JP5992031B2 - Lubricating liquid - Google Patents

Description

  The present invention is a lubricity adjusting liquid for adjusting the lubricity of the surface of silicone rubber, and is suitable for use as a circulating fluid for a catheter simulator using a blood vessel model made of silicone rubber.

Silicone rubber is used as an elastic material in various industrial fields, and it may be necessary to control the lubricity of the surface of the silicone rubber.
The present inventor has developed and launched a catheter simulator simulating a human body shape (see Patent Document 1). In this catheter simulator, a partition member is built in a mannequin body made of a transparent material, and a blood vessel model as a three-dimensional model is supported on one surface of the partition member, and an auxiliary device for operating the blood vessel model is disposed. The The blood vessel model is formed of silicone rubber, and the auxiliary device includes a tank, a pump, and a connecting pipe. Circulating fluid is stored in the tank, and this circulating fluid is circulated in the blood vessel model through a connecting pipe by a pump. When a catheter is inserted into this blood vessel model, the lubricity of the silicone rubber surface becomes a problem.
Reference should be made to Patent Document 2 as a document disclosing a technique related to the present invention.

JP 2006-267565 A JP-A-9-53064

According to the catheter simulator disclosed in Patent Document 1, the catheter can be inserted into the blood vessel model while circulating the circulating fluid through the blood vessel model made of silicone rubber.
Circulating fluids are mainly composed of silicone oil (oil-based circulating fluid) and water-based (aqueous circulating fluid), but due to cost and similarities to blood. From the viewpoint, an aqueous circulating fluid is preferable. When water is simply circulated through the blood vessel model, the contact resistance of the catheter with the inner wall of the blood vessel model increases, and the catheter cannot be inserted smoothly.
Therefore, a surfactant is mixed with water as a lubricity adjuster. As a result, the contact resistance between the catheter and the inner wall of the blood vessel model is reduced, and the catheter can be smoothly inserted into the blood vessel model.

However, even if a circulating fluid obtained by mixing a surfactant with water is circulated to the blood vessel model, the blood vessel through which the actual blood circulates is not reproduced. Therefore, in the simulator using the circulating fluid, it cannot be denied that the feeling of insertion of the catheter is uncomfortable as compared to the actual operation. For example, the contact resistance of the site where the blood vessel model meanders is extremely large as compared to the actual operation. Also, if the inserted catheter is allowed to stand for a few seconds, the coefficient of static friction between the catheter and the blood vessel model becomes abnormally large, making it difficult to pull out the inserted catheter (this phenomenon is referred to as “adhesion”). Was seen.
If silicone oil is used as the circulating fluid, the above problems will not occur, but silicone oil is expensive, and so-called oil-based silicone oil has very different physical properties from blood. Disappear.
In order to reduce the contact resistance with respect to the inner wall of the blood vessel model, an attempt was made to increase the mixing amount of the surfactant, but the problem of increased resistance and adhesion at the meandering site could not be solved. Moreover, it is not preferable to increase the mixing amount of the surfactant because a circulating feeling is generated in the circulating fluid.

As a result of intensive studies to make the insertion feeling of the catheter when using a so-called water-based circulating fluid equal to the insertion feeling at the time of actual surgery, the present inventors have obtained a surfactant as a lubricity adjusting agent. It has been found that the combined use of a water-soluble ionic compound makes the catheter insertion feeling into the blood vessel model very close to the catheter insertion feeling during actual surgery. As a result, the insertion resistance does not increase even in the meandering blood vessel model, and adhesion between the blood vessel model and the catheter hardly occurs.
That is, the first aspect of the present invention is defined as follows.
A lubricity adjusting liquid for adjusting the lubricity of the silicone rubber surface,
A lubricity adjusting liquid containing water, a surfactant, and a water-soluble ionic compound.

The main component of the lubricity adjusting liquid is water, and a surfactant and a water-soluble ionic compound are added and mixed as a lubricity adjusting agent. In addition, when surfactant itself is an ionic compound, a water-soluble ionic compound shall mean the water-soluble ionic compound except the surfactant in this specification.
The role of the surfactant is mainly to reduce the dynamic friction coefficient between the silicone rubber and the member in contact with the silicone rubber. Thereby, for example, when silicone rubber is a blood vessel model and the member that contacts the silicone rubber is a catheter, the resistance when inserting the catheter is reduced, and the operator can smoothly insert the catheter into the blood vessel model. Become.
On the other hand, the role of the water-soluble ionic compound is to prevent adhesion between the silicone rubber and the member in contact with the silicone rubber (that is, reduce the static friction coefficient) in addition to the reduction of the dynamic friction coefficient.
That is, the lubricity adjusting liquid of the present invention is characterized in that not only the dynamic friction coefficient between the silicone rubber and the member in contact with the silicone rubber but also the static friction coefficient is reduced by the coexistence of the surfactant and the water-soluble ionic compound. It is to be.

  However, when the surfactant is a cationic surfactant, it is possible to prevent adhesion between the silicone rubber and the member in contact with the silicone rubber even if it does not contain a water-soluble ionic compound. . However, even in this case, the resistance at the time of insertion of the catheter is reduced by further adding a water-soluble metal salt.

As the surfactant, one or more of the group consisting of a cationic surfactant, an anionic surfactant, a nonionic surfactant and an amphoteric surfactant can be used.
Among these, when a cationic surfactant is used in combination with a water-soluble ionic compound, the resistance increase and adhesion at the meandering site are particularly small and preferable. In addition, since the cationic surfactant is excellent in bactericidal action, it can also exert fungicidal and bactericidal effects on the silicone rubber surface.
On the other hand, it is also preferable to use a nonionic surfactant as the surfactant. If it is like this, the raise of the density | concentration of the ion of the lubricity adjustment liquid by addition of surfactant can be prevented, pH will also become near neutrality and it will become difficult to corrode a metal.

  The concentration of the surfactant may be appropriately adjusted depending on the type of the surfactant, but is preferably 0.005 mmol / L or more and 100 mmol / L or less. When the concentration of the surfactant is less than 0.005 mmol / L, the contact resistance between the silicone rubber and the member in contact with the silicone rubber increases or adhesion is not preferable. On the other hand, when the blending amount exceeds 100 mmol / L, the physical properties of the lubricity adjusting liquid are impaired (a null-null feeling appears), which is not preferable. More preferably, it is 0.05 mmol / L or more and 10 mmol / L or less.

Moreover, as a water-soluble ionic compound, a water-soluble metal salt, a water-soluble ammonium salt (for example, ammonium chloride, ammonium sulfate), etc. can be used. As the water-soluble metal salt, one or more members selected from the group consisting of alkali metal salts, alkaline earth metal salts, aluminum salts and iron salts can be used. According to the test results of the inventors, when these water-soluble metal salts are used in combination with a surfactant, the lubricity on the surface of the silicone rubber can be improved compared to the case of using only the surfactant, and adhesion can be achieved. Can also prevent problems. The reason for this is not clear, but metal ions coordinate to oxygen in the siloxane skeleton of the silicone rubber to prevent the adsorption of surfactants and polar groups and hydrogen present in the members that contact the silicone rubber. It is speculated that this may be caused by preventing the formation of a bond. Therefore, the silicone rubber to which the lubricity adjusting liquid of the present invention is applied is not particularly limited as long as it has a siloxane skeleton in the basic skeleton.
Examples of the water-soluble alkali metal salt include sodium chloride, potassium chloride, cesium chloride, sodium sulfate, potassium sulfate, cesium sulfate, sodium nitrate, potassium nitrate, cesium nitrate and the like. Examples of the water-soluble alkaline earth metal salt include magnesium chloride, calcium chloride, barium chloride, magnesium nitrate, calcium nitrate, and barium nitrate. Furthermore, examples of the aluminum salt include aluminum chloride, aluminum sulfate, and aluminum nitrate. Examples of the iron salt include ferrous chloride, ferric chloride, ferrous sulfate, ferric sulfate, ferrous nitrate, and ferric nitrate. In addition to the above, it is also possible to use a water-soluble alkali metal salt, alkaline earth metal salt, metal organic acid salt (for example, sodium acetate) or a complex.

The concentration of the water-soluble metal salt in the lubricity adjusting liquid is preferably 1 mmol / L or more and 100 mmol / L or less. When the concentration of the water-soluble metal salt is less than 1 mmol / L, adhesion between the silicone rubber and the member in contact with the silicone rubber tends to occur. On the other hand, when the concentration of the water-soluble metal salt exceeds 100 mmol / L, metal corrosion due to the lubricating preparation liquid tends to occur. More preferred is 2 mmol / L or more and 50 mmol / L or less.
On the other hand, in the case where the water-soluble ionic compound is an ammonium salt such as ammonium chloride or ammonium sulfate, the inventors added 0.03 mol / L or more (preferably 0.07 mol / L) at the silicone rubber surface. It has been confirmed that the lubricity can be improved.

The lubricity adjusting liquid of the present invention can be prepared by adding water to a preparation containing a surfactant and a water-soluble ionic compound and dissolving it.
That is, the preparation agent of the present invention is a preparation agent for a lubricity adjusting liquid for adjusting the lubricity of the surface of the silicone rubber, and includes a surfactant and a water-soluble ionic compound. To do.

  The preparation kit of the present invention is a kit for preparing a lubricity adjusting liquid for adjusting the lubricity of the surface of the silicone rubber, and includes a first agent containing a surfactant and a water-soluble ionic compound. It consists of the 2nd agent containing. According to this preparation kit, the lubricity adjusting liquid can be easily prepared by mixing the first agent and the second agent.

It is a front view of the pseudo blood vessel model used for the lubricity evaluation test. It is a graph which shows the relationship between the rotation angle and the density | concentration of a metal salt in the lubricity evaluation test of the lubricity adjustment liquid of Examples 1-8. It is a graph which shows the relationship between the rotation angle in the lubricity evaluation test of the lubricity adjustment liquid of Example 9 and Example 16, and the density | concentration of a metal salt. It is a graph which shows the relationship between the rotation angle and the density | concentration of a metal salt in the lubricity evaluation test of the lubricity adjustment liquid of Examples 10 and 11 and Comparative Examples 10 and 11. It is a graph which shows the relationship between the rotation angle in the lubricity evaluation test of the lubricity adjustment liquid of Example 12 and Comparative Example 12, and the density | concentration of a metal salt. It is a graph which shows the relationship between the rotation angle in the lubricity evaluation test of the lubricity adjustment liquid of Example 13 and Comparative Example 13, and the density | concentration of a metal salt. It is a graph which shows the relationship between the rotation angle in the lubricity evaluation test of the lubricity adjustment liquid of Example 14, and the density | concentration of the added bitter juice. It is a graph which shows the relationship between the rotation angle in the lubricity evaluation test of the lubricity adjustment liquid of the comparative example 14-1, and the density | concentration of the added surfactant. It is a graph which shows the relationship between the rotation angle in the lubricity evaluation test of the lubricity adjustment liquid of Comparative Example 14-2, and the density | concentration of the added bitter juice. Is a graph showing the relationship between the mixing amount of the rotation angle and MgCl ₂ in lubricity evaluation test using silicone rubber (1) and (2).

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited only to a following example. In addition, various modifications may be included in the present invention as long as those skilled in the art can easily conceive without departing from the scope of the claims.

(Examples 1-8)
In Examples 1-8, 16 wt% aqueous solution containing alkyl ether sulfate sodium and fatty acid alkanolamide in a 2: 1 weight ratio as a surfactant was used, and various water-soluble metal salts shown in Table 1 were added. A lubricity adjusting liquid was used. In addition, the concentration of the water-soluble metal salt was 0.0025, 0.005, 0.01, 0.03, 0.07, and 0.20 (mol / L) in each example.

(Comparative Examples 1-8)
In Comparative Examples 1 to 8, no water-soluble metal salt was added (that is, Comparative Examples 1 to 8 all have the same composition). About others, it is the same as that of Examples 1-8, and abbreviate | omits description.

<Evaluation>
A lubricity evaluation test and an adhesion evaluation test for silicone rubber of the lubricity adjusting liquids of Examples 1 to 8 and Comparative Examples 1 to 8 were performed. The evaluation method is as follows.
・ Lubricity evaluation test Silicone tube with 3 mm inner diameter (trade name: Laboran Silicone Tube manufactured by ASONE Co., Ltd.) was prepared. As shown in FIG. 1, a silicone tube was attached to a cylindrical tube 11 made of transparent acrylic resin with a diameter of 7 cm. A pseudo blood vessel model 10 was prepared in which 12 was wound and fixed three times, and both ends protruded and extended. Then, the catheter 20 (having a thickness of 6.0 F (2.0 mmφ) manufactured by Chaperon) was manually inserted from one end side of the silicone tube 12 with a constant force. As a result, the catheter 20 enters while rotating inside the silicone tube. Further, insertion was continued until the catheter 20 could not resist the frictional resistance and stopped, and the rotation angle at the stopped position was measured, and this angle was used as an index of lubricity. The measurement was performed a plurality of times.
・ Adhesiveness evaluation test Further, when the catheter 20 is held at the position where it is stopped for about 10 seconds and then pulled in the direction in which the catheter 20 retracts, it can be easily pulled out. Evaluated as “with adhesion”. The measurement was performed 3 times. Even in the case of adhesion, the catheter 20 was able to be pulled out by quickly repeating the force in the intrusion direction and the force in the backward direction on the catheter 20.

  The result about the rotation angle about the said Examples 1-8 and Comparative Examples 1-8 and the presence or absence of adhesion is shown in Table 2 (when the metal salt concentration in a table | surface is 0, it corresponds to Comparative Examples 1-8). Moreover, the graph which shows the relationship between a rotation angle and the density | concentration of a metal salt is shown in FIG.

As shown in FIG. 2, in Examples 1-8, even if the surfactant concentration was constant, the rotation angle increased dramatically by adding a water-soluble metal salt. Also, water-soluble metal salt rotation angle as _{(NaCl, KCl, MgCl 2,} CaCl 2, Al 2 (SO 3), FeCl 3, MgCl 2 + NaCl, CH 3 COONa) increasing the amount of rise, water When the concentration of the metallic metal salt was 0.005 mol / L or more, the value was almost constant. From the above results, it was found that the lubricity of the silicone rubber surface was dramatically improved by the combined use of the surfactant and the water-soluble metal salt.
Moreover, as shown in Table 2, when no water-soluble metal salt was added to the surfactant (that is, in the case of Comparative Examples 1 to 8), adhesion sometimes occurred (during 24 measurements). On the other hand, when 0.0025 mol / L or more of a water-soluble metal salt was added, adhesion did not occur.

(Examples 9 to 13)
In Examples 9 to 13, magnesium chloride was used as the water-soluble metal salt, and mixed with various surfactants to prepare a lubricity adjusting solution (see Table 2). In addition, the density | concentration of surfactant prepared the solution of the density | concentration of 0, 0.00005, 0.000075, 0.0001, 0.0002, 0.0004, 0.0005, 0.00075, 0.001, 0.002, and 0.004 (mol / L) about each Example.

(Example 16 and Comparative Examples 10-13)
In Example 16 and Comparative Examples 10 to 13, no magnesium chloride was added, and the others were the same as in Examples 9 to 13 (see Table 3).

<Evaluation>
About the lubricity adjustment liquid of Examples 9-13, Example 16, and Comparative Examples 10-13, the evaluation result of lubricity is shown in FIGS. 3-6, and the evaluation result about adhesiveness is shown in Table 4, respectively. In addition, as a silicone tube used for lubricity evaluation, a 3 mm inner diameter Laboran silicone tube (As One Co., Ltd.) was used.

  In Example 9 and Example 16 using trimethylstearylammonium chloride, which is a cationic surfactant, as shown in FIG. 3, in Example 9 to which magnesium chloride was added, In comparison, the lubricity at a low surfactant concentration of 0.2 mmol / L or less was excellent. As for the adhesion, no adhesion occurred in any of Example 9 and Example 16 when the surfactant was 0.05 mmol / L or more. However, the resistance when inserting the catheter was clearly smaller in Example 9 than in Example 16, and it was found that the catheter could be inserted very smoothly by coexisting magnesium chloride with the cationic surfactant. .

In Examples 10 and 11 and Comparative Examples 10 and 11 using an anionic surfactant, as shown in FIG. 4, in Examples 10 and 11 in which magnesium chloride was added, Comparative Examples in which magnesium chloride was not added. Compared with 10 and 11, the lubricity was remarkably excellent. Regarding the adhesion, in Examples 10 and 11, adhesion did not occur when the surfactant was 0.5 mmol / L or more, whereas in Comparative Example 10, the surfactant was 0.5 mmol / L or less. Then, adhesion occurred at 2 mmol / L or less. From the above, it was found that the coexistence of an anionic surfactant and magnesium chloride improves both lubricity and non-adhesiveness.

Further, in Example 12 and Comparative Example 12 using a zwitterionic (betaine type) surfactant, as shown in FIG. 5, in Example 12 in which magnesium chloride was added, Comparative Example 12 in which magnesium chloride was not added. Compared with, the lubricity was excellent. As for adhesion, as shown in Table 4 above, neither Example 9 nor Comparative Example 9 caused adhesion when the surfactant was 0.5 mmol / L or more. From the above, it has been found that the coexistence of an amphoteric (betaine) surfactant and magnesium chloride improves both lubricity and non-adhesiveness .

Moreover, in Example 13 and Comparative Example 13 using a nonionic surfactant, both Example 13 and Comparative Example 13 were excellent in lubricity, as shown in FIG.
Regarding the adhesion, as shown in Table 4 above, in Comparative Example 13, adhesion occurred when the surfactant was 0.5 mmol / L or less, whereas in Example 13, adhesion occurred at 0.5 mmol / L or more. There wasn't. Furthermore, the resistance when inserting the catheter was clearly smaller in Example 13 than in Comparative Example 13, and it was found that the catheter could be inserted very smoothly by allowing magnesium chloride to coexist with the nonionic surfactant.

(Example 14)
In Example 14, 500 ml of distilled water, 1 ml of a commercially available kitchen detergent (anionic surfactant + nonionic surfactant mixture, concentration 16% by weight), and a commercially available bitter solution (Aramami no Nigari Akanami Aramami Salt) A mixed solution of 4318 mg of magnesium, 3810 mg of potassium, 3048 mg of sodium and 2032 mg of calcium was prepared in 100 ml of this bitter solution manufactured by Co., Ltd., and this was used as a lubricity adjusting solution. The concentration of bitter juice was 0, 0.25, 5, 10, 15 (ml / distilled water 1 L), and evaluation was performed by the above-described evaluation methods for lubricity and adhesion. As the silicone tube used for the lubricity evaluation, a Labran silicone tube (As One Co., Ltd.) having an inner diameter of 3 mm was used.

(Comparative Example 14-1)
In Example 14-1, the same liquid as in Example 14 was used as the lubricity adjusting liquid without adding bitter juice.

(Comparative Example 14-2)
In Example 14-2, the same liquid as in Example 14 was used as the lubricity adjusting liquid without adding the surfactant.

<Evaluation>
It shows in Table 5-Table 7 of evaluation of lubricity and adhesiveness about Example 14, Comparative Example 14-1, and Comparative Example 14-2. Moreover, the graph about lubricity is shown in FIGS. In addition, as a silicone tube used for lubricity evaluation, a 3 mm inner diameter Laboran silicone tube (As One Co., Ltd.) was used.

-Evaluation result about lubricity In Example 14, as shown in FIG.7 and Table 5, by adding bitter juice to the mixed solution of distilled water and a commercial kitchen detergent as a lubricity adjustment liquid, compared with before adding. The rotation angle has increased dramatically. Furthermore, the rotation angle increased as the amount of bitter juice added was increased, and the rotation angle became a constant value when the bitter juice concentration reached a certain level. The maximum value of the rotation angle was 768 °.
Further, in Comparative Example 14-1 in which no bitter juice was added, as shown in FIG. 8 and Table 6, the rotation angle increased as the concentration of the commercially available kitchen detergent increased, and rotation was reached when a certain concentration was reached. The angle became a constant value. However, the maximum rotation angle was 511 °, which was considerably lower than the maximum rotation angle of 768 ° in Example 14 in which bitter juice was added to the mixed solution.
Furthermore, in Comparative Example 14-2 in which no surfactant was added, as shown in FIG. 9 and Table 7, the lubricity was extremely poor and the catheter could hardly be inserted.

-Evaluation result about adhesiveness In Example 14, as shown in Table 5, it did not adhere at all. On the other hand, in Comparative Example 14-1, adhesion occurred when the concentration of the surfactant was not more than a certain level as shown in Table 6. Furthermore, in Comparative Example 14-2, as shown in Table 7, adhesion sometimes occurred even when the concentration of bitter juice was increased.

  From the above results, it was found that the lubricating preparation liquid using the surfactant and the bitter juice together can improve the lubricity of the silicone rubber surface and prevent the adhesion phenomenon.

[Evaluation of various silicone rubbers]
As Example 15, a lubricity adjusting liquid comprising a mixed solution of 1 L of distilled water, 0.29 g (0.001 mol / L) of sodium lauryl sulfate and magnesium chloride (hexahydrate) was prepared. The concentration of magnesium chloride in the lubricity adjusting solution was 0, 0.0025, 0.005, 0.01, 0.03, 0.07, 0.20 (mol / 1 L of distilled water).
Using the lubricity adjusting liquid of Example 15, the lubricity and adhesion of the following two types of silicone rubber were evaluated.
Silicone rubber (1):
Laboran silicone tube with an inner diameter of 3 mm (As One Corporation)
Silicone rubber (2):
ELASTOSIL on the inner wall of Laboran silicone tube (As One Co., Ltd.) with an inner diameter of 6 mm
A silicone tube coated with M8520 (Asahi Kasei Wacker Silicone Co., Ltd.) with a thickness of 1.5 mm.

(Evaluation)
Table 8 shows the evaluation of lubricity and adhesion of silicone rubbers (1) and (2). Moreover, evaluation about lubricity is shown in FIG.

・潤滑性についての評価結果
表８及び図１０に示すように、シリコーンゴム（１）及びシリコーンゴム（２）ともに、塩化マグネシウムの添加量の増加に従って、回転角度が飛躍的に大きくなる（すなわち、潤滑性が飛躍的に大きくなることが分かった。以上のことから、潤滑性について、シリコーンゴムの種類によらず、有効であることが強く支持された。

-Evaluation result about lubricity As shown in Table 8 and FIG. 10, with respect to both the silicone rubber (1) and the silicone rubber (2), the rotation angle increases dramatically as the amount of magnesium chloride added increases (that is, From the above, it was strongly supported that the lubricity is effective regardless of the type of silicone rubber.

-Evaluation result about adhesion property As shown in Table 8, it was found that the adhesion phenomenon did not occur in both silicone rubber (1) and silicone rubber (2) as the amount of magnesium chloride added increased. From the above, it was strongly supported that it is effective against the adhesion phenomenon regardless of the type of silicone rubber.

As shown in the evaluation results of the silicone rubber (1) and the silicone rubber (2), the silicone rubber to which the lubricity adjusting liquid of the present invention is applied is a rubber having a siloxane skeleton in the basic skeleton. There is no particular limitation. Specific examples of such silicone rubber include the following.
ELASTOSIL N 2010, ELASTOSIL N 2034, ELASTOSIL N 2189, ELASTOSIL N 2197, ELASTOSIL N 9132S, ELASTOSIL RT K, WACKER SilGel 612, ELASTOSIL RT 601, ELASTOSIL RT 602, ELASTOSIL RT 604, ELASTOSIL RT 607, ELASTOSIL RT 741, ELASTOSIL RT 741 745, ELASTOSIL RT 745 “S”, ELASTOSIL RT 707 W, ELASTOSIL RT 713, SEMICOSIL 987 GR, SEMICOSIL 988 / 1K, SEMICOSIL 989 / 1K, ELASTOSIL M8520
All of the above are Laboran silicone tubes manufactured by Asahi Kasei Wacker Silicone Co., Ltd.

The reagents used in the examples and comparative examples are shown below.
・ Sodium chloride (99% or more, manufactured by the Salt Business Center)
・ Potassium chloride (99% or more, manufactured by Naito Shoten Co., Ltd.)
・ Magnesium chloride hexahydrate (99% or more, manufactured by Naito Shoten Co., Ltd.)
・ Calcium chloride (manufactured by Naito Shoten Co., Ltd.)
・ Aluminum sulfate 14-18 hydrate (Wako Pure Chemical Industries, Ltd.)
・ Ferric chloride hexahydrate (Wako Pure Chemical Industries, Ltd.)
・ Trimethyl stearyl ammonium chloride (manufactured by Tokyo Chemical Industry Co., Ltd.)
・ Sodium lauryl sulfate (Tokyo Chemical Industry Co., Ltd.)
・ Sodium 1-dodecanesulfonate (manufactured by Tokyo Chemical Industry Co., Ltd.)
・ Myristyl sulfobetaine (manufactured by Tokyo Chemical Industry Co., Ltd.)
・ Tween20 (manufactured by Tokyo Chemical Industry Co., Ltd.)
・ Bitter (Agarami no Nigari Ako Aramami Salt Co., Ltd.)

<Use for blood vessel model made of silicone rubber>
A blood vessel model made of silicone rubber is assembled to a case of a human body model provided by the applicant, and a tank, piping and a pump are attached as auxiliary devices. Add 10 liters of tap water to the tank and inject 300 ml of bitter solution. 100 ml of this bitter solution contains 4318 mg of magnesium, 3810 mg of potassium, 3048 mg of sodium, and 2032 mg of calcium. 40 ml of the surfactant used in Example 1 is added to a reference solution obtained by mixing a predetermined amount of bitter juice into water. It is preferable that the amount of the surfactant added can be adjusted by the user as desired.

If necessary, pigments, bactericides, preservatives, and other auxiliaries can be added to the circulating fluid. When such a circulating fluid was used, a plurality of doctors evaluated that the insertion feeling of the catheter into the blood vessel model was close to that at the time of surgery.
More specifically, a catheter could be inserted without resistance into a meandering blood vessel model, and no adhesion occurred between the two even when the catheter was inserted into the blood vessel model.

  The present invention is not limited to the description of the embodiments and examples of the invention described above. Various modifications are also included in the present invention as long as those skilled in the art can easily conceive without departing from the scope of the claims.

10 ... pseudo blood vessel model, 11 ... cylindrical tube, 12 ... silicone tube, 20 ... catheter

Claims (13)

A circulating fluid filled in a blood vessel model for a catheter simulator made of silicone rubber,
Water, surfactants, and water-soluble ionic compounds seen including,
The circulating liquid, wherein the ionic compound is one or more of the group consisting of alkali metal salts, alkaline earth metal salts, aluminum salts and iron salts. The circulating fluid according to claim 1, wherein the silicone rubber is a blood vessel model for simulating a catheter.
The circulating fluid according to claim 1 or 2, wherein the surfactant is one or more of the group consisting of a cationic surfactant, an anionic surfactant, a nonionic surfactant and a zwitterionic surfactant. . The circulating fluid according to claim 1 or 2, wherein the surfactant contains at least a cationic surfactant. A preparation for an aqueous circulating fluid filled in a blood vessel model for a catheter simulator made of silicone rubber, comprising a surfactant and a water-soluble ionic compound,
The ionic compound is a preparation agent that is one or more of the group consisting of alkali metal salts, alkaline earth metal salts, aluminum salts, and iron salts . The regulator according to claim 5, wherein the surfactant is one or more of the group consisting of a cationic surfactant, an anionic surfactant, a nonionic surfactant, and a zwitterionic surfactant. A kit for preparing an aqueous circulating fluid filled in a blood vessel model for a catheter simulator made of silicone rubber, comprising a first agent containing a surfactant and a second agent containing a water-soluble ionic compound Become
The preparation kit, wherein the ionic compound contained in the second agent is one or more of the group consisting of an alkali metal salt, an alkaline earth metal salt, an aluminum salt and an iron salt . The surfactant contained in the first agent is one or more of the group consisting of a cationic surfactant, an anionic surfactant, a nonionic surfactant, and a zwitterionic surfactant. 8. The adjustment kit according to 7. A method for adjusting the lubricity of the inner surface of a blood vessel model for a catheter simulator made of silicone rubber, comprising a surfactant, an alkali metal salt, an alkaline earth metal salt, an aluminum salt and an iron salt in an aqueous circulating fluid And a water-soluble ionic compound selected from one or more of the above .   The lubricity of the inner surface of a blood vessel model for a catheter simulator made of silicone rubber is adjusted by defining the type and concentration of the surfactant and the type and concentration of the water-soluble ionic compound. Item 10. The method for adjusting lubricity according to Item 9. Preparing a reference solution containing water and a water-soluble ionic compound selected from one or more of the group consisting of alkali metal salts, alkaline earth metal salts, aluminum salts and iron salts ;
Adjusting the amount of the surfactant to be blended with the reference solution, and adjusting the lubricity of the inner surface of the blood vessel model for a catheter simulator made of silicone rubber. The lubrication according to claim 11, wherein the surfactant is selected from one or more of the group consisting of a cationic surfactant, an anionic surfactant, a nonionic surfactant and a zwitterionic surfactant. Sex adjustment method. A lubricity adjusting liquid for adjusting the lubricity of the inner surface of a blood vessel model for a catheter simulator made of silicone rubber,
A lubricity adjusting liquid containing water and a cationic surfactant.

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