JP6125705B2 - MEDICAL IMAGE DIAGNOSIS DEVICE AND METHOD OF OPERATING MEDICAL IMAGE DIAGNOSIS DEVICE - Google Patents

Description

Embodiments described herein relate generally to a medical image diagnostic apparatus and a method for operating the medical image diagnostic apparatus .

  There are still many deaths due to so-called thrombosis such as cerebral infarction and myocardial infarction. One cause of myocardial infarction is plaque detachment. Plaque is a deposit of substances such as cholesterol fat and macrophages in the blood on the intima of coronary blood vessels. When the plaque is peeled off due to internal pressure or the like, a thrombus is formed at the peeled portion, and the thrombus flows on the bloodstream to close the coronary artery, thereby causing myocardial infarction. Therefore, in order to prevent myocardial infarction, it is necessary to remove plaque with high possibility of peeling by catheter surgery or the like. To determine whether catheter surgery is necessary, the measurement result of FFR (Functional Flow Reserve) using a pressure wire is used. However, since the measurement of FFR requires the insertion of a pressure wire, the burden on the patient is great. Therefore, it is desired to be able to determine whether catheter surgery is necessary by a method that can reduce the burden on the patient.

  Currently, there is a technique for estimating a plaque property based on a CT value of a CT image taken by a CT (Computed Tomography) apparatus so that a burden on a patient can be reduced. However, it is difficult to determine whether the plaque is a high-risk plaque that is likely to peel off.

It is an object of the present invention to provide a medical image diagnostic apparatus and a medical image diagnostic apparatus operating method capable of estimating a plaque with a high degree of risk.

The medical image diagnostic apparatus according to the present embodiment includes an image acquisition unit that acquires CT image data including a blood vessel, and an estimation unit that estimates the position and hardness of the plaque in the blood vessel based on the CT image data. , An extraction unit for extracting a blood vessel wall structure from the CT image, and calculating a stress value applied to the plaque by fluid analysis based on the blood vessel wall structure, and based on both the stress value and the hardness , And a calculation unit for calculating an index value indicating the degree of risk.

FIG. 1 is a block diagram illustrating an example of a configuration of a medical image diagnostic apparatus according to the present embodiment. FIG. 2 is a flowchart for explaining the plaque emphasis display process included in the medical image diagnostic apparatus according to the present embodiment. FIG. 3 is a diagram illustrating an example of a three-dimensional superimposed image displayed on the display unit by the plaque emphasis display function of the medical image diagnostic apparatus according to the present embodiment. FIG. 4 is a diagram illustrating an example of a two-dimensional superimposed image displayed on the display unit by the plaque emphasis display function of the medical image diagnostic apparatus according to the present embodiment.

  Hereinafter, the medical image diagnostic apparatus 1 according to the present embodiment will be described with reference to the drawings. In the following description, components having substantially the same function and configuration are denoted by the same reference numerals, and redundant description will be given only when necessary.

  FIG. 1 is a block diagram showing an example of the configuration of a medical image diagnostic apparatus 1 according to this embodiment. As shown in FIG. 1, the medical image diagnostic apparatus 1 includes a communication interface unit 11, a storage unit 12, a control unit 13, an input unit 14, a reconstruction unit 15, and a coronary artery analysis unit 16 (extraction unit 16). A plaque position estimation unit 17, a color map conversion unit 18, a hardness estimation unit 19, a plaque map generation unit 20, a risk evaluation unit (specification unit) 21, an annotation generation unit 22, and a display unit 23. And having.

  The medical image diagnostic apparatus 1 according to the present embodiment includes a CT apparatus, a SPECT apparatus, a PET apparatus, a PACS (Picture Archiving and Communication System) via a network such as a LAN (Local Area Network) or a public electronic communication line. System).

  The medical image diagnostic apparatus 1 includes a communication interface unit 11 for connecting to an external apparatus via a network. The communication interface unit 11 includes, for example, a connector unit (not shown) for connecting to an external device or the like with a wired cable, a wireless signal receiving unit (not shown) for receiving a radio signal from the external device, etc. Have The medical diagnostic imaging apparatus 1 transmits / receives data to / from an external device via the communication interface unit 11 according to control of the control unit 13 described later.

  The storage unit 12 is a semiconductor storage device such as a flash SSD (Solid State Disk) that is a semiconductor storage element, an HDD (Hard Disk Drive), or the like. The storage unit 12 stores data of an image to be processed by the medical image diagnostic apparatus 1 transmitted from the external device according to control by the control unit 13. The image data to be processed is a series of image data obtained by continuously and repeatedly imaging a coronary artery with a tracer over one cycle of heartbeat. The series of image data is typically time-series CT volume data constituting one cycle of heartbeat collected by the CT apparatus.

  In addition, the storage unit 12 stores data related to a CT value correspondence table in which a plurality of CT values are associated with a plurality of hardnesses.

  The control unit 13 includes a CPU (Central Processing Unit), a memory circuit, and the like. The control unit 13 receives the information input from the input unit 1417 and temporarily stores the input information in the memory circuit. The control unit 13 controls each unit of the medical image diagnostic apparatus 1 based on the input information. In addition, the control unit 13 collectively controls writing processing of data generated or received in each unit to the storage unit 12 and data reading processing from the storage unit 12 to each unit.

  The input unit 14 functions as an interface for receiving instruction information from the user to the medical image diagnostic apparatus 1. For the input unit 14, input devices such as a mouse, a keyboard, a trackball, a touch panel, and buttons can be used as appropriate. Specifically, the input unit 14 receives an input of a cross-sectional image of a coronary artery desired by the user. The input unit 14 receives a desired coronary artery according to a user operation on a three-dimensional morphological image related to the coronary artery displayed on the display unit 23 described later, for example.

  The reconstruction unit 15 reconstructs a three-dimensional or two-dimensional morphological image related to the coronary artery based on CT (Computed Tomography) volume data. Hereinafter, the three-dimensional and two-dimensional morphological images related to the coronary artery are simply referred to as morphological images related to the coronary artery.

  The coronary artery analysis unit 16 calculates a stress value in each region of the coronary artery based on time-series CT volume data constituting one cycle of heartbeat. Then, a stress value distribution diagram is generated. The detailed description of the coronary artery analysis unit 16 will be described later.

  The plaque position estimation unit 17 estimates a plaque position on the morphological image related to the coronary artery. For the estimation of the plaque position, for example, a change in the inner diameter of the coronary artery is used. The inner diameter is defined by a length perpendicular to the core line of the coronary artery in the coronary artery. The plaque position estimation unit 17 calculates the size of the inner diameter at a plurality of points of the coronary artery. And the range of the coronary artery in which the magnitude | size of an internal diameter becomes narrow suddenly is estimated as a position where a plaque exists.

  The color map conversion unit 18 converts the stress value distribution map generated by the coronary artery analysis unit 16 into a stress value color map based on a LUT (Look Up Table) of stress values stored in the storage unit 12 in advance.

  The hardness estimation unit 19 estimates the hardness of the plaque based on the CT value of the plaque position estimated by the plaque position estimation unit 17. Specifically, the hardness estimation unit 19 reads a CT value correspondence table stored in the storage unit 12. Then, the hardness estimation unit 19 can estimate the hardness by referring to the CT value correspondence table and comparing the CT value of the target plaque with a plurality of CT values in the CT correspondence table.

  The plaque map generation unit 20 generates a plaque map in which color information is added to the mark representing the plaque on the morphological image related to the coronary artery according to the hardness of the plaque. The color information only needs to be identified according to the hardness of the plaque, and includes, for example, the type of color and the color density.

  The risk level evaluation unit 21 evaluates the risk level of the plaque based on the hardness and stress value of the plaque. Specifically, the danger value is calculated based on the hardness and stress value of the plaque. The risk evaluation unit 21 evaluates the risk of the plaque according to the calculated risk value. For example, when the risk level is represented by three levels, “no risk level”, “low risk level”, and “high risk level”, the range of risk values evaluated at each level is different for each level. Assigned. Then, the risk evaluation unit 21 evaluates the risk according to the calculated risk value and the range of the risk value assigned to each stage.

  The annotation generator 22 generates an annotation for emphasizing a high-risk plaque. The annotation includes, for example, text information related to the plaque risk evaluation result or graphic information corresponding to the plaque risk evaluation result. The graphic information is, for example, a mark such as a flag, a circle, a rectangle, and a star.

  The display unit 23 displays a superimposed image in which the stress value color map is superimposed on the plaque map. The display unit 23 displays the annotation generated by the annotation generation unit 22. Note that the display unit 23 switches display of the plaque map, the stress value color map, and the superimposed image in accordance with a user instruction via the input unit 14.

(Plaque highlighting function)
The plaque emphasis display function is a function in which the display unit 23 of the medical image diagnostic apparatus 1 according to the present embodiment emphasizes and displays a high-risk plaque on a superimposed image obtained by superimposing a stress value map on the plaque map. . Hereinafter, processing according to the plaque highlighting function (hereinafter referred to as plaque highlighting processing) will be described with reference to FIG.

  FIG. 2 is a flowchart for explaining the plaque emphasis display process provided in the medical image diagnostic apparatus 1 according to the present embodiment. First, time series CT volume data constituting one cycle of heartbeat of the coronary artery is received from an external device via the communication interface unit 11 (step S11). The received CT volume data is stored in the storage unit 12.

  Based on the volume data, the coronary artery analysis unit 16 extracts information related to the anatomical structure of the coronary artery such as the coronary artery vascular core and the inner wall of the blood vessel (step S12). Based on the extracted anatomical structure of the coronary artery and physical parameters such as the viscosity value of blood flowing through the coronary artery, the coronary artery analysis unit 16 performs structural fluid analysis on the stress value of each region of the coronary artery ( Step S13). Then, a stress value distribution diagram is generated by the coronary artery analysis unit 16 (step S14). The color map converter 18 converts the stress value distribution map into a stress value color map (step S15).

  Based on the volume data, the plaque position estimation unit 17 estimates the plaque position on the morphological image related to the coronary artery (step S16). Based on the CT value of the plaque position estimated by the plaque position estimation unit 17, the hardness estimation unit 19 estimates the hardness of the plaque (step S17). Then, the plaque map generation unit 20 generates a plaque map in which color information is added to the plaque on the morphological image related to the coronary artery according to the hardness (step S18).

  Based on the hardness and stress value of the plaque, the risk evaluation unit evaluates the risk of the plaque (step S19). As a result of the evaluation, when a plaque with a high risk is on the morphological image, the annotation generator 22 generates an annotation for emphasizing the plaque with a high risk (step S20). Then, the display unit 23 displays the superimposed image and the annotation in which the stress value color map is superimposed on the plaque map (step S21).

  An example of the superimposed image and annotation displayed on the display unit 23 in step S20 will be described with reference to FIGS.

  FIG. 3 is a diagram illustrating an example of a three-dimensional superimposed image displayed on the display unit 23 by the plaque highlighting function of the medical image diagnostic apparatus 1 according to the present embodiment. In FIG. 3, a superimposed image obtained by superimposing a stress value color map on a three-dimensional plaque map related to the coronary artery, a color bar, and a plurality of annotations are displayed. The superimposition image, the plaque map, and the map based on the stress value can be appropriately switched in accordance with a user instruction via the input unit 14. An icon for switching these images may be displayed in the display area. The color bar is an LUT used by the color map conversion unit 18 to convert the stress value distribution chart into a stress value color map. As shown in FIG. 3, three blood vessel regions are emphasized by annotation. The annotation includes text information related to plaque properties (hardness) and stress values. Each of these blood vessel regions has a different combination of plaque hardness and stress value. However, the plaque in each of these blood vessel regions indicates that the degree of risk is determined by the risk evaluation unit 21 to be high. The criterion for determining the degree of risk by the degree-of-risk evaluation unit 21 can be appropriately changed according to a user instruction.

  FIG. 4 is a diagram illustrating an example of a two-dimensional superimposed image displayed on the display unit 23 by the plaque highlighting function of the medical image diagnostic apparatus 1 according to the present embodiment. In FIG. 4, a superimposed image obtained by superimposing a stress value color map on a two-dimensional plaque map related to the coronary artery, a color bar, an annotation, and a plaque response table are displayed. The stress value color map only needs to know the stress value applied to the blood vessel wall. For example, as shown in FIG. 4, the stress value color map is displayed along the blood vessel contour. The two-dimensional superimposed image can represent the plaque position in more detail than the three-dimensional superimposed image shown in FIG. The plaque correspondence table indicates the hardness of the plaque. For example, as shown in FIG. 4, a color corresponding to the hardness of the plaque is displayed. The color bar is displayed based on the LUT used to convert the stress value distribution map into the stress value color map by the color map conversion unit 18, and the color bar is used to express the magnitude of the stress value in color. Is.

  Note that the three-dimensional superimposed image and the two-dimensional superimposed image shown in FIGS. 3 and 4 can be switched in accordance with a user instruction via the input unit 14. The stress value color map display method, plaque position display method, plaque property display method, and annotation display method shown in FIGS. 3 and 4 are examples. The display method is not limited to the above as long as the user can display a superimposed image in which the stress value color map and the plaque map are superimposed and display a plaque position with a high degree of risk.

According to the plaque emphasis display function described above, the following effects can be obtained.
According to the medical image diagnostic apparatus 1 according to the present embodiment having the plaque highlighting function, for example, based on time-series CT volume data constituting one cycle of heartbeat of a coronary artery collected by a CT apparatus or the like, A map and a stress value color map can be generated. Then, a superimposed image in which the stress value color map is superimposed on the plaque map can be displayed. Then, plaque with a high degree of risk can be highlighted and displayed on the superimposed image or the like. The risk level can be automatically determined by the risk level evaluation unit 21 based on the hardness of the plaque and the stress value applied to the blood vessel where the plaque is located. Therefore, the degree of risk of the plaque can be estimated in consideration of not only the properties of the plaque but also the stress value applied to the plaque.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. These embodiments and modifications thereof are included in the scope and spirit of the invention, and are also included in the invention described in the claims and equivalents thereof.

DESCRIPTION OF SYMBOLS 1 ... Medical diagnostic imaging apparatus, 11 ... Communication interface part, 12 ... Memory | storage part, 13 ... Control part, 14 ... Input part, 15 ... Reconstruction part, 16 ... Coronary artery analysis part (extraction part), 17 ... Plaque position estimation part , 18 ... color map conversion unit, 19 ... hardness estimation unit, 20 ... plaque map generation unit, 21 ... risk evaluation unit (specification unit), 22 ... annotation generation unit, 23 ... display unit.

Claims (26)

An image acquisition unit for acquiring CT image data including blood vessels;
An estimation unit for estimating the position and hardness of the plaque in the blood vessel based on the data of the CT image;
An extraction unit for extracting a blood vessel wall structure from the CT image;
Calculating a stress value applied to the plaque by fluid analysis based on the blood vessel wall structure, and calculating an index value indicating the degree of risk of the plaque based on both the stress value and the hardness ;
A medical image diagnostic apparatus comprising: An image acquisition unit for acquiring CT image data including blood vessels;
An estimation unit that estimates the position and properties of plaque in the blood vessel based on the data of the CT image;
An extraction unit for extracting a blood vessel wall structure from the CT image;
Calculating a stress value applied to the plaque by fluid analysis based on the blood vessel wall structure, and calculating an index value indicating a risk of the plaque based on both the stress value and the property;
A medical image diagnostic apparatus comprising :
The said estimation part is a medical image diagnostic apparatus which estimates the said position of the said plaque based on the change of the internal diameter of the said blood vessel. An image acquisition unit for acquiring CT image data including blood vessels;
An estimation unit that estimates the position and properties of plaque in the blood vessel based on the data of the CT image;
An extraction unit for extracting a blood vessel wall structure from the CT image;
Calculating a stress value applied to the plaque by fluid analysis based on the blood vessel wall structure, and calculating an index value indicating a risk of the plaque based on both the stress value and the property;
A display unit for displaying a mark corresponding to the plaque and a distribution diagram of the stress value on the CT image,
A medical image diagnostic apparatus comprising: An image acquisition unit for acquiring CT image data including blood vessels;
An estimation unit that estimates the position and properties of plaque in the blood vessel based on the data of the CT image;
An extraction unit for extracting a blood vessel wall structure from the CT image;
A calculator you calculate the stress value applied to the plaque by the fluid analysis based on the blood vessel wall structure,
A color map showing a distribution of the stress value applied to the plaque in the blood vessel wall structure, a display unit for displaying a mark corresponding to the position and property of the plaque;
A medical image diagnostic apparatus comprising: The estimation unit estimates the property based on the CT value before Symbol position location of the plaque, the medical image diagnostic apparatus according to any one of claims 2 to 4. The medical image diagnostic apparatus according to any one of claims 2 to 4 , wherein the property is hardness of the plaque. Data of the CT image is time-series data including at least a portion of one cycle of heart beat, a medical image diagnostic apparatus according to any one of claims 1 to 4. The medical image diagnostic apparatus according to claim 1 , wherein the estimation unit estimates the position of the plaque based on a change in an inner diameter of the blood vessel. The medical image diagnostic apparatus according to any one of claims 1 and 2, further comprising a display unit that displays a mark corresponding to the plaque and a distribution diagram of the stress value on the CT image. The medical image diagnostic apparatus according to claim 3 , wherein the distribution map is a color map corresponding to the stress value. The medical image diagnostic apparatus according to any one of claims 4 and 10, wherein the color map is a map in which pixels indicating the stress value are assigned along an outline of the blood vessel. The medical image diagnostic apparatus according to claim 3 , wherein the mark represents the hardness of the plaque. The medical image diagnostic apparatus according to any one of claims 3 and 9, wherein the display unit highlights and displays a mark corresponding to the high-risk plaque. Medical image diagnostic apparatus, an estimating step of estimating the location and stiffness of the plaque within said vessel based on the analysis against the data of the CT image including the blood vessel,
An extraction step in which the medical image diagnostic apparatus extracts a blood vessel wall structure from the CT image;
The medical image diagnostic apparatus calculates a stress value applied to the plaque by fluid analysis based on the blood vessel wall structure, and calculates an index value indicating a risk degree of the plaque based on both the stress value and the hardness A calculation process to
A method for operating a medical image diagnostic apparatus comprising:   An image acquisition process in which the medical image diagnostic apparatus acquires CT image data including blood vessels;
  An estimation step in which the medical image diagnostic apparatus estimates the position and properties of the plaque in the blood vessel based on the analysis of the CT image data;
  An extraction step in which the medical image diagnostic apparatus extracts a blood vessel wall structure from the CT image;
  The medical image diagnostic apparatus calculates a stress value applied to the plaque by fluid analysis based on the blood vessel wall structure, and calculates an index value indicating the risk of the plaque based on both the stress value and the property. Calculation process;
  A method for operating a medical diagnostic imaging apparatus comprising:
  The method of operating a medical image diagnostic apparatus, wherein the estimating step estimates the position of the plaque based on a change in an inner diameter of the blood vessel.   An image acquisition process in which the medical image diagnostic apparatus acquires CT image data including blood vessels;
  An estimation step in which the medical image diagnostic apparatus estimates the position and properties of the plaque in the blood vessel based on the analysis of the CT image data;
  An extraction step in which the medical image diagnostic apparatus extracts a blood vessel wall structure from the CT image;
  The medical image diagnostic apparatus calculates a stress value applied to the plaque by fluid analysis based on the blood vessel wall structure, and calculates an index value indicating the risk of the plaque based on both the stress value and the property. Calculation process;
  A display step in which the medical image diagnostic apparatus displays a mark corresponding to the plaque and a distribution diagram of the stress value on the CT image on the display unit;
  A method for operating a medical image diagnostic apparatus comprising:   An image acquisition process in which the medical image diagnostic apparatus acquires CT image data including blood vessels;
  An estimation step in which the medical image diagnostic apparatus estimates the position and properties of the plaque in the blood vessel based on the analysis of the CT image data;
  An extraction step in which the medical image diagnostic apparatus extracts a blood vessel wall structure from the CT image;
  The medical image diagnostic apparatus calculates a stress value applied to the plaque by fluid analysis based on the blood vessel wall structure;
  A display step in which the medical image diagnostic apparatus displays a mark corresponding to a position and a property of the plaque on a display unit on a color map indicating a distribution of the stress value applied to the plaque in the blood vessel wall structure;
  A method for operating a medical image diagnostic apparatus comprising: The estimating step estimates the property based on the CT value before Symbol position location of the plaque, a method of operating a medical image diagnostic apparatus according to any one of claims 15 to 17. The operation method of the medical diagnostic imaging apparatus according to any one of claims 15 to 17 , wherein the property is a hardness of the plaque. The method of operating a medical image diagnostic apparatus according to any one of claims 14 to 17, wherein the CT image data is time-series data including at least one part of one cycle of heartbeat. The operation method of the medical image diagnostic apparatus according to claim 14 , wherein the estimation step estimates the position of the plaque based on a change in an inner diameter of the blood vessel. The medical image diagnostic apparatus, in any one of claims 14 to 15 display step, further comprising displaying a distribution diagram of the mark and the stress value corresponding to the plaque on the display unit superposed on the CT image An operation method of the medical diagnostic imaging apparatus described. The method of operating a medical image diagnostic apparatus according to any one of claims 16 and 22, wherein the distribution map is a color map corresponding to the stress value. The method of operating a medical image diagnostic apparatus according to any one of claims 17 and 23, wherein the color map is a map in which pixels indicating the stress value are assigned along the outline of the blood vessel. The method of operating a medical image diagnostic apparatus according to any one of claims 16, 17 and 22 , wherein the mark represents the hardness of the plaque. The operation method of the medical image diagnostic apparatus according to any one of claims 16 and 22, wherein in the display step, a mark corresponding to the plaque having a high risk level is highlighted and displayed on the display unit.