[go: up one dir, main page]

JP4571631B2 - イミダゾール誘導体ｉｉｉ - Google Patents

イミダゾール誘導体ｉｉｉ Download PDF

Info

Publication number
JP4571631B2
JP4571631B2 JP2006518089A JP2006518089A JP4571631B2 JP 4571631 B2 JP4571631 B2 JP 4571631B2 JP 2006518089 A JP2006518089 A JP 2006518089A JP 2006518089 A JP2006518089 A JP 2006518089A JP 4571631 B2 JP4571631 B2 JP 4571631B2
Authority
JP
Japan
Prior art keywords
methyl
pyridine
ylethynyl
imidazol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006518089A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009500291A (ja
Inventor
ビュッテルマン，ベルント
チェッカレッリ，シモーナ・マリーア
ヤーシュケ，ゲオルク
コルツェヴスキ，サビーネ
ポーター，リチャード・ヒュー・フィリップ
フィエイラ，エリック
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2009500291A publication Critical patent/JP2009500291A/ja
Application granted granted Critical
Publication of JP4571631B2 publication Critical patent/JP4571631B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006518089A 2003-07-03 2004-07-01 イミダゾール誘導体ｉｉｉ Expired - Fee Related JP4571631B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03014512 2003-07-03
PCT/EP2004/007177 WO2005003117A1 (en) 2003-07-03 2004-07-01 Imidazole derivatives iii

Publications (2)

Publication Number Publication Date
JP2009500291A JP2009500291A (ja) 2009-01-08
JP4571631B2 true JP4571631B2 (ja) 2010-10-27

Family

ID=33560749

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006518089A Expired - Fee Related JP4571631B2 (ja) 2003-07-03 2004-07-01 イミダゾール誘導体ｉｉｉ

Country Status (27)

Country Link
US (1) US7091222B2 (de)
EP (1) EP1644351B1 (de)
JP (1) JP4571631B2 (de)
KR (1) KR100719653B1 (de)
CN (1) CN100562520C (de)
AR (1) AR044973A1 (de)
AT (1) ATE388145T1 (de)
AU (1) AU2004253657B2 (de)
BR (1) BRPI0412158A (de)
CA (1) CA2531210C (de)
CO (1) CO5660258A2 (de)
DE (1) DE602004012268T2 (de)
DK (1) DK1644351T3 (de)
ES (1) ES2300789T3 (de)
HR (1) HRP20080173T3 (de)
IL (1) IL172821A (de)
MX (1) MXPA06000193A (de)
MY (1) MY142085A (de)
NO (1) NO20060112L (de)
NZ (1) NZ544454A (de)
PL (1) PL1644351T3 (de)
PT (1) PT1644351E (de)
RU (1) RU2360911C2 (de)
SI (1) SI1644351T1 (de)
TW (1) TWI252849B (de)
WO (1) WO2005003117A1 (de)
ZA (1) ZA200600026B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
HRP20080363T3 (hr) * 2004-06-01 2008-09-30 F. Hoffmann - La Roche Ag Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora
DE602005007350D1 (de) * 2004-06-01 2008-07-17 Hoffmann La Roche Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors
US20060173048A1 (en) * 2005-02-03 2006-08-03 Mcarthur Silvia G Imidazole derivatives
DE102005062987A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
CN101568531B (zh) 2006-12-21 2013-11-13 弗·哈夫曼-拉罗切有限公司 Mglur5受体拮抗剂的多晶型物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US304910A (en) * 1884-09-09 Robeet h
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
US7531529B2 (en) * 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives

Also Published As

Publication number Publication date
IL172821A (en) 2011-01-31
DE602004012268T2 (de) 2009-03-12
AU2004253657B2 (en) 2009-09-03
AR044973A1 (es) 2005-10-12
EP1644351B1 (de) 2008-03-05
JP2009500291A (ja) 2009-01-08
ATE388145T1 (de) 2008-03-15
BRPI0412158A (pt) 2006-08-22
DK1644351T3 (da) 2008-06-23
CA2531210C (en) 2012-05-29
MXPA06000193A (es) 2006-04-11
CN100562520C (zh) 2009-11-25
EP1644351A1 (de) 2006-04-12
MY142085A (en) 2010-08-30
CA2531210A1 (en) 2005-01-13
CN1823054A (zh) 2006-08-23
TWI252849B (en) 2006-04-11
KR20060029677A (ko) 2006-04-06
WO2005003117A1 (en) 2005-01-13
CO5660258A2 (es) 2006-07-31
SI1644351T1 (sl) 2008-06-30
IL172821A0 (en) 2006-06-11
US7091222B2 (en) 2006-08-15
RU2006103009A (ru) 2006-08-27
RU2360911C2 (ru) 2009-07-10
AU2004253657A1 (en) 2005-01-13
TW200514779A (en) 2005-05-01
PT1644351E (pt) 2008-04-21
NZ544454A (en) 2008-08-29
DE602004012268D1 (de) 2008-04-17
US20050009878A1 (en) 2005-01-13
PL1644351T3 (pl) 2008-08-29
HRP20080173T3 (hr) 2008-06-30
ES2300789T3 (es) 2008-06-16
NO20060112L (no) 2006-01-24
ZA200600026B (en) 2007-05-30
KR100719653B1 (ko) 2007-05-18

Similar Documents

Publication Publication Date Title
US8481548B2 (en) Imidazole derivatives
JP4404896B2 (ja) イミダゾール−４−イル−エチニル−ピリジン誘導体
MXPA06013603A (es) Piridin-4-il-etinil-imidazoles y pirazoles como antagonistas del receptor mglu5.
JP4571631B2 (ja) イミダゾール誘導体ｉｉｉ
JP4490423B2 (ja) イミダゾール誘導体
JP4690395B2 (ja) ｍＧｌｕ５レセプターアンタゴニストとしてのピリジン−４−エチニル−イミダゾール及びピラゾール
JP4395512B2 (ja) グルタミン酸受容体アンタゴニストであるヘテロアリール置換イミダゾール誘導体
EP2456765B1 (de) Imidazolderivate als mglur5-antagonisten
HK1093070B (en) Imidazole derivatives as glutamate receptor antagonists
HK1093071B (en) Heteroaryl-substituted imdazole derivatives as glutamate receptor antagonists

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091110

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100205

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100309

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100413

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100712

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100810

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100812

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130820

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees