JP5634969B2 - Biochemical analyzer and rotational conveyance method - Google Patents

Description

  The present invention relates to a biochemical analysis apparatus that performs biochemical analysis using an analysis chip that analyzes a sample such as blood or urine, and in particular, a rotation in which a plurality of analysis chips are placed concentrically on a rotating member and rotated and conveyed. The present invention relates to a biochemical analysis apparatus having a member and a rotational conveyance method using the apparatus.

  Conventionally, a specific color component of a dry analytical element or sample that can quantitatively analyze a specific chemical component or formed component contained in this sample simply by spotting and supplying a small droplet of the sample An electrolyte type dry analytical element capable of measuring ion activity of ions has been developed and put into practical use. Biochemical analyzers using these dry analytical elements are suitable for use in medical institutions, laboratories and the like because they can easily and quickly analyze samples.

  In the colorimetric measurement method using a colorimetric type dry analytical element, after a sample is spotted on the dry analytical element, the sample is held at a constant temperature in an incubator for a color reaction (dye generation reaction), and then the sample The dry analytical element is irradiated with measurement irradiation light containing a wavelength selected in advance by a combination of a predetermined biochemical substance and a reagent contained in the dry analytical element, and the optical density is measured. The concentration of the biochemical substance is obtained using a calibration curve representing the correspondence between the optical density obtained in advance and the substance concentration of the predetermined biochemical substance. On the other hand, the potential difference measurement method using an electrolyte type dry analytical element is included in a sample spotted on an electrode pair consisting of two pairs of the same kind of dry ion selective electrodes instead of measuring the above optical density. The activity of specific ions is determined by quantitative analysis with potentiometry using a reference solution.

  In any of the above methods, a liquid sample is accommodated in a sample container (such as a blood collection tube) and set in the apparatus, and a dry analytical element necessary for the measurement is mounted on the apparatus, and the dry analytical element is mounted from the mounting position. While being transported to the landing part and the incubator, the specimen is supplied from the mounting position to the spotting part by the spotting nozzle of the spotting mechanism and spotted to the dry analytical element.

  In an analyzer using an analysis chip such as the dry analysis element described above, an analysis chip is inserted on the outer peripheral upper surface of the rotating member in order to transport the dry analysis element in a predetermined section such as from the spotting position to the measurement position of the specimen. For this purpose, a storage chamber having an opening on the outer peripheral side is provided, and a dry analytical element can be transported by rotating a rotating member while holding the analysis chip in the analysis chip holding chamber. In such an analyzer, when the analysis chip is stored in the storage chamber and the rotary member is rotated and conveyed, centrifugal force acts on the analysis chip stored in the analysis chip holding chamber, so that the analysis chip moves to the outer peripheral side. There is a possibility of going out of the opening of the storage chamber.

  Here, in Patent Document 1, the concave portion that holds the analysis slide provided on the outer periphery of the rotary table of the chemical analysis measurement device has a structure including a bottom wall that is inclined downward toward the inner side of the rotary table. It discloses that the displacement of the analysis chip toward the outer peripheral side can be suppressed with respect to the rotation of the rotary table.

  Patent Document 2 discloses an apparatus that enables positioning of an analysis slide by providing a spring clip or the like in a holding chamber for holding the analysis slide provided on a rotating disk.

JP 58-156835 A Japanese Patent Laid-Open No. 2-78958

  However, in the method of Patent Document 1, it is difficult to dispose of the analysis chip from the outer peripheral side of the holding chamber by inclining the bottom surface of the holding chamber of the analysis chip, and the measured analysis chip is discarded from the holding chamber. This is not preferable because the mechanism for rejection becomes complicated.

  Further, the method of Patent Document 2 requires that a holding portion such as a spring clip for holding the analysis chip is provided in the holding chamber of the analysis chip, so that the structure of the holding chamber of the analysis chip becomes complicated. The number of parts constituting the analyzer is increased by the amount of the holding portion. Further, the force for pressing the analysis chip may cause deformation or scratches on the analysis chip, which is not preferable.

  SUMMARY OF THE INVENTION The present invention has been made in view of the above, and an object of the present invention is to provide a biochemical analyzer and a rotary transport method capable of holding an analysis chip so as not to be misaligned with a simple structure during the rotary transport of the analysis chip. .

  A biochemical analyzer according to the present invention is a biochemical analyzer for measuring a specimen using an analysis chip, and a rotating member that rotates and conveys a plurality of the analysis chips concentrically around a rotation center. A control unit for rotationally driving the rotating member, the rotating member including a storage chamber having an opening on the outer periphery for storing the analysis chip, and the rotating direction of the storage chamber The distance in the rotational direction between the side surface on the near side and the straight line including the side surface and the center of the analysis chip in a state in which the analysis chip is stored in the storage chamber is decreased as the distance in the radial direction increases. It is characterized by being inclined.

  The method for rotating and conveying an analysis chip according to the present invention uses a biochemical analyzer having a rotating member in which a plurality of storage chambers having openings on the outer periphery for storing an analysis chip are arranged concentrically around a rotation center. A method of rotating and transporting the analysis chip around the rotation center, in the biochemical apparatus, on the side surface of the storage chamber on the near side with respect to the rotation direction of the rotating member, An inclination is provided so that the distance in the rotational direction between the rotation center of the rotating member and the straight line including the center of the analysis chip in a state in which the analysis chip is stored in the storage chamber becomes smaller as it goes radially outward. The analysis chip is rotated and conveyed by rotating the rotating member in a state where the analysis chip is housed in a chamber.

  In the biochemical analysis apparatus or method, in the state where the analysis chip is stored in the storage chamber, the static frictional force acting on the analysis chip during rotation of the analysis chip is directed toward the outside of the rotating member. The rotating member is driven at a first speed that is greater than or equal to the force acting on the analysis chip, and when the analysis chip is discarded, the static frictional force acting on the analysis chip moves toward the outside of the rotating member. It is preferable to drive the rotating member at a second speed that is smaller than the force acting on the analysis chip.

  In the above case, the control unit may reverse the rotation direction between when the analysis chip is rotated and conveyed and when the analysis chip is discarded.

  In the biochemical analyzer, the control unit drives the rotating member in both directions in order to rotate and convey the analysis chip, and the side surfaces on both sides of the storage chamber are the side surfaces, Inclined so that the distance in the rotational direction between the rotation center of the rotating member and the straight line including the center of the analysis chip in the state in which the analysis chip is stored in the storage chamber becomes smaller as it goes radially outward. There may be.

  Moreover, the said biochemical analyzer WHEREIN: It is preferable that the said inclined side surface has a larger static friction coefficient than the bottom face of the said storage chamber.

  In the biochemical analyzer, a protrusion may be provided in the vicinity of the opening on the side surface of the storage chamber where the slope is provided.

  The analysis chip in the present invention has a surface in contact with the side surface of the storage chamber, and this surface is configured to generate a frictional force between the side surface of the storage chamber and the surface in contact with the side surface. . In addition, the surface contacting the side surface of the storage chamber does not necessarily need to be a perfect plane as long as it generates a frictional force between the side surface of the storage chamber and the surface contacting the side surface, and has a saw-like unevenness. It may be one that draws a gentle curved surface. Preferably, the surface in contact with the side surface of the storage chamber is preferably a surface having a flat region that can be in line contact with the side surface of the storage chamber, and the larger the area that can be contacted with the side surface of the storage chamber, the better. In addition, both end edges that are radially inside and outside of the rotating member when placed on the rotating member are easily pushed and moved by the member that moves in the radial direction when the analysis chip is inserted into and removed from the rotating member. Basically, it is preferably a straight line extending perpendicular to the radial direction. In the embodiment described later, a slide-like chip having a flat rectangle is used, which is a normal form that has been widely used in the past, but the shape is limited to that provided that the above conditions are provided. is not.

  According to the present invention as described above, in the biochemical analyzer for measuring a sample using an analysis chip, the storage chamber having an opening on the outer periphery for storing the analysis chip is provided, and the storage chamber rotates. The side surface on the near side with respect to the direction becomes smaller as the distance in the rotational direction between the side surface and the straight line including the center of rotation and the center of the analysis chip in the state where the analysis chip is stored in the storage chamber becomes radially outward. Therefore, the analysis chip can be brought into contact with the side surface by the centrifugal force, and the displacement of the analysis chip can be suppressed by the frictional force due to the side surface. As a result, with a simple structure, the analysis chip can be suitably held so as not to be misaligned during the rotational conveyance of the analysis chip.

The partial cross section front view which shows schematic structure of the biochemical analyzer by 1st Embodiment FIG. 1 is a plan view of the main part mechanism excluding the spotting mechanism at the element transfer position of the biochemical analyzer of FIG. Sectional front view of the transport path portion of the dry analytical element of FIG. Schematic which expanded a part of rotation member in a 1st embodiment. Schematic which expanded a part of rotating member in a 2nd embodiment.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In this embodiment, a biochemical analyzer to which the present invention is applied will be described. FIG. 1 is a partial cross-sectional front view showing a schematic configuration of the biochemical analyzer according to the first embodiment, and FIG. 2 is a diagram of a main part mechanism excluding a spotting mechanism at an element transport position of the biochemical analyzer of FIG. FIG. 3 is a plan view showing a main part of a transport path portion of a dry analytical element including a spotting portion of the biochemical analyzer of the first embodiment, and FIG. 4 is a rotating member in the first embodiment. It is the schematic which expanded some.

  The overall configuration of the biochemical analyzer 1 will be described with reference to FIGS. The measurement mechanism of the biochemical analyzer 1 includes a sample tray 2, a spotting unit 3, a first incubator 4, a second incubator 5, a spotting mechanism 6, an element transport mechanism 7, a transfer mechanism 8, and a chip discarding unit. 9. An element discarding mechanism 10 and a control unit for controlling various mechanisms are provided. In the following embodiment, an example is shown in which a rotating member for rotating and conveying the analysis chip according to the present invention is applied to the first incubator 4 that performs colorimetric measurement.

  As shown in FIG. 2, the sample tray 2 has a circular shape, a specimen container 11 containing a specimen, and an element cartridge 13 containing unused dry analysis elements 12 (colorimetric type dry analysis element and electrolyte type dry analysis element). The consumables (nozzle tip 14, diluent container 15, mixing cup 16 and reference liquid container 17) are mounted. The sample container 11 is mounted via a sample adapter 18, and a large number of nozzle chips 14 are stored and mounted in a chip rack 19.

  The spotting unit 3 is arranged on an extension of the center line of the sample tray 2 and is used for spotting a specimen such as plasma, whole blood, serum, urine, etc. on the transported dry analytical element 12. 6, the sample is applied to the colorimetric dry analysis element 12 and the sample and the reference liquid are applied to the electrolyte type dry analysis element 12. Subsequent to the spotting unit 3, a chip discarding unit 9 in which the nozzle tip 14 is discarded is arranged.

  The first incubator 4 has a circular shape and is disposed at an extended position of the chip discarding unit 9. The first incubator 4 accommodates a colorimetric type dry analytical element 12 and keeps the temperature constant for a predetermined time to perform colorimetric measurement. The second incubator 5 (see FIG. 2) is disposed at an adjacent position on the side of the spotting portion 3, accommodates the electrolyte-type dry analysis element 12, maintains a constant temperature for a predetermined time, and performs a potential difference measurement.

  The element transport mechanism 7 (see FIG. 3), which is not shown in detail, is disposed inside the sample tray 2 and connects the center of the sample tray 2 and the center of the first incubator 4 to the spotted portion. 3 and an element transport for transporting the dry analytical element 12 from the sample tray 2 to the spotting section 3 and further to the first incubator 4 along a linear element transport path R (FIG. 2) passing through the chip discarding section 9 and the chip discarding section 9. A member 71 (conveying bar) is provided. The element conveying member 71 is slidably supported by a guide rod 38, and is reciprocated by a drive mechanism (not shown). The tip end portion is inserted into the guide hole 34a of the vertical plate 34, and slides in the guide hole 34a.

  The transfer mechanism 8 is also installed as the spotting unit 3, and transfers the electrolyte type dry analytical element 12 from the spotting unit 3 to the second incubator 5 in a direction orthogonal to the element transport path R.

  The spotting mechanism 6 is disposed in the upper part, and a spotting nozzle 45 that moves up and down moves on the same straight line as the above-described element transporting path R, spotting the specimen and the reference liquid, and diluting and mixing the specimen with the diluent. . The spotting nozzle 45 has a nozzle tip 14 attached to the tip, and sucks and discharges a sample, a reference liquid, and the like in the nozzle tip 14, and is provided with a syringe means (not shown) for performing the suction and discharge. The nozzle tip 14 is removed by the tip discarding unit 9 and discarded.

  The element discarding mechanism 10 (see FIG. 2) is attached to the first incubator 4 and pushes the colorimetric dry analytical element 12 after measurement to the center of the first incubator 4 to drop and discard. The element transport mechanism 7 can also be discarded. Further, the electrolyte type dry analytical element 12 after being measured by the second incubator 5 is discarded into the disposal hole 69 by the transfer mechanism 8.

  In addition, a blood filtration unit (not shown) that separates plasma from blood is installed in the vicinity of the sample tray 2.

  The mechanism of each part will be specifically described below. First, the sample tray 2 has a disk-shaped rotating disk 21 that is rotationally driven in the forward direction and the reverse direction, and a disk-shaped non-rotating part 22 at the center.

  As shown in FIG. 2, the rotating disk 21 is adjacent to five sample mounting portions 23 of A to E that hold a sample container 11 such as a blood collection tube containing each sample via a sample adapter 18. The five element mounting portions 24 for holding the element cartridges 13 accommodated in a stacked state of the unused dry analysis elements 12 that normally require a plurality of types corresponding to the measurement items of each specimen, and a number of nozzles Two chip mounting portions 25 that hold a chip rack 19 that stores the chips 14 side by side in the holding holes, a diluent mounting portion 26 that holds three diluent containers 15 that store the diluent, a diluent and a sample, And a cup mounting portion 27 for holding a mixing cup 16 (a molded product in which a large number of cup-shaped recesses are arranged) are arranged in an arc shape.

  Further, the non-rotating part 22 is provided with a cylindrical reference liquid mounting part 28 for holding the reference liquid container 17 containing the reference liquid in the movement range of the spotting nozzle 45 on the extension of the element transport path R, The reference liquid mounting section 28 is provided with an evaporation prevention lid 35 (FIG. 1) that opens and closes the opening of the reference liquid container 17.

  The evaporation prevention lid 35 is held by a swing member 37 pivotally supported by the non-rotating portion 22 at the lower end, and is biased in the closing direction. The upper end locking portion 37a of the swinging member 37 can be in contact with the lower end corner portion 42a of the moving frame 42 of the spotting mechanism 6, and the swinging member 37 is moved in the opening direction by the moving frame 42 that has moved close when the reference liquid is sucked. The evaporation prevention lid 35 opens the reference liquid container 17 so that the reference liquid can be sucked by the spotting nozzle 45. In other states, the evaporation prevention lid 35 closes the opening of the reference liquid container 17 to prevent the reference liquid from evaporating and prevents a decrease in measurement accuracy due to a change in concentration.

  The rotating disk 21 has an outer peripheral portion supported by a support roller 31 and a central portion rotatably held on a support shaft (not shown). Further, a timing belt (not shown) is wound around the outer periphery of the rotary disk 21 and is driven to rotate in the forward direction or the reverse direction by a drive motor. The non-rotating part 22 is non-rotatably attached to the support shaft.

  As shown in FIG. 3, the element cartridges 13 are usually stacked with a plurality of unused dry analytical elements 12 stacked from above. When loaded in the element mounting portion 24, the lower end portion is held on the bottom wall 24a of the element mounting portion 24, and the dry analytical element 12 at the lowermost end portion is positioned at the same height as the element transport surface. An opening 13a through which only one dry analytical element 12 can pass is formed on the front side, and an opening 13b through which the element transport member 71 can be inserted is formed on the rear side.

  In addition, a window portion 13 c is provided on the bottom surface of the element cartridge 13, and a bottom wall 24 a of the element mounting portion 24 is provided on the bottom wall 24 a so that the element information given to the lower surface of the dry analytical element 12 can be read from below the element cartridge 13. Are formed respectively.

  A reader 33 that reads element information based on a dot array pattern (not shown) of the dry analysis element 12 is installed below the sample tray 2. In the reader 33, the rotating disk 21 is rotated by the operation of the sample tray 2 from the element transport position shown in FIG. 3, and the sample container 11 (sample mounting portion 23) is a spotting nozzle as shown in FIG. When the element cartridge 13 (element mounting portion 24) containing the dry analytical element 12 used for the measurement of the sample is moved to the suction position on the movement path (element transport path R) of 45, the position is below the position where the element cartridge 13 is moved. is set up. That is, in the illustrated case, the reader 33 is installed at the rotation position of the element mounting unit 24 with a phase angle that is shifted from the element transport path R by the phase pitch between the sample mounting unit 23 and the element mounting unit 24. In FIG. 3, the rotary disk 21 is partially cut away to show the reader 33, and in FIG. 3, the reader 33 is shown below the element mounting portion 24 in the element transport path R for convenience.

  The reader 33 is composed of a CCD camera corresponding to the dot recording method. The reading of the element information of the dry analysis element 12 by the reader 33 is performed prior to the sample suction from the corresponding sample container 11 and the transport of the dry analysis element 12. Then, the reagent type information, reagent lot information, etc. can be obtained from the 6-digit or 4-digit number obtained by reading the element information given to the dry analytical element 12, and from the recording pattern, etc. The direction can be recognized. Thereby, a set failure can be detected and a warning can be issued.

  The sample adapter 18 is formed in a cylindrical shape, and the sample container 11 is inserted from above. The sample adapter 18 includes an identification unit (not shown), and information such as the type of sample (processing information) and the type (size) of the sample container 11 is set. The identification sensor 30 (FIG. 2) provided reads the identification, and determines whether or not the sample is diluted, whether or not the plasma is filtered, and calculates the amount of liquid level fluctuation associated with the size of the sample container 11. Processing control is performed accordingly. For the specimen container 11 that requires plasma filtration, the specimen container 11 is inserted into the adapter 18 and a holder equipped with a filtration filter is mounted via a spacer (both not shown).

  The spotting unit 3 and the transfer mechanism 8 include a support base 61 that is long between the sample tray 2 and the first incubator 4 in a direction perpendicular to the element transport path R, and a sliding frame 62 is movable on the support base 61. is set up. A first element presser 63 and a second element presser 64 in which spot wearing openings 63a (FIG. 3) are formed are attached to the sliding frame 62 so as to be movable integrally with each other. The first element presser 63 (the same applies to the second element presser 64) has a recess 63b on the bottom surface facing the support base 61 through which the dry analysis element 12 passes along the element transport path R. The sliding frame 62 is guided at one end by the guide bar 65, the pin 66 is engaged with the long groove 62a at the other end, and the drive gear 67 of the drive motor 68 is engaged with the rack gear 62b. Is done. The support base 61 is provided with a second incubator 5 and a disposal hole 69.

  As shown in FIG. 2, when the first element presser 63 is positioned at the spotting portion 3, the colorimetric type dry analytical element 12 after the spotting is pushed out by the element transport mechanism and the first incubator 4. It is transferred to. On the other hand, when spotting is performed on the electrolyte type dry analytical element 12, the sliding frame 62 is moved, and the dry analytical element 12 after spotting is held on the support base 61 while being held by the first element presser 63. It is transferred to the second incubator 5 so as to slide, and a potential difference measurement is performed. At that time, the second element presser 64 moves to the spotting unit 3 (spotting position), and then the specimen is spotted on the colorimetric dry analytical element 12 and then transported to the first incubator 4. Can be transported. When the measurement in the second incubator 5 is completed, the sliding frame 62 is further moved, and the dry analytical element 12 after the measurement is transferred to the disposal hole 69 to be dropped and discarded.

  When the colorimetric type dry analytical element 12 is transported, the second element presser 64 is moved to the spotting section 3 and only when the electrolyte type dry analytical element 12 is transported. You may make it move 63 to the spotting part 3. FIG.

  The imaging member 33 reads other information in addition to reading the dot arrangement pattern. For this purpose, an additional light source (not shown) is installed. As this additional light source, a light source having a specific wavelength, such as an infrared light source or a deterioration detection light source, is installed according to the detection mode. The spot information and other readings by the information reader will be described later.

  The spotting mechanism 6 (FIG. 1) includes a moving frame 42 held on a horizontal guide rail 41 of a fixed frame 40 so as to be movable in the lateral direction, and two spotting nozzles that can be moved up and down on the moving frame 42. 45 is installed. A vertical guide rail 43 is fixed to the center of the moving frame 42, and two nozzle fixing bases 44 are slidably held on both sides of the vertical guide rail 43. An upper end portion of the spotting nozzle 45 is fixed to the lower portion of the nozzle fixing base 44, and a shaft-like member extending upward is inserted into the drive transmission member 47. A fitting force of the nozzle tip 14 is obtained by a compression spring interposed between the nozzle fixing base 44 and the drive transmission member 47. The nozzle fixing base 44 can move up and down integrally with the drive transmission member 47, and is driven relative to the nozzle fixing base 44 by compression of a compression spring when the nozzle tip 14 is fitted to the tip of the spotting nozzle 45. The transmission member 47 can move downward. The drive transmission member 47 is fixed to a belt 50 stretched around upper and lower pulleys 49 and moves up and down in accordance with the travel of the belt 50 by a motor (not shown). A balance weight 51 is attached to the outer portion of the belt 50 to prevent the descent nozzle 45 from moving down when not driven.

  The moving frame 42 is driven in the horizontal direction by a belt drive mechanism (not shown), and the horizontal movement and the vertical movement are controlled so that the two nozzle fixing bases 44 independently move up and down. Moves horizontally and moves up and down independently. For example, one spotting nozzle 45 is for a specimen, and the other spotting nozzle 45 is for a diluting liquid and a reference liquid.

  Both the spotting nozzles 45 are formed in a rod shape, an air passage extending in the axial direction is provided inside, and a pipette nozzle tip 14 is fitted in a sealed state at the lower end. Each spotting nozzle 45 is connected to an air tube connected to a syringe pump (not shown) and supplied with suction / discharge pressure. Further, the liquid level of the sample or the like can be detected based on the change in the suction pressure.

  The chip discarding unit 9 is provided so as to intersect the transport path R in the vertical direction, and includes an upper member 81 and a lower member 82. The support base 61 in the chip discarding unit 9 is formed with a drop port 83 that is opened in an elliptical shape. The upper member 81 is fixed to the upper surface of the support base 61, an engagement notch 84 is provided immediately above the drop opening 83, and the lower member 82 is cylindrical so as to surround the lower side of the drop opening 83 on the lower face of the support base 61. The nozzle tip 14 that is formed and falls is guided.

  Then, the spotting nozzle 45 to which the nozzle tip 14 is mounted is moved down in the upper member 81 and then moved in the lateral direction, and the upper end of the nozzle tip 14 is engaged with the engagement notch 84. The nozzle tip 14 is extracted by moving the landing nozzle 45 upward, and the detached nozzle tip 14 is dropped and discarded through the drop port 83.

  The first incubator 4 that performs the colorimetric measurement includes an annular rotating member 87 on the outer peripheral portion, and the rotating member 87 rotates with an inclined rotating cylinder 88 fixed to an inner peripheral lower portion supported by a lower bearing 89. It is free. An upper member 90 is disposed on an upper portion of the rotating member 87 so as to be integrally rotatable. The upper surface of the upper member 90 is flat, and a plurality of (13 in the case of FIG. 1) concave portions are formed on the upper surface of the rotating member 87 at predetermined intervals on the circumference, and a slit-like space is formed between the members 87 and 90. An element chamber 91 is formed, and the height of the bottom surface of the element chamber 91 is the same as the height of the transfer surface. Further, the inner hole of the inclined rotating cylinder 88 is formed in the disposal hole 92 of the dry analytical element 12 after the measurement, and the dry analytical element 12 in the element chamber 91 is moved to the center side as it is and dropped and discarded. 2, the element chamber 91 shows only the arrangement on the rotating member 87, and the details of the shape of the element chamber 91 are shown in FIG.

  FIG. 4 is a partially enlarged view showing in detail one element chamber 91 (analysis chip storage chamber) of the rotating member 87. The element chamber has a side surface 91b on the near side toward the direction of rotational conveyance, a side surface 91b provided opposite to the side surface 91b, a bottom surface 91d, and an opening for inserting an element provided on the outer peripheral side of the rotating member. 91e. As shown in FIG. 4, the rotating member 87 is analyzed in a state where the side surface 91b on the near side in the direction of rotational conveyance indicated by the arrow P is stored in the side surface 91b, the rotation center of the rotating member, and the storage chamber. The distance in the rotation direction from the straight line L including the center of the chip is inclined so as to become smaller as it becomes radially outward. That is, the analysis chip is inclined so that the component force of the centrifugal force acting when the rotation member 87 rotates is received by the inclined surface. Here, as shown in FIG. 4, the inclination angle of the side surface 91b with respect to the straight line L is defined as an inclination angle θ.

  When the rotating member 87 starts to rotate and convey, a centrifugal force F is generated in the dry analytical element 12 outward in the radial direction according to the rotation speed of the rotating member. As shown in FIG. 4, the dry analytical element 12 moves from the insertion position 12b inserted in the radial direction by the conveying bar 71 to a position where it abuts on the side surface 91b by the action of the centrifugal force component, and the side surface 91b. , And stops at the holding position 12a.

Even in the holding position 12a, the centrifugal force F acts on the dry analytical element 12 according to the rotational speed of the rotating member. Here, the weight of the dry analytical element is m, the rotational speed at the center of the dry analytical element 12 is V, the friction coefficient of the bottom surface 91d is μ, the friction coefficient of the side surface 91b is μ ′, the gravity is g, and the dry analytical element from the center of rotation. Assuming that the distance to the center of 12 is r, the centrifugal force F, the force F1 that pushes the dry analytical element 12 toward the outer peripheral side of the rotating member 87 along the side surface 91b, and the rest that tries to keep still at the holding position 12a. The frictional force F2 can be expressed by equations (1) to (3), respectively. Note that F · sin θ corresponds to a component of centrifugal force acting on the slope receiving the centrifugal force.
F = mV ² / r (1)
F1 = F · cos θ = mV ² / r · cos θ (2)
F2 = (friction force on the bottom surface) + (friction force on the side surface) = μmg + μ′F · sin θ
= Μmg + μ ′ (mV ² / r) · sin θ (3)

In the conventional configuration in which the side surface 91b does not have the above-described inclination, the force for pushing the dry analytical element 12 toward the outer peripheral side of the rotating member 87 is F1 ′ = mV ² / r, and the static friction force is F2 ′ = μmg ( Static friction force on the bottom surface 91d). On the other hand, in the apparatus having the inclination as described above, when the dry analytical element 12 having the same rotation speed V and the same mass is used, as shown in the above formulas (2) and (3), the dry analysis is performed. The force for pushing the element 12 to the outer peripheral side of the rotating member 87 can be made smaller, and the static frictional force of the dry analysis element 12 can be made larger.

In addition, when the forces F1 and F2 defined in the above formulas (2) and (3) satisfy the following formula (4), the static frictional force acting on the dry analytical element 12 causes the dry analytical element 12 to rotate the rotating member 87. The dry analytical element 12 is stationary because the force is greater than the force pushing toward the outer peripheral side, and when the expression (5) is satisfied, the dry analytical element 12 rotates the dry analytical element 12 due to the static frictional force acting on the dry analytical element 12. Since it is smaller than the force pushing to the outer peripheral side of the member 87, the dry analytical element 12 moves toward the outer side of the rotating member.
F1 ≦ F2 (4)
F1> F2 (5)

  The apparatus carries the dry analytical element 12 in the holding position by carrying out the rotary conveyance at the speed (first speed V1) satisfying the above formula (4) during the rotary conveyance. The speed V (first speed V1) at the time of rotating and conveying the rotating member 87 can be arbitrarily set as long as it satisfies the above formula (4), and the control unit keeps the rotating speed V of the rotating member constant. It may be maintained or may be changed variously.

  The inclination angle θ of the side surface 91b can be arbitrarily configured within the range of 0 ° <θ <90 ° as long as the above formula (4) can be satisfied, while maintaining the element chamber 91 compact, In order to keep the position of the dry analytical element 12 at the time of rotational conveyance with high accuracy, it is preferably in the range of 0 ° <θ <45 °, and more preferably in the range of 0 ° <θ <30 °. It should be noted that, particularly in an apparatus in which the measurement position of the dry analytical element 12 is on the rotation conveyance path, such as the biological analysis apparatus of the present embodiment, the position of the dry analysis element during the rotation conveyance is particularly accurately maintained. Is preferred.

  Further, the static frictional force F2 acting on the dry analytical element 12 shown in Expression (3) is adjusted by setting the static friction coefficients μ and μ ′ of the bottom surface 91d and the side surface 91b of the element chamber 91 to appropriate values. can do. Since the static frictional force on the side surface is a force acting at the holding position during the rotation conveyance, it is preferably as large as possible, and it is preferable as the static friction coefficient μ ′ is large. Further, since the static frictional force on the bottom surface 91d acts also when the dry analytical element 12 is inserted or discharged, the static friction coefficient μ on the bottom surface 91d is any value that does not interfere with the insertion or disposal of the dry analytical element 12. Any value is acceptable.

  Various methods can be applied as long as they can realize the desired coefficient of friction μ and μ ′ of the side surface 91b and the bottom surface 91d. For example, members having a desired coefficient of friction may be affixed to the surfaces of the bottom surface 91d and the side surface 91b of the element chamber 91, and the rotating member 87 may be formed of a material having a desired coefficient of friction. Further, a desired friction coefficient may be realized by performing processing for realizing an appropriate surface roughness on the surfaces of the bottom surface 91d and the side surface 91b of the element chamber 91.

  As shown in FIG. 4, the opening 91 e of the element chamber 91 may have a size that allows the dry analysis element 12 to be inserted, and the dry analysis element 12 can be held in the element chamber 91 at a position where measurement is possible. The size of the element chamber 91 may be arbitrarily determined within the range. For example, in the case of the rectangular dry analysis element 12 as shown in FIG. 4, if the length in the longitudinal direction of the dry analysis element 12 is x1 and the length in the short direction is x2 (x1> x2), the opening 91e The width W may be at least larger than x2. Further, in order to prevent the dry analytical element 12 from moving outward in the radial direction due to the centrifugal force due to rotation and coming out of the opening 91e, the width W of the opening 91e is x2 <W <x1. It is preferable.

  More preferably, the width W of the opening 91e is larger than x2, and W ′ (= W · cos θ) shown in FIG. 4 is smaller than the length x2 of the dry analytical element 12 in the short direction. Is preferred. In the above case, it is unlikely that the dry analytical element 12 will come out of the opening 91e of the element chamber 91 due to the centrifugal force during the rotation conveyance.

  Further, the range in which the inclination is provided may be longer than the length of the side in contact with the side surface 91b of the dry analysis element 12 so that the dry analysis element 12 can be held along the inclination, even if the entire side surface 91b is inclined. Alternatively, a part of the side surface 91b may be inclined.

  The upper member 90 is provided with a heating means (not shown), and the temperature of the dry analytical element 12 in the element chamber 91 is kept constant at a predetermined temperature. Further, as shown in FIG. 4, the upper member 90 is provided with a pressing member 93 corresponding to the element chamber 91 to press the mount of the dry analysis element 12 from above to prevent the sample from evaporating. A heat retaining cover 94 is disposed on the upper surface of the upper member 90, while the first incubator 4 is entirely covered with a light shielding cover 95. Further, an opening window 91a for photometry is formed in the center of the bottom surface of each element chamber 91 of the rotating member 87, and the reflection of the dry analytical element 12 by the photometric head 96 disposed at the position shown in FIG. 2 through the opening window 91a. An optical density measurement is performed. The first incubator 4 is rotationally driven by a belt mechanism (not shown) and is driven to reciprocate.

  The disposal mechanism 10 includes a disposal bar 101 that moves forward and backward in the element chamber 91 in the center direction from the outer peripheral side. The disposal bar 101 is fixed to a belt 102 whose rear end travels in a horizontal direction, and the measured dry analytical element 12 is pushed out from the element chamber 91 in accordance with the traveling of the belt 102 driven by the drive motor 103 and discarded. To do. A recovery box for recovering the dry analytical element 12 after measurement is disposed below the disposal hole 92.

  Further, in the second incubator 5 for measuring the ion activity, the first element presser 63 of the sliding frame 62 serves as an upper member, and one element chamber is provided between the upper surface of the measurement main body 97 by the concave portion at the bottom. Is formed. The second incubator 5 is provided with a heating means (not shown), and a temperature measuring portion of the dry analytical element 12 for measuring the ion activity is isothermally heated to a predetermined temperature. Further, three pairs of potential measurement probes 98 for measuring the ion activity are provided on the side portion of the measurement main body 97 so as to come into contact with the ion selective electrode of the dry analytical element 12.

  A plasma filtration unit (not shown) is inserted through a holder (not shown) having a filter made of glass fiber inserted into the specimen container 11 (collecting blood vessel) held in the sample tray 2 and attached to the upper end opening. Plasma is separated and sucked from blood, and the filtered plasma is held in the cup at the upper end of the holder.

  The operation of the biochemical analyzer 1 as described above, setting of measurement conditions, and the like are performed by input from an operation panel 55 (not shown) installed in the housing 20 (not shown). The operation panel 55 (interface) performs various instruction operations by pressing with a fingertip such as a display screen, a start key, a stop key, a specimen key, a consumable key, a manual key, an emergency key, a calibration key, a numeric keypad, and a print key. Operation keys are provided. The operation panel 55 is connected to a control unit (not shown), and measurement calculation processing based on a control program registered therein is set, automatic measurement operation, manual measurement operation, emergency measurement operation, calibration operation, and printing operation. Are selected and executed, and the analysis result (component concentration) is calculated based on the measurement information based on the analysis information corresponding to the element information. Then, in order to output and record the measurement results, these data are printed by the printer 57 in order to confirm the set values.

  Next, the overall operation of the biochemical analyzer 1 will be described. First, before performing the analysis, in each of the mounting portions 23 to 28 of the sample tray 2, a specimen container 11 containing each specimen, an element cartridge 13 loaded with a dry analytical element 12, a chip rack 19 containing a nozzle chip 14, The mixing cup 16, the diluent container 15 and the reference liquid container 17 are mounted to prepare for measurement.

  Thereafter, the analysis process is started. First, in the case of a specimen that requires plasma filtration, the whole blood in the specimen container 11 is filtered by a blood filtration unit to obtain a plasma component. Next, the element cartridge 13 of the sample to be measured by rotating the rotating disk 21 is stopped at the element take-out position corresponding to the spotting unit 3, and the dry analysis element 12 is taken out from the element cartridge 13 by the element transport mechanism and is spotted. 3 to transport. Note that the analysis information given to the dry analysis element 12 is read before being transported to the spotting unit 3, and the subsequent operation is controlled.

  When the measurement item is colorimetric measurement, the dry analytical element 12 is transported in a state where the element presser 64 is positioned at the spotting portion, and then the sample tray 2 is rotated to rotate the spotting nozzle 45. The nozzle tip 14 of the tip rack 19 is moved downward and attached to the spotting nozzle 45. Subsequently, the specimen container 11 is moved, the spotting nozzle 45 is lowered, the specimen is sucked into the nozzle tip 14, the spotting nozzle 45 is moved to the spotting part 3, and the specimen is spotted on the dry analytical element 12. .

  Then, the colorimetric dry analytical element 12 on which the specimen is spotted is inserted into the first incubator 4. Next, after the element chamber 91 is rotated and held at a constant temperature for a predetermined time, the inserted dry analysis element 12 is sequentially moved to the position of the photometric head 96, and the reflection optical density of the dry analysis element 12 is measured.

  When rotating the element chamber 91, the control unit rotates the rotating member 87 at the first speed V1 that satisfies the above-described formula (4).

  When the rotation of the rotating member 87 starts, a centrifugal force F is generated outward in the radial direction in the dry analysis element 12 housed in the element chamber 91 according to the rotation speed. By the action of the centrifugal force component, the dry analytical element moves from the insertion position 12b to the side surface 91b, rotates to a posture along the side surface 91b, and stops at the holding position 12a.

  In this embodiment, the rotational speed V of the rotating member 87 at the center position of the dry analytical element 12 is 15 [mm / sec], the distance r from the rotational center to the center of the dry analytical element 12 is 75 [mm], the dry analytical element The weight of 12 is 3 [g], θ = 45 [°], and the rotating member 87 is rotated at a substantially constant speed. Further, the material of the dry analytical element 12 is polyacetal, the surface of the element chamber 91 is subjected to rubber coating treatment, the coefficient of static friction μ between the side surface 91b and the dry analytical element 12, and the bottom surface 91d and the dry analytical element. The coefficient of static friction μ ′ between the two is 0.8. In the above case, F1 = 6.36 [N] and F2 = 7.49 [N] according to the equations (2) and (3), so that the static frictional force F2 causes the dry analytical element 12 to move outside the rotating member. The dry analytical element 12 can be suitably held at the holding position 12a, which is larger than the force F1 to move toward the head.

  After the measurement is completed, the measured dry analytical element 12 is pushed out to the center side and discarded. The measurement result is output, and the used nozzle tip 14 is removed from the spotting nozzle 45 by the tip discarding unit 9 and dropped downward and discarded, and the processing is completed. During the colorimetric measurement, in the second incubator 5, as described above, the lower block 71 is raised and the upper block 63 is preheated.

  Next, when the inspection item is a dilution request, for example, when the blood concentration is too high to perform an accurate inspection, the dry analytical element 12 is transported to the spotting position, and then the nozzle tip 14 is moved. The nozzle is attached to the spotting nozzle 45, and the spotting nozzle 45 is lowered to suck the sample into the nozzle tip 14. After the aspirated specimen is dispensed from the nozzle tip 14 into the mixing cup 16, the used nozzle tip 14 is removed. Next, a new nozzle tip 14 is attached to the spotting nozzle 45, and the diluent is sucked from the diluent container 15 into the nozzle tip 14. The sucked diluted liquid is discharged from the nozzle tip 14 to the mixing cup 16. Then, the nozzle tip 14 is inserted into the mixing cup 16 and agitation is performed by repeating suction and discharge. After agitation, the diluted specimen is sucked into the nozzle tip 14, the spotting nozzle 45 is moved to the spotting section 3, and the specimen is spotted on the dry analytical element 12. Thereafter, similarly, constant temperature holding, photometry, element discarding, result output and chip discarding are performed, and the process is terminated.

  Next, in the case of measuring the ion activity, the upper block 63 is moved to the spotting unit 3 as described above, and the electrolyte type dry analytical element 12 is transported to the spotting position. The nozzle tip 14 is attached to the nozzle 45 and the specimen is aspirated. Next, the nozzle tip 14 is attached to the other spotting nozzle 45 and the reference liquid is sucked from the reference liquid container 17. Next, the specimen is spotted on one liquid supply hole of the dry analytical element 12 by one spotting nozzle 45, and the reference liquid is spotted on the other liquid supply hole of the dry analytical element 12 by the other spotting nozzle 45. To wear.

  Then, the dry analytical element 12 on which the sample and the reference liquid are spotted is transferred to the second incubator 5 by the movement of the sliding frame 62 together with the upper block 63 from the spotting portion 3, and kept at a constant temperature by raising the lower block 71. Meanwhile, the ion activity is measured by the potential measuring probe 78. After the measurement is completed, the dry analytical element 12 after measurement is transferred to the discard hole 69 by the movement of the sliding frame 62 and discarded. Then, the measurement result is output, both the used nozzle tips 14 are removed from both spotting nozzles 45 and discarded, and the process is terminated.

  According to the present embodiment, the side surface is such that the distance in the rotational direction between the side surface and the straight line including the center of rotation and the center of the analysis chip in the state in which the analysis chip is stored in the storage chamber becomes smaller as it goes radially outward. By tilting 91b, the static frictional force acting on the dry analytical element 12 can be increased, so that the dry analytical element 12 can be suitably held at the holding position during rotary conveyance with a simple structure. It can suppress suitably that element 12 receives an outward force at the time of rotation conveyance, and moves.

  FIG. 5 is a diagram illustrating a modification of the first embodiment. In the first embodiment, the side surface 91b is inclined only. However, if the biochemical analyzer 1 rotates on both sides, as shown in FIG. 5, both side surfaces 91b and 91c, the rotation center, and the storage are provided. Both side surfaces 91b and 91c may be inclined so that the distance in the rotation direction from the straight line L including the center of the analysis chip in a state where the analysis chip is housed in the chamber decreases toward the outer side in the radial direction. Regardless of the direction in which the dry analytical element 12 is rotated and transported, the dry analytical element 12 can be suitably held in the holding position during the rotational transport with a simple structure, and the dry analytical element 12 is directed outward during the rotational transport. It can suppress suitably that it receives power and moves. In addition, the inclination angles of both side surfaces 91b and 91c may be different from each other or may be equal.

  Moreover, you may provide the protrusion part 91f as shown with a broken line in FIG. 5 near the opening part 91e of the said inclined side surface 91b. Even when the dry analytical element 12 moves to the outside of the rotating member during the rotation conveyance, the dry analytical element 12 comes into contact with the protruding portion 91f so that the dry analytical element 12 moves toward the outer side of the rotating member from the protruding portion 91f. It is possible to prevent moving forward. For this reason, it can further suppress that dry analysis element 12 comes out to the rotation member outside. The protrusion 91f may have any shape and size as long as it does not hinder insertion and disposal of the dry analytical element 12. Further, as shown in FIG. 5, in the biochemical analyzer that can rotate on both sides, when the side surfaces 91b and 91c are inclined, the side surfaces 91b and 91c may be provided with protrusions.

  The second embodiment will be described below. In the second embodiment, using the disposal mechanism in the first embodiment, the dry analysis element 12 is pushed out of the element chamber 91 by the disposal bar 101 and discarded, and rotated at the second speed. Only the point that the dry analysis element 12 is discarded by rotating the member 87 is different from the first embodiment. In the second embodiment, the control unit rotates the rotating member 87 in the same direction at the first and second speeds with different speeds. The following description will focus on the differences from the first embodiment, and the description of the same points as in the first embodiment will be omitted.

  The controller rotates the rotating member 87 at the first speed V1 that satisfies the above-described equation (4) during the rotation conveyance. As a result, the static friction force acting on the dry analytical element 12 during rotation conveyance is greater than the force pushing the dry analytical element 12 to the outside of the rotating member, so that the dry analytical element 12 can be stably held at the holding position 12a. . At the time of disposal, the rotating member 87 is rotated at the second speed V2 that satisfies the above-described equation (5). Thus, at the time of disposal, the static frictional force acting on the dry analysis element 12 is smaller than the force pushing the dry analysis element 12 to the outside of the rotating member. Therefore, at the time of disposal, the dry analysis element 12 is moved toward the outside of the rotating member. It can be moved and discarded. The first speed V1 can be arbitrarily set as long as the expression (4) is satisfied, and the second speed V2 can be arbitrarily set as long as the expression (5) is satisfied.

  According to the second embodiment, since it is not necessary to provide the disposal mechanism 10 such as the disposal bar 101, the biochemical analyzer 1 can have a simple structure, and the biochemical analyzer can be made at lower cost. 1 can be manufactured. Moreover, the conventional analyzer can be used as the biochemical analyzer of the second embodiment only by changing the control, and the versatility is high.

As a modification of the second embodiment, the control unit may rotate the rotating member 87 in different directions at the first and second speeds. In this case, the side surface 91b in the rotation direction at the time of the rotation conveyance is structured to be inclined so that the distance in the rotation direction between the side surface 91b and the straight line L becomes smaller toward the outer side in the radial direction. The distance in the rotational direction between 91c and the straight line L increases as it goes outward in the radial direction, or does not change regardless of the radial position. When rotating and transporting, it rotates at the first speed V1 that satisfies the above formula (4), and when disposing of the dry analytical element 12, it reverses that when rotating and transporting at the second speed V2 that satisfies the following formula (5) ′. Rotate. In Formula (5) ′, F1 ′ represents a force for pushing the dry analytical element 12 toward the outside of the rotating member at the time of disposal, and F2 ′ is a static friction applied to the dry analytical element 12 at the time of disposal. It represents power.
F1 '>F2' ... Formula (5) '

  In the above case, when the dry analytical element 12 is rotated and conveyed, the dry analytical element 12 is stably held at the holding position in contact with the side surface 91b as in the first embodiment. On the other hand, when the dry analytical element 12 is discarded, when the rotating member 87 starts rotating at the second speed V2, the dry analytical element 12 moves away from the side surface 91b toward the side surface 91c due to inertial force. For this reason, in the above formula (5), the force F1 ′ = F that pushes the dry analytical element 12 toward the outside of the rotating member at the time of disposal becomes a static frictional force F2 ′ = load applied to the dry analytical element 12 at the time of disposal. μmg. When F1 ′ and F2 ′ satisfy the above formula (5) at the time of disposal, the static friction force acting on the dry analytical element 12 is smaller than the force pushing the dry analytical element 12 to the outside of the rotating member. The element 12 can be moved to the outside of the rotating member and dropped and discarded outside the rotating member 87.

  In the modification of the second embodiment, the force F1 ′ that pushes the dry analytical element 12 to the outside of the rotating member at the time of disposal is larger than the force F1 that pushes the dry analytical element 12 to the outside of the rotating member at the time of rotary conveyance. Further, the static friction force F2 ′ at the time of disposal becomes smaller than the static friction force F2 when it is located at the holding position. For this reason, it is easier to move the dry analytical element 12 toward the outside of the rotating member 87 at the time of disposal than at the time of rotational conveyance, and the rotational speed at the time of disposal can be made relatively low.

  The first speed V1 can be arbitrarily set as long as the expression (4) is satisfied, and the second speed V2 is arbitrary as long as the following expression (5) ′ is satisfied at the time of disposal. Can be set.

  Each embodiment described above shows only one aspect of the present invention, and can be arbitrarily modified and applied without departing from the gist of the present invention.

DESCRIPTION OF SYMBOLS 1 Biochemical analyzer 2 Sample tray 3 Spotting part 4 1st incubator 5 2nd incubator 6 Spotting mechanism 7 Element conveyance mechanism 8 Transfer mechanism 9 Chip discarding part 10 Element discarding mechanism 12 Dry analysis element (analysis chip) )
12a Dry analytical element holding position 12b Dry analytical element insertion position 87 Rotating member 91 Element chamber (storage chamber)
91b, 91c Side surface 91e Opening 91f Protrusion F1, F1 ′ Force F2 for pushing the dry analytical element toward the outer peripheral side of the rotating member F2, F2 ′ Static friction force V1 acting on the dry analytical element V1 First speed V2 Second speed

Claims (9)

A biochemical analyzer for measuring a sample using an analysis chip,
A rotating member that rotates and conveys the plurality of analysis chips concentrically around a rotation center;
A controller for rotationally driving the rotating member,
The rotating member includes a storage chamber having an opening on the outer periphery for storing the analysis chip,
The side surface on the near side with respect to the direction of rotation of the storage chamber is a rotation direction of the side surface and a straight line including the rotation center and the center of the analysis chip in a state where the analysis chip is stored in the storage chamber. A biochemical analyzer characterized by being inclined so that the distance becomes smaller toward the outside in the radial direction.   In a state where the analysis chip is stored in the storage chamber by the control unit, a static frictional force acting on the analysis chip during rotation conveyance of the analysis chip acts on the analysis chip toward the outside of the rotating member. The rotary member is driven at the first speed having the above magnitude, and the static friction force acting on the analysis chip when the analysis chip is discarded is the force acting on the analysis chip toward the outside of the rotation member. The biochemical analyzer according to claim 1, wherein the rotating member is driven at a second speed that is smaller.   3. The biochemical analyzer according to claim 2, wherein the control unit reverses the rotation direction when the analysis chip is rotated and conveyed and when the analysis chip is discarded. The controller drives the rotating member in both rotational directions in order to rotate and transport the analysis chip;
The distance in the rotation direction between the side surfaces on both sides of the storage chamber is a radial direction between the side surface, a rotation center of the rotating member, and a straight line including the center of the analysis chip in a state where the analysis chip is stored in the storage chamber. 2. The biochemical analyzer according to claim 1, wherein the biochemical analyzer is inclined so as to become smaller toward the outside.   The biochemical analyzer according to any one of claims 1 to 4, wherein the inclined side surface has a larger coefficient of static friction than the bottom surface of the storage chamber.   The biochemical analyzer according to any one of claims 1 to 5, wherein a protrusion is provided in the vicinity of the opening on a side surface of the storage chamber where the slope is provided. Using a biochemical analyzer having a rotating member in which a plurality of storage chambers provided with openings on the outer periphery for storing an analysis chip are arranged concentrically around the rotation center, the analysis chip is placed around the rotation center. A method of rotating and conveying
In the biochemical device, the side surface of the storage chamber on the near side with respect to the rotation direction of the rotating member, the rotation center of the rotating member, and the analysis chip in a state of storing the analysis chip in the storage chamber. Inclination is provided so that the distance in the rotational direction from the straight line including the center of the analysis chip becomes smaller as it goes radially outward,
Rotating and transporting the analysis chip by rotating and rotating the rotating member in a state where the analysis chip is housed in the storage chamber.   In the rotation control, when the analysis chip is stored in the storage chamber, a static friction force acting on the analysis chip acts on the analysis chip toward the outside of the rotating member when the analysis chip is rotated and conveyed. The rotating member is driven at a first speed that is greater than a force, and when the analysis chip is discarded, a static friction force acting on the analysis chip acts on the analysis chip toward the outside of the rotation member. The method for rotating and conveying an analysis chip according to claim 7, wherein the rotation of the rotating member is controlled at a second speed that is smaller than a force to be applied.   9. The method for rotating and conveying an analysis chip according to claim 8, wherein in the rotation control, the rotation direction is reversed between the rotation and conveyance of the analysis chip and the disposal of the analysis chip.

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