JP5161245B2 - ＰＫＣ阻害剤としての３−アミノ−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルボアルデヒド誘導体 - Google Patents
ＰＫＣ阻害剤としての３−アミノ−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルボアルデヒド誘導体 Download PDFInfo
- Publication number
- JP5161245B2 JP5161245B2 JP2009548766A JP2009548766A JP5161245B2 JP 5161245 B2 JP5161245 B2 JP 5161245B2 JP 2009548766 A JP2009548766 A JP 2009548766A JP 2009548766 A JP2009548766 A JP 2009548766A JP 5161245 B2 JP5161245 B2 JP 5161245B2
- Authority
- JP
- Japan
- Prior art keywords
- dimethyl
- carbonyl
- pyrazol
- tetrahydropyrrolo
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *Cc(nc1Cl)ncc1F Chemical compound *Cc(nc1Cl)ncc1F 0.000 description 10
- DMADJUKSPHZYSK-UHFFFAOYSA-N C1OC11CCOCC1 Chemical compound C1OC11CCOCC1 DMADJUKSPHZYSK-UHFFFAOYSA-N 0.000 description 1
- NSELYKZLLNWRED-UHFFFAOYSA-N C=C1CCOCC1 Chemical compound C=C1CCOCC1 NSELYKZLLNWRED-UHFFFAOYSA-N 0.000 description 1
- RYEBTHRWMHOBAF-UHFFFAOYSA-N CC1N(Cc2ccccc2)CCN(CC2(CCOCC2)O)C1 Chemical compound CC1N(Cc2ccccc2)CCN(CC2(CCOCC2)O)C1 RYEBTHRWMHOBAF-UHFFFAOYSA-N 0.000 description 1
- ZWPGIZIJHZJKRC-PIJUOVFKSA-N CC[C@H]1N(CC2(CCOCC2)O)CC(C)NC1 Chemical compound CC[C@H]1N(CC2(CCOCC2)O)CC(C)NC1 ZWPGIZIJHZJKRC-PIJUOVFKSA-N 0.000 description 1
- NMOLENLWWGEOAA-LBPRGKRZSA-N C[C@@H](CN(C)C1(CCCC1)C1)N1C(N(C1)C(C)(C)c2c1c(N)n[nH]2)=O Chemical compound C[C@@H](CN(C)C1(CCCC1)C1)N1C(N(C1)C(C)(C)c2c1c(N)n[nH]2)=O NMOLENLWWGEOAA-LBPRGKRZSA-N 0.000 description 1
- XZCSQNOUJUIWEB-AWEZNQCLSA-N C[C@@H](CN(C)C1(CCCC1)C1)N1C(N(C1)C(C)(C)c2c1c(Nc1nc(C)ncc1F)n[nH]2)=O Chemical compound C[C@@H](CN(C)C1(CCCC1)C1)N1C(N(C1)C(C)(C)c2c1c(Nc1nc(C)ncc1F)n[nH]2)=O XZCSQNOUJUIWEB-AWEZNQCLSA-N 0.000 description 1
- WJTCHBVEUFDSIK-JHJMLUEUSA-N C[C@H]1NCC(C)N(Cc2ccccc2)C1 Chemical compound C[C@H]1NCC(C)N(Cc2ccccc2)C1 WJTCHBVEUFDSIK-JHJMLUEUSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88874907P | 2007-02-07 | 2007-02-07 | |
| US60/888,749 | 2007-02-07 | ||
| US98908607P | 2007-11-19 | 2007-11-19 | |
| US60/989,086 | 2007-11-19 | ||
| US2096508P | 2008-01-14 | 2008-01-14 | |
| US61/020,965 | 2008-01-14 | ||
| PCT/IB2008/000297 WO2008096260A1 (fr) | 2007-02-07 | 2008-02-04 | Nouveaux dérivés de 3-amino-pyrrolo[3,4-c]pyrazole-5(1h,4h,6h) carbaldéhyde |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518069A JP2010518069A (ja) | 2010-05-27 |
| JP5161245B2 true JP5161245B2 (ja) | 2013-03-13 |
Family
ID=39493354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548766A Active JP5161245B2 (ja) | 2007-02-07 | 2008-02-04 | ＰＫＣ阻害剤としての３−アミノ−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルボアルデヒド誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US8183255B2 (fr) |
| EP (1) | EP2118112B1 (fr) |
| JP (1) | JP5161245B2 (fr) |
| KR (1) | KR101060892B1 (fr) |
| AP (1) | AP2009004958A0 (fr) |
| AU (1) | AU2008212625B2 (fr) |
| BR (1) | BRPI0807346B8 (fr) |
| CA (1) | CA2677572C (fr) |
| CR (1) | CR10968A (fr) |
| DO (1) | DOP2009000201A (fr) |
| EA (1) | EA017937B1 (fr) |
| EC (1) | ECSP099569A (fr) |
| IL (1) | IL200270A (fr) |
| MA (1) | MA31178B1 (fr) |
| MX (1) | MX2009008546A (fr) |
| NZ (1) | NZ578876A (fr) |
| TN (1) | TN2009000331A1 (fr) |
| WO (1) | WO2008096260A1 (fr) |
| ZA (1) | ZA200906032B (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2677572C (fr) | 2007-02-07 | 2012-12-18 | Pfizer Inc. | Nouveaux derives de 3-amino-pyrrolo[3,4-c]pyrazole-5(1h,4h,6h) carbaldehyde |
| US9180127B2 (en) | 2009-12-29 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
| WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
| EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| US9382229B2 (en) | 2011-02-15 | 2016-07-05 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
| CN102093366B (zh) * | 2011-03-04 | 2012-11-28 | 中国医学科学院医药生物技术研究所 | 双环氨基吡唑类化合物及其在抗柯萨奇病毒中的应用 |
| EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
| WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
| EP2760862B1 (fr) | 2011-09-27 | 2015-10-21 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
| US9382239B2 (en) | 2011-11-17 | 2016-07-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
| ES2658395T3 (es) * | 2012-04-04 | 2018-03-09 | Rigel Pharmaceuticals, Inc. | Inhibidores de proteína cinasa C y usos de los mismos |
| WO2013164323A1 (fr) * | 2012-05-03 | 2013-11-07 | F. Hoffmann-La Roche Ag | Dérivés de pyrazole aminopyrimidine en tant que modulateurs de lrrk2 destinés à être utilisés dans le traitement de la maladie de parkinson |
| WO2014063068A1 (fr) | 2012-10-18 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de cycline-dépendante kinase 7 (cdk7) |
| USRE48175E1 (en) | 2012-10-19 | 2020-08-25 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
| US10000483B2 (en) | 2012-10-19 | 2018-06-19 | Dana-Farber Cancer Institute, Inc. | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| WO2014151900A1 (fr) | 2013-03-14 | 2014-09-25 | Rigel Pharmaceuticals, Inc. | Inhibiteurs de protéine kinase c et leurs utilisations |
| EP3057955B1 (fr) | 2013-10-18 | 2018-04-11 | Syros Pharmaceuticals, Inc. | Composes heteroaromatiques utiles dans le traitement de maladies proliferatives |
| AU2014337044A1 (en) | 2013-10-18 | 2016-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
| WO2015164604A1 (fr) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de janus kinase marqués de manière hydrophobe et utilisations associées |
| US10017477B2 (en) | 2014-04-23 | 2018-07-10 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
| JP2017516853A (ja) * | 2014-05-23 | 2017-06-22 | ミングサイト ファーマシューティカルズ，インク． | 自己免疫性疾患の処置 |
| US10870651B2 (en) | 2014-12-23 | 2020-12-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| US10550121B2 (en) | 2015-03-27 | 2020-02-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| EP3307728A4 (fr) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | Thérapie d'association utilisant des inhibiteurs de transcription et des inhibiteurs de kinases |
| WO2017044858A2 (fr) | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinases cycline-dépendantes |
| WO2017087318A1 (fr) * | 2015-11-20 | 2017-05-26 | Mingsight Pharmaceuticals, Inc. | Traitement de maladie auto-immune |
| CN106727582B (zh) * | 2015-11-20 | 2020-06-12 | 深圳明赛瑞霖药业有限公司 | 自身免疫疾病的治疗 |
| AU2017295858A1 (en) | 2016-07-14 | 2019-01-24 | Mingsight Pharmaceuticals, Inc. | Treatment of cancer |
| JP2020522472A (ja) * | 2017-05-25 | 2020-07-30 | ミングサイト ファーマシューティカルズ，インク． | Ｐｋｃ阻害剤の固体状態形態 |
| JP7362600B2 (ja) | 2017-10-11 | 2023-10-17 | エフ． ホフマン－ラ ロシュ アーゲー | Ｒｉｐ１キナーゼ阻害剤として使用するための二環式化合物 |
| US20210069194A1 (en) * | 2018-01-17 | 2021-03-11 | Mingsight Pharmaceuticals, Inc. | Combination therapy for the treatment of cancer |
| CA3099763A1 (fr) | 2018-06-25 | 2020-01-02 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinase de la famille taire et utilisations correspondantes |
| JP7660063B2 (ja) * | 2018-12-28 | 2025-04-10 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用 |
| WO2022261214A1 (fr) * | 2021-06-09 | 2022-12-15 | Mingsight Pharmaceuticals, Inc. | Compositions comprenant des inhibiteurs de pkc-bêta et procédés de préparation associés |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0113176A (pt) | 2000-08-10 | 2003-06-17 | Pharmacia Italia Spa | Compostos biciclo-pirazol, composições farmacêuticas compreendendo os compostos, uso dos compostos na fabricação de medicamentos, processos para a preparação dos compostos, coleção quìmica combinatória e métodos para o tratamento de mamìferos incluindo humanos utilizando os compostos |
| UA81790C2 (uk) | 2002-12-19 | 2008-02-11 | Фармация Италия С.П.А. | Заміщені піролопіразольні похідні як інгібітори кінази |
| BRPI0518509A2 (pt) * | 2005-01-10 | 2008-11-25 | Pfizer | pirrolopirazàis, inibidores de cinase potentes |
| CA2677572C (fr) | 2007-02-07 | 2012-12-18 | Pfizer Inc. | Nouveaux derives de 3-amino-pyrrolo[3,4-c]pyrazole-5(1h,4h,6h) carbaldehyde |
-
2008
- 2008-02-04 CA CA2677572A patent/CA2677572C/fr active Active
- 2008-02-04 AP AP2009004958A patent/AP2009004958A0/xx unknown
- 2008-02-04 JP JP2009548766A patent/JP5161245B2/ja active Active
- 2008-02-04 MX MX2009008546A patent/MX2009008546A/es active IP Right Grant
- 2008-02-04 US US12/523,965 patent/US8183255B2/en active Active
- 2008-02-04 BR BRPI0807346A patent/BRPI0807346B8/pt active IP Right Grant
- 2008-02-04 WO PCT/IB2008/000297 patent/WO2008096260A1/fr not_active Ceased
- 2008-02-04 EA EA200970670A patent/EA017937B1/ru not_active IP Right Cessation
- 2008-02-04 NZ NZ578876A patent/NZ578876A/xx unknown
- 2008-02-04 EP EP08702370.1A patent/EP2118112B1/fr active Active
- 2008-02-04 AU AU2008212625A patent/AU2008212625B2/en active Active
- 2008-02-04 KR KR1020097018673A patent/KR101060892B1/ko active Active
-
2009
- 2009-08-05 TN TNP2009000331A patent/TN2009000331A1/fr unknown
- 2009-08-06 CR CR10968A patent/CR10968A/es unknown
- 2009-08-06 IL IL200270A patent/IL200270A/en not_active IP Right Cessation
- 2009-08-07 DO DO2009000201A patent/DOP2009000201A/es unknown
- 2009-08-07 EC EC2009009569A patent/ECSP099569A/es unknown
- 2009-08-07 MA MA32158A patent/MA31178B1/fr unknown
- 2009-08-31 ZA ZA2009/06032A patent/ZA200906032B/en unknown
-
2012
- 2012-04-18 US US13/450,388 patent/US8877761B2/en active Active
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2014
- 2014-10-03 US US14/506,470 patent/US9518060B2/en active Active
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2016
- 2016-12-12 US US15/376,279 patent/US10316045B2/en active Active
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2019
- 2019-04-17 US US16/387,369 patent/US11220518B2/en active Active
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2021
- 2021-12-01 US US17/539,948 patent/US11780853B2/en active Active
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