JP3557877B2 - Cosmetics obtained by dispersing a lipid dispersion composition in an aqueous medium - Google Patents
Cosmetics obtained by dispersing a lipid dispersion composition in an aqueous medium Download PDFInfo
- Publication number
- JP3557877B2 JP3557877B2 JP30961797A JP30961797A JP3557877B2 JP 3557877 B2 JP3557877 B2 JP 3557877B2 JP 30961797 A JP30961797 A JP 30961797A JP 30961797 A JP30961797 A JP 30961797A JP 3557877 B2 JP3557877 B2 JP 3557877B2
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- Prior art keywords
- dispersion composition
- lipid dispersion
- present
- aqueous medium
- dispersing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006185 dispersion Substances 0.000 title claims description 31
- 239000000203 mixture Substances 0.000 title claims description 27
- 150000002632 lipids Chemical class 0.000 title claims description 23
- 239000002537 cosmetic Substances 0.000 title claims description 17
- 239000012736 aqueous medium Substances 0.000 title claims description 6
- IEZRNEGTKRQRFV-LFBNJJMOSA-N N-octadecanoyl-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC IEZRNEGTKRQRFV-LFBNJJMOSA-N 0.000 claims description 22
- 150000003904 phospholipids Chemical class 0.000 claims description 11
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 10
- 150000005846 sugar alcohols Polymers 0.000 claims description 6
- 235000012000 cholesterol Nutrition 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 description 8
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 7
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 7
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 7
- 230000003020 moisturizing effect Effects 0.000 description 7
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000000686 essence Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 description 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- 102000004201 Ceramidases Human genes 0.000 description 1
- 108090000751 Ceramidases Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 229930183167 cerebroside Natural products 0.000 description 1
- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229940113120 dipropylene glycol Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 1
- 229940033329 phytosphingosine Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明は、保水性、保湿性、エモリエント効果に優れるとともに、Ｎ−ステアロイルフィトスフィンゴシンの結晶性を抑え、安定性が良好な化粧料に関する。
【０００２】
【従来の技術】
セラミドは、皮膚の角質層に存在し、水分保持に必要な脂質バリアを構築し、維持していくために重要な役割を果たしている。角質層にあるセラミドは、セレブロシドがセレブロシダーゼという酵素により分解し変化したものである。セラミドの一部は、セラミダーゼと呼ばれる酵素により、フィトスフィンゴシンおよびスフィンゴシンに変化し、細胞の増殖および分化の調節剤として重要であることが知られている。人間の皮膚には、６種類の異なったタイプのセラミドが存在し、機能もそれぞれ異なっている。また、リン脂質は天然由来の乳化剤として知られており、多くの分野で多目的に利用されている。化粧品分野においては、極めて安全性の高い乳化剤、あるいは保湿剤として多剤型に使用されている。
【０００３】
【発明が解決しようとする課題】
しかしながら、セラミドは、結晶性が高く、溶解する油剤が少ないことから、化粧料中に多量に配合すると、結晶が析出して製品の安定性に支障をきたしたり、セラミドを溶解する油剤によっては、安全性上好ましくない場合があった。そのため、安定性及び安全性の観点から化粧料への配合量には自ずと制約があり、多量に配合できないのが現状であった。従って、セラミドの有する水分保持機能をより発現するために多量に配合することが可能で、かつ、製品中に安定に存在して、結晶析出等の問題を生じることのない安定性並びに安全性に優れた化粧料の開発が望まれていた。
【０００４】
【課題を解決するための手段】
上記実状に鑑み、本発明者らは鋭意研究を重ねた結果、リン脂質とセラミドの一種のＮ−ステアロイルフィトスフィンゴシンを特定重量比で多価アルコールに混合した脂質分散組成物を配合することによって、Ｎ−ステアロイルフィトスフィンゴシンを多量に、かつ安定に配合することが可能で、安全性も高い化粧料を得ることができることを見出し、本発明を完成するに至った。
【０００５】
すなわち本発明は、次の成分（ａ）〜（ｄ）；
（ａ）リン脂質（リゾリン脂質を除く）
（ｂ）Ｎ−ステアロイルフィトスフィンゴシン
（ｃ）多価アルコール
（ｄ）コレステロール又はフィトステロール
を含有し、かつ成分（ａ）と（ｂ）の重量比を（ａ）：（ｂ）＝２：１〜１００：１の範囲に調整した脂質分散組成物を、水性媒体に分散させてなる化粧料である。以下、詳述する。
【０００６】
【発明に実施の形態】
本発明で用いられる成分（ａ）のリン脂質としては、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、ホスファチジルグリセロール、ホスファチジルイノシトール、スフィンゴリン脂質等が挙げられ、もちろんこれらの類似物あるいはこれらの成分を含有する組成物すなわち大豆レシチン、卵黄レシチン等、あるいはそれらの水素添加物も挙げられる。本発明においては、これらのリン脂質を１種又は２種以上組み合わせて用いることができる。
【０００７】
本発明で用いられる成分（ｂ）は、Ｎ−ステアロイルフィトスフィンゴシンである。
【０００８】
本発明で用いられる成分（ｃ）の多価アルコールとしては、１，３−ブチレングリコール、プロピレングリコール、ジプロピレングリコール、グリセリン、ジグリセリン、ソルビトール、マルチトール、ポリエチレングリコール等が挙げられる。本発明においては以上の様な多価アルコールを１種または２種以上を組み合わせて用いることができる。
【０００９】
本発明の脂質分散組成物においては、成分（ａ）と（ｂ）の重量比が、（ａ）：（ｂ）＝２：１〜１００：１であることを必須とし、より好ましくは、（ａ）：（ｂ）＝３：１〜２０：１である。成分（ｂ）に対する成分（ａ）の重量比が２未満であると、リン脂質中へのＮ−ステアロイルフィトスフィンゴシンの分散性が不充分となり、Ｎ−ステアロイルフィトスフィンゴシンの結晶が析出してしまう。また、成分（ｂ）に対する成分（ａ）の重量比が１００を超えると、脂質分散組成物中のＮ−ステアロイルフィトスフィンゴシン量が少ないため、それ自身の効果が得られない。
【００１０】
本発明の脂質分散組成物中に占める成分（ａ）と（ｂ）の合計量は、５〜８０重量％（以下、単に「％」と記す）が好ましく、より好ましくは、１０〜６０％である。脂質分散組成物中の成分（ａ）と（ｂ）の合計量が５％未満であると、Ｎ−ステアロイルフィトスフィンゴシン配合による保湿効果が得られにくい場合があり、また、８０％を超えて配合すると、リン脂質中へのＮ−ステアロイルフィトスフィンゴシンの分散性が不充分となる場合がある。
【００１１】
本発明の脂質分散組成物には、さらに成分（ｄ）として、細胞間脂質の一つであり、皮膚の保湿又は水分の蒸散を防ぐ働きを有するコレステロール及び／又はフィトステロールを配合する。この配合により、皮膚のバリア機能が高まり、また安定性も良好なものとなる。これらの１種又は２種以上を組み合わせて用いることができる。
【００１２】
脂質分散組成物中のコレステロール及び／又はフィトステロールの含有量は、リン脂質に対して０．１〜１倍量であることが好ましい。この範囲で用いれば、より安定性が顕著に向上する。
【００１３】
この脂質分散組成物の化粧料への含有量は特に限定されないが、好ましくは、化粧料中での成分（ａ）と（ｂ）の合計量が０．０５〜１０％、より好ましくは、０．１〜５％となるように配合すると良い。
【００１４】
本発明の化粧料は、上述した特定重量比の成分（ａ）〜（ｄ）を含有する脂質分散組成物を水性媒体に分散させることにより得られるが、より好適には、予め加熱混合して均一な分散状態とした脂質分散組成物を用いることが好ましい。予め加熱混合して均一な分散状態とすることにより、リン脂質へのＮ−ステアロイルフィトスフィンゴシンの分散性を良好なものとし、Ｎ−ステアロイルフィトスフィンゴシンの結晶防止性をより優れたものとすることができる。
【００１５】
さらに、より好ましい化粧料としては、上述した予め加熱混合して均一な分散状態とした脂質分散組成物を、同程度の温度とした水性媒体に攪拌しながら混合し、それを冷却して化粧料とすることが好ましい。水性媒体としては、水を必須とし、さらに低級アルコール、多価アルコール、水溶性高分子、水溶性美容成分等を配合することができる。
【００１６】
本発明の化粧料は、上記必須成分の他に、化粧料に配合される成分、例えば、油剤、界面活性剤、粉体、顔料、染料、水溶性高分子、紫外線吸収剤、防腐剤、香料等を本発明の効果を妨げない範囲で配合することができる。
【００１７】
【実施例】
以下に実施例を挙げて本発明をさらに詳述するが、本発明はこれらによりなんら限定されるものではない。
【００１８】
実施例１〜２及び比較例１〜４ 脂質分散組成物
下記表１に示す組成の脂質分散組成物を製造し、リン脂質中へのＮ−ステアロイルフィトスフィンゴシンの分散性及び分散安定性について評価した。
【００１９】
【表１】
（製造方法）
成分１〜５を８０℃に加熱混合し、均一に分散して脂質分散組成物を得た。
【００２１】
（評価方法）
Ｎ−ステアロイルフィトスフィンゴシンの分散性及び分散安定性得られた脂質分散組成物を１０％希釈物となるように精製水に分散混合し、これを顕微鏡にて観察して、Ｎ−ステアロイルフィトスフィンゴシンの結晶析出の有無を下記基準より評価した。さらに、この希釈サンプルを４０℃の恒温槽に４週間セットして、同様に評価した。
［評価］
◎：全く認められない。
○：ほとんど認められない。
△：やや認められる。
×：明らかに認められる。
得られた結果を表１に併せて示す。
【００２２】
表１の結果から明らかなように、本発明に係わる実施例１〜２の脂質分散組成物は、Ｎ−ステアロイルフィトスフィンゴシンの分散性及び分散安定性に優れたものであった。それに対し、比較例においては、良好な結果が得られなかった。
【００２３】
実施例３〜４及び比較例５〜８ 美容液
下記表２に示す組成の美容液を製造し、Ｎ−ステアロイルフィトスフィンゴシンの分散性及び分散安定性、並びに保湿効果について評価した。
【００２４】
【表２】
（製造方法）
Ａ：成分１〜５を９０℃にて加熱混合する。
Ｂ：成分６〜９を９０℃にて加熱混合する。
Ｃ：ＢにＡを添加して攪拌し、これを冷却して美容液を得た。
【００２６】
（評価方法）
Ｎ−ステアロイルフィトスフィンゴシンの分散性及び分散安定性については、前述と同様の方法で評価を行った。保湿効果については、得られた化粧水を専門評価パネル８名により皮膚に塗布した際の保湿効果を下記基準にて５段階評価し、さらにその平均点から判定した。
［評価］
５点：非常に良好。
４点：良好。
３点：普通。
２点：やや不良。
１点：不良。
［判定］
◎：平均点４．５点以上
○：平均点３．５点以上４．５点未満
△：平均点２．５点以上３．５点未満
×：平均点２．５点未満
得られた結果を表２に併せて示す。
【００２７】
表２の結果から明らかなように、本発明に係わる実施例３〜４の美容液は、Ｎ−ステアロイルフィトスフィンゴシンの分散性及び分散安定性に優れ、且つ良好な保湿効果を兼ね備えたものであった。それに対し、比較例においては、全ての項目を満足し得る結果は得られなかった。
【００２８】
実施例５ 化粧水
（成分） （％）
１．水素添加大豆リン脂質 ２．０
２．Ｎ−ステアロイルフィトスフィンゴシン ０．５
３．コレステロール ０．５
４．１，３−ブチレングリコール １５．０
５．グリセリン ５．０
６．キサンタンガム ０．１
７．防腐剤 適量
８．精製水 残量
【００２９】
（製造方法）
Ａ：成分１〜５を９０℃にて加熱混合する。
Ｂ：成分６〜８を９０℃にて加熱混合する。
Ｃ：ＢにＡを添加して攪拌し、これを冷却して化粧水を得た。
実施例５は、保湿性とエモリエント感に優れ、安定性も良好な化粧水であった。
【００３０】
【発明の効果】
以上詳述したように、本発明の脂質分散組成物は、Ｎ−ステアロイルフィトスフィンゴシンの分散性及び分散安定性に優れたものである。さらに、その脂質分散組成物を配合した化粧料は、Ｎ−ステアロイルフィトスフィンゴシンを安定に、且つ多量に配合することができ、保湿効果に優れたものである。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention, water retention, moisture retention, excellent in emollient effect, reducing the crystallinity of the N- stearoyl sulfide preparative sphingosine, Stability good reduction粧料.
[0002]
[Prior art]
Ceramide is present in the stratum corneum of the skin and plays an important role in building and maintaining the lipid barrier required for water retention. Ceramide in the stratum corneum is obtained by degrading cerebroside by an enzyme called cerebrosidase. A part of ceramide is converted to phytosphingosine and sphingosine by an enzyme called ceramidase, and is known to be important as a regulator of cell growth and differentiation. There are six different types of ceramides in human skin, each with different functions. Phospholipids are known as naturally-derived emulsifiers and are used for many purposes in many fields. In the cosmetics field, it is used as a highly safe emulsifier or humectant in a multi-drug form.
[0003]
[Problems to be solved by the invention]
However, since ceramide has high crystallinity and dissolves a small amount of oil, if incorporated in a large amount in cosmetics, crystals will precipitate and hinder the stability of the product, or depending on the oil which dissolves ceramide, There were cases where safety was not favorable. Therefore, from the viewpoints of stability and safety, there is naturally a limitation on the amount of the compounding agent in cosmetics, and at present, it is not possible to compound a large amount. Therefore, it can be blended in a large amount in order to further exhibit the water retention function of ceramide, and is present in the product stably and without causing problems such as crystal precipitation and stability. The development of excellent cosmetics has been desired.
[0004]
[Means for Solving the Problems]
In view of the above situation, the present inventors have conducted intensive studies, and as a result, by blending a lipid dispersion composition in which N-stearoylphytosphingosine, a kind of phospholipid and ceramide , is mixed with a polyhydric alcohol at a specific weight ratio, The present inventors have found that a large amount of N-stearoylphytosphingosine can be stably blended and a highly safe cosmetic can be obtained, and the present invention has been completed.
[0005]
That is, the present invention provides the following components (a) to ( d ):
(A) Phospholipids (excluding lysophospholipids)
(B) N-stearoyl phytosphingosine (c) polyhydric alcohol
(D) a lipid dispersion composition containing cholesterol or phytosterol and wherein the weight ratio of components (a) and (b) is adjusted to the range of (a) :( b) = 2: 1 to 100: 1. It is a cosmetic prepared by dispersing a substance in an aqueous medium . The details will be described below.
[0006]
BEST MODE FOR CARRYING OUT THE INVENTION
Examples of the phospholipid of the component (a) used in the present invention include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingolipids and the like, and of course contain analogs thereof or these components. The composition, that is, soybean lecithin, egg yolk lecithin, or the like, or a hydrogenated product thereof is also included. In the present invention, these phospholipids can be used alone or in combination of two or more.
[0007]
Component (b) used in the present invention is N -stearoyl phytosphingosine.
[0008]
Examples of the polyhydric alcohol of the component (c) used in the present invention include 1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin, diglycerin, sorbitol, maltitol, polyethylene glycol and the like. In the present invention, the above polyhydric alcohols can be used alone or in combination of two or more.
[0009]
In the lipid dispersion composition of the present invention, the weight ratio of Ingredient (a) and (b) is, (a) :( b) = 2: 1~100: and mandatory to be a 1, more preferably, (A): (b) = 3: 1 to 20: 1. If the weight ratio of the component (a) to the component (b) is less than 2, the dispersibility of N-stearoyl phytosphingosine in the phospholipid will be insufficient, and crystals of N-stearoyl phytosphingosine will precipitate. On the other hand, if the weight ratio of the component (a) to the component (b) exceeds 100, the effect of itself cannot be obtained because the amount of N-stearoylphytosphingosine in the lipid dispersion composition is small.
[0010]
The total amount of components (a) and (b) occupying in the lipid dispersion composition of the present invention is preferably from 5 to 80% by weight (hereinafter simply referred to as "%"), more preferably from 10 to 60%. is there. When the total amount of the components (a) and (b) in the lipid dispersion composition is less than 5%, the moisturizing effect of N-stearoyl phytosphingosine may not be obtained, and more than 80% may be added. Then, the dispersibility of N-stearoyl phytosphingosine in the phospholipid may be insufficient.
[0011]
The lipid dispersion composition of the present invention, further as a component (d), is one of the intercellular lipids, you blended cholesterol and / or phytosterol has a function of preventing the evaporation of moisturizing or moisture of the skin. This formulation increases the barrier function of the skin, also that Do a favorable stability. It can be used in combination of one or more of these.
[0012]
The content of cholesterol and / or phytosterol in the lipid dispersion composition is preferably 0.1 to 1 times the amount of the phospholipid. When used in this range, the stability is remarkably improved.
[0013]
The content of the lipid dispersion composition in the cosmetic is not particularly limited, but preferably, the total amount of the components (a) and (b) in the cosmetic is 0.05 to 10%, more preferably 0 to 10%. It may be blended so as to be 0.1 to 5%.
[0014]
The cosmetic of the present invention can be obtained by dispersing the lipid dispersion composition containing the components (a) to (d) in the above-described specific weight ratio in an aqueous medium . More preferably, the cosmetic is heated and mixed in advance. It is preferable to use a lipid dispersion composition in a uniform dispersion state. By preliminarily heating and mixing to form a uniform dispersion state, the dispersibility of N-stearoyl phytosphingosine in the phospholipid can be improved, and the anti-crystallization property of N-stearoyl phytosphingosine can be improved. it can.
[0015]
Further, as a more preferable cosmetic, the above-mentioned lipid dispersion composition in a uniform dispersion state by heating and mixing in advance is mixed with an aqueous medium having a similar temperature while stirring, and then cooled to obtain a cosmetic. It is preferable that As the aqueous medium, water is essential, and a lower alcohol, a polyhydric alcohol, a water-soluble polymer, a water-soluble cosmetic ingredient, and the like can be further blended.
[0016]
The cosmetic of the present invention includes, in addition to the above essential components, components to be blended in the cosmetic, such as oils, surfactants, powders, pigments, dyes, water-soluble polymers, ultraviolet absorbers, preservatives, and fragrances. And the like can be blended in a range that does not impair the effects of the present invention.
[0017]
【Example】
Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.
[0018]
Examples 1 and 2 and Comparative Examples 1 to 4 Lipid dispersion composition A lipid dispersion composition having the composition shown in Table 1 below was produced, and the dispersibility and dispersion stability of N-stearoylphytosphingosine in phospholipid were evaluated. .
[0019]
[Table 1]
(Production method)
Components 1 to 5 were heated and mixed at 80 ° C. and uniformly dispersed to obtain a lipid dispersion composition.
[0021]
(Evaluation method)
Dispersibility and dispersion stability of N-stearoyl phytosphingosine The obtained lipid dispersion composition was dispersed and mixed in purified water so as to be a 10% dilution, and this was observed with a microscope, and the N-stearoyl phytosphingosine was analyzed . The presence or absence of crystal precipitation was evaluated based on the following criteria. Further, this diluted sample was set in a thermostat at 40 ° C. for 4 weeks, and evaluated in the same manner.
[Evaluation]
◎: Not recognized at all.
：: Almost no recognition.
Δ: Slightly recognized.
×: clearly recognized.
The results obtained are shown in Table 1.
[0022]
As is clear from the results in Table 1, the lipid dispersion compositions of Examples 1 and 2 according to the present invention were excellent in the dispersibility and dispersion stability of N-stearoyl phytosphingosine . On the other hand, in the comparative example, good results were not obtained.
[0023]
Examples 3 to 4 and Comparative Examples 5 to 8 Essence Essences having the composition shown in Table 2 below were produced, and the dispersibility and dispersion stability of N-stearoyl phytosphingosine and the moisturizing effect were evaluated.
[0024]
[Table 2]
(Production method)
A: Components 1 to 5 are heated and mixed at 90 ° C.
B: Components 6 to 9 are heated and mixed at 90 ° C.
C: A was added to B and stirred, and the mixture was cooled to obtain a serum.
[0026]
(Evaluation method)
The dispersibility and dispersion stability of N-stearoyl phytosphingosine were evaluated in the same manner as described above. With respect to the moisturizing effect, the moisturizing effect when the obtained lotion was applied to the skin by eight professional evaluation panels was evaluated on a 5-point scale based on the following criteria, and further determined from the average score.
[Evaluation]
5 points: very good.
4 points: good.
3 points: Normal.
2 points: Somewhat poor.
1 point: defective.
[Judgment]
◎: Average point of 4.5 points or more ：: Average point of 3.5 points or more and less than 4.5 points △: Average point of 2.5 points or more and less than 3.5 points X: Result obtained with an average point of less than 2.5 points Are also shown in Table 2.
[0027]
As is clear from the results in Table 2, the essences of Examples 3 to 4 according to the present invention have excellent dispersibility and dispersion stability of N-stearoylphytosphingosine and have a good moisturizing effect. Was. On the other hand, in the comparative example, a result satisfying all items was not obtained.
[0028]
Example 5 Lotion (Ingredient) (%)
1. Hydrogenated soybean phospholipid 2.0
2. N-stearoyl phytosphingosine 0.5
3. Cholesterol 0.5
4.1 1,3-butylene glycol 15.0
5. Glycerin 5.0
6. Xanthan gum 0.1
7. Preservative qs 8. Purified water balance
(Production method)
A: Components 1 to 5 are heated and mixed at 90 ° C.
B: Components 6 to 8 are heated and mixed at 90 ° C.
C: A was added to B and stirred, and the mixture was cooled to obtain a lotion.
Example 5 was a lotion having excellent moisture retention and emollient feeling and good stability.
[0030]
【The invention's effect】
As described above in detail, the lipid dispersion composition of the present invention has excellent dispersibility and dispersion stability of N-stearoylphytosphingosine . Furthermore, the cosmetics containing the lipid dispersion composition can stably and in large amounts contain N-stearoyl phytosphingosine and have an excellent moisturizing effect.
Claims (1)
（ａ）リン脂質（リゾリン脂質を除く）
（ｂ）Ｎ−ステアロイルフィトスフィンゴシン
（ｃ）多価アルコール
（ｄ）コレステロール又はフィトステロール
を含有し、かつ成分（ａ）と（ｂ）の重量比を（ａ）：（ｂ）＝２：１〜１００：１の範囲に調整した脂質分散組成物を、水性媒体に分散させてなる化粧料。The following components (a) to ( d ):
(A) Phospholipids (excluding lysophospholipids)
(B) N-stearoyl phytosphingosine (c) polyhydric alcohol
(D) a lipid dispersion composition containing cholesterol or phytosterol and wherein the weight ratio of components (a) and (b) is adjusted to the range of (a) :( b) = 2: 1 to 100: 1. Cosmetics obtained by dispersing a substance in an aqueous medium .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30961797A JP3557877B2 (en) | 1997-10-24 | 1997-10-24 | Cosmetics obtained by dispersing a lipid dispersion composition in an aqueous medium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30961797A JP3557877B2 (en) | 1997-10-24 | 1997-10-24 | Cosmetics obtained by dispersing a lipid dispersion composition in an aqueous medium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11130651A JPH11130651A (en) | 1999-05-18 |
| JP3557877B2 true JP3557877B2 (en) | 2004-08-25 |
Family
ID=17995197
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP30961797A Expired - Lifetime JP3557877B2 (en) | 1997-10-24 | 1997-10-24 | Cosmetics obtained by dispersing a lipid dispersion composition in an aqueous medium |
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| Country | Link |
|---|---|
| JP (1) | JP3557877B2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5109065B2 (en) * | 2006-10-04 | 2012-12-26 | 株式会社コーセー | Vesicle composition and skin external preparation using the same |
| JP5112673B2 (en) * | 2006-10-16 | 2013-01-09 | 株式会社コーセー | Ceramide-containing composition and external preparation for skin containing the same |
| JP5882108B2 (en) | 2011-03-31 | 2016-03-09 | 花王株式会社 | Vesicle composition |
| JP6118524B2 (en) * | 2012-08-23 | 2017-04-19 | 花王株式会社 | Aqueous composition in a container |
| KR102084672B1 (en) * | 2016-09-28 | 2020-03-04 | 가부시키가이샤 만다무 | Cosmetic composition |
| JP7008036B2 (en) * | 2016-12-27 | 2022-02-10 | 花王株式会社 | Method for manufacturing ceramide fine particle dispersion |
| CN113226277B (en) | 2018-12-26 | 2023-12-01 | 日本精化株式会社 | Whitening agent, hyaluronic acid production promoter, collagen production promoter, intracellular active oxygen scavenger, irritation relieving agent, wrinkle improving agent, complex, cosmetic and skin external preparation |
| WO2022102730A1 (en) * | 2020-11-13 | 2022-05-19 | 株式会社日本触媒 | Lipid-particle-containing cosmetic composition including phospholipid, and cosmetic quasi-drug |
| JP7734501B2 (en) * | 2021-01-26 | 2025-09-05 | 株式会社アルビオン | Cosmetic composition and method for producing the same |
| JP2022167254A (en) * | 2021-04-23 | 2022-11-04 | クラシエホームプロダクツ株式会社 | aftershave agent |
-
1997
- 1997-10-24 JP JP30961797A patent/JP3557877B2/en not_active Expired - Lifetime
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