be re-collected from the patient with the abnormal sample. Waste of time and blood can be eliminated.

[Example] An example of the present invention will be described below with reference to FIGS. 1 to 6.

FIG. 1 is a schematic diagram of an automatic analyzer for clinical testing in which the present invention is implemented. The arm 4 supporting the nozzle 3 descends into the sample container 2 containing the sample set on the sample table 1, and after inhaling the sample, the arm 4 rises 1", rotates, and sets it on the reaction table 5. A sample is dispensed into a reaction container 6, and the change in scattered light is measured. To measure changes in scattered light, light emitted from a light source 7 at the bottom of the reaction vessel 6 is scattered when an agglutination reaction is initiated within the reaction vessel 6, and is detected by a side detector 8.

The signal that has passed through the measurement detector 8 is sent to the lock-in amplifier lO1 logarithmic converter 11 . A/D converter 1
Memory element (RAM) 1' by the CPU 13 via 2
5. The signal is stored in the RAM 15 at fixed intervals (for example, every 0.1 seconds), and calculations are performed sequentially, and the results are sent to the printer 16 or CRT 17.
Print or display on.

Here, determination of coagulation will be explained using FIGS. 3 to 5.

The temporal change in the amount of scattered light that increases as the aggregation reaction progresses takes the form shown in FIG. In determining the coagulation time, the position Q,1 where the slope of this waveform (Fig. 3) is the largest is defined as the coagulation point, and the time from the start of measurement to this coagulation point is called the coagulation time. Various conditions must be met to determine the clotting time. First, a -th differential waveform (Fig. 4) is taken, and the -th differential value is above a certain threshold (hereinafter referred to as threshold level C1), and the double integral waveform (Fig. 5) is taken. ), when the conditions such as the double integral value (corresponding to the area of the shaded area in Figure 3) being above a certain threshold (hereinafter referred to as threshold level C2) are simultaneously satisfied. , T is the clotting time. These threshold levels CI and C2 are normally set to values that take into account a safety factor in order to distinguish them from the noise signal P2 due to floating particles, bubbles, etc. generated during the reaction process. However, in reality, it is very difficult to set these threshold levels CI and C2, and the current situation is that they cannot be satisfied for all patient samples.

Under these conditions, raw data (reaction process data) and measurement results of the sample that became uncoagulated as a result of calculation are stored in RAM1.
5 to the floppy disk 19, which can be read out at any time, and recalculated while looking at the waveform of the raw data (Fig. 3). It was found that there was a clear peak in the -order differential waveform (Fig. 6). However, if the threshold level C1 is set too high and is determined to be uncoagulated, the value of the threshold level C1 is lowered by human judgment and the coagulation time is obtained by recalculating. The results obtained by human judgment are re-stored on the floppy disk 19 with a mark attached, and when the results are output later, it is possible to identify whether the results were determined by the device or by a human. can be identified.

In addition, before starting the measurement, you can set whether to display the waveform of the uncoagulated sample using the keyboard 18, and if you select Yes, all the first-order differential waveforms of the uncoagulated sample will be displayed at the end of the measurement, allowing the user to to influence judgment.

According to the present example, the threshold level CI is maintained even though the solidification is clearly occurring.

It is possible to eliminate the waste of having to re-examine the product because it is determined that the product is not coagulated due to an incorrect C2 setting. In particular, it is unacceptable to waste plasma (specimen) obtained from infants and other patients whose blood collection is difficult, so this mode is extremely necessary.

[Effects of the Invention] According to the present invention, at the end of the measurement, the first-order differential waveforms of all uncoagulated samples are displayed on the CRT, or the first-order differential waveforms of any number of uncoagulated samples can be called up and displayed from the floppy disk. By doing so, the data can be confirmed, preventing errors in judgment by the machine, and having the effect of preventing re-examinations due to errors.

[Brief explanation of drawings]

Fig. 1 is a schematic diagram of the mechanism of an embodiment of the present invention, Fig. 2 is a signal system block diagram, Fig. 3 is a coagulation signal (original waveform) diagram, and Fig. 4 is a first-order differential waveform diagram of the original waveform. , FIG. 5 is a double integral waveform diagram, and FIG. 6 is a first-order differential waveform diagram when the threshold level CI is set high, and is determined to be non-coagulated. 1 ・Sample table, 2...sample container, 3...
Nozzle, 4...Sample arm, 5...Reaction table, 6...Reaction container, 7...Light source, 8...Side detector, 9...Light source driver, 10...Lock-in amplifier , 11... Logarithmic converter, 12... A/D converter, 13
...CPU, 14...ROM, 15...RAM,
16...Printer, 17...CRT, 18...Keyboard, 19...Flora song,

Claims (1)

[Claims] 1. In an apparatus having a function of constantly storing measurement results in a memory (RAM, floppy disk, etc.),
A function is provided to store not only measurement results but also reaction process data of abnormal samples in memory, and that data can be accessed at any time by CR.
An automatic analysis device characterized by being provided with a function to display on a display medium such as a T-shirt and leave things that are difficult to judge by the device to the judgment of humans (physicians and laboratory technicians). 2. The automatic analysis device according to claim 1, characterized in that the data left to human judgment is marked with a mark, so that it can be later identified whether the data was judged by a machine or by a human.