JP7771981B2 - Dentifrice composition - Google Patents

Description

The present invention relates to a dentifrice composition that has moderately suppressed foaming, is low-foaming, and has a pleasant feel when used.

Dentifrice compositions generally contain abrasives, surfactants, humectants, binders, etc., and by incorporating an anionic surfactant as the surfactant, they exhibit a cleansing effect, such as removing stains from the oral cavity, as well as a bactericidal effect, and can impart a refreshing feeling to the oral cavity after brushing.
However, users of dentifrice compositions, such as elderly people who require nursing care, tend to rinse insufficiently after brushing their teeth due to a decline in oral function. Furthermore, when rinsing is difficult, they often simply wipe the inside of their mouths with wet tissues or the like, which can result in insufficient removal of foam from the mouth, leaving behind irritation or an unpleasant taste.
However, anionic surfactants have high foaming properties even when used in small amounts, and therefore, in order to suppress foaming in dentifrice compositions containing anionic surfactants, it is necessary to add a relatively large amount of an ingredient with anti-foaming properties. Commonly used flavoring ingredients also have anti-foaming properties, but adding these ingredients can affect the feel of use of the dentifrice composition and limit the composition design. As a result, it has not been possible to suppress foaming to achieve low foaming properties while ensuring a good feel of use and imparting a refreshing feel to the oral cavity.

Japanese Patent Application Laid-Open No. 2005-289917 JP 2015-89870 A JP 2015-231972 A

The present invention has been made in consideration of the above circumstances, and aims to provide a dentifrice composition containing an anionic surfactant that has moderately suppressed foaming, is low-foaming, and has a good feel when used.

As a result of extensive research conducted by the inventors to achieve the above-mentioned objective, they discovered that when a dentifrice composition containing a specific anionic surfactant is blended with a specific amount of a fatty acid triglyceride or a specific vegetable or animal oil in a specific ratio relative to the anionic surfactant, and a nonionic surfactant is also blended in combination, foaming is moderately suppressed, resulting in low foaming, even though the anionic surfactant is included.Furthermore, even if almost no foaming is felt, a refreshing feeling in the mouth after brushing (hereinafter sometimes abbreviated as "refreshing feeling") can be imparted, and the appearance stability can also be ensured. That is, according to the present invention, it has been discovered that a dentifrice composition containing (A) one or more anionic surfactants selected from acyltaurines, acylamino acids, alkyl sulfates, and salts thereof, (B) one or more selected from fatty acid triglycerides, vegetable oils, and animal oils that are liquid at 25°C, and (C) a nonionic surfactant, wherein the content of component (B) is 0.05 to 1.5% by mass and the mass ratio of (B)/(A) is 1 to 10, exhibits moderately suppressed foaming, is low-foaming, has a good feel when used, and has stable appearance, leading to the present invention.

In the present invention, when component (A) is used in combination with component (B) in a specific amount with a (B)/(A) mass ratio within a specific range, and when component (C) is also added, component (A) and component (B) interact stably and specifically, thereby imparting the above-mentioned exceptional action and effect.
In this case, in the present invention, the combination of components (A), (B), and (C) maintains the cleaning effect and other functional effects of component (A), while suppressing foaming properties and foam persistence, resulting in less foaming, and component (B) is stably incorporated over time.As a result, even with a low foaming property that produces little foam, a refreshing feeling is imparted to the oral cavity after use, and the appearance stability can be ensured.
As shown in the comparative examples described below, Comparative Examples 1, 3, and 4, in which the dentifrice compositions contained component (A) but not component (B), exhibited poor foaming properties even though they contained liquid paraffin or shea butter along with component (C), and Comparative Examples 5 and 6, in which components (A) and (B) were contained but not component (C), exhibited poor appearance stability even though they contained the amphoteric surfactant coconut oil fatty acid amidopropyl betaine. Comparative Examples 7 and 8, in which components (A), (B), and (C) were contained but the mass ratio of (B)/(A) was inappropriate, exhibited poor foaming properties or a refreshing feeling, and Comparative Example 9, in which the amount of component (B) was too high, exhibited poor refreshing properties and poor appearance stability. In contrast, as shown in the examples, a dentifrice composition of the present invention containing the components (A), (B), and (C) and in which the amount of component (B) and the mass ratio of (B)/(A) are within a specific range exhibited excellent foaming resistance, a refreshing feeling, and good appearance stability.
Dentifrice compositions containing an anionic surfactant, a sucrose fatty acid ester, or a liquid oil are disclosed in Patent Documents 1 to 3, but these do not suppress foaming. From Patent Documents 1 to 3, it is difficult to imagine that the present invention can achieve low foaming and ensure stable feel and appearance by combining component (A) with a combination of components (B) and (C).

Accordingly, the present invention provides the following dentifrice compositions.
[1]
(A) one or more anionic surfactants selected from acyltaurine, acylamino acid, alkyl sulfate, and salts thereof;
A dentifrice composition comprising (B) one or more oils selected from a fatty acid triglyceride, a vegetable oil and an animal oil that are liquid at 25°C, and (C) a nonionic surfactant, wherein the content of component (B) is 0.05 to 1.5% by mass, and the mass ratio of (B)/(A) is 1 to 10.
[2]
The dentifrice composition according to [1], wherein component (A) is selected from acylamino acids and salts thereof.
[3]
The dentifrice composition according to [1] or [2], wherein the fatty acid triglyceride is a fatty acid triglyceride in which the fatty acid has 6 to 20 carbon atoms and is liquid at 25°C, and the vegetable oil or animal oil that is liquid at 25°C is selected from soybean oil, safflower oil, olive oil, avocado oil, corn germ oil, cod liver oil, and shark oil.
[4]
The dentifrice composition according to any one of [1] to [3], wherein component (C) is a polyglycerol fatty acid ester having a fatty acid having 12 to 18 carbon atoms.
[5]
The dentifrice composition according to [4], wherein the polyglycerol fatty acid ester having a fatty acid carbon number of 12 to 18 is at least one selected from hexadecaglyceryl laurate and decaglyceryl laurate.
[6]
The dentifrice composition according to any one of [1] to [5], which contains 0.05 to 1.5% by mass of component (A) and 0.1 to 2% by mass of component (C).
[7]
The dentifrice composition according to any one of [1] to [6], wherein the mass ratio of (C)/(B) is 0.5 to 5.

The present invention provides a dentifrice composition containing an anionic surfactant that exhibits moderately suppressed foaming, low foaming properties, and a pleasant feel when used. This dentifrice composition can remove foam from the mouth by simply rinsing or wiping after brushing, providing a cleansing effect due to component (A) and leaving the mouth feeling refreshed, making it effective for oral care for a wide range of users.

The present invention will be described in further detail below.
The dentifrice composition of the present invention contains (A) one or more anionic surfactants selected from acyltaurine salts, acylamino acid salts, and alkyl sulfates, (B) one or more fatty acid triglycerides, and vegetable and animal oils that are liquid at 25°C, and (C) a nonionic surfactant.

Component (A) is one or more anionic surfactants selected from acyltaurine, acylamino acid, alkyl sulfate, and salts thereof.
The acyltaurine, acylamino acid, or salt thereof preferably has an acyl group having 8 to 18 carbon atoms, and the alkyl sulfate or salt thereof preferably has an alkyl group having 8 to 12 carbon atoms. These salts are preferably alkali metal salts such as sodium salts.
Examples of component (A) include acylamino acid salts such as sodium lauroyl sarcosinate and sodium cocoyl sarcosinate, acyltaurine salts such as sodium cocoyl methyl taurate and sodium lauroyl methyl taurate, and alkyl sulfates such as sodium lauryl sulfate and ammonium lauryl sulfate. In particular, acylamino acid salts are preferred from the standpoints of foaming inhibition and refreshing feeling, and sodium lauroyl sarcosinate is more preferred.

The amount of component (A) blended is preferably 0.05 to 1.5% (% by mass, hereinafter the same) of the total composition, more preferably 0.1 to 1%, and even more preferably 0.1 to 0.3%. The higher the blend amount, the more refreshing the feeling obtained, and when the blend amount is 1.5% or less, foaming is sufficiently suppressed and excellent low-foaming properties are achieved.

In addition to component (A), the dentifrice composition of the present invention may contain other anionic surfactants, such as alkyl phosphates and polyoxyethylene monoalkyl phosphates, to the extent that the effects of the present invention are not impaired; however, these optional anionic surfactants do not have to be included.

Component (B) is one or more selected from fatty acid triglycerides, vegetable oils, and animal oils that are liquid at 25° C. These act as defoaming agents to maintain the cleaning effect and other functional effects of component (A) and to moderately suppress foaming, thereby achieving low-foam properties.
As component (B), any of fatty acid triglycerides, vegetable oils that are liquid at 25° C., and animal oils that are liquid at 25° C. can be used, and from the viewpoint of the effectiveness, two or three of these can also be used in combination. Among these, fatty acid triglycerides are preferred from the viewpoint of low foaming.

Fatty acid triglycerides are preferred that are liquid at 25°C and have fatty acids with 6 to 20 carbon atoms, with 8 to 10 being particularly preferred. Examples include medium-chain fatty acid triglycerides (a mixture of fatty acids with 8 and 10 carbon atoms).

Examples of vegetable oils and animal oils that are liquid at 25°C include vegetable oils such as soybean oil, safflower oil, olive oil, avocado oil, and corn germ oil, and animal oils such as cod liver oil and shark oil, with vegetable oils being particularly preferred in terms of their lack of foaming.
The component (B) may be a single compound or a combination of two or more compounds, and commercially available products may be used.

The blending amount of component (B) is 0.05 to 1.5% of the total composition, preferably 0.1 to 1%, and more preferably 0.1 to 0.5%. If the blending amount is less than 0.05%, the lack of foaming will be poor, and if it exceeds 1.5%, the refreshing feeling will decrease and liquid separation will occur after storage, resulting in poor appearance stability.

The nonionic surfactant (C) acts as a solubilizer to stably blend the component (B) even after storage, and to provide stability to the appearance.
Examples of (C) nonionic surfactants include glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene hydrogenated castor oils having an average number of added moles of ethylene oxide of 3 to 30 (particularly 5 to 20), polyoxyethylene alkyl ethers having an alkyl group with 12 to 18 carbon atoms and an average number of added moles of ethylene oxide of 2 to 40 (particularly 5 to 20), and polyoxyethylene sorbitan fatty acid esters. Glycerin fatty acid esters having a fatty acid carbon number of 12 to 18 are preferred, and specific examples include glyceryl myristate and glyceryl oleate. Polyglycerin fatty acid esters having a fatty acid carbon number of 12 to 18 are preferred, and specific examples include hexadecaglyceryl laurate, decaglyceryl laurate, decaglyceryl oleate, decaglyceryl pentaoleate, and decaglyceryl distearate. Among these, polyglycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ethers are preferred in terms of appearance stability and a refreshing feeling, and polyglycerin fatty acid esters are more preferred in terms of a particularly refreshing feeling, with hexadecaglyceryl laurate and decaglyceryl laurate being even more preferred.
The nonionic surfactant may be used alone or in combination of two or more kinds, and commercially available products may also be used.

The blending amount of component (C) is preferably 0.1 to 2% of the total composition, more preferably 0.2 to 1%, and even more preferably 0.2 to 0.7%. When the blending amount is 0.1% or more, component (B) remains stable even after storage, and sufficient stability of appearance is achieved. When the blending amount is 2% or less, no foaming and a sufficiently refreshing feeling are achieved. When the blending amount exceeds 2%, foaming cannot be suppressed and a sufficiently refreshing feeling may not be achieved.

(B)/(A), which represents the ratio of the amounts of component (A) to component (B), is a mass ratio of 1 to 10, preferably 2 to 7, and more preferably 3 to 5. If the mass ratio of (B)/(A) is less than 1, foaming cannot be suppressed and the foaming ability will be poor, while if it exceeds 10, the product will have an oily feel and will not have a refreshing feeling.

Furthermore, (C)/(B), which represents the ratio of the amounts of component (B) to component (C), is preferably a mass ratio of 0.5 to 5, more preferably 1 to 3. Within the above range, the lack of foaming is even better, the refreshing feeling is even better, and the appearance stability is even better. If the mass ratio of (C)/(B) is less than 0.5, the appearance stability may decrease, and if it exceeds 5, it may become difficult to suppress foaming.

The dentifrice composition of the present invention can be formulated into various dosage forms, such as toothpaste, liquid dentifrice, liquid dentifrice, and lubricant dentifrice, but is particularly suitable as a toothpaste. In this case, appropriate known ingredients in addition to the ingredients mentioned above can be added depending on the purpose and dosage form of the composition. For example, abrasives, humectants, binders, surfactants, and, if necessary, preservatives, sweeteners, colorants, flavorings, pH adjusters, active ingredients, etc. can be added, and the dentifrice composition can be produced by mixing these ingredients with water. These optional ingredients can be added in conventional amounts as needed. In the following, the amount added is the amount relative to the entire composition.

Examples of abrasives include silica-based abrasives such as silicic anhydride, precipitated silica, aluminosilicate, and zirconosilicate, calcium phosphate-based compounds such as dibasic calcium phosphate dihydrate or anhydrate, calcium carbonate, and synthetic resin-based abrasives. The amount of abrasive to be added is preferably 0 to 50%, and if added, it is preferably 5 to 15%.
The dentifrice composition of the present invention does not need to contain an abrasive, and the effects of the present invention can be obtained even when it is prepared as a non-abrasive toothpaste.

Humectants include sugar alcohols such as sorbitol and xylitol, and polyhydric alcohols such as glycerin and propylene glycol. The amount of humectant used is usually 5-50%, and particularly 10-30%.

The binder may be an organic or inorganic binder. Specific examples include organic binders such as cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, and hydroxymethylcellulose, alginic acid derivatives, gums such as xanthan gum, and sodium polyacrylate, and inorganic binders such as thickening silica and thickening aluminum silica. The amount of binder blended is usually 0.1 to 10%.
In the present invention, organic binders are particularly preferred, and the blending amount of the organic binder is preferably 0.1 to 5%, and more preferably 0.5 to 3%.

Examples of the optional surfactant include cationic surfactants such as alkylammonium type and alkylbenzylammonium salts, acetic acid betaine type such as alkyl betaine and fatty acid amidopropyl betaine, and imidazolinium betaine (alkylimidazole) type amphoteric surfactants such as alkylimidazolinium betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.
The amount of any surfactant to be added is 0 to 10%, and if added, it is preferably 0.001 to 10%, particularly preferably 0.1 to 5%.

Examples of preservatives include parahydroxybenzoic acid esters such as methylparaben (methyl parahydroxybenzoate), benzoic acid, and salts thereof.
Sweeteners include saccharin sodium and the like.
Examples of colorants include Blue No. 1, Yellow No. 4, and titanium dioxide.

Fragrances include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, mint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweet jasmine oil, Natural fragrances such as yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, and processed fragrances (front end cut, tail end cut, fractional distillation, liquid-liquid extraction, essence, powdered fragrance, etc.) of these natural fragrances, as well as menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, It is possible to use a combination of known flavor materials used in oral compositions, such as single flavors such as menthone, menthyl acetate, N-substituted-paramenthan-3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbeyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenyl glycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, and ethyl thioacetate, as well as blended flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and tropical fruit flavor, and the flavors are not limited to those described in the examples.
The amount of the fragrance to be added is not particularly limited, but the above fragrance materials are preferably used in an amount of 0.000001 to 1% in the composition, and fragrances using the above fragrance materials are preferably used in an amount of 0.1 to 2% in the composition.

A pH adjuster may be added, such as citric acid or its salts, such as citric acid or sodium citrate.

Active ingredients include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, nonionic disinfectants such as isopropylmethylphenol, cationic disinfectants such as cetylpyridinium chloride, anti-inflammatory agents such as tranexamic acid and allantoin, enzymes such as dextranase, water-soluble phosphate compounds, inorganic salts such as sodium chloride, potassium nitrate, and aluminum lactate, vitamins such as ascorbic acid and tocopherol acetate, plant extracts, anti-tartar agents, and anti-plaque agents. The active ingredients can be incorporated in effective amounts as long as they do not interfere with the effects of the present invention.

The present invention will be explained in detail below using examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by conventional methods and used as samples to be evaluated by the following methods. The results are also shown in the tables.

<Evaluation method for usability (lack of foaming, refreshing feeling)>
Immediately after preparation, the samples were evaluated for feel in use (lack of foaming, refreshing feeling) by five expert panelists.
1 g of the sample was placed on a toothbrush (Clinica Advantage Toothbrush, 4-row compact regular type, manufactured by Lion Corporation), and the teeth were brushed for 3 minutes, followed by rinsing with water.
The foaming during use (during tooth brushing) and the refreshing feeling in the oral cavity after use (after rinsing) were evaluated according to the following rating scale. The scores of the five panelists were averaged, and the lack of foaming and the refreshing feeling were evaluated based on the following rating scale.

Rating criteria for lack of foaming: 5: Almost no foaming felt 4: Slight foaming felt 3: Some foaming felt 2: Considerable foaming felt 1: Extremely foaming felt Evaluation criteria for lack of foaming (○ or above was considered a pass)
☆: The average score of the five people is 4.5 points or more. ◎: The average score of the five people is 4 points or more but less than 4.5 points. ○: The average score of the five people is 3 points or more but less than 4 points. ×: The average score of the five people is less than 3 points.

Rating criteria for refreshing feeling 5: Very refreshing feeling 4: Refreshing feeling 3: Somewhat refreshing feeling 2: Not very refreshing feeling 1: Not refreshing feeling at all Evaluation criteria for refreshing feeling (○ or above is considered a pass)
☆: The average score of the five people is 4.5 points or more. ◎: The average score of the five people is 4 points or more but less than 4.5 points. ○: The average score of the five people is 3 points or more but less than 4 points. ×: The average score of the five people is less than 3 points.

<Method for evaluating appearance stability>
Immediately after preparation, 90 g of the sample was filled into a common aluminum laminated tube container and stored at 60°C for 1 month. After that, the sample was extruded from the container and the appearance of the preparation (absence of liquid separation) was visually inspected, and the appearance stability was evaluated according to the following evaluation criteria.
Appearance stability evaluation criteria (above 0 is considered pass)
◎: No liquid separation at all ○: Slight liquid separation is observed at the opening of the tube, but not at a level that is problematic ×: Liquid separation is observed from the opening of the tube to the inside

Details of the raw materials used are shown below.
(A) Component: Sodium lauroyl sarcosinate:
Kawaken Fine Chemicals Co., Ltd., product name: Soybon SLP
Sodium Lauryl Sulfate:
BASF Japan Ltd., trade name: Texapon OC-P
Sodium Methyl Lauroyl Taurate:
Nikko Chemicals Co., Ltd., trade name: NIKKOL LMT
(B) Component fatty acid triglyceride:
(A mixture of fatty acids with 8 and 10 carbon atoms, with the fatty acid carbon chain composition ratio of C8: 70% and C10: 30%)
Fuji Oil Co., Ltd., product name: MCT-73
olive oil:
NIKKOL Olive Oil and Safflower Oil, manufactured by Nikko Chemicals Co., Ltd.
Nikko Chemicals Co., Ltd., trade name: NIKKOL Safflower Oil (B') Liquid Paraffin (comparative component):
Sanko Chemical Industry Co., Ltd., trade name: Liquid Paraffin 350-S
(B') Shea butter (comparison component):
Croda Japan, product name: Cropure Shea Butter (C) Ingredient: Decaglyceryl laurate:
SY Glyster, manufactured by Sakamoto Pharmaceutical Co., Ltd. Polyoxyethylene (20) hydrogenated castor oil:
Manufactured by Nippon Surfactant Industries Co., Ltd., product name: NIKKOL HC
O-20
Polyoxyethylene (5) stearyl ether:
Lion Chemical Company, trade name: RHA-155 SCE
(C') Coconut oil fatty acid amidopropyl betaine (30% aqueous solution) (comparison component): manufactured by Degussa, trade name: TEGO BETAIN CK-OK
In the table, the amounts of components (A) to (C), (B') and (C') are shown in terms of pure content.

Claims (6)

(A) one or more anionic surfactants selected from sodium lauroyl sarcosinate, sodium lauryl sulfate, and sodium lauroyl methyl taurate ;
(B) one or more selected from fatty acid triglycerides having a fatty acid carbon number of 8 to 10, olive oil, safflower oil, olive oil and safflower oil ;
and (C) one or more nonionic surfactants selected from decaglyceryl laurate, polyoxyethylene (20) hydrogenated castor oil, and polyoxyethylene (5) stearyl ether , wherein the content of component (B) is 0.05 to 1.5% by mass and the mass ratio of (B)/(A) is 2 to 8 . 2. The toothpaste composition according to claim 1 , wherein component (A) is one or two anionic surfactants selected from the group consisting of sodium lauroyl sarcosinate and sodium lauroyl methyl taurate . 3. The toothpaste composition according to claim 1, wherein the mass ratio of (B)/(A) is 3 to 5. The toothpaste composition according to any one of claims 1 to 3 , comprising 0.05 to 1.5% by mass of component (A) and 0.1 to 2% by mass of component (C). 5. The toothpaste composition according to claim 1, wherein the mass ratio of (C)/(B) is 0.5 to 5 . 5. The toothpaste composition according to claim 1, wherein the mass ratio of (C)/(B) is 1 to 3.