JP5788019B2 - Transdermal administration device - Google Patents

Description

  The present invention relates to a transdermal administration device that scratches the stratum corneum of the epidermis and administers a drug solution from the scratched portion to the body.

  A syringe is used for human administration of a drug solution that cannot be administered orally. Administration with a syringe is painful. In addition, transdermal administration using a patch containing a drug solution takes time to develop the drug effect, and the types of drug solutions that can be used are limited.

  In order to solve these problems, a percutaneous administration device has been proposed that uses a needle with an extremely small diameter to reduce pain caused by needle puncture. However, when the diameter of the needle is reduced, there is a drawback that the flow resistance during injection of the drug solution increases.

  Therefore, in order to reduce the flow resistance during the injection of the drug solution, Japanese Patent Application Publication No. 2005-527249 (Patent Document 1), Japanese Patent Application Laid-Open No. 2005-87521 (Patent Document 2), Japanese Patent Application Laid-Open No. 2003-135598 (Patent Document). In 3), a transdermal administration device using a plurality of needles having a small diameter is proposed.

  However, when a chemical solution is to be administered into the skin using these devices, the chemical solution may not be supplied to an appropriate depth in the skin if the device is not properly operated by the user. For example, if the user presses the device too far against the skin, the needle tip will go too deep into the skin. In addition, when the user operates the device quickly, the drug solution may leak into the skin.

  In order to solve these problems, Japanese Patent Application Laid-Open No. 2004-532698 (Patent Document 4) provides a protrusion on the lower surface of the apparatus, and the stratum corneum is formed by “scratching” the protrusion on the skin. An apparatus is described that is removed and from which the drug solution is absorbed through the epithelial layer below the stratum corneum (eg, paragraph 0011).

  Japanese Patent Application Laid-Open No. 11-509123 (Patent Document 5) also describes an apparatus for administering a drug solution by scratching the skin surface with a fine blade (for example, page 4, lines 9-18).

  However, these devices have a drawback in that the degree of scraping of the stratum corneum varies because the user operates the device by hand, so that the medicinal solution cannot be supplied to a desired depth position in the skin. Fear the patient to manually move the device in front of him.

JP 2005-527249 A JP-A-2005-87521 JP 2003-135598 A JP 2004-532698 A Japanese National Patent Publication No. 11-509123

  The present invention has been made to solve the above-described drawbacks, and provides a transdermal administration device that can supply a drug solution to a desired site in the skin without causing pain during injection. For that purpose.

  Another object of the present invention is to provide a transdermal administration device that does not vary in the degree of stratum corneum scraping, can supply a drug solution to a desired depth position in the skin, and does not give a fear to the patient. There is to do.

In order to solve the above problems, the present invention is characterized by the following.
(Item 1) A housing having an opening on the lower surface side on the skin side, a lock member disposed in the housing, projecting downward from the lower surface of the housing and immersing into the housing, and disposed on the lower surface of the housing And a biasing force that moves the needle holding portion in the direction along the lower surface of the housing when the lock member is unlocked when the lock member is immersed in the housing. A transdermal administration device, wherein the needle protrudes downward from the lower surface of the needle holding portion, and a drug solution impregnating member is provided on the lower surface of the needle holding portion.
(Item 2) The item according to Item 1, wherein the lock member is a cylindrical member disposed around the needle holding portion, and the cylindrical member is biased to protrude toward the skin side by an elastic member. Transdermal dosing device.
(Item 3) The transdermal administration device according to item 1 or 2, wherein the medicinal solution-impregnated member is disposed in the vicinity of the needle and disposed on the moving direction side of the needle.
(Item 4) The number of needles protruding from the lower end of the needle holding part is 2 to 10, and the protruding dimension of the needle protruding from the lower end surface of the needle holding part is 0.1 to 3 mm. 4. The transdermal administration device according to any one of 3 above.

  When the transdermal administration device of the present invention is placed on the skin surface and pressed toward the skin side, the needle protruding from the lower surface of the needle holding portion enters the skin, and at the same time, the lock member is unlocked and the needle holding portion is energized. Move along the skin surface by means. Therefore, the skin surface is scratched by the needle tip. Since the chemical solution impregnated member impregnated with the chemical solution is applied to the scratched portion, the chemical solution is administered into the skin through the scratched portion.

  Therefore, since the stratum corneum can be removed with a needle, the drug can be appropriately administered without causing excessive invasion into the epithelial layer below the stratum corneum. In addition, since the administration of the drug solution is performed instantaneously, the patient does not feel fear.

It is a front view of the transdermal administration device of the present invention. FIG. 2 is a plan view of the transdermal administration device shown in FIG. 1. It is a bottom view of the transdermal administration device shown in FIG. It is a left view of the transdermal administration device shown in FIG. FIG. 2 is a right side view of the transdermal administration device shown in FIG. 1. It is AA sectional view taken on the line of the transdermal administration device shown in FIG. It is BB sectional drawing of the transdermal administration device shown in FIG.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  As shown in FIG. 1 to FIG. 7, a transdermal administration device 5 of the present invention includes a housing 2 that opens on the lower surface side of the skin, and is disposed in the housing 2, and projects downward from the lower surface of the housing 2. When the lock member 4 that can be inserted into the housing 2, the needle holding portion 1 that is disposed in the housing 2 and is movable in a direction along the lower surface of the housing 2, and the lock member 4 is inserted into the housing 2, And an urging means 31 for moving the needle holding portion 1 in a direction along the lower surface of the housing 2 when the lock member 4 is unlocked.

  The housing 2 has an upper surface 21 and a peripheral wall 22, and a base 6 is disposed and fixed in an opening formed in the lower surface of the housing 2. A through hole 7 is formed in the base 6, and the needle holding portion 1 and the lock member 4 are disposed in the through hole 7 so as to be movable in the horizontal direction.

  A guide member 8 for guiding the movement of the needle holding portion 1 in the horizontal direction is disposed in the housing 2.

  The needle holder 1 and the lock member 4 are disposed in the housing 2 so as to be movable toward the skin side (lower surface side).

  Details of each member are as follows.

  The needle holder 1 includes a substantially cylindrical cylinder 12 provided with a hole for holding the needle 11, a horizontal piece 13 extending laterally from the upper end of the cylinder 12, and the horizontal And a spring stopper 14 extending upward from the piece 13.

  A needle 11 protrudes downward from the lower surface of the needle holder 1. The constituent material of the needle 11 includes, but is not limited to, stainless steel, aluminum or aluminum alloy, metal material such as titanium or titanium alloy, plastic material, and the like. The needle 11 can be composed of a solid bar or a hollow tube.

  The protruding dimension of the needle 11 protruding downward from the lower surface of the needle holding portion 1 is preferably 0.1 to 3.0 mm, more preferably 0.5 to 2.0 mm, and 0.5 to 1 More preferably, it is about 5 mm. The maximum outer diameter of the needle 11 is more preferably about 0.1 to 0.6 mm, and still more preferably about 0.1 to 0.4 mm.

  In this embodiment, the number of the plurality of needles 11 attached to the lower surface of the needle holding unit 1 is three, but may be one, two, or four or more. The number is preferably 2 to 10, more preferably 3 to 6.

  Further, a recess 16 is formed on the lower surface of the needle holder 1, and a chemical solution impregnated member 17 impregnated with a chemical solution is held in the recess 16. The chemical solution impregnating member 17 can be made of a porous material such as a nonwoven fabric or sponge impregnated with the chemical solution. The chemical solution impregnating member 17 protrudes downward from the lower surface of the needle holder 1. The chemical solution impregnating member 17 is preferably disposed in the vicinity of the needle 11 and disposed on the moving direction side of the needle.

  The lock member 4 is disposed around the cylindrical body 12 of the needle holding unit 1 so as to be movable toward the skin side and in the horizontal direction. The lock member 4 includes a cylindrical main body 26 having a U-shaped cross section, and a lock portion 27 extending laterally from the upper end portion of the main body 26. A concave portion 29 for arranging a coil spring 28 is formed in the main body 26.

  A cylindrical skirt 18 suspended downward from the horizontal piece 13 of the needle holder 1 is inserted into a recess 29 formed in the main body 26 of the lock member 4, and the tip of the skirt 18 is arranged in the recess 29. The provided spring 28 is elastically biased.

  A vertical piece 30 is vertically suspended from the base 6. A spring 31 as a biasing means is disposed between the vertical piece 30 and the spring stopper 14 in a state of being pulled and biased.

  In the state shown in FIG. 6, the lock portion 27 of the lock member 4 is disposed in an engagement recess 33 formed at the upper end edge of the base portion 6.

  The guide member 8 is disposed in the housing 2 so as to be movable in the lateral direction (direction along the lower surface). A recess 35 is formed on the lower surface of the guide member 8, and a protrusion 15 formed on the upper end of the needle holding portion 1 is loosely fitted in the recess 35 so as to be movable up and down. Further, a compressed coil spring 38 is disposed in a concave groove 37 formed in the cylindrical body 12 of the needle holding portion 1, and the upper end of the coil spring 38 abuts on the lower surface of the guide member 8, whereby the needle holding portion 1. Is pressed downward and biased.

  A locking piece 39 protrudes upward from the end of the base portion 6, and a locking portion 40 formed on the locking member 4 is locked to the locking piece 39.

  The apparatus of the present invention can be manufactured by injection molding or the like using a thermoplastic resin such as polycarbonate, polypropylene, ABS resin, or polystyrene, except for the needle.

  Next, a method for using the transdermal administration device 5 of the present invention will be described.

  Since the lower end of the lock member 4 protrudes about 1 to 2 mm downward from the lower surface of the housing 2, the lock member 4 enters the housing 2 when the lower surface of the housing 2 is pressed against the skin surface. At this time, the spring 28 in the recess 29 is compressed.

  When the lock member 4 moves into the housing 2, the lock portion 27 is disengaged from the engagement recess 33 of the base portion 6. Therefore, the lock member 4, the needle holding portion 1, and the guide member 8 are moved together and moved rightward in FIGS. 3 and 6 by the pulling force of the coil spring 31.

  Since the needle 11 protrudes downward on the lower surface of the needle holding portion 1, the lower end of the needle 11 scratches the surface of the skin as the needle holding portion 1 moves. Moreover, since the chemical | medical solution impregnation member 17 which impregnates a chemical | medical solution is provided in the lower surface of the needle holding part 1, a chemical | medical solution is apply | coated on skin.

  Therefore, since the stratum corneum of the skin is scraped off by the needle following the chemical applied on the skin, the chemical enters the skin from the portion where the stratum corneum has been removed.

  In the present invention, the protrusion dimension of the needle 11 protruding from the lower surface of the needle holder 1 is preferably 0.5 to 2.0 mm. When the needle 11 is strongly pressed against the skin surface, the coil spring 38 disposed between the needle holding part 1 and the guide member 8 is compressed and the needle holding part 1 enters the housing 2. Therefore, the protruding dimension of the needle 11 from the lower surface of the housing 2 is adjusted.

  The drug solution used in the drug solution injector 5 of the present invention is typically a solution, gel or suspension containing a drug. The drug that can be used is not substantially limited as long as the drug is not suitable for transdermal administration.

  In the above embodiment, the chemical liquid impregnating member 17 applies the chemical liquid onto the skin, and then the surface of the skin is scratched by the movement of the lower end of the needle 11. After scratching the surface of the skin by movement, the chemical solution impregnating member 17 may apply the chemical solution to the scratched portion of the skin. In this case, the chemical liquid impregnating member 17 is disposed on the side opposite to the moving direction of the needle 11 with respect to the needle 11. Moreover, although it comprised so that the needle holding part 1 might be moved only once along the skin surface, you may comprise so that the needle holding part 1 may be reciprocated or vibrated several times along the skin surface.

  Furthermore, although the chemical solution impregnated member 17 is disposed in the vicinity of the needle 11, the chemical solution impregnated member 17 may be disposed at the attachment position of the needle 11 (base portion of the needle 11).

  The biasing means 31 is not limited to a coil spring, and a known material such as rubber can also be used.

  By using the transdermal administration device of the present invention, drugs, cosmetics and the like can be transdermally administered to a desired position in the skin, and the patient does not feel pain or fear.

DESCRIPTION OF SYMBOLS 1 Needle holding | maintenance part 2 Housing 4 Lock member 5 Transdermal medication apparatus 11 Needle 17 Chemical liquid holding member

Claims (4)

A housing having an opening on the lower surface side of the skin side, a lock member disposed in the housing, projecting downward from the lower surface of the housing and immersing into the housing, and a direction disposed in the housing along the lower surface of the housing And a urging means for moving the needle holding portion in a direction along the lower surface of the housing when the lock member is unlocked when the lock member is immersed in the housing. A transdermal administration device, wherein the needle protrudes downward from the lower surface of the needle holding portion, and a liquid solution impregnating member is provided on the lower surface of the needle holding portion. The percutaneous body according to claim 1, wherein the lock member is a cylindrical member disposed around the needle holding portion, and the cylindrical member is urged to protrude toward the skin side by an elastic member. Dosing device. The transdermal administration device according to claim 1, wherein the medicinal solution impregnating member is disposed in the vicinity of the needle and is disposed on the moving direction side of the needle. 2. The warp according to claim 1, wherein the number of needles protruding from the lower end of the needle holding part is 2 to 10 and the protruding dimension of the needle protruding from the lower end surface of the needle holding part is 0.1 to 3 mm. Skin dosing device.

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