JP2799268B2 - Automatic analyzer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic analyzer for analyzing blood, various body fluids and the like in a hospital or a laboratory.

[0002]

2. Description of the Related Art There is an automatic analyzer for separating a sample such as blood into a liquid component portion and a solid component portion by centrifugation, extracting only the liquid component from the separated sample, and analyzing the extracted liquid component. In this automatic analyzer, of the liquid component and the solid component in the sample container, the liquid component is sucked by the suction and discharge mechanism. At this time, the amount of the liquid component in the sample container is estimated by irradiating the sample container with white light. In other words, utilizing the fact that the transmittance of the white light is different between the liquid component layer and the solid component layer of the specimen,
A boundary point between the liquid component and the solid component in the sample container is detected. Then, the amount of the liquid component is estimated from the detected boundary point, and it is determined whether or not the amount satisfies the amount of the sample required for the test.

When the amount of the liquid component satisfies the amount required for the inspection, the liquid component sucked by the suction and discharge mechanism is discharged to the inspection container. Then, the sample liquid component in the test container is analyzed. Known examples of automatic analyzers include those described in Japanese Patent Publication No. 1-29111,
There is one described in JP-A-58-105066.

Among the above known examples, Japanese Patent Application Laid-Open No. 58-105
No. 066 discloses a technique in which a predetermined amount of a sample is sucked from a sample container by a suction and discharge mechanism. When the inside of a nozzle is clogged or the viscosity of a sample liquid component is high, the sample is sucked. This is a countermeasure for the case where the amount of the sample to be measured becomes less than a certain amount. That is, the pressure in the liquid suction / discharge cylinder is detected, and the detected pressure value is determined.
When the pressure value is larger than a predetermined value, for example, it is determined that a certain amount of the sample cannot be aspirated, the operation is stopped, and a warning is issued.

[0005]

However, in an automatic analyzer that separates a sample into a liquid component and a solid component, aspirates and extracts the liquid component from the separated sample, and analyzes the extracted liquid component, Since the boundary between the liquid component and the solid component is detected and estimated by, for example, white light irradiation, the amount of the liquid is estimated, and therefore, there are the following first, second, and third problems. First, the separation boundary layer between the liquid component and the solid component by centrifugation or the like is not always perpendicular to the sample container. That is, as shown in FIG.
And the solid component 13 may be inclined with respect to the sample container 1. In this case, as shown in FIG.
It is assumed that the upper inclined portion 2 of 2 is detected as a boundary surface between the liquid component and the solid component. Then, of the liquid components 9,
The liquid component 9 </ b> R located below the upper part 2 remains in the sample container 1. Therefore, the secondary specimen container 4
The upper surface 4 of the liquid component 9 </ b> A discharged to 6 is lower than the upper surface 7 when the entire liquid component 9 is discharged to the container 46. As a result, there is a possibility that the inspection process must be interrupted due to a shortage of the sample amount even though there is a sufficient amount of the liquid component. In addition, as shown in FIG. 6B, it is assumed that the inclined lower portion 3 of the separating agent 12 is detected as a boundary surface. In this case, the upper surface 5 of the liquid component 9A discharged into the secondary sample container 46 is lower than the upper surface 8 of the estimated liquid amount, which also becomes insufficient in the sample amount, and the test process must be interrupted. There was a possibility.

Second, a label for specimen identification is usually attached around the specimen container 1. If the label covers the above-mentioned boundary surface for some reason, the boundary surface is illuminated by white light irradiation. The detection became impossible, and the inspection process had to be interrupted.

Third, there is no problem if a predetermined volume of the sample is placed in the sample container 1, but in practice, the amount of the sample to be previously stored fluctuates. When the sample volume is small, even if the interface between the liquid component and the solid component is accurately detected, it may not be possible to extract the liquid volume required for the test. did not become.

Recently, an automatic analyzer that executes a plurality of types of inspection items by combining a plurality of inspection units has been proposed. In this case, the sample amount required for a plurality of types of test items must be accurately and efficiently extracted from the sample container 1. Further, after one test item is completed, it is necessary to have a sample amount management function such as judging whether or not the sample amount remains in a necessary amount for the next test item.

Therefore, an object of the present invention is to realize an automatic analyzer that can efficiently extract a liquid component from a sample separated into a liquid component and a solid component and accurately detect the amount of the extracted liquid component. . Furthermore, another object of the present invention is to efficiently extract a liquid component from a sample separated into a liquid component and a solid component, accurately detect the amount of the extracted liquid component, and after the test is completed. It is an object of the present invention to realize an automatic analyzer having a function of grasping and managing an accurate remaining sample amount.

[0010]

SUMMARY OF THE INVENTION The present invention is configured as follows to achieve the above object. A sample container for holding a sample in which a solid component and a liquid component are separated, a nozzle, a suction / discharge mechanism for suctioning and discharging the liquid component, and a suction / discharge pressure of the suction / discharge mechanism detected by the nozzle; Pressure detector, nozzle moving means for moving the nozzle, a nozzle position determining unit for determining the position of the nozzle based on a detection signal from the pressure detector, and storage for storing the amount of the liquid component extracted from the sample container. Part and the nozzle, while performing the suction operation, moved to the opening of the sample container, by the position signal from the determination unit, to determine that the nozzle has moved from the liquid component upper surface in the sample container to the solid component upper surface, The amount of liquid component sucked by the suction and discharge mechanism is calculated from the operation amount of the suction and discharge mechanism during this movement, the calculated amount of liquid component is stored in the storage unit, and the nozzle is set to the sample volume. Comprising an arithmetic control unit for moving from the inner to the outside.

Preferably, in the above automatic analyzer,
The sucked liquid component is discharged into the transparent container, the light emitting means for irradiating the transparent container with light, the light from the light emitting means, the photoelectric conversion means for irradiating through the transparent container, and the light from the photoelectric conversion means A liquid amount calculating unit that calculates the liquid component amount in the transparent container based on the signal of the liquid container, and a calibration unit that updates the liquid component amount stored in the storage unit to the liquid component amount calculated by the liquid amount calculating unit. And further comprising:

A sample container placement section in which a sample container containing a sample in which a solid component and a liquid component are separated is placed; and a liquid component is extracted from the sample contained in the sample container.
A sample extraction unit that discharges to a secondary sample container, a plurality of inspection units that test a sample, a sample transport unit that transports a secondary sample container to the inspection unit, the sample extraction unit, a plurality of inspection units, A controller for controlling the operation of the sample transporter, wherein the sample extractor has a nozzle and a suction and discharge mechanism for suctioning and discharging the liquid component by the nozzle, and a suction and discharge mechanism A pressure detector that detects the suction and discharge pressure of the mechanism, and a nozzle moving unit that moves the nozzle, and the control unit has a detection signal from the pressure detector,
A nozzle position determining unit that determines the position of the nozzle, a storage unit that stores the amount of the liquid component extracted from the sample container, and a nozzle that is moved to the opening of the sample container while performing a suction operation. Based on the position signal, it is determined that the nozzle has moved from the upper surface of the liquid component in the sample container to the upper surface of the solid component, and the amount of the liquid component sucked by the suction / ejection mechanism is calculated from the operation amount of the suction / ejection mechanism during this movement. And, while storing the calculated liquid component amount in the storage unit, an operation control unit that moves the nozzle from the inside of the sample container to the outside,
An analysis instructing unit that instructs the operation of the plurality of test units and the sample transport unit, a usage amount calculating unit that calculates a sample usage amount in each testing unit, and a usage amount calculated by the usage amount calculation unit is stored in a storage unit. A calibration unit for subtracting and updating the calculated liquid component amount.

Preferably, in the above automatic analyzer,
The sucked liquid component is discharged into the transparent container, the light emitting means for irradiating the transparent container with light, the light from the light emitting means, the photoelectric conversion means for irradiating through the transparent container, and the light from the photoelectric conversion means And a liquid amount calculation unit for calculating the amount of the liquid component in the transparent container based on the signal of (a), and a sample amount measuring means in the secondary container having the liquid component stored in the storage unit. The amount is updated to the liquid component amount calculated by the liquid amount calculation unit, and every time the liquid component in the secondary sample container is used for the test, the sample amount in the secondary container
The amount of the remaining liquid component in the secondary sample container is detected.

Preferably, in the above automatic analyzer, the analysis instructing unit compares the sample usage amount calculated by the usage amount calculation unit with the residual liquid component amount in the secondary sample container, and If the residual liquid component amount is smaller than the used amount, the operation of the inspection unit is stopped.

Still preferably, in the above-mentioned automatic analyzer, the analysis instructing section performs an alarm display by the display means when the amount of the remaining liquid component is smaller than the amount of the sample used.

[0016]

The nozzle approaches the upper surface of the liquid component in the sample container while performing the suction operation. When the nozzle contacts the upper surface of the liquid component, the suction pressure of the suction / discharge mechanism changes suddenly. Accordingly, the nozzle position determination unit detects that the nozzle has reached the upper surface of the liquid component. Subsequently, the nozzle moves toward the upper surface of the solid component in the sample container while sucking the liquid component. When the nozzle contacts the upper surface of the solid component, the suction pressure of the suction and discharge mechanism changes suddenly. Thus, the nozzle position determination unit detects that the nozzle has reached the upper surface of the solid component. Then, the suction operation of the nozzle is stopped. The arithmetic control unit calculates the amount of the liquid component sucked while the nozzle moves from the upper surface of the liquid component to the upper surface of the solid component, and stores the calculated amount of the liquid component in the storage unit. When a part of the sucked liquid component amount is used for inspection, the used liquid component amount is subtracted from the liquid component amount stored in the storage unit. Then, the remaining liquid component amount is stored in the storage unit.

[0017]

FIG. 1 is a schematic diagram showing a main part of an automatic analyzer according to an embodiment of the present invention. In FIG. 1, 47 is a syringe, 48 is a syringe drive motor, and 41 is a dispensing nozzle. 63 is the syringe 47 and the dispensing nozzle 41
The tube 50 is connected to and is a pressure detector for detecting the pressure in the tube 63. The nozzle 41, the tube 63, the syringe 47, and the motor 48 constitute a suction / discharge mechanism. Reference numeral 40 denotes a motor for driving the nozzle up and down, and 55 denotes a motor for driving the nozzle left and right. These motors 40 and 55 constitute a nozzle moving unit. Further, 57 is a light emitting lamp, 58 is a lens for converting parallel light, 62 is a filter for separating light, 59 is a photoelectric converter, 6
1 is a control unit. The control unit 61 has the functional blocks shown in FIG.

That is, in FIG. 2, reference numeral 611 denotes a nozzle position judging unit for judging a nozzle position based on a pressure signal from the pressure detector 50, 612 an arithmetic control unit, and 613 a nozzle driving unit for driving the motors 40 and 55. , 614 are syringe driving units for driving the motor 48. 615
Is a memory that stores the liquid amount of the sample, and 617 is a liquid amount calculation unit that calculates the sample liquid amount based on the signal from the photoelectric converter 59. Reference numeral 616 denotes a calibration unit for calibrating the liquid amount stored in the memory 615.

In FIG. 1 and FIG.
When the instruction to start the sample extraction is issued from Step 6, the arithmetic control unit 612
Drives the motor 55 via the nozzle driving unit 613,
The dispensing nozzle 41 is moved to a substantially vertical center line of the sample container 42. Then, the arithmetic control unit 612 outputs the time t0.
Thereafter, the nozzle drive unit 613 and the syringe drive unit 614 are controlled so that the nozzle 41 approaches the sample container 42 substantially along the vertical center line while performing the suction operation, and is inserted into the opening. Here, 51 indicates the driving pattern of the nozzle tip, 52 indicates the operation pattern of the syringe, and 60 indicates the pressure in the tube 63.

When the tip of the nozzle 41 reaches the upper surface of the liquid component 43 at time t1, the signal of the pressure detector 50 sharply rises (waveform 53). At this point, nozzle 41
Is temporarily stopped, the nozzle 41 is raised by a certain amount, and the syringe 47 is returned to the original state. Then, the liquid component in the sample container 42 is sucked into the nozzle 41 while lowering the syringe 47 and the nozzle 41 again from the time point t2.

During suction lowering, at time t3, the nozzle 41
However, when it enters the separating agent 44, the signal of the pressure detector 50 sharply rises (waveform 54). At this point, nozzle 41
And the suction by the syringe 47 is stopped. The amount of liquid to be extracted from the nozzle 56
Is accurately calculated by the arithmetic control unit 612. That is, instead of estimating the liquid component amount in the sample container 42 by optical means or the like, the liquid amount actually extracted by the nozzle 41 is calculated. Therefore, for example, as shown in FIG. 6C, even when the separating agent 12 is inclined, the amount of the extracted liquid can be accurately grasped. In addition, nozzle 4
1 descends and contacts the separating agent 12 at the position where the separating agent 1
2, the liquid component 9R remaining in the container 1 after the extraction of the liquid component is about half as compared with the case shown in FIG.

The liquid amount calculated as described above is stored in the memory 615. Thereafter, the nozzle 41 is moved up to the initial position at time t4. Next, the nozzle 41 is moved in the left-right direction to a position above another container. Then, at time t5, the nozzle 41 is lowered with respect to the other containers, and from time t6 to t7, of the liquid components,
The desired amount is discharged.

The liquid component 4 sucked into the nozzle 41
3, it is assumed that a certain amount is ejected for the inspection and the liquid component remains in the syringe 47. In this case, in order to accurately measure the remaining amount of the liquid component of the syringe 47, it is necessary to dispense the remaining liquid component into a container. In such a case, the remaining liquid component is discharged into the secondary sample container 46.
Then, the secondary specimen container 46 is irradiated with white light from the light emitting lamp 57 via the lens 58. The light transmitted through the secondary sample container 46 is separated into three primary colors via the filter 62, and the separated light is detected by the photoelectric converter 59.
Then, the detection signal from the photoelectric converter 59 is supplied to the liquid amount calculation unit 617. In this case, the portion corresponding to the liquid is yellow to red, and the red light and the green light have high intensity. Further, since the portion other than the liquid is transparent, the red light, the green light, and the blue light are observed as having substantially the same intensity. In this way, the liquid amount calculation unit 617 identifies where the liquid level is in the secondary sample container 46, and calculates the remaining liquid component. The liquid amount calculation unit 617 supplies a signal indicating the remaining amount of the liquid component to the calibration unit 616. The calibration unit 616 updates the liquid amount stored in the memory 615 to the remaining amount of the liquid component supplied from the liquid amount calculation unit 617.

As described above, according to one embodiment of the present invention, the sample container 4
2 and the liquid component suction amount is calculated based on a change in the pressure in the tube 63. Thus, the suction of the liquid component and the calculation of the suction amount are performed almost simultaneously, so that the efficiency of the liquid component extraction and the detection of the liquid component amount and the accuracy of the liquid component amount detection are improved. Therefore, it is possible to realize an automatic analyzer that can efficiently extract a liquid component and accurately detect the amount of the extracted liquid component. Further, according to the embodiment of the present invention, the amount of the liquid component sucked by the dispensing nozzle 41 is stored in the memory 615, and the remaining liquid after the test is discharged to the secondary sample container 46 to be discharged. The liquid amount is optically detected, and the liquid component amount stored in the memory 615 is updated to the detected remaining liquid amount. Therefore, it is possible to realize an automatic analyzer having a function of automatically grasping and managing an accurate remaining sample amount.

FIG. 3 is a schematic configuration diagram of another embodiment of the present invention, and FIG. 4 is a functional block diagram of the control unit 61A.
The example of FIG. 3 is an example in which a plurality of inspection units are combined and applied to an automatic analyzer that executes a plurality of types of inspection items. Although not shown in the example of FIG. 3, the sample extracting unit is the same as the example of FIG. Further, in the example of FIG. 4, the same parts as those in the example of FIG. 2 are denoted by the same reference numerals. The example of FIG. 4 is obtained by adding an analysis instruction unit 618, a usage amount calculation unit 619, and a sample amount table 620 to the example of FIG.

3 and 4, a sample container 30 containing a sample is set in a sample erection section 21 by an operator. Subsequently, the operator instructs the analysis instruction unit 618 to move the sample via the console 66. Then, the analysis instruction unit 618 operates the sample transport unit 23 via the control line 28 to transport the sample container 30 to the sample extracting unit 22. In the sample extracting section 22, only the liquid component is extracted from the sample container 30 and discharged to the secondary sample container 31, as in the example of FIG. At this time, the amount of the extracted liquid component is supplied from the arithmetic control unit 621 to the memory 615. Next, the analysis instruction unit 618
Performs an analysis instruction based on the inspection request information. That is,
In step 100 of FIG. 5, the analysis instruction unit 618
The remaining sample amount α stored in the memory 615 is read. Then, in step 101, the usage amount calculation unit 619 integrates the required sample amount β in the test item of the test request information from the sample amount table 620 and supplies the integrated value to the analysis instruction unit 618. Next, in step 102, the analysis instruction unit 618 determines whether the remaining sample amount α is larger than the required sample amount β. If the remaining sample amount α is smaller than the required sample amount β, the usage amount calculation unit 619 supplies the sample usage amount to the calibration unit 616. The calibration unit 616 subtracts the used amount of the sample from the remaining amount of the sample stored in the memory 615, and stores the result of the subtraction in the memory 615. Next, the process proceeds to step 104, where the display 29
To display an alarm and warn the operator. In step 102, if the remaining sample amount α is larger than the required sample amount β,
Proceed to step 103. In this step 103,
The analysis instruction section 618 operates the transport section 23 to transport the sample container 31 to the test sections 24 and 25. Then, in each of the test sections 24 and 25, only a necessary amount of the sample is extracted from the sample container 31, and the test is performed. When the test is completed, the sample container 31 is transported to the sample reservoir 26.

When a test request is made again for the sample in the sample storage section 26, the control section 61A confirms that the sample in an amount required for the test item remains in the secondary container 31, The confirmed sample is transported to the inspection units 24 and 25 by the sample transport unit 23. Then, an inspection is performed.

As described above, according to the example of FIG. 3, there is provided an automatic analyzer in which a plurality of inspection units are combined to execute a plurality of types of inspection items. It is possible to realize an automatic analyzer having improved efficiency, capable of detecting an accurate liquid component amount, and having a function of automatically grasping and managing an accurate remaining liquid component amount after completion of an inspection.

[0029]

Since the present invention is configured as described above, it has the following effects. A suction / discharge mechanism having a nozzle, a pressure detector for detecting a suction / discharge pressure, a nozzle moving means, a nozzle position determination unit, a storage unit for storing a liquid component amount, and a nozzle for performing a suction operation on a sample container. Then, it is determined that the nozzle has moved from the upper surface of the liquid component in the sample container to the upper surface of the solid component, and the amount of the sucked liquid component is calculated from the operation amount of the suction and discharge mechanism during this movement, and stored in the storage unit. And an operation control unit for causing the operation to be performed. Therefore, it is possible to realize an automatic analyzer in which the efficiency of extraction of the liquid component and the detection of the amount of the extracted liquid component are improved, and the accuracy of detecting the amount of the liquid component is improved.

Further, in the above automatic analyzer, a light emitting means for irradiating light to the transparent container from which the liquid component has been discharged,
A photoelectric conversion unit in which light from the light emitting unit is irradiated through the transparent container, a liquid amount calculation unit that calculates a liquid component amount in the transparent container based on a signal from the photoelectric conversion unit, and a storage unit that is stored in the storage unit. And the calibration unit for updating the calculated liquid component amount to the calculated liquid component amount, the efficiency of extraction of the liquid component and detection of the liquid component amount is improved, and an accurate liquid component amount is obtained. It is possible to realize an automatic analyzer that has a function of automatically detecting and managing the accurate remaining liquid component amount after the end of the test, which can be detected.

Also, a sample container placement unit in which a sample container is placed, a sample extraction unit that extracts a liquid component from a sample in the sample container and discharges the sample to a secondary sample container, a plurality of test units, and a secondary sample container. An automatic analyzer having a sample transport unit that transports the sample to the test unit, and a control unit that controls the operations of the sample extraction unit, the test unit, and the sample transport unit. The control unit includes a discharge mechanism, a pressure detector of a suction / discharge mechanism, and a nozzle moving unit. The control unit includes a nozzle position determination unit, a storage unit that stores a liquid component amount, and a sample that performs a suction operation on the nozzle. Move to the opening of the container,
An arithmetic control unit that determines that the nozzle has moved from the upper surface of the liquid component to the upper surface of the solid component of the sample container, calculates the amount of the sucked liquid component from the operation amount of the suction and discharge mechanism during this time, and stores the calculated amount in the storage unit; And a calibration unit for subtracting the calculated amount of use from the stored liquid component amount and updating the same. Therefore, it has a plurality of inspection units, the efficiency of extracting the liquid component and detecting the amount of the extracted liquid component is improved, the accuracy of detecting the liquid component amount is improved, and the accurate remaining liquid component amount after the inspection is completed is improved. Thus, it is possible to realize an automatic analyzer having a function of automatically grasping and managing.

[Brief description of the drawings]

FIG. 1 is a schematic diagram of a main part of an embodiment of the present invention.

FIG. 2 is a functional block diagram of a control unit in the example of FIG.

FIG. 3 is a schematic configuration diagram of another embodiment of the present invention.

FIG. 4 is a functional block diagram of a control unit in the example of FIG.

FIG. 5 is a schematic operation flowchart of the example of FIG. 3;

FIG. 6 shows a case where a solid component is inclined with respect to a sample container.
It is explanatory drawing about detection of a liquid component amount.

[Explanation of symbols]

 Reference Signs List 21 Sample installation part 22 Sample extraction part 23 Sample transport part 24 Inspection part 25 Inspection part 26 Sample accumulation part 29 Alarm display part 30 Sample container 31 Secondary sample container 40 Nozzle up / down drive motor 41 Dispensing nozzle 42 Sample container 43 Liquid component 44 Separating agent 45 Solid component 46 Secondary sample container 47 Syringe 48 Syringe drive motor 50 Pressure detector 51 Driving pattern at nozzle tip 52 Syringe operation pattern 55 Nozzle moving motor 56 Extraction amount 57 light emitting lamp 58 parallel light conversion lens 59 photoelectric converter 61, 61A control unit 62 filter 63 tube 66 console 611 nozzle position determination unit 612 arithmetic control unit 613 nozzle drive unit 614 syringe drive unit 615 memory 616 calibration unit 617 liquid volume Calculation unit 618 Analysis instruction unit 619 Usage calculation unit 62 Amount of specimen table

──────────────────────────────────────────────────続 き Continuation of front page (56) References JP-A-2-195261 (JP, A) JP-A-61-202165 (JP, A) JP-A-62-21063 (JP, A) JP-A-3-202 24461 (JP, A) JP-A 2-122354 (JP, U) (58) Fields investigated (Int. Cl. ⁶ , DB name) G01N 35/00-35/08 G01N 1/00 101

Claims (6)

(57) [Claims] 1. A sample container in which a sample in which a solid component and a liquid component are separated is housed, a nozzle, and a suction and discharge mechanism for suctioning and discharging the liquid component by the nozzle; A pressure detector for detecting the suction / discharge pressure, a nozzle moving means for moving the nozzle, a nozzle position determining unit for determining the position of the nozzle based on a detection signal from the pressure detector, and a liquid component extracted from the sample container. The nozzle is moved to the opening of the sample container while performing the suction operation by the storage unit for storing the amount, the suction / ejection mechanism and the nozzle moving means, and the nozzle is moved to the liquid in the sample container by the position signal from the determination unit. It is determined that the liquid has moved from the upper surface of the component to the upper surface of the solid component, and the amount of the liquid component sucked by the suction and discharge mechanism is calculated from the operation amount of the suction and discharge mechanism during this movement. An automatic control device for storing an amount of components in the storage unit, and an operation control unit for moving a nozzle from inside the sample container to outside by a nozzle moving unit. 2. The automatic analyzer according to claim 1, wherein the sucked liquid component is discharged into a transparent container, and light emitting means for irradiating the transparent container with light; and light from the light emitting means is used for the transparent container. A photoelectric conversion unit that is radiated through the liquid crystal unit, a liquid amount calculation unit that calculates an amount of the liquid component in the transparent container based on a signal from the photoelectric conversion unit, and a liquid component amount stored in the storage unit. An automatic analyzer, further comprising: a calibration unit that updates the amount of the liquid component calculated by the amount calculation unit. 3. A sample container placement section in which a sample container containing a sample in which a solid component and a liquid component are separated is placed,
A sample extraction unit that extracts a liquid component from a sample contained in a sample container and discharges the liquid component to a secondary sample container, a plurality of inspection units that test the sample, and a sample transport that transports the secondary sample container to the inspection unit A control unit that controls the operation of the sample extraction unit, the plurality of test units, and the sample transport unit, wherein the sample extraction unit has a nozzle, and the liquid A suction / discharge mechanism for suctioning / discharging the component, a pressure detector for detecting a suction / discharge pressure of the suction / discharge mechanism, and a nozzle moving means for moving a nozzle; A nozzle position determining unit that determines the position of the nozzle based on the detection signal, a storage unit that stores the amount of the liquid component extracted from the sample container, and a suction / ejection mechanism and a nozzle moving unit that causes the nozzle to perform a suction operation. Inspection Moved to the opening of the container, it is determined from the position signal from the determination unit that the nozzle has moved from the upper surface of the liquid component in the sample container to the upper surface of the solid component, from the amount of operation of the suction and ejection mechanism during this movement Calculating a liquid component amount sucked by the suction / ejection mechanism, storing the calculated liquid component amount in the storage unit, and moving the nozzle from the inside of the sample container to the outside by the nozzle moving means, An analysis instructing unit that instructs the operation of the testing unit and the sample transport unit, a usage calculating unit that calculates a sample usage in each testing unit, and the usage calculated by the usage calculating unit is stored in the storage unit. An automatic analyzer, comprising: a calibration unit that updates by subtracting from a liquid component amount. 4. The automatic analyzer according to claim 3, wherein
The sucked liquid component is discharged into the transparent container, the light emitting means for irradiating the transparent container with light, the light from the light emitting means, the photoelectric conversion means for irradiating through the transparent container, and the light from the photoelectric conversion means And a liquid amount calculation unit for calculating the amount of the liquid component in the transparent container based on the signal of (a), and a sample amount measuring means in the secondary container having the liquid component stored in the storage unit. The amount is updated to the liquid component amount calculated by the liquid amount calculation unit, and every time the liquid component in the secondary sample container is used for the test, the sample amount in the secondary container
An automatic analyzer for detecting an amount of a liquid component remaining in a secondary sample container. 5. The automatic analyzer according to claim 3, wherein
The analysis instruction unit compares the sample usage amount calculated by the usage amount calculation unit with the residual liquid component amount in the secondary sample container, and when the residual liquid component amount is smaller than the sample usage amount, An automatic analyzer, wherein the operation of the inspection unit is stopped. 6. The automatic analyzer according to claim 5, wherein
The automatic analyzer, wherein the analysis instructing unit performs an alarm display on the display unit when the amount of the remaining liquid component is smaller than the used amount of the sample.