JP2024008170A - toothpaste - Google Patents

Abstract

[Problem] To provide a toothpaste that is extremely unlikely to cause chronic toxicity through long-term ingestion, is made of naturally occurring ingredients and is virtually harmless to the human body, does not contain abrasives, and can whiten teeth while remineralizing and regenerating the gums without grinding the teeth. [Solution] A toothpaste that contains fossil coral powder, which is a porous material with a median particle size of 3 μm, hydroxyapatite, which is a porous material with a median particle size of 6 μm and has amphoteric ion exchange properties, a moisturizing agent with mutans antibacterial properties and anti-inflammatory properties, a binder containing cellulose gum and silica, and calcium, phosphorus, and magnesium. [Selected Figure] Figure 2

Description

TECHNICAL FIELD This disclosure relates to dentifrices. More specifically, the present invention relates to a toothpaste that is made of naturally derived ingredients, is virtually harmless to the human body, and can whiten teeth while remineralizing and regenerating the gums without damaging the teeth.

Generally, toothpastes contain synthetic surfactants such as sodium lauryl sulfate, synthetic sweeteners such as sodium saccharin, humectants such as propylene glycol, and preservatives such as parabens. It has been pointed out that all of these may be harmful to the human body.

For example, Patent Document 1 discloses a toothpaste containing sodium laurate, propylene glycol, and paraben.

JP 2021-4209 Publication

In general, the oral mucosa of the human body absorbs about 10 to 20 times more components than the human skin. Teeth brushing is generally done multiple times a day, although there are individual differences, and even though the amount of harmful substances absorbed each time is small, there are warnings about chronic toxicity due to long-term ingestion. Therefore, depending on the toothpaste, it may have a harmful effect on the human body depending on the number of years of use.

For example, sodium lauryl sulfate, which is widely used in topical pharmaceutical preparations, is a moderately toxic substance with acute toxicity including irritation to the skin, eyes, mucous membranes, upper respiratory tract, and stomach. Repeated and long-term exposure to dilute solutions can cause contact dermatitis, including dryness and cracking of the skin. Animal studies have also shown that intravenous injection causes significant toxicity to the lungs, kidneys, and liver.

Furthermore, for example, it is known that when parabens are irradiated with ultraviolet rays, the mortality rate of skin cells and the amount of lipid peroxides in the area to which they are applied triple, leading to skin aging. Additionally, parabens are easily absorbed through the skin and are known to cause skin problems such as rough skin and allergies. Parabens are also substances that accumulate in the body. Furthermore, research results have been reported in which parabens were detected in the cell tissues of cancer patients, and although the carcinogenicity of parabens accumulated in the body has not been fully proven, it is still considered a problem.

Additionally, it has been pointed out that fluoride may affect intellectual development. For example, it has been reported that there is an inverse correlation between a mother's urinary fluoride concentration during pregnancy and her child's intellectual development index (MDI) from 1 to 3 years of age.

Other known risk ingredients that may be included in common toothpastes include sodium lauroylsarcosine, cetylpyridinium chloride, and isopropylmethylphenol.

However, until now, the risk of chronic toxicity due to long-term ingestion is extremely low, it is a naturally derived ingredient that is almost harmless to the human body, and it does not contain abrasive materials and does not shave the teeth, but it can remineralize and regenerate the gums. It was not possible to provide a toothpaste that could whiten the teeth.

The present disclosure has been made to solve the above problems. The purpose of the present disclosure is to have an extremely low risk of chronic toxicity due to long-term ingestion, a naturally derived ingredient that is almost harmless to the human body, and a material that does not contain abrasive materials and does not shave teeth, while remineralizing and regenerating the gums. To provide a toothpaste that can whiten teeth.

The toothpaste according to the present disclosure includes:
Fossil coral powder, which is a porous body with a center particle size of 3 μm,
Hydroxyapatite is a porous material with a central particle size of 6 μm and has amphoteric ion exchange properties;
mutans antibacterial and anti-inflammatory properties;
a binder containing cellulose gum and silica;
A toothpaste containing calcium, phosphorus and magnesium.

In one embodiment of the present disclosure, the hydroxyapatite is of a low crystalline type.

In one embodiment of the present disclosure, the hydroxyapatite has a particle size of 17 μm or more and 10% or less.

In one form of the present disclosure, the hydroxyapatite has a palladium removal rate of 99% or more in 100 ml of 5 ppm palladium with 1 gram or less of the hydroxyapatite.

In one form of the present invention, the humectant includes at least two of allantoin, trehalose, and onion root extract.

It is one form of the invention to include a solubilizer comprising propanediol and PEG 40-80 hydrogenated castor oil.

Containing persimmon tannin is one form of the present disclosure.

Including peppermint oil is an aspect of the present disclosure.

Including orange oil is an aspect of the present disclosure.

It is an aspect of the present disclosure that it is free of synthetic surfactants, synthetic sweeteners, propylene glycol and parabens.

It is one form of the present disclosure to include dental pulp-derived stem cells.

The dental pulp-derived stem cells contain PDGF (platelet-derived growth factor), BMP (bone morphogenetic protein), FGF (fibroblast growth factor), IGF (insulin-like growth factor), VEGF (vascular endothelial growth factor), or TGF-β ( Transforming growth factor).

According to the present disclosure, the risk of chronic toxicity due to long-term ingestion is extremely low, it is a naturally derived ingredient and is almost harmless to the human body, and it does not contain abrasives and does not shave teeth, remineralizes and regenerates the gums. A dentifrice that can whiten teeth can be provided.

FIG. 1 is an image taken using a low-acceleration scanning electron microscope showing the surface of an untreated human front tooth. FIG. 2 is an image taken using a low-acceleration scanning electron microscope showing the surface of a human front tooth after treatment. FIG. 3 is a diagram showing the results of a heavy metal adsorption test. FIG. 4 is a diagram showing the results of a palladium heavy metal adsorption test. FIG. 5 is a diagram showing the results of a malodorous substance adsorption test. FIG. 6 is an image showing the surface of a human deciduous tooth before spreading. FIG. 7 is an image showing the surface of a human deciduous tooth after spreading. FIG. 8 is an image showing the surface of a human deciduous tooth after spreading in a comparative example. FIG. 9 is a diagram showing the results of polishing tests of various materials containing the toothpaste that does not contain an abrasive of the present invention.

Embodiments will be described with appropriate reference to the accompanying drawings. In each figure, the same or corresponding parts are given the same reference numerals. Duplicate explanations of the relevant parts will be simplified or omitted as appropriate.

The dentifrice of the present invention contains fossilized coral powder, which is a porous body with a center particle size of 3 μm. Since fossil coral powder is porous, it can absorb stains, bacteria, pigments, odors, and heavy metals in the oral cavity.

The fossil coral powder contains 35% to 45% by weight of calcium and 45% to 49% by weight of carbonate. Furthermore, fossil coral powder contains all the so-called essential minerals sodium, magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, cobalt, copper, zinc, selenium, molybdenum, and iodine. This allows the user of the dentifrice of the present invention to absorb essential minerals from the oral mucosa every time the user brushes their teeth.

The fossilized coral powder contained in the dentifrice of the present invention can be unfired fossilized coral powder. Thereby, it is possible to obtain a toothpaste containing essential minerals with little alteration or deterioration.

The fossilized coral powder contained in the toothpaste of the present invention is made from fossilized coral that grew in the sea more than 50,000 years ago from 2022, rose up due to subsequent tectonic movements, and fossilized on land. Can be done. This makes it possible to provide a toothpaste that is less likely to be affected by marine pollution. More desirably, from 2022, fossilized coral powder can be obtained from fossilized coral that grew in the sea more than 100,000 years ago, was uplifted by subsequent tectonic movements, and fossilized on land. This makes it possible to create a toothpaste that is less likely to be affected by marine pollution.

The dentifrice of the present invention contains hydroxyapatite, which is a porous material with a central particle size of 6 μm and has amphoteric ion exchange properties. Since the hydroxyapatite contained in the dentifrice of the present invention is porous and has amphoteric ion exchange characteristics, it can react flexibly to other substances.

This not only remineralizes the tooth surface, but also adsorbs all kinds of organic substances such as sugars, proteins, lipids, bacteria, pigments, and odors, and removes them from the oral cavity.

Furthermore, it can adsorb harmful metals such as cadmium, lead, mercury, and palladium. This can prevent allergies caused by the heavy metal palladium used in silver and gold teeth.

The hydroxyapatite contained in the dentifrice of the present invention has an excellent remineralization effect. In order to confirm the excellent remineralization effect of hydroxyapatite contained in the toothpaste of the present invention, the inventors filled the scratches on the tooth surface with fine apatite powder, and then remineralized the tooth with intraoral body fluids. This work was carried out in accordance with the so-called microfilling theory, in which apatite fills in the irregularities on the tooth surface.

FIG. 1 is an image taken using a low-acceleration scanning electron microscope showing the surface of an untreated human front tooth. In this state, as a pretreatment, a paste made by mixing hydroxyapatite contained in the dentifrice of the present invention and the same amount of pure water was applied to the tooth surface, and washed with water after 15 minutes. Thereafter, hydroxyapatite contained in the dentifrice of the present invention was applied, and 15 minutes later, it was washed with water. Thereafter, they were immersed in a simulated body fluid containing Tris, sodium chloride, and magnesium chloride at 37 degrees Celsius for two days.

After these series of treatments, the tooth surface was observed again using a low-acceleration scanning electron microscope. FIG. 2 is an image taken using a low-acceleration scanning electron microscope showing the surface of a human front tooth after treatment. As shown in Figure 2, fine apatite particles adhere to the tooth surface and remineralize it. This revealed that the hydroxyapatite contained in the dentifrice of the present invention has an excellent remineralization effect.

According to one example, the hydroxyapatite contained in the dentifrice of the present invention can have a particle size of 17 μm or more and 10% or less. This allows more apatite to adhere to the tooth surface as fine particles, further enhancing the remineralization effect.

The hydroxyapatite contained in the dentifrice of the present invention has an excellent ability to adsorb oral bacteria. The inventors conducted an oral bacteria adsorption test on hydroxyapatite contained in the dentifrice of the present invention.

In the adsorption test, the subjects first gargled with water, and the vomit was used as a bacterial solution. The bacterial solution contained approximately 150 bacteria per milliliter. Next, 300 mg of hydroxyapatite contained in the dentifrice of the present invention was added to 10 ml of the bacterial solution and stirred. After that, when the precipitate settled out, the tap water was taken and the number of bacteria was confirmed, and it was found that the number of bacteria was about 1 per milliliter.

Therefore, the adsorption rate of bacteria was 99% or more. This revealed that the hydroxyapatite contained in the dentifrice of the present invention has an excellent ability to adsorb oral bacteria.

The hydroxyapatite contained in the dentifrice of the present invention has an excellent ability to adsorb heavy metals. The inventors conducted a heavy metal adsorption test on hydroxyapatite contained in the dentifrice of the present invention.

The adsorption test was conducted using standard solutions in which each of the elements cadmium, mercury, and lead was adjusted to 5 ppm. Two sheets of impregnated paper impregnated with hydroxyapatite contained in the dentifrice of the present invention were set in a funnel, and 30 ml of the standard solution was passed through it for measurement.

FIG. 3 is a diagram showing the results of a heavy metal adsorption test. As shown in FIG. 3, the adsorption rate of cadmium was 92%, the adsorption rate of mercury was 88%, and the adsorption rate of lead was 96%. This revealed that the hydroxyapatite contained in the dentifrice of the present invention has an excellent ability to adsorb heavy metals.

The hydroxyapatite contained in the dentifrice of the present invention has an excellent ability to adsorb palladium heavy metals. The inventors conducted a palladium heavy metal adsorption test on hydroxyapatite contained in the dentifrice of the present invention.

The adsorption test was conducted using a standard solution in which palladium was adjusted to 5 ppm. 100 ml of this standard solution is placed in a beaker and maintained at 37 degrees Celsius in a water bath. One gram of hydroxyapatite contained in the dentifrice of the present invention was added thereto and stirred. The solution stirred for 1 minute and the solution stirred for 3 minutes were each filtered. The palladium concentration of each of the passed solutions was measured by ICP.

FIG. 4 is a diagram showing the results of a palladium heavy metal adsorption test. As shown in FIG. 4, the adsorption rate of palladium heavy metal was 99% or more in both the solution stirred for 1 minute and the solution stirred for 3 minutes. This revealed that the hydroxyapatite contained in the dentifrice of the present invention has an excellent ability to adsorb palladium heavy metals.

The hydroxyapatite contained in the dentifrice of the present invention has an excellent ability to adsorb malodorous substances. The inventors conducted a malodorous substance adsorption test on hydroxyapatite contained in the dentifrice of the present invention.

The adsorption test was conducted using standard solutions in which ammonia was adjusted to 18 ppm, trimethylamine to 11 ppm, and n-butyric acid to 9 ppm. 100 ml of this standard solution is placed in a beaker and maintained at 37 degrees Celsius in a water bath. One gram of hydroxyapatite contained in the dentifrice of the present invention was added thereto and stirred for 60 minutes. After stirring, the solution was filtered and measured.

FIG. 5 is a diagram showing the results of a malodorous substance adsorption test. As shown in FIG. 5, the adsorption rate of ammonia was 72%, the adsorption rate of trimethylamine was 82%, and the adsorption rate of n-butyric acid was 56%. This revealed that the hydroxyapatite contained in the dentifrice of the present invention has an excellent ability to adsorb malodorous substances.

According to one example, the hydroxyapatite included in the dentifrice of the present invention can be in a low crystalline form. The inventors confirmed the remineralization effect of low-crystalline hydroxyapatite contained in the dentifrice of the present invention.

FIG. 6 is an image showing the surface of a human deciduous tooth before spreading. Low-crystalline hydroxyapatite contained in the dentifrice of the present invention was applied to the surface of human deciduous primary teeth and left overnight. After rinsing with tap water, the surface was brushed 10 times with a toothbrush. Washed again with tap water. After drying, the surface after the spreading treatment was observed using an electron microscope.

FIG. 7 is an image showing the surface of a human deciduous tooth after spreading. As shown in FIG. 7, it can be seen that the low-crystalline hydroxyapatite contained in the dentifrice of the present invention neatly fills the fine grooves formed on the tooth surface.

As a comparative example, a treatment similar to the above-mentioned spreading treatment was performed using general crystalline hydroxyapatite. FIG. 8 is an image showing the surface of a human deciduous tooth after spreading in a comparative example. As shown in FIG. 8, it can be seen that more fine scratches formed on the tooth surface remain compared to the low-crystalline hydroxyapatite contained in the dentifrice of the present invention.

This shows that, according to the example of low-crystalline hydroxyapatite contained in the dentifrice of the present invention, a very excellent remineralization effect can be expected.

The dentifrice of the present invention comprises a humectant with mutans antibacterial and anti-inflammatory properties. Onion root extract (quercetin) can be used as a humectant with S. mutans antibacterial properties. Onion root extract (quercetin) has excellent antibacterial, anti-inflammatory and antioxidant properties. Onion root extract (quercetin) is extracted by boiling the outer skin of onions, so it is a naturally derived ingredient and can be said to be extremely safe.

According to one example, the humectant may include allantoin. Allantoin has anti-inflammatory effects and is an effective ingredient for oral bleeding. Allantoin is extracted from plant leaves, roots, and grain germs, and is a naturally derived ingredient that is extremely safe. According to a further example, the wetting agent may include trehalose. Trehalose is extracted from corn starch, is a naturally derived ingredient, and is extremely safe.

The dentifrice of the present invention comprises a binder comprising cellulose gum and silica. Cellulose gum and silica are extracted from naturally derived materials such as pulp, and highly safe adhesives can be used.

According to one example, the dentifrice of the present invention may include a solubilizer comprising propanediol and PEG 40-80 hydrogenated castor oil. It is possible to use highly safe solubilizers extracted from naturally derived materials such as sugarcane and castor oil.

According to one example, the dentifrice of the present invention may contain persimmon tannin. Persimmon tannin has excellent deodorizing and antibacterial effects. Persimmon tannin is extracted from persimmons, is a naturally derived ingredient, and is extremely safe. Thereby, a toothpaste containing a highly safe deodorant antibacterial agent can be provided.

According to one example, the dentifrice of the invention may contain peppermint oil as a flavoring agent. Peppermint oil is extracted from natural peppermint, is a naturally derived ingredient, and is extremely safe. Thereby, a toothpaste containing a highly safe flavoring agent can be provided.

According to one example, the dentifrice of the invention may include orange oil as a flavoring agent. Orange oil is extracted from natural oranges, is a naturally derived ingredient, and is extremely safe. Thereby, a toothpaste containing a highly safe flavoring agent can be provided. It is especially useful as a toothpaste for children who do not like peppermint.

According to one example, the dentifrice of the present invention may include sodium bicarbonate as a pH adjusting agent. Sodium bicarbonate can have baking soda used in food. Thereby, a toothpaste containing a highly safe pH adjuster can be provided. By making the toothpaste slightly alkaline, the decomposition of stains (especially proteins) is promoted. Moreover, the effect of lifting and removing coloring becomes higher. The cleaning effect is 1.5 times greater than that of neutral toothpaste. Thereby, it is possible to provide a toothpaste that is highly safe and highly effective for cleaning the oral cavity.

According to one example, the dentifrice of the invention may contain phenoxyethanol as a preservative. Phenoxyethanol can be extracted from Gyokuro and other tea leaves. It is a naturally derived ingredient and is extremely safe. Thereby, a toothpaste containing a highly safe preservative can be provided.

According to one example, the dentifrice of the present invention may be free of synthetic surfactants, synthetic sweeteners, propylene glycol, and parabens. This makes it possible to avoid chronic toxicity due to long-term use and provide an extremely safe toothpaste.

According to one example, the dentifrice of the present invention may be free of abrasives. It can be used as a toothpaste that removes dirt and stains by adsorption without polishing, promotes remineralization, and whitens teeth. The non-abrasive toothpaste of the present invention has an excellent effect of smoothing tooth surfaces.

The inventors conducted an abrasive test on the abrasive-free toothpaste of the present invention. The polishing test proceeded as follows. First, Flow Plus . Next, the hard resin after polishing was applied to various materials, gel toothpaste (without abrasive) A, treatment paste (without abrasive) B, paste toothpaste (with abrasive) C, and the polishing of the present invention. 0.1 g of each of dentifrice-free dentifrice D and dentifrice-free E was applied, and polished (secondary polishing) using a handy motor at a rotational speed of 1920 rms for 1 minute. After the second polishing, the surface roughness was measured again using a non-contact three-dimensional measuring device.

FIG. 9 is a diagram showing the results of polishing tests of various materials containing the toothpaste that does not contain an abrasive of the present invention. Various materials: Gel-like toothpaste (without abrasives) A, treatment paste (without abrasives) B, paste toothpaste (with abrasives) C, toothpaste D without abrasives of the present invention, and toothpaste The results of the first polishing and second polishing without E are shown by A to E, respectively.

As shown in Figure 9, gel-like toothpaste (without abrasives) A, treatment paste (without abrasives) B, and paste toothpaste (with abrasives) C have surface roughness due to secondary polishing. has increased significantly. On the other hand, the surface roughness of the toothpaste D which does not contain an abrasive of the present invention hardly increases after the second polishing.

As a result, according to the example of the non-abrasive toothpaste of the present invention, it is possible to remove dirt and stains by adsorption without polishing, promote remineralization, and whiten teeth. It can be seen that an excellent effect on smoothing the surface can be expected.

According to one example, the dentifrice of the present invention may include dental pulp-derived stem cells. In addition, dental pulp-derived stem cells contain PDGF (platelet-derived growth factor), BMP (bone morphogenetic protein), FGF (fibroblast growth factor), IGF (insulin-like growth factor), VEGF (vascular endothelial growth factor), or TGF-β. (Transforming growth factors).

According to the dentifrice containing the dental pulp-derived stem cells of the present invention, it is possible to provide a dentifrice that can be expected to have the effect of alleviating nervous system diseases and pain every time you brush your teeth.

According to the embodiment described above, the risk of chronic toxicity due to long-term ingestion is extremely low, the ingredients are of natural origin and are almost harmless to the human body, and they do not contain abrasives and can remineralize without cutting teeth. At the same time, it is possible to provide a toothpaste that can whiten teeth while regenerating the gums.

While several aspects of at least one embodiment have been described, it is to be understood that various alterations, modifications, and improvements will readily occur to those skilled in the art. Such alterations, modifications, and improvements are intended to be part of, and are intended to be within the scope of, this disclosure.

It should be understood that the method and apparatus embodiments described herein are not limited to application to the details of structure and arrangement of components described in the foregoing description or illustrated in the accompanying drawings. The methods and apparatus may be implemented in other embodiments and of being practiced or carried out in various ways.

Specific implementations are provided herein for illustrative purposes only and are not intended to be limiting.

The expressions and terminology used in this disclosure are for descriptive purposes and should not be considered limiting. The use of "comprising," "comprising," "having," "including" and variations thereof herein means the inclusion of the items listed below and their equivalents and additional items.

References to "or" shall be construed to mean that any term listed using "or" refers to one, more than one, and all of the listed terms. can be done.

References to front and back, left and right, top and bottom, horizontal and vertical, and front and back are intended for convenience of description. Such reference is not intended to limit the components of the present disclosure to any one positional or spatial orientation. Accordingly, the above description and drawings are illustrative only.

Claims (12)

Fossil coral powder, which is a porous body with a center particle size of 3 μm,
Hydroxyapatite is a porous material with a central particle size of 6 μm and has amphoteric ion exchange properties;
mutans antibacterial and anti-inflammatory properties;
a binder containing cellulose gum and silica;
Toothpaste with calcium, phosphorus and magnesium. The dentifrice according to claim 1, wherein the hydroxyapatite is of a low crystalline type. The toothpaste according to claim 1, wherein the hydroxyapatite has a particle size of 17 μm or more and 10% or less. The toothpaste according to claim 1, wherein the hydroxyapatite has a palladium removal rate of 99% or more in 100 ml of 5 ppm palladium with 1 gram or less of the hydroxyapatite. The toothpaste according to claim 1, wherein the humectant includes at least two of allantoin, trehalose, and onion root extract. The dentifrice of claim 1, comprising a solubilizer comprising propanediol and PEG 40-80 hydrogenated castor oil. The toothpaste according to claim 1, containing persimmon tannin. The toothpaste according to claim 1, comprising peppermint oil. The toothpaste according to claim 1, comprising orange oil. The toothpaste according to claim 1, which does not contain synthetic surfactants, synthetic sweeteners, propylene glycol, and parabens. The toothpaste according to claim 1, which contains dental pulp-derived stem cells. The dental pulp-derived stem cells contain PDGF (platelet-derived growth factor), BMP (bone morphogenetic protein), FGF (fibroblast growth factor), IGF (insulin-like growth factor), VEGF (vascular endothelial growth factor), or TGF-β ( The dentifrice according to claim 1, comprising at least one of the following: (transforming growth factor).

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